The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008] See more...

Aliases for PLPPR3 Gene

Aliases for PLPPR3 Gene

  • Phospholipid Phosphatase Related 3 2 3 5
  • Lipid Phosphate Phosphatase-Related Protein Type 3 3 4
  • Phospholipid Phosphatase-Related Protein Type 3 3 4
  • Plasticity-Related Gene 2 Protein 3 4
  • PAP-2-Like Protein 2 3 4
  • EC 3.1.3.4 4 52
  • LPPR3 3 4
  • PRG-2 3 4
  • PRG2 3 4
  • EC 3.1.3 52
  • LPR3 3
  • PHP2 4

External Ids for PLPPR3 Gene

Summaries for PLPPR3 Gene

Entrez Gene Summary for PLPPR3 Gene

  • The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLPPR3 Gene

PLPPR3 (Phospholipid Phosphatase Related 3) is a Protein Coding gene. Diseases associated with PLPPR3 include Pseudopseudohypoparathyroidism and Pseudohypoparathyroidism, Type Ia. Among its related pathways are Signaling by GPCR and Lysosphingolipid and LPA receptors. An important paralog of this gene is PLPPR4.

Additional gene information for PLPPR3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPPR3 Gene

Genomics for PLPPR3 Gene

GeneHancer (GH) Regulatory Elements for PLPPR3 Gene

Promoters and enhancers for PLPPR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000823 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 512.9 +0.2 242 1.6 ZBTB11 AFF1 TOE1 RUNX1 CTBP1 MYC KDM4B MIER1 HDAC3 NCOR1 AZU1 PLPPR3 PRTN3 ELANE PTBP1 PRSS57 BSG lnc-MED16-3
GH19J000821 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +2.4 2442 2.4 HNRNPK NRF1 PHF8 MYC ZBTB7A EZH2 MIER1 NFRKB MXI1 POLR2A AZU1 PLPPR3 lnc-MED16-3 MIR3187
GH19J000380 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas 9.7 +441.5 441512 4.1 CTCF PHB2 TSC22D4 BCL11A NCOR1 TRIM25 TCF12 EZH2 NFIC SP2 ENSG00000286667 MG598806 PLPPR3 C2CD4C MIER2 SHC2
GH19J000479 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 9.7 +344.0 343993 0.9 FOXK2 CTCF USF1 NONO PHB2 ZNF639 ZIC2 ZBTB10 ZNF623 REST DAZAP1 PTBP1 TMEM259 ENSG00000267317 MIER2 CNN2 CFD SBNO2 GRIN3B MED16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPPR3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPPR3

Genomic Locations for PLPPR3 Gene

Genomic Locations for PLPPR3 Gene
chr19:812,488-824,243
(GRCh38/hg38)
Size:
11,756 bases
Orientation:
Minus strand
chr19:812,518-821,967
(GRCh37/hg19)
Size:
9,450 bases
Orientation:
Minus strand

Genomic View for PLPPR3 Gene

Genes around PLPPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR3 Gene

Proteins for PLPPR3 Gene

  • Protein details for PLPPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6T4P5-PLPR3_HUMAN
    Recommended name:
    Phospholipid phosphatase-related protein type 3
    Protein Accession:
    Q6T4P5
    Secondary Accessions:
    • Q86XQ4
    • Q96EH1
    • Q9BQF9
    • Q9HAJ4

    Protein attributes for PLPPR3 Gene

    Size:
    718 amino acids
    Molecular mass:
    76037 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLPPR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPPR3 Gene

Selected DME Specific Peptides for PLPPR3 Gene

Q6T4P5:
  • EGLPPLG
  • LVHIPEE
  • ARKTFPS
  • FLTVCKP

Post-translational modifications for PLPPR3 Gene

  • Glycosylation at Asn169 and Asn318
  • Ubiquitination at Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for PLPPR3 Gene

Domains & Families for PLPPR3 Gene

Gene Families for PLPPR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPPR3 Gene

Blocks:
  • PA-phosphatase related phosphoesterase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLPPR3 Gene

GenScript: Design optimal peptide antigens:
  • Plasticity-related gene 2 protein (LPPR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6T4P5

UniProtKB/Swiss-Prot:

PLPR3_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR3: view

Function for PLPPR3 Gene

Molecular function for PLPPR3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4;.

Enzyme Numbers (IUBMB) for PLPPR3 Gene

Phenotypes From GWAS Catalog for PLPPR3 Gene

Gene Ontology (GO) - Molecular Function for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity IBA,IEA 21873635
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IBA 21873635
GO:0042577 lipid phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with PLPPR3: view
genes like me logo Genes that share phenotypes with PLPPR3: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPPR3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPPR3 Gene

Localization for PLPPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPPR3 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPPR3: view

Pathways & Interactions for PLPPR3 Gene

genes like me logo Genes that share pathways with PLPPR3: view

Pathways by source for PLPPR3 Gene

Interacting Proteins for PLPPR3 Gene

;

Gene Ontology (GO) - Biological Process for PLPPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA 21873635
GO:0046839 phospholipid dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PLPPR3: view

No data available for SIGNOR curated interactions for PLPPR3 Gene

Drugs & Compounds for PLPPR3 Gene

(2) Drugs for PLPPR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PLPPR3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PLPPR3: view

Transcripts for PLPPR3 Gene

mRNA/cDNA for PLPPR3 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPPR3

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR3 Gene

No ASD Table

Relevant External Links for PLPPR3 Gene

GeneLoc Exon Structure for
PLPPR3

Expression for PLPPR3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPPR3

Evidence on tissue expression from TISSUES for PLPPR3 Gene

  • Nervous system(4.2)
  • Eye(4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPPR3 Gene

Orthologs for PLPPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPPR3 30
  • 89.97 (n)
-- 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC005764 31 30
  • 80.74 (n)
OneToOne
Plppr3 17
rat
(Rattus norvegicus)
Mammalia Lppr3 30
  • 80.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858410 30
  • 79.09 (n)
-- 31
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lppr3 30
  • 62.98 (n)
Str.10644 30
zebrafish
(Danio rerio)
Actinopterygii lppr3a 30
  • 67.12 (n)
lppr3b 31
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T06D8.3 31
  • 23 (a)
OneToMany
Species where no ortholog for PLPPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPPR3 Gene

ENSEMBL:
Gene Tree for PLPPR3 (if available)
TreeFam:
Gene Tree for PLPPR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPPR3: view image

Paralogs for PLPPR3 Gene

genes like me logo Genes that share paralogs with PLPPR3: view

Variants for PLPPR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPPR3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1540615 - p.Ile193Thr
rs3746136 - p.Ala690Val

Additional dbSNP identifiers (rs#s) for PLPPR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLPPR3 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
dgv1678n106 CNV deletion 24896259
dgv566n67 CNV gain 20364138
dgv6176n54 CNV loss 21841781
esv26343 CNV gain 19812545
esv2675158 CNV deletion 23128226
esv2717790 CNV deletion 23290073
esv2717791 CNV deletion 23290073
esv2717792 CNV deletion 23290073
esv2717793 CNV deletion 23290073
esv2743119 CNV deletion 23290073
esv3555827 CNV deletion 23714750
nsv1072291 CNV deletion 25765185
nsv1072292 CNV deletion 25765185
nsv1144848 CNV deletion 24896259
nsv1147444 CNV deletion 26484159
nsv458321 CNV loss 19166990
nsv470101 CNV loss 18288195
nsv578167 CNV loss 21841781
nsv578172 CNV loss 21841781
nsv828354 CNV gain 20364138
nsv828357 CNV loss 20364138
nsv953938 CNV deletion 24416366
nsv954615 CNV deletion 24416366

Variation tolerance for PLPPR3 Gene

Gene Damage Index Score: 9.00; 87.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPPR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPPR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPPR3 Gene

Disorders for PLPPR3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PLPPR3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pseudopseudohypoparathyroidism
  • pphp
pseudohypoparathyroidism, type ia
  • php1a
acrodysostosis
  • acrodysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PLPPR3

genes like me logo Genes that share disorders with PLPPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPPR3 Gene

Publications for PLPPR3 Gene

  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. (PMID: 12730698) Bräuer AU … Nitsch R (Nature neuroscience 2003) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for PLPPR3 Gene

Sources for PLPPR3 Gene