Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLS3 Gene

Aliases for PLS3 Gene

  • Plastin 3 2 3 5
  • T-Plastin 3 4
  • Plastin 3 (T Isoform) 2
  • T Fimbrin 3
  • T Plastin 3
  • Plastin-3 3
  • BMND18 3

External Ids for PLS3 Gene

Previous GeneCards Identifiers for PLS3 Gene

  • GC0XP109814
  • GC0XP111920
  • GC0XP112831
  • GC0XP113559
  • GC0XP114618
  • GC0XP114795
  • GC0XP104379

Summaries for PLS3 Gene

Entrez Gene Summary for PLS3 Gene

  • Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

GeneCards Summary for PLS3 Gene

PLS3 (Plastin 3) is a Protein Coding gene. Diseases associated with PLS3 include Bone Mineral Density Quantitative Trait Locus 18 and Sezary's Disease. Gene Ontology (GO) annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is LCP1.

UniProtKB/Swiss-Prot for PLS3 Gene

  • Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Gene Wiki entry for PLS3 Gene

Additional gene information for PLS3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLS3 Gene

Genomics for PLS3 Gene

GeneHancer (GH) Regulatory Elements for PLS3 Gene

Promoters and enhancers for PLS3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ115559 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 665.1 +1.2 1169 5.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 YY1 GLIS2 ZNF213 FOS PLS3 PLS3-AS1 API5P1 LRCH2
GH0XJ115591 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.3 +32.5 32526 4.6 SCRT1 SRF ZNF768 TAF1 ZNF189 JUN ZNF398 PRDM6 POLR2A SCRT2 PLS3 PIR39078 PLS3-AS1
GH0XJ115581 Enhancer 0.8 Ensembl ENCODE 0.3 +22.3 22326 2.9 ZNF639 PKNOX1 MZF1 OSR2 PRDM6 IKZF1 IKZF2 RUNX3 PRDM1 TRIM28 PLS3 PLS3-AS1 PIR39078
GH0XJ115613 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.2 +55.3 55287 4.3 SIN3A FEZF1 BATF IRF4 ZNF366 ATF7 FOS ETV6 IKZF2 RUNX3 PIR39078 PLS3-AS1 PLS3
GH0XJ115604 Enhancer 0.6 ENCODE 0.3 +42.3 42314 0.2 ZBTB21 JUN CEBPB ZEB1 ZNF335 PRDM6 ZNF366 ZNF629 WT1 SP7 PIR39078 PLS3 PLS3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLS3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLS3 gene promoter:
  • AREB6
  • Nkx2-5
  • GATA-3
  • GATA-2
  • GATA-1
  • Evi-1
  • FOXO1a
  • RSRFC4
  • FOXO1
  • HOXA5

Genomic Locations for PLS3 Gene

Genomic Locations for PLS3 Gene
90,012 bases
Plus strand
90,005 bases
Plus strand

Genomic View for PLS3 Gene

Genes around PLS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLS3 Gene

Proteins for PLS3 Gene

  • Protein details for PLS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K579
    • B1AQ09
    • B4DGB4
    • B7Z6M1
    • Q86YI6

    Protein attributes for PLS3 Gene

    630 amino acids
    Molecular mass:
    70811 Da
    Quaternary structure:
    • Monomer.
    • Sequence=CAI39884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLS3 Gene

    Alternative splice isoforms for PLS3 Gene


neXtProt entry for PLS3 Gene

Post-translational modifications for PLS3 Gene

  • Ubiquitination at isoforms=2, 3437, Lys382, isoforms=2, 3300, isoforms=2, 3168, isoforms=2, 3100, Lys59, and Lys52
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PLS3 Gene

Domains & Families for PLS3 Gene

Gene Families for PLS3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLS3: view

No data available for UniProtKB/Swiss-Prot for PLS3 Gene

Function for PLS3 Gene

Molecular function for PLS3 Gene

UniProtKB/Swiss-Prot Function:
Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Gene Ontology (GO) - Molecular Function for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with PLS3: view
genes like me logo Genes that share phenotypes with PLS3: view

Human Phenotype Ontology for PLS3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLS3 Gene

MGI Knock Outs for PLS3:
  • Pls3 Pls3<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLS3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for PLS3 Gene

Localization for PLS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLS3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLS3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 4
peroxisome 2
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
GO:0005884 actin filament IBA --
GO:0005886 plasma membrane IDA --
GO:0032432 actin filament bundle IBA --
genes like me logo Genes that share ontologies with PLS3: view

Pathways & Interactions for PLS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051017 actin filament bundle assembly IBA --
GO:0051639 actin filament network formation IBA --
GO:0051764 actin crosslink formation IBA --
GO:0060348 bone development IMP 24088043
genes like me logo Genes that share ontologies with PLS3: view

No data available for Pathways by source and SIGNOR curated interactions for PLS3 Gene

Drugs & Compounds for PLS3 Gene

No Compound Related Data Available

Transcripts for PLS3 Gene

Unigene Clusters for PLS3 Gene

Plastin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLS3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLS3 Gene

No ASD Table

Relevant External Links for PLS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLS3 Gene

This gene is overexpressed in Artery - Aorta (x6.3) and Artery - Tibial (x5.0).

Protein differential expression in normal tissues from HIPED for PLS3 Gene

This gene is overexpressed in Amniocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLS3 Gene

Protein tissue co-expression partners for PLS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLS3 Gene:


SOURCE GeneReport for Unigene cluster for PLS3 Gene:


mRNA Expression by UniProt/SwissProt for PLS3 Gene:

Tissue specificity: Expressed in a variety of organs, including muscle, brain, uterus and esophagus.

Evidence on tissue expression from TISSUES for PLS3 Gene

  • Nervous system(5)
  • Skin(4.7)
  • Kidney(4.6)
  • Liver(4.4)
  • Lung(3.7)
  • Intestine(2.4)
  • Blood(2.2)
  • Spleen(2.2)
  • Thyroid gland(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PLS3 Gene

Germ Layers:
  • mesoderm
  • skeleton
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with PLS3: view

Orthologs for PLS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLS3 34 33
  • 99.61 (n)
(Monodelphis domestica)
Mammalia PLS3 34
  • 95 (a)
(Bos Taurus)
Mammalia PLS3 34 33
  • 94.71 (n)
(Canis familiaris)
Mammalia PLS3 34 33
  • 93.54 (n)
(Rattus norvegicus)
Mammalia Pls3 33
  • 91.22 (n)
(Mus musculus)
Mammalia Pls3 16 34 33
  • 90.79 (n)
(Ornithorhynchus anatinus)
Mammalia PLS3 34
  • 84 (a)
(Gallus gallus)
Aves PLS3 34 33
  • 82.11 (n)
(Anolis carolinensis)
Reptilia PLS3 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pls3 33
  • 79.09 (n)
Str.17623 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68681 33
(Danio rerio)
Actinopterygii pls3 34 33
  • 74.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fim 34 35
  • 52 (a)
(Caenorhabditis elegans)
Secernentea Y104H12BR.1 35
  • 59 (a)
plst-1 34
  • 52 (a)
Y104H12BL.1 35
  • 51 (a)
Y73B3B.1 34 35
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC6 36 34
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G48460 33
  • 53.58 (n)
(Oryza sativa)
Liliopsida Os01g0514600 33
  • 50.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8022 34
  • 49 (a)
Cin.4644 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4644 33
Species where no ortholog for PLS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLS3 Gene

Gene Tree for PLS3 (if available)
Gene Tree for PLS3 (if available)
Evolutionary constrained regions (ECRs) for PLS3: view image

Paralogs for PLS3 Gene

Paralogs for PLS3 Gene

(2) SIMAP similar genes for PLS3 Gene using alignment to 9 proteins:

  • A7E2S2_HUMAN
  • B4DI60_HUMAN
  • B7Z6M1_HUMAN
  • F2Z2Z9_HUMAN
  • F8W8D8_HUMAN
  • H7C4N2_HUMAN
genes like me logo Genes that share paralogs with PLS3: view

Variants for PLS3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PLS3 Gene

Genetic variations in PLS3 define the bone mineral density quantitative trait locus 18 (BMND18) [MIM:300910]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.

Sequence variations from dbSNP and Humsavar for PLS3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs140121121 association, Bone mineral density quantitative trait locus 18 115,629,281(+) T/A coding_sequence_variant, synonymous_variant
rs397518421 association, Bone mineral density quantitative trait locus 18 115,646,495(+) C/T coding_sequence_variant, stop_gained
rs397518463 association, Bone mineral density quantitative trait locus 18 115,622,405(+) TTT/TT coding_sequence_variant, frameshift, intron_variant
VAR_035462 A breast cancer sample p.Asp488Ala
rs1000058798 -- 115,636,156(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLS3 Gene

Variant ID Type Subtype PubMed ID
esv2666518 CNV deletion 23128226
esv33994 CNV gain+loss 17666407
esv3559212 CNV deletion 23714750
esv3577051 CNV gain 25503493

Variation tolerance for PLS3 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 13.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLS3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for PLS3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for PLS3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PLS3 in MalaCards View complete list of genes associated with diseases


  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269 PubMed:24088043}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for PLS3

genes like me logo Genes that share disorders with PLS3: view

No data available for Genatlas for PLS3 Gene

Publications for PLS3 Gene

  1. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. (PMID: 8428952) Lin CS … Leavitt J (The Journal of biological chemistry 1993) 2 3 4 58
  2. Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. (PMID: 2378651) Lin CS … Leavitt J (Molecular and cellular biology 1990) 3 4 22 58
  3. PLS3 mutations in X-linked osteoporosis with fractures. (PMID: 24088043) van Dijk FS … Pals G (The New England journal of medicine 2013) 3 4 58
  4. Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma. (PMID: 18569641) Capriotti E … Hess AD (Leukemia & lymphoma 2008) 3 22 58
  5. Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement. (PMID: 15741236) Giganti A … Friederich E (Journal of cell science 2005) 3 22 58

Products for PLS3 Gene

Sources for PLS3 Gene

Loading form....