Aliases for PLPPR2 Gene

Aliases for PLPPR2 Gene

  • Phospholipid Phosphatase Related 2 2 3 5
  • LPPR2 2 3 4
  • Lipid Phosphate Phosphatase-Related Protein Type 2 3 4
  • Phospholipid Phosphatase-Related Protein Type 2 3 4
  • Plasticity-Related Gene 4 Protein 3 4
  • EC 4 50
  • PRG-4 2 4
  • PRG4 3 4
  • Plasticity Related Gene 4 3
  • PLPPR2 5

External Ids for PLPPR2 Gene

Previous GeneCards Identifiers for PLPPR2 Gene

  • GC19P011356
  • GC19P011358

Summaries for PLPPR2 Gene

GeneCards Summary for PLPPR2 Gene

PLPPR2 (Phospholipid Phosphatase Related 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Lysosphingolipid and LPA receptors. An important paralog of this gene is PLPPR5.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPPR2 Gene

Genomics for PLPPR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLPPR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011354 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 308.9 +0.5 507 2.2 NCOR1 ZNF600 ZNF580 POLR2A ZBTB10 CTCF ZNF639 MCM7 ZBTB7B SIN3A PLPPR2 HSALNG0124019 ZNF627 ZNF625 ZNF20 ILF3 ZNF844 ENSG00000242615 ZNF136 ZNF439
GH19J011373 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.8 +20.9 20934 6.2 SP1 ZNF207 MYC ZNF600 JUND ZNF580 ZMYM3 ATF2 POLR2A CEBPA TMEM205 ENSG00000267277 HSALNG0124021 SWSAP1 piR-38729 ILF3 ZNF136 ZNF627 ZNF442 ZNF625
GH19J011293 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 8 -61.4 -61393 1.3 SP1 ZNF654 ZNF600 IKZF1 ZNF580 ZMYM3 ZBTB10 YY1 MXD4 CTCF ILF3 ENSG00000267174 KRI1 ZNF136 RAVER1 ZNF627 ZNF700 CDC37 ZNF844 ZNF823
GH19J011360 Promoter/Enhancer 1 Ensembl ENCODE 13 +6.6 6606 1.7 POLR2A ZIC2 REST ETS1 ZNF341 MNT SIN3A SMARCA4 EHMT2 ZBTB33 RGL3 PLPPR2 EPOR TSPAN16 HSALNG0124019 SWSAP1
GH19J011386 Enhancer 0.7 ENCODE 18.2 +32.0 31974 1.1 CEBPA KMT2B THAP11 FOXA2 SAP130 CUX1 DMAP1 SPI1 ZBTB33 ZNF792 RGL3 PLPPR2 KANK2 EPOR HSALNG0124023
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPPR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPPR2

Genomic Locations for PLPPR2 Gene

Latest Assembly
10,313 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
10,267 bases
Plus strand

(GRCh37/hg19 by Ensembl)
10,313 bases
Plus strand

Genomic View for PLPPR2 Gene

Genes around PLPPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR2 Gene

Proteins for PLPPR2 Gene

  • Protein details for PLPPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid phosphatase-related protein type 2
    Protein Accession:
    Secondary Accessions:
    • Q5CZ76
    • Q8N1U4
    • Q9H929

    Protein attributes for PLPPR2 Gene

    343 amino acids
    Molecular mass:
    36880 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLPPR2 Gene


neXtProt entry for PLPPR2 Gene

Selected DME Specific Peptides for PLPPR2 Gene


Post-translational modifications for PLPPR2 Gene

  • Glycosylation at Asn165
  • Modification sites at PhosphoSitePlus

Domains & Families for PLPPR2 Gene

Gene Families for PLPPR2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPPR2 Gene

  • PA-phosphatase related phosphoesterase

Suggested Antigen Peptide Sequences for PLPPR2 Gene

GenScript: Design optimal peptide antigens:
  • Plasticity-related gene 4 protein (LPPR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA-phosphatase related phosphoesterase family.
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR2: view

Function for PLPPR2 Gene

Molecular function for PLPPR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=;.

Enzyme Numbers (IUBMB) for PLPPR2 Gene

Phenotypes From GWAS Catalog for PLPPR2 Gene

Gene Ontology (GO) - Molecular Function for PLPPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008195 phosphatidate phosphatase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0042577 lipid phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with PLPPR2: view
genes like me logo Genes that share phenotypes with PLPPR2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPPR2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPPR2 Gene

Localization for PLPPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPPR2 gene
Compartment Confidence
plasma membrane 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLPPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPPR2: view

Pathways & Interactions for PLPPR2 Gene

genes like me logo Genes that share pathways with PLPPR2: view

Pathways by source for PLPPR2 Gene

Gene Ontology (GO) - Biological Process for PLPPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA 21873635
GO:0007165 signal transduction IBA 21873635
GO:0016311 dephosphorylation IEA --
GO:0046839 phospholipid dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PLPPR2: view

No data available for SIGNOR curated interactions for PLPPR2 Gene

Drugs & Compounds for PLPPR2 Gene

(2) Drugs for PLPPR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PLPPR2: view

Transcripts for PLPPR2 Gene

mRNA/cDNA for PLPPR2 Gene

9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPPR2

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR2 Gene

No ASD Table

Relevant External Links for PLPPR2 Gene

GeneLoc Exon Structure for

Expression for PLPPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPPR2

Evidence on tissue expression from TISSUES for PLPPR2 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with PLPPR2: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPPR2 Gene

Orthologs for PLPPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLPPR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 30
  • 97 (a)
LPPR2 29
  • 92.46 (n)
(Canis familiaris)
Mammalia LPPR2 29
  • 91.88 (n)
-- 30
  • 66 (a)
(Mus musculus)
Mammalia BC018242 29 30
  • 87.74 (n)
Plppr2 16
(Rattus norvegicus)
Mammalia Lppr2 29
  • 87.29 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 58 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485784 29
  • 63.12 (n)
(Danio rerio)
Actinopterygii LOC571463 29
  • 66.67 (n)
lppr2a 30
  • 56 (a)
CABZ01025393.1 30
  • 52 (a)
-- 29
Species where no ortholog for PLPPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLPPR2 Gene

Gene Tree for PLPPR2 (if available)
Gene Tree for PLPPR2 (if available)
Evolutionary constrained regions (ECRs) for PLPPR2: view image
Alliance of Genome Resources:
Additional Orthologs for PLPPR2

Paralogs for PLPPR2 Gene

genes like me logo Genes that share paralogs with PLPPR2: view

Variants for PLPPR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPPR2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_038546 A colorectal cancer sample p.Thr155Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLPPR2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLPPR2 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv833752 CNV loss 17160897

Variation tolerance for PLPPR2 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPPR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPPR2 Gene

Disorders for PLPPR2 Gene

Additional Disease Information for PLPPR2

No disorders were found for PLPPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPPR2 Gene

Publications for PLPPR2 Gene

  1. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. (PMID: 14750979) Savaskan NE … Nitsch R (The European journal of neuroscience 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for PLPPR2 Gene

Sources for PLPPR2 Gene