Aliases for PLPP7 Gene

Aliases for PLPP7 Gene

  • Phospholipid Phosphatase 7 (Inactive) 2 3 5
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 3 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 3 2 3
  • Nuclear Envelope Transmembrane Protein NET39 2 3
  • Inactive Phospholipid Phosphatase 7 3 4
  • C9orf67 3 4
  • PPAPDC3 3 4
  • Probable Lipid Phosphate Phosphatase PPAPDC3 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Chromosome 9 Open Reading Frame 67 2
  • EC 3.1.3 54
  • NET39 3

External Ids for PLPP7 Gene

Previous HGNC Symbols for PLPP7 Gene

  • C9orf67

Summaries for PLPP7 Gene

GeneCards Summary for PLPP7 Gene

PLPP7 (Phospholipid Phosphatase 7 (Inactive)) is a Protein Coding gene. An important paralog of this gene is PLPP6.

UniProtKB/Swiss-Prot Summary for PLPP7 Gene

  • Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

Additional gene information for PLPP7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPP7 Gene

Genomics for PLPP7 Gene

GeneHancer (GH) Regulatory Elements for PLPP7 Gene

Promoters and enhancers for PLPP7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLPP7 Gene

Genomic Locations for PLPP7 Gene
69,564 bases
Plus strand
19,569 bases
Plus strand

Genomic View for PLPP7 Gene

Genes around PLPP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP7 Gene

Proteins for PLPP7 Gene

  • Protein details for PLPP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipid phosphatase 7
    Protein Accession:
    Secondary Accessions:
    • Q5T6P0
    • Q96SS7
    • Q9BRC3

    Protein attributes for PLPP7 Gene

    271 amino acids
    Molecular mass:
    29448 Da
    Quaternary structure:
    • Homo and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).

neXtProt entry for PLPP7 Gene

Selected DME Specific Peptides for PLPP7 Gene


Post-translational modifications for PLPP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP7 Gene

Domains & Families for PLPP7 Gene

Gene Families for PLPP7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PLPP7 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidic acid phosphatase type 2 domain-containing protein 3 (PPAC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA-phosphatase related phosphoesterase family.
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP7: view

Function for PLPP7 Gene

Molecular function for PLPP7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

Enzyme Numbers (IUBMB) for PLPP7 Gene

genes like me logo Genes that share phenotypes with PLPP7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP7

No data available for Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLPP7 Gene

Localization for PLPP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP7 Gene

Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP7 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 3
peroxisome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP7: view

Pathways & Interactions for PLPP7 Gene

PathCards logo

SuperPathways for PLPP7 Gene

No Data Available

Interacting Proteins for PLPP7 Gene

Selected Interacting proteins: Q8NBV4-PLPP7_HUMAN for PLPP7 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PLPP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010832 negative regulation of myotube differentiation IEA --
genes like me logo Genes that share ontologies with PLPP7: view

No data available for Pathways by source and SIGNOR curated interactions for PLPP7 Gene

Drugs & Compounds for PLPP7 Gene

(12) Additional Compounds for PLPP7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP7: view

Transcripts for PLPP7 Gene

mRNA/cDNA for PLPP7 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(66) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP7

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP7 Gene

No ASD Table

Relevant External Links for PLPP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLPP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLPP7 Gene:


Evidence on tissue expression from TISSUES for PLPP7 Gene

  • Nervous system(4.7)
  • Heart(3.3)
  • Muscle(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP7 Gene

Orthologs for PLPP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPAPDC3 33 32
  • 94.65 (n)
(Canis familiaris)
Mammalia PPAPDC3 33 32
  • 92.37 (n)
(Bos Taurus)
Mammalia PPAPDC3 33 32
  • 91.64 (n)
(Mus musculus)
Mammalia Ppapdc3 33 32
  • 89.42 (n)
Plpp7 17
(Rattus norvegicus)
Mammalia Ppapdc3 32
  • 88.93 (n)
(Monodelphis domestica)
Mammalia PPAPDC3 33
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia PPAPDC3 33
  • 87 (a)
(Gallus gallus)
Aves PPAPDC3 33 32
  • 78.97 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppapdc3 32
  • 68.4 (n)
(Danio rerio)
Actinopterygii ppapdc3 33 32
  • 68.03 (n)
PPAPDC3 (1 of 2) 33
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31717 33
  • 27 (a)
(Caenorhabditis elegans)
Secernentea T13C5.6 33
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 37 (a)
Species where no ortholog for PLPP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP7 Gene

Gene Tree for PLPP7 (if available)
Gene Tree for PLPP7 (if available)
Evolutionary constrained regions (ECRs) for PLPP7: view image

Paralogs for PLPP7 Gene

Paralogs for PLPP7 Gene

genes like me logo Genes that share paralogs with PLPP7: view

Variants for PLPP7 Gene

Sequence variations from dbSNP and Humsavar for PLPP7 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000035008 -- 131,305,919(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000086827 -- 131,306,186(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000437345 -- 131,295,992(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000529509 -- 131,301,763(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000542952 -- 131,306,164(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLPP7 Gene

Variant ID Type Subtype PubMed ID
nsv1124483 CNV deletion 24896259
nsv466602 CNV loss 19166990
nsv509327 CNV insertion 20534489
nsv615535 CNV loss 21841781
nsv615536 CNV loss 21841781
nsv831739 CNV loss 17160897

Variation tolerance for PLPP7 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP7 Gene

Disorders for PLPP7 Gene

Additional Disease Information for PLPP7

No disorders were found for PLPP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP7 Gene

Publications for PLPP7 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 56
  5. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer EC … Gerace L (Science (New York, N.Y.) 2003) 2 3 56

Products for PLPP7 Gene

Sources for PLPP7 Gene