The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated b... See more...

Aliases for PLPPR5 Gene

Aliases for PLPPR5 Gene

  • Phospholipid Phosphatase Related 5 2 3 5
  • LPPR5 2 3 4
  • PAP2D 2 3 4
  • PRG5 2 3 4
  • Lipid Phosphate Phosphatase-Related Protein Type 5 3 4
  • Phospholipid Phosphatase-Related Protein Type 5 3 4
  • Phosphatidic Acid Phosphatase Type 2d 3 4
  • Plasticity-Related Gene 5 Protein 3 4
  • PRG-5 3 4
  • PAP2 2 3
  • Phosphatidic Acid Phosphatase Type 2 3
  • Phosphatidic Acid Phosphatase 2d 3
  • Plasticity-Related Protein 5 3
  • Plasticity-Related Gene 5 2
  • EC 3.1.3.4 51
  • EC 3.1.3.- 4
  • PLPPR5 5

External Ids for PLPPR5 Gene

Summaries for PLPPR5 Gene

Entrez Gene Summary for PLPPR5 Gene

  • The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLPPR5 Gene

PLPPR5 (Phospholipid Phosphatase Related 5) is a Protein Coding gene. Diseases associated with PLPPR5 include Deafness, Autosomal Dominant 1 and Bardet-Biedl Syndrome 10. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. An important paralog of this gene is PLPPR1.

UniProtKB/Swiss-Prot Summary for PLPPR5 Gene

  • Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPPR5 Gene

Genomics for PLPPR5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLPPR5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J099004 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.7 1682 2.5 TEAD4 ZIC2 EZH2 ZFHX2 CTCF TBP BACH1 L3MBTL2 EGR1 ENSG00000232825 LOC100129620 PLPPR5 lnc-FRRS1-5 SNX7
GH01J099005 Promoter 0.5 EPDnew 600.7 +0.3 324 0.1 TEAD4 EZH2 ENSG00000232825 LOC100129620 PLPPR5 lnc-FRRS1-5 SNX7
GH01J098903 Enhancer 0.6 Ensembl ENCODE 28.3 +102.6 102629 1.4 POLR2A RFX1 CEBPB ZKSCAN1 JUND JUN PLPPR5 SNX7 piR-48222-014 ENSG00000232825 LOC100129620 lnc-SNX7-3
GH01J098920 Enhancer 0.5 Ensembl ENCODE 28.8 +84.9 84930 2.4 JUND GATA3 PLPPR5 SNX7 piR-48222-014 ENSG00000232825 LOC100129620 lnc-SNX7-3
GH01J098906 Enhancer 0.5 Ensembl 26.8 +99.5 99529 1.2 JUN MAFF MAFK TCF7L2 JUND PLPPR5 SNX7 piR-48222-014 LOC100129620 ENSG00000232825 lnc-SNX7-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPPR5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPPR5

Genomic Locations for PLPPR5 Gene

Genomic Locations for PLPPR5 Gene
chr1:98,890,245-99,006,130
(GRCh38/hg38)
Size:
115,886 bases
Orientation:
Minus strand
chr1:99,355,801-99,470,588
(GRCh37/hg19)
Size:
114,788 bases
Orientation:
Minus strand

Genomic View for PLPPR5 Gene

Genes around PLPPR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR5 Gene

Proteins for PLPPR5 Gene

  • Protein details for PLPPR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32ZL2-PLPR5_HUMAN
    Recommended name:
    Phospholipid phosphatase-related protein type 5
    Protein Accession:
    Q32ZL2
    Secondary Accessions:
    • A8MPX4
    • B7UCH3
    • Q32ZD0
    • Q3ZCU7

    Protein attributes for PLPPR5 Gene

    Size:
    321 amino acids
    Molecular mass:
    35427 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40174.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLPPR5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPPR5 Gene

Selected DME Specific Peptides for PLPPR5 Gene

Q32ZL2:
  • PNYTALGC
  • RVAEYRNHWSDV
  • NAGQVVTGN
  • ARKTFPS

Post-translational modifications for PLPPR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPPR5 Gene

Domains & Families for PLPPR5 Gene

Gene Families for PLPPR5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PLPPR5 Gene

InterPro:
Blocks:
  • PA-phosphatase related phosphoesterase
ProtoNet:

Suggested Antigen Peptide Sequences for PLPPR5 Gene

GenScript: Design optimal peptide antigens:
  • Plasticity-related gene 5 protein (LPPR5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q32ZL2

UniProtKB/Swiss-Prot:

PLPR5_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR5: view

Function for PLPPR5 Gene

Molecular function for PLPPR5 Gene

UniProtKB/Swiss-Prot Function:
Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.

Enzyme Numbers (IUBMB) for PLPPR5 Gene

Phenotypes From GWAS Catalog for PLPPR5 Gene

Gene Ontology (GO) - Molecular Function for PLPPR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IBA 21873635
GO:0042577 lipid phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with PLPPR5: view
genes like me logo Genes that share phenotypes with PLPPR5: view

miRNA for PLPPR5 Gene

miRTarBase miRNAs that target PLPPR5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPPR5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLPPR5 Gene

Localization for PLPPR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPPR5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPPR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPPR5: view

Pathways & Interactions for PLPPR5 Gene

genes like me logo Genes that share pathways with PLPPR5: view

Interacting Proteins for PLPPR5 Gene

Gene Ontology (GO) - Biological Process for PLPPR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA 21873635
GO:0007165 signal transduction IBA 21873635
GO:0010976 positive regulation of neuron projection development ISS --
GO:0046839 phospholipid dephosphorylation IBA 21873635
GO:0051491 positive regulation of filopodium assembly ISS --
genes like me logo Genes that share ontologies with PLPPR5: view

No data available for SIGNOR curated interactions for PLPPR5 Gene

Drugs & Compounds for PLPPR5 Gene

(12) Additional Compounds for PLPPR5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
PA(16:0/18:1(9Z))
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
PA(16:0/18:2(9Z,12Z))
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPPR5: view

Transcripts for PLPPR5 Gene

mRNA/cDNA for PLPPR5 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPPR5

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR5 Gene

No ASD Table

Relevant External Links for PLPPR5 Gene

GeneLoc Exon Structure for
PLPPR5

Expression for PLPPR5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPPR5

mRNA Expression by UniProt/SwissProt for PLPPR5 Gene:

Q32ZL2-PLPR5_HUMAN
Tissue specificity: Isoform 1 is expressed in brain, lung, kidney and colon. Isoform 2 is expressed in placenta, skeletal muscle and kidney.

Evidence on tissue expression from TISSUES for PLPPR5 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with PLPPR5: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPPR5 Gene

Orthologs for PLPPR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPPR5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToOne
LOC457049 30
  • 99.79 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 97 (a)
OneToOne
LOC479934 30
  • 92.43 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 96 (a)
OneToOne
LOC100848786 30
  • 93.25 (n)
Rat
(Rattus norvegicus)
Mammalia Lppr5 30
  • 90.08 (n)
Mouse
(Mus musculus)
Mammalia 4833424O15Rik 30 31
  • 89.56 (n)
OneToOne
Plppr5 17
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 89 (a)
OneToOne
LPPR5 30
  • 84.83 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100491270 30
  • 82.08 (n)
Zebrafish
(Danio rerio)
Actinopterygii lppr5a 31
  • 69 (a)
OneToMany
lppr5b 30 31
  • 68.58 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T06D8.3 30
  • 43.83 (n)
Species where no ortholog for PLPPR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLPPR5 Gene

ENSEMBL:
Gene Tree for PLPPR5 (if available)
TreeFam:
Gene Tree for PLPPR5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPPR5: view image

Paralogs for PLPPR5 Gene

genes like me logo Genes that share paralogs with PLPPR5: view

Variants for PLPPR5 Gene

Additional dbSNP identifiers (rs#s) for PLPPR5 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLPPR5 Gene

Variant ID Type Subtype PubMed ID
dgv378n54 CNV loss 21841781
dgv63e212 CNV loss 25503493
esv26224 CNV loss 19812545
esv2667493 CNV deletion 23128226
esv33622 CNV loss 17666407
esv3566370 CNV deletion 23714750
esv3586911 CNV loss 21293372
esv3586912 CNV gain 21293372
nsv546876 CNV loss 21841781
nsv546884 CNV loss 21841781
nsv830760 CNV gain 17160897
nsv830771 CNV loss 17160897
nsv950519 CNV duplication 24416366

Variation tolerance for PLPPR5 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPPR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPPR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPPR5 Gene

Disorders for PLPPR5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLPPR5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal dominant 1
  • dfna1
bardet-biedl syndrome 10
  • bbs10
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PLPPR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPPR5 Gene

Publications for PLPPR5 Gene

  1. Cloning and characterization of a novel human phosphatidic acid phosphatase type 2, PAP2d, with two different transcripts PAP2d_v1 and PAP2d_v2. (PMID: 16010976) Sun L … Mao Y (Molecular and cellular biochemistry 2005) 2 3 4 23
  2. Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction. (PMID: 20032306) Broggini T … Savaskan NE (Molecular biology of the cell 2010) 3 4
  3. Identification of a genetic variant at 2q12.1 associated with blood pressure in East Asians by genome-wide scan including gene-environment interactions. (PMID: 24903457) Kim YK … Kim BJ (BMC medical genetics 2014) 3
  4. GWAS of dental caries patterns in the permanent dentition. (PMID: 23064961) Shaffer JR … Marazita ML (Journal of dental research 2013) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3

Products for PLPPR5 Gene

Sources for PLPPR5 Gene