Aliases for PLPPR4 Gene
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
GeneCards Summary for PLPPR4 Gene
PLPPR4 (Phospholipid Phosphatase Related 4) is a Protein Coding gene. Diseases associated with PLPPR4 include Dihydropyrimidine Dehydrogenase Deficiency and 46,Xy Sex Reversal 8. Among its related pathways are Signaling by GPCR and Lysosphingolipid and LPA receptors. An important paralog of this gene is PLPPR3.
UniProtKB/Swiss-Prot Summary for PLPPR4 Gene
Hydrolyzes lysophosphatidic acid (LPA) and participates to the axonal outgrowth during development by attenuating phospholipid-induced axon collapse in neuron.