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Aliases for PLPPR3 Gene

Aliases for PLPPR3 Gene

  • Phospholipid Phosphatase Related 3 2 3 5
  • Lipid Phosphate Phosphatase-Related Protein Type 3 3 4
  • Plasticity-Related Gene 2 Protein 3 4
  • PAP-2-Like Protein 2 3 4
  • EC 4 56
  • LPPR3 3 4
  • PRG-2 3 4
  • PRG2 3 4
  • Phospholipid Phosphatase-Related Protein Type 3 3
  • EC 3.1.3 56
  • LPR3 3
  • PHP2 4

External Ids for PLPPR3 Gene

Summaries for PLPPR3 Gene

Entrez Gene Summary for PLPPR3 Gene

  • The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLPPR3 Gene

PLPPR3 (Phospholipid Phosphatase Related 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and triacylglycerol biosynthesis. An important paralog of this gene is PLPPR4.

Additional gene information for PLPPR3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPPR3 Gene

Genomics for PLPPR3 Gene

GeneHancer (GH) Regulatory Elements for PLPPR3 Gene

Promoters and enhancers for PLPPR3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I000821 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +2.2 2226 1.6 BRD4 BCOR MXI1 ZNF48 CCNT2 ZNF766 POLR2A ADNP VEZF1 PRDM10 GC19P000823 PLPPR3 MIR3187
GH19I000823 Enhancer 1.2 FANTOM5 ENCODE 563 +0.5 531 0.5 ATF1 POLR2B ZNF766 ATF7 NCOA1 REST ZNF592 MBD2 ATF4 GMEB1 AZU1 PLPPR3 GC19P000823 PRTN3 ELANE PRSS57 BSG PTBP1
GH19I000824 Enhancer 0.6 ENCODE 550.8 -0.2 -180 0.3 HDAC1 E2F5 ZNF644 ZNF592 ZNF148 ZNF766 ZBTB33 CUX1 ZFX AZU1 GC19P000823 PLPPR3
GH19I000479 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.7 +344.0 343958 0.8 HDGF PKNOX1 ATF1 ARNT ZNF133 ARID4B SIN3A YBX1 ZNF2 TCF12 DAZAP1 TMEM259 PTBP1 ENSG00000267317 MIER2 GRIN3B MED16 CNN2 RPS15 RNF126
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLPPR3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLPPR3 Gene

Genomic Locations for PLPPR3 Gene
11,756 bases
Minus strand

Genomic View for PLPPR3 Gene

Genes around PLPPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR3 Gene

Proteins for PLPPR3 Gene

  • Protein details for PLPPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid phosphatase-related protein type 3
    Protein Accession:
    Secondary Accessions:
    • Q86XQ4
    • Q96EH1
    • Q9BQF9
    • Q9HAJ4

    Protein attributes for PLPPR3 Gene

    718 amino acids
    Molecular mass:
    76037 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLPPR3 Gene


neXtProt entry for PLPPR3 Gene

Selected DME Specific Peptides for PLPPR3 Gene


Post-translational modifications for PLPPR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPPR3 Gene

Domains & Families for PLPPR3 Gene

Gene Families for PLPPR3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PLPPR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA-phosphatase related phosphoesterase family.
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR3: view

Function for PLPPR3 Gene

Molecular function for PLPPR3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme Numbers (IUBMB) for PLPPR3 Gene

Gene Ontology (GO) - Molecular Function for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0042577 lipid phosphatase activity IBA --
genes like me logo Genes that share ontologies with PLPPR3: view
genes like me logo Genes that share phenotypes with PLPPR3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPPR3

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPPR3 Gene

Localization for PLPPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPPR3 gene
Compartment Confidence
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPPR3: view

Pathways & Interactions for PLPPR3 Gene

genes like me logo Genes that share pathways with PLPPR3: view

Pathways by source for PLPPR3 Gene

Interacting Proteins for PLPPR3 Gene

Gene Ontology (GO) - Biological Process for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
GO:0046839 phospholipid dephosphorylation IBA --
genes like me logo Genes that share ontologies with PLPPR3: view

No data available for SIGNOR curated interactions for PLPPR3 Gene

Drugs & Compounds for PLPPR3 Gene

(2) Drugs for PLPPR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PLPPR3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with PLPPR3: view

Transcripts for PLPPR3 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR3 Gene

No ASD Table

Relevant External Links for PLPPR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLPPR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLPPR3 Gene:


Evidence on tissue expression from TISSUES for PLPPR3 Gene

  • Nervous system(4.2)
  • Eye(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPPR3 Gene

Orthologs for PLPPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPPR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
(Canis familiaris)
Mammalia LPPR3 33
  • 89.97 (n)
-- 34
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
(Mus musculus)
Mammalia BC005764 34 33
  • 80.74 (n)
Plppr3 16
(Rattus norvegicus)
Mammalia Lppr3 33
  • 80.39 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
(Gallus gallus)
Aves LOC100858410 33
  • 79.09 (n)
-- 34
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lppr3 33
  • 62.98 (n)
Str.10644 33
(Danio rerio)
Actinopterygii lppr3a 33
  • 67.12 (n)
lppr3b 34
  • 59 (a)
(Caenorhabditis elegans)
Secernentea T06D8.3 34
  • 23 (a)
Species where no ortholog for PLPPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPPR3 Gene

Gene Tree for PLPPR3 (if available)
Gene Tree for PLPPR3 (if available)

Paralogs for PLPPR3 Gene

Paralogs for PLPPR3 Gene

genes like me logo Genes that share paralogs with PLPPR3: view

Variants for PLPPR3 Gene

Sequence variations from dbSNP and Humsavar for PLPPR3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000037722 -- 822,050(-) C/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000050520 -- 813,986(-) GGGGG/GGGG intron_variant
rs1000106016 -- 822,831(-) G/A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000134201 -- 825,696(-) G/T upstream_transcript_variant
rs1000187086 -- 825,590(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLPPR3 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
dgv1678n106 CNV deletion 24896259
dgv566n67 CNV gain 20364138
dgv6176n54 CNV loss 21841781
esv26343 CNV gain 19812545
esv2675158 CNV deletion 23128226
esv2717790 CNV deletion 23290073
esv2717791 CNV deletion 23290073
esv2717792 CNV deletion 23290073
esv2717793 CNV deletion 23290073
esv2743119 CNV deletion 23290073
esv3555827 CNV deletion 23714750
nsv1072291 CNV deletion 25765185
nsv1072292 CNV deletion 25765185
nsv1144848 CNV deletion 24896259
nsv1147444 CNV deletion 26484159
nsv458321 CNV loss 19166990
nsv470101 CNV loss 18288195
nsv578167 CNV loss 21841781
nsv578172 CNV loss 21841781
nsv828354 CNV gain 20364138
nsv828357 CNV loss 20364138
nsv953938 CNV deletion 24416366
nsv954615 CNV deletion 24416366

Variation tolerance for PLPPR3 Gene

Gene Damage Index Score: 9.00; 87.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPPR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPPR3 Gene

Disorders for PLPPR3 Gene

No disorders were found for PLPPR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPPR3 Gene

Publications for PLPPR3 Gene

  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. (PMID: 12730698) Bräuer AU … Nitsch R (Nature neuroscience 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for PLPPR3 Gene

Sources for PLPPR3 Gene

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