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Aliases for PLPP6 Gene

Aliases for PLPP6 Gene

  • Phospholipid Phosphatase 6 2 3 5
  • Presqualene Diphosphate Phosphatase 2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 2 3
  • Polyisoprenoid Diphosphate Phosphatase Type 1 2 3
  • PPAP2 Domain-Containing Protein 2 3 4
  • PPAPDC2 3 4
  • EC 3.1.3.- 4
  • BA6J24.6 3
  • EC 3.1.3 56
  • PDP1 3
  • PSDP 3

External Ids for PLPP6 Gene

Previous HGNC Symbols for PLPP6 Gene

  • PPAPDC2

Summaries for PLPP6 Gene

GeneCards Summary for PLPP6 Gene

PLPP6 (Phospholipid Phosphatase 6) is a Protein Coding gene. Among its related pathways are Inhibitory action of Lipoxins on Superoxide production in neutrophils and DAG and IP3 signaling. An important paralog of this gene is PLPP7.

UniProtKB/Swiss-Prot for PLPP6 Gene

  • Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.

Additional gene information for PLPP6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP6 Gene

Genomics for PLPP6 Gene

GeneHancer (GH) Regulatory Elements for PLPP6 Gene

Promoters and enhancers for PLPP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I004661 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560 +1.9 1892 5.8 HDGF FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B PLPP6 SPATA6L AK3 CDC37L1-AS1
GH09I004738 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.5 +79.1 79130 5.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF213 AK3 CDC37L1 RIC1 JAK2 PLPP6 MTND5P14 GC09P004695
GH09I004291 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 -365.1 -365076 12 PKNOX1 ARID4B SIN3A ZNF2 BRCA1 YY1 GLIS2 FOS SP3 RXRA GLIS3 MTND4P14 ENSG00000228322 PLPP6 GC09M004258
GH09I004595 Enhancer 0.9 Ensembl ENCODE 10.8 -66.1 -66099 1.9 FOXA2 TAF1 MAX EBF1 RAD21 YY1 ZFHX2 HNF4G MAFK EGR2 SPATA6L PLPP6 CDC37L1 PIR55745 RPS6P11
GH09I004619 Enhancer 0.6 ENCODE 11.6 -41.3 -41323 2 POLR2A JUN MAX CREB1 ATF7 MYC RUNX3 ATF2 PLPP6 SPATA6L RPS6P11 PIR55745
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLPP6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLPP6 Gene

Genomic Locations for PLPP6 Gene
chr9:4,662,294-4,665,274
(GRCh38/hg38)
Size:
2,981 bases
Orientation:
Plus strand
chr9:4,662,298-4,665,258
(GRCh37/hg19)

Genomic View for PLPP6 Gene

Genes around PLPP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP6 Gene

Proteins for PLPP6 Gene

  • Protein details for PLPP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY26-PLPP6_HUMAN
    Recommended name:
    Phospholipid phosphatase 6
    Protein Accession:
    Q8IY26
    Secondary Accessions:
    • B3KY05
    • Q5JVJ6
    • Q8NCK9

    Protein attributes for PLPP6 Gene

    Size:
    295 amino acids
    Molecular mass:
    32194 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK074672; Type=Frameshift; Positions=267; Evidence={ECO:0000305};

neXtProt entry for PLPP6 Gene

Selected DME Specific Peptides for PLPP6 Gene

Q8IY26:
  • LGRHNVTDVAFGFF
  • SGHGIPWL
  • SLLAIDLWLSK
  • YSFPSGHATRAA
  • VRRRRPAHN
  • RSDSWAGREVLMNLLFALLLDLLLV
  • LNHLVLA

Post-translational modifications for PLPP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLPP6 Gene

Gene Families for PLPP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PLPP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IY26

UniProtKB/Swiss-Prot:

PLPP6_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP6: view

Function for PLPP6 Gene

Molecular function for PLPP6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7-8. {ECO:0000269 PubMed:16464866};
UniProtKB/Swiss-Prot Function:
Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.

Enzyme Numbers (IUBMB) for PLPP6 Gene

Phenotypes From GWAS Catalog for PLPP6 Gene

Gene Ontology (GO) - Molecular Function for PLPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity TAS --
GO:0042577 lipid phosphatase activity IDA 16464866
genes like me logo Genes that share ontologies with PLPP6: view
genes like me logo Genes that share phenotypes with PLPP6: view

Animal Models for PLPP6 Gene

MGI Knock Outs for PLPP6:

miRNA for PLPP6 Gene

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP6 Gene

Localization for PLPP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP6 gene
Compartment Confidence
plasma membrane 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP6: view

Pathways & Interactions for PLPP6 Gene

genes like me logo Genes that share pathways with PLPP6: view

Interacting Proteins for PLPP6 Gene

Gene Ontology (GO) - Biological Process for PLPP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0046839 phospholipid dephosphorylation IDA 16464866
genes like me logo Genes that share ontologies with PLPP6: view

No data available for SIGNOR curated interactions for PLPP6 Gene

Drugs & Compounds for PLPP6 Gene

(12) Additional Compounds for PLPP6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP6: view

Transcripts for PLPP6 Gene

mRNA/cDNA for PLPP6 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP6 Gene

No ASD Table

Relevant External Links for PLPP6 Gene

GeneLoc Exon Structure for
PLPP6
ECgene alternative splicing isoforms for
PLPP6

Expression for PLPP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLPP6 Gene:

PLPP6

mRNA Expression by UniProt/SwissProt for PLPP6 Gene:

Q8IY26-PLPP6_HUMAN
Tissue specificity: Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.

Evidence on tissue expression from TISSUES for PLPP6 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with PLPP6: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP6 Gene

Orthologs for PLPP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC2 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia PPAPDC2 33 34
  • 89.32 (n)
cow
(Bos Taurus)
Mammalia PPAPDC2 33 34
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Ppapdc2 33
  • 87.51 (n)
mouse
(Mus musculus)
Mammalia Ppapdc2 33 34
  • 87.4 (n)
Plpp6 16
oppossum
(Monodelphis domestica)
Mammalia PPAPDC2 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAPDC2 33 34
  • 76.95 (n)
lizard
(Anolis carolinensis)
Reptilia PPAPDC2 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppapdc2 33
  • 65.88 (n)
zebrafish
(Danio rerio)
Actinopterygii ppapdc2 34
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005824 33
  • 50.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31717 33 34
  • 50.19 (n)
worm
(Caenorhabditis elegans)
Secernentea T13C5.6 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
Species where no ortholog for PLPP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP6 Gene

ENSEMBL:
Gene Tree for PLPP6 (if available)
TreeFam:
Gene Tree for PLPP6 (if available)

Paralogs for PLPP6 Gene

Paralogs for PLPP6 Gene

genes like me logo Genes that share paralogs with PLPP6: view

Variants for PLPP6 Gene

Sequence variations from dbSNP and Humsavar for PLPP6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000112166 -- 4,661,002(+) T/C upstream_transcript_variant
rs1000441433 -- 4,660,851(+) A/G upstream_transcript_variant
rs1000956267 -- 4,661,112(+) A/C upstream_transcript_variant
rs1001437537 -- 4,664,736(+) G/A 3_prime_UTR_variant
rs1001537336 -- 4,660,688(+) C/A upstream_transcript_variant

Variation tolerance for PLPP6 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP6 Gene

Human Gene Mutation Database (HGMD)
PLPP6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLPP6 Gene

Disorders for PLPP6 Gene

No disorders were found for PLPP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP6 Gene

Publications for PLPP6 Gene

  1. Identification and functional characterization of a presqualene diphosphate phosphatase. (PMID: 16464866) Fukunaga K … Levy BD (The Journal of biological chemistry 2006) 2 3 4 58
  2. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. (PMID: 20110354) Miriyala S … Morris AJ (The Journal of biological chemistry 2010) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PLPP6 Gene

Sources for PLPP6 Gene

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