Aliases for PLPPR2 Gene

Aliases for PLPPR2 Gene

  • Phospholipid Phosphatase Related 2 2 3 5
  • Lipid Phosphate Phosphatase-Related Protein Type 2 3 4
  • Phospholipid Phosphatase-Related Protein Type 2 3 4
  • Plasticity-Related Gene 4 Protein 3 4
  • EC 4 52
  • LPPR2 3 4
  • PRG-4 3 4
  • PRG4 3 4
  • Plasticity Related Gene 4 3

External Ids for PLPPR2 Gene

Summaries for PLPPR2 Gene

GeneCards Summary for PLPPR2 Gene

PLPPR2 (Phospholipid Phosphatase Related 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Lysosphingolipid and LPA receptors. An important paralog of this gene is PLPPR5.

Additional gene information for PLPPR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPPR2 Gene

Genomics for PLPPR2 Gene

GeneHancer (GH) Regulatory Elements for PLPPR2 Gene

Promoters and enhancers for PLPPR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011354 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 558.9 +0.5 507 2.2 NRF1 POLR2G BCLAF1 RBAK PHF8 ZNF639 ZBTB5 POLR2A ZBTB10 ZNF623 PLPPR2 ZNF627 ZNF20 ENSG00000242615 ZNF439 ZNF44 ZNF441 ZNF625 ZNF433 ZNF763
GH19J011373 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.8 +20.9 20934 6.2 FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 TCF12 POLR2G TMEM205 ENSG00000267277 SWSAP1 piR-38729 ILF3 RAB3D CCDC159 KRI1 ZNF136 TIMM29
GH19J011293 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 8 -61.4 -61393 1.3 ZNF217 CTCF SP1 BCLAF1 RBAK ZBTB5 ZBTB10 ZBTB11 ZBTB26 REST ENSG00000267174 RAVER1 KRI1 ILF3 ZNF700 ZNF136 CDC37 ZNF763 ZNF878 ZNF439
GH19J011360 Promoter/Enhancer 1.1 Ensembl ENCODE 13 +6.6 6606 1.7 NRF1 MYC ZIC2 REST SAP30 ZNF341 POLR2A MIER1 ZNF263 POLR2G RGL3 PLPPR2 EPOR TSPAN16 SWSAP1
GH19J011386 Enhancer 0.7 ENCODE 18.2 +32.0 31974 1.1 CUX1 KMT2B FOXA2 SAP130 SPI1 ZGPAT THAP11 DMAP1 KDM1A ZNF792 RGL3 PLPPR2 KANK2 EPOR lnc-EPOR-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPPR2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPPR2

Genomic Locations for PLPPR2 Gene

Genomic Locations for PLPPR2 Gene
10,313 bases
Plus strand
10,313 bases
Plus strand

Genomic View for PLPPR2 Gene

Genes around PLPPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPPR2 Gene

Proteins for PLPPR2 Gene

  • Protein details for PLPPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid phosphatase-related protein type 2
    Protein Accession:
    Secondary Accessions:
    • Q5CZ76
    • Q8N1U4
    • Q9H929

    Protein attributes for PLPPR2 Gene

    343 amino acids
    Molecular mass:
    36880 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLPPR2 Gene


neXtProt entry for PLPPR2 Gene

Selected DME Specific Peptides for PLPPR2 Gene


Post-translational modifications for PLPPR2 Gene

  • Glycosylation at Asn165
  • Modification sites at PhosphoSitePlus

Domains & Families for PLPPR2 Gene

Gene Families for PLPPR2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPPR2 Gene

  • PA-phosphatase related phosphoesterase

Suggested Antigen Peptide Sequences for PLPPR2 Gene

GenScript: Design optimal peptide antigens:
  • Plasticity-related gene 4 protein (LPPR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA-phosphatase related phosphoesterase family.
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPPR2: view

Function for PLPPR2 Gene

Molecular function for PLPPR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=;.

Enzyme Numbers (IUBMB) for PLPPR2 Gene

Gene Ontology (GO) - Molecular Function for PLPPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity IBA,IEA 21873635
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IBA 21873635
GO:0042577 lipid phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with PLPPR2: view
genes like me logo Genes that share phenotypes with PLPPR2: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPPR2 Gene

Localization for PLPPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPPR2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPPR2 gene
Compartment Confidence
plasma membrane 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLPPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPPR2: view

Pathways & Interactions for PLPPR2 Gene

genes like me logo Genes that share pathways with PLPPR2: view

Pathways by source for PLPPR2 Gene

Gene Ontology (GO) - Biological Process for PLPPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA 21873635
GO:0046839 phospholipid dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PLPPR2: view

No data available for SIGNOR curated interactions for PLPPR2 Gene

Drugs & Compounds for PLPPR2 Gene

(2) Drugs for PLPPR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for PLPPR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with PLPPR2: view

Transcripts for PLPPR2 Gene

mRNA/cDNA for PLPPR2 Gene

9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPPR2 Gene

No ASD Table

Relevant External Links for PLPPR2 Gene

GeneLoc Exon Structure for

Expression for PLPPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPPR2

Evidence on tissue expression from TISSUES for PLPPR2 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with PLPPR2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPPR2 Gene

Orthologs for PLPPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLPPR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 31
  • 97 (a)
LPPR2 30
  • 92.46 (n)
(Canis familiaris)
Mammalia LPPR2 30
  • 91.88 (n)
-- 31
  • 66 (a)
(Mus musculus)
Mammalia BC018242 31 30
  • 87.74 (n)
Plppr2 17
(Rattus norvegicus)
Mammalia Lppr2 30
  • 87.29 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485784 30
  • 63.12 (n)
(Danio rerio)
Actinopterygii LOC571463 30
  • 66.67 (n)
lppr2a 31
  • 56 (a)
CABZ01025393.1 31
  • 52 (a)
-- 30
Species where no ortholog for PLPPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLPPR2 Gene

Gene Tree for PLPPR2 (if available)
Gene Tree for PLPPR2 (if available)
Evolutionary constrained regions (ECRs) for PLPPR2: view image

Paralogs for PLPPR2 Gene

genes like me logo Genes that share paralogs with PLPPR2: view

Variants for PLPPR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPPR2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
VAR_038546 A colorectal cancer sample p.Thr155Met

Additional dbSNP identifiers (rs#s) for PLPPR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLPPR2 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv833752 CNV loss 17160897

Variation tolerance for PLPPR2 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPPR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPPR2 Gene

Disorders for PLPPR2 Gene

Additional Disease Information for PLPPR2

No disorders were found for PLPPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPPR2 Gene

Publications for PLPPR2 Gene

  1. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. (PMID: 14750979) Savaskan NE … Nitsch R (The European journal of neuroscience 2004) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for PLPPR2 Gene

Sources for PLPPR2 Gene