Aliases for PLPPR5 Gene
The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLPPR5 Gene
PLPPR5 (Phospholipid Phosphatase Related 5) is a Protein Coding gene. Diseases associated with PLPPR5 include Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia and Bardet-Biedl Syndrome 10. Among its related pathways are Signaling by GPCR and Lysosphingolipid and LPA receptors. An important paralog of this gene is PLPPR1.
UniProtKB/Swiss-Prot Summary for PLPPR5 Gene
Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.