Aliases for PLRG1 Gene
External Ids for PLRG1 Gene
Previous GeneCards Identifiers for PLRG1 Gene
This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for PLRG1 Gene
PLRG1 (Pleiotropic Regulator 1) is a Protein Coding gene. Diseases associated with PLRG1 include Poikiloderma With Neutropenia. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and transcription corepressor activity. An important paralog of this gene is STRN3.
UniProtKB/Swiss-Prot for PLRG1 Gene
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).