Aliases for PLPP5 Gene

Aliases for PLPP5 Gene

  • Phospholipid Phosphatase 5 2 3 4 5
  • DPPL1 2 3 4
  • HTPAP 2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1B 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1B 2 3
  • Diacylglycerol Pyrophosphate Phosphatase-Like 1 2 3
  • PPAPDC1B 3 4
  • Diacylglycerol Pyrophosphate Like 1 3
  • Phosphatidate Phosphatase PPAPDC1B 3
  • Testicular Secretory Protein Li 38 3
  • EC 3.1.3.81 4
  • EC 3.1.3.4 4
  • PLPP5 5

External Ids for PLPP5 Gene

Previous HGNC Symbols for PLPP5 Gene

  • PPAPDC1B

Summaries for PLPP5 Gene

GeneCards Summary for PLPP5 Gene

PLPP5 (Phospholipid Phosphatase 5) is a Protein Coding gene. Diseases associated with PLPP5 include Cone-Rod Dystrophy 9 and Hepatocellular Carcinoma. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Innate Immune System. An important paralog of this gene is PLPP4.

UniProtKB/Swiss-Prot Summary for PLPP5 Gene

  • Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPP5 Gene

Genomics for PLPP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLPP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPP5

Genomic Locations for PLPP5 Gene

Latest Assembly
chr8:38,261,790-38,269,435
(GRCh38/hg38)
Size:
7,646 bases
Orientation:
Minus strand

Previous Assembly
chr8:38,120,648-38,126,742
(GRCh37/hg19 by Entrez Gene)
Size:
6,095 bases
Orientation:
Minus strand

chr8:38,120,648-38,126,761
(GRCh37/hg19 by Ensembl)
Size:
6,114 bases
Orientation:
Minus strand

Genomic View for PLPP5 Gene

Genes around PLPP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP5 Gene

Proteins for PLPP5 Gene

  • Protein details for PLPP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEB5-PLPP5_HUMAN
    Recommended name:
    Phospholipid phosphatase 5
    Protein Accession:
    Q8NEB5
    Secondary Accessions:
    • C9JKF5
    • Q3KQX6
    • Q9BY45

    Protein attributes for PLPP5 Gene

    Size:
    264 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI06015.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK14924.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • May be a metastatic suppressor for hepatocellular carcinoma.

    Alternative splice isoforms for PLPP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP5 Gene

Post-translational modifications for PLPP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLPP5 Gene

Domains & Families for PLPP5 Gene

Gene Families for PLPP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPP5 Gene

InterPro:
Blocks:
  • PA-phosphatase related phosphoesterase

Suggested Antigen Peptide Sequences for PLPP5 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidic acid phosphatase type 2 domain-containing protein 1B (PPC1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEB5

UniProtKB/Swiss-Prot:

PLPP5_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP5: view

Function for PLPP5 Gene

Molecular function for PLPP5 Gene

UniProtKB/Swiss-Prot Function:
Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:27449, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608, ChEBI:CHEBI:59996; EC=3.1.3.81; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:42856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:78229, ChEBI:CHEBI:82765; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:42860, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:76979, ChEBI:CHEBI:78229; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=41 uM for 1,2-dioctanoyl-sn-glycero-3-diphosphate/diacylglycerol pyrophosphate {ECO:0000269|PubMed:17590538}; KM=277 uM for 1,2-dioctanoyl-sn-glycero-3-phosphate/phosphatidate {ECO:0000269|PubMed:17590538}; KM=295 uM for 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate/lysophosphatidate {ECO:0000269|PubMed:17590538};
UniProtKB/Swiss-Prot EnzymeRegulation:
Magnesium-independent phospholipid phosphatase (PubMed:17590538). Inhibited by N-ethylmaleimide (PubMed:17590538).

Enzyme Numbers (IUBMB) for PLPP5 Gene

Phenotypes From GWAS Catalog for PLPP5 Gene

Gene Ontology (GO) - Molecular Function for PLPP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000810 diacylglycerol diphosphate phosphatase activity IEA,IDA 17590538
GO:0005515 protein binding IPI 32296183
GO:0008195 phosphatidate phosphatase activity IBA,IDA 17590538
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLPP5: view
genes like me logo Genes that share phenotypes with PLPP5: view

Animal Models for PLPP5 Gene

MGI Knock Outs for PLPP5:
  • Plpp5 Plpp5<tm1(KOMP)Mbp>

Animal Models for research

  • Taconic Biosciences Mouse Models for PLPP5

miRNA for PLPP5 Gene

miRTarBase miRNAs that target PLPP5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP5 Gene

Localization for PLPP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP5 gene
Compartment Confidence
plasma membrane 5
nucleus 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLPP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 21219541
GO:0005886 plasma membrane TAS 21219541
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP5: view

Pathways & Interactions for PLPP5 Gene

genes like me logo Genes that share pathways with PLPP5: view

UniProtKB/Swiss-Prot Q8NEB5-PLPP5_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for PLPP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0046839 phospholipid dephosphorylation IBA,IDA 17590538
genes like me logo Genes that share ontologies with PLPP5: view

No data available for SIGNOR curated interactions for PLPP5 Gene

Drugs & Compounds for PLPP5 Gene

(2) Drugs for PLPP5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0

(12) Additional Compounds for PLPP5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
PA(16:0/18:1(9Z))
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
PA(16:0/18:2(9Z,12Z))
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
PA(18:0/18:2(9Z,12Z))
  • (2R)-1-(Phosphonooxy)-3-(stearoyloxy)propan-2-yl (9Z,12Z)-octadeca-9,12-dienoate
  • 1-18:0-2-18:2-Phosphatidic acid
  • 1-Octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate
  • 1-Octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate
  • 18:0-18:2-PA
genes like me logo Genes that share compounds with PLPP5: view

Transcripts for PLPP5 Gene

mRNA/cDNA for PLPP5 Gene

9 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP5

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP5 Gene

No ASD Table

Relevant External Links for PLPP5 Gene

GeneLoc Exon Structure for
PLPP5

Expression for PLPP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPP5

mRNA Expression by UniProt/SwissProt for PLPP5 Gene:

Q8NEB5-PLPP5_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PLPP5 Gene

  • Lung(4.3)
  • Liver(4.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with PLPP5: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP5 Gene

Orthologs for PLPP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLPP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPAPDC1B 29 30
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPAPDC1B 29 30
  • 87.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppapdc1b 29 30
  • 85.85 (n)
OneToOne
Plpp5 16
Rat
(Rattus norvegicus)
Mammalia Ppapdc1b 29
  • 85.05 (n)
Cow
(Bos Taurus)
Mammalia LOC616337 29
  • 83.47 (n)
PPAPDC1B 30
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPAPDC1B 30
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPAPDC1B 30
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPAPDC1B 29 30
  • 66.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPAPDC1B 30
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppapdc1b 29
  • 66.12 (n)
Zebrafish
(Danio rerio)
Actinopterygii ppapdc1b 29 30
  • 63.23 (n)
OneToOne
-- 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG12746 29 30
  • 55.81 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPP1 30
  • 29 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons LPP3 29
  • 48.68 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0139600 29
  • 48.99 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToMany
Species where no ortholog for PLPP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLPP5 Gene

ENSEMBL:
Gene Tree for PLPP5 (if available)
TreeFam:
Gene Tree for PLPP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPP5: view image
Alliance of Genome Resources:
Additional Orthologs for PLPP5

Paralogs for PLPP5 Gene

genes like me logo Genes that share paralogs with PLPP5: view

Variants for PLPP5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLPP5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLPP5 Gene

Variant ID Type Subtype PubMed ID
dgv7164n100 CNV gain 25217958

Variation tolerance for PLPP5 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP5
Leiden Open Variation Database (LOVD)
PLPP5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPP5 Gene

Disorders for PLPP5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PLPP5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cone-rod dystrophy 9
  • cord9
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search PLPP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLPP5

genes like me logo Genes that share disorders with PLPP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP5 Gene

Publications for PLPP5 Gene

  1. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PMID: 17590538) Takeuchi M … Kamatani N (Gene 2007) 2 3 4
  2. HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma. (PMID: 16261160) Wu X … Qin LX (Oncogene 2006) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  5. Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma. (PMID: 24603412) Wu JC … Ren N (PloS one 2014) 3

Products for PLPP5 Gene

Sources for PLPP5 Gene