Aliases for PLPP4 Gene

Aliases for PLPP4 Gene

  • Phospholipid Phosphatase 4 2 3 4 5
  • DPPL2 2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1A 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A 2 3
  • Diacylglycerol Pyrophosphate Phosphatase-Like 2 2 3
  • PPAPDC1A 3 4
  • PPAPDC1 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1 2
  • Diacylglycerol Pyrophosphate Like 2 3
  • Phosphatidate Phosphatase PPAPDC1A 3
  • EC 4
  • EC 4
  • PLPP4 5

External Ids for PLPP4 Gene

Previous HGNC Symbols for PLPP4 Gene


Summaries for PLPP4 Gene

GeneCards Summary for PLPP4 Gene

PLPP4 (Phospholipid Phosphatase 4) is a Protein Coding gene. Diseases associated with PLPP4 include Diffuse Gastric Cancer. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Innate Immune System. An important paralog of this gene is PLPP5.

UniProtKB/Swiss-Prot Summary for PLPP4 Gene

  • Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360).

Gene Wiki entry for PLPP4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPP4 Gene

Genomics for PLPP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLPP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J120456 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 256 +0.4 447 2 ZIC2 ZBTB48 IKZF1 GLIS1 ZBTB8A ZFX EZH2 OSR2 ZBTB17 GLIS2 PLPP4 HSALNG0081100 WDR11
GH10J120161 Promoter/Enhancer 0.9 EPDnew dbSUPER 250.1 -295.4 -295444 0.1 IKZF1 TARDBP ZNF660 ZNF687 MTA2 PRDM10 ARNT RELB GATAD2B lnc-PLPP4-4 piR-55705-008 PLPP4 lnc-SEC23IP-2 SEC23IP
GH10J120453 Promoter 0.3 EPDnew 250.7 -3.0 -3013 0.1 PLPP4 piR-57965-007 SEC23IP
GH10J120455 Enhancer 0.2 Ensembl 250.7 -1.1 -1053 0.2 HSALNG0081100 PLPP4 piR-57965-007 SEC23IP
GH10J120555 Enhancer 0.6 Ensembl ENCODE 38.4 +99.5 99546 2.6 ZIC2 ZBTB40 NANOG PRDM10 USF1 PLPP4 LINC01561 piR-32909 HSALNG0081102 WDR11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPP4

Genomic Locations for PLPP4 Gene

Latest Assembly
143,170 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
135,112 bases
Plus strand

(GRCh37/hg19 by Ensembl)
132,902 bases
Plus strand

Genomic View for PLPP4 Gene

Genes around PLPP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP4 Gene

Proteins for PLPP4 Gene

  • Protein details for PLPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid phosphatase 4
    Protein Accession:
    Secondary Accessions:
    • A2RU82
    • Q08EQ2
    • Q0IIP2
    • Q495B4
    • Q5VZY1

    Protein attributes for PLPP4 Gene

    271 amino acids
    Molecular mass:
    30395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLPP4 Gene


neXtProt entry for PLPP4 Gene

Post-translational modifications for PLPP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLPP4 Gene

Domains & Families for PLPP4 Gene

Gene Families for PLPP4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPP4 Gene

  • PA-phosphatase related phosphoesterase

Suggested Antigen Peptide Sequences for PLPP4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55218, highly similar to Homo sapiens phosphatidic acid phosphatase type 2 domain containing 1A (PPAPDC1A), mRNA (B7Z3R3_HUMAN)
  • Phosphatidic acid phosphatase type 2 domain-containing protein 1A (PPC1A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA-phosphatase related phosphoesterase family.
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP4: view

Function for PLPP4 Gene

Molecular function for PLPP4 Gene

UniProtKB/Swiss-Prot Function:
Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:27449, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608, ChEBI:CHEBI:59996; EC=; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:42856, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:78229, ChEBI:CHEBI:82765; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:42860, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:76979, ChEBI:CHEBI:78229; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence={ECO:0000269|PubMed:17590538};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=104 uM for 1,2-dioctanoyl-sn-glycero-3-diphosphate/diacylglycerol pyrophosphate {ECO:0000269|PubMed:17590538}; KM=506 uM for 1,2-dioctanoyl-sn-glycero-3-phosphate/phosphatidate {ECO:0000269|PubMed:17590538}; KM=580 uM for 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate/lysophosphatidate {ECO:0000269|PubMed:17590538};
UniProtKB/Swiss-Prot EnzymeRegulation:
Magnesium-independent phospholipid phosphatase (PubMed:17590538). Inhibited by N-ethylmaleimide (PubMed:17590538).

Enzyme Numbers (IUBMB) for PLPP4 Gene

Phenotypes From GWAS Catalog for PLPP4 Gene

Gene Ontology (GO) - Molecular Function for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000810 diacylglycerol diphosphate phosphatase activity IEA,IDA 17590538
GO:0005515 protein binding IPI 32296183
GO:0008195 phosphatidate phosphatase activity IBA,IDA 17590538
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with PLPP4: view
genes like me logo Genes that share phenotypes with PLPP4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLPP4 Gene

Localization for PLPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP4 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP4 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 1
cytoskeleton 1
lysosome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoli rim (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP4: view

Pathways & Interactions for PLPP4 Gene

genes like me logo Genes that share pathways with PLPP4: view

Pathways by source for PLPP4 Gene

UniProtKB/Swiss-Prot Q5VZY2-PLPP4_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001835 blastocyst hatching IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0046839 phospholipid dephosphorylation IBA,IDA 17590538
genes like me logo Genes that share ontologies with PLPP4: view

No data available for SIGNOR curated interactions for PLPP4 Gene

Drugs & Compounds for PLPP4 Gene

(2) Drugs for PLPP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0

(12) Additional Compounds for PLPP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • (2R)-1-(Phosphonooxy)-3-(stearoyloxy)propan-2-yl (9Z,12Z)-octadeca-9,12-dienoate
  • 1-18:0-2-18:2-Phosphatidic acid
  • 1-Octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate
  • 1-Octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate
  • 18:0-18:2-PA
genes like me logo Genes that share compounds with PLPP4: view

Transcripts for PLPP4 Gene

mRNA/cDNA for PLPP4 Gene

15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP4

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP4 Gene

No ASD Table

Relevant External Links for PLPP4 Gene

GeneLoc Exon Structure for

Expression for PLPP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPP4

mRNA Expression by UniProt/SwissProt for PLPP4 Gene:

Tissue specificity: Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus, prostate, liver and uterus.

Evidence on tissue expression from TISSUES for PLPP4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PLPP4: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP4 Gene

Orthologs for PLPP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLPP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPAPDC1A 29 30
  • 99.75 (n)
(Monodelphis domestica)
Mammalia PPAPDC1A 30
  • 96 (a)
(Canis familiaris)
Mammalia PPAPDC1A 29 30
  • 94.75 (n)
(Bos Taurus)
Mammalia PPAPDC1A 29 30
  • 93.48 (n)
(Rattus norvegicus)
Mammalia Ppapdc1a 29
  • 92.5 (n)
(Mus musculus)
Mammalia Ppapdc1a 29 30
  • 92 (n)
Plpp4 16
(Ornithorhynchus anatinus)
Mammalia PPAPDC1A 30
  • 92 (a)
(Gallus gallus)
Aves PPAPDC1A 29 30
  • 84.13 (n)
(Anolis carolinensis)
Reptilia PPAPDC1A 30
  • 78 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100487728 29
  • 73.43 (n)
(Danio rerio)
Actinopterygii ppapdc1a 30
  • 75 (a)
LOC100334794 29
  • 73.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001941 29
  • 53.49 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12746 30
  • 31 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPP1 30
  • 27 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons LPP2 29
  • 49.09 (n)
(Oryza sativa)
Liliopsida Os08g0359200 29
  • 47.85 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 44 (a)
Species where no ortholog for PLPP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLPP4 Gene

Gene Tree for PLPP4 (if available)
Gene Tree for PLPP4 (if available)
Evolutionary constrained regions (ECRs) for PLPP4: view image
Alliance of Genome Resources:
Additional Orthologs for PLPP4

Paralogs for PLPP4 Gene

genes like me logo Genes that share paralogs with PLPP4: view

Variants for PLPP4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLPP4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLPP4 Gene

Variant ID Type Subtype PubMed ID
dgv1402n54 CNV gain 21841781
dgv1403n54 CNV gain 21841781
dgv1404n54 CNV gain+loss 21841781
dgv174n67 CNV loss 20364138
dgv17e180 CNV gain 20482838
esv2546781 CNV deletion 19546169
esv26675 CNV gain 19812545
esv2669932 CNV deletion 23128226
esv2676968 CNV deletion 23128226
esv2741940 CNV deletion 23290073
esv3260274 CNV deletion 24192839
esv3546941 CNV deletion 23714750
esv3624729 CNV loss 21293372
esv3624730 CNV loss 21293372
esv995047 CNV deletion 20482838
nsv1119840 CNV deletion 24896259
nsv1119841 CNV deletion 24896259
nsv1121823 CNV deletion 24896259
nsv436106 CNV deletion 17901297
nsv498743 CNV loss 21111241
nsv508610 CNV deletion 20534489
nsv511435 CNV loss 21212237
nsv512187 CNV loss 21212237
nsv528787 CNV gain 19592680
nsv552222 CNV loss 21841781
nsv552223 CNV gain 21841781
nsv7572 CNV deletion 18451855
nsv821211 CNV deletion 20802225
nsv955610 CNV deletion 24416366

Variation tolerance for PLPP4 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPP4 Gene

Disorders for PLPP4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPP4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
diffuse gastric cancer
  • signet cell adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PLPP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLPP4

genes like me logo Genes that share disorders with PLPP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP4 Gene

Publications for PLPP4 Gene

  1. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PMID: 17590538) Takeuchi M … Kamatani N (Gene 2007) 2 3 4
  2. Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells. (PMID: 28851360) Zhang X … Huang Y (Molecular cancer 2017) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer. (PMID: 30361512) Yang H … Kim HK (Nature communications 2018) 3
  5. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3

Products for PLPP4 Gene

Sources for PLPP4 Gene