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Aliases for PLPP4 Gene

Aliases for PLPP4 Gene

  • Phospholipid Phosphatase 4 2 3 3 5
  • Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1A 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A 2 3
  • Diacylglycerol Pyrophosphate Phosphatase-Like 2 2 3
  • PPAPDC1A 3 4
  • PPAPDC1 3 4
  • DPPL2 3 4
  • Phosphatidic Acid Phosphatase Type 2 Domain Containing 1 2
  • Diacylglycerol Pyrophosphate Like 2 3
  • Phosphatidate Phosphatase PPAPDC1A 3
  • EC 3.1.3.4 4

External Ids for PLPP4 Gene

Previous HGNC Symbols for PLPP4 Gene

  • PPAPDC1
  • PPAPDC1A

Summaries for PLPP4 Gene

GeneCards Summary for PLPP4 Gene

PLPP4 (Phospholipid Phosphatase 4) is a Protein Coding gene. Among its related pathways are Glycerolipid metabolism and Innate Immune System. An important paralog of this gene is PLPP5.

UniProtKB/Swiss-Prot for PLPP4 Gene

  • Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.

Gene Wiki entry for PLPP4 Gene

Additional gene information for PLPP4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP4 Gene

Genomics for PLPP4 Gene

GeneHancer (GH) Regulatory Elements for PLPP4 Gene

Promoters and enhancers for PLPP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J120456 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 656.1 +0.1 141 0.6 MXI1 ZBTB8A ZIC2 OSR2 ZNF335 HIC1 ZBTB48 GLIS1 IKZF1 ZFX PLPP4 PIR43908
GH10J120161 Promoter/Enhancer 1 EPDnew dbSUPER 650.1 -295.4 -295444 0.1 ZNF687 SMAD1 TARDBP IKZF1 ATF7 MEF2B SPI1 PLPP4 LOC105378515 ENSG00000223455
GH10J120453 Promoter 0.5 EPDnew 650.7 -3.0 -3013 0.1 PLPP4 ENSG00000234522
GH10J120555 Enhancer 0.4 ENCODE 27.6 +99.0 99030 0.2 NANOG PRDM10 PLPP4 PIR43908 LINC01561
GH10J120422 Enhancer 0.8 Ensembl ENCODE 11.1 -33.4 -33427 2.9 MEIS2 CTCF PKNOX1 ZNF654 JUN TRIM22 REST TSHZ1 RAD21 JUND PLPP4 GC10M120361 ENSG00000234522
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLPP4 Gene

Genomic Locations for PLPP4 Gene
chr10:120,456,954-120,589,855
(GRCh38/hg38)
Size:
132,902 bases
Orientation:
Plus strand
chr10:122,216,466-122,349,367
(GRCh37/hg19)
Size:
132,902 bases
Orientation:
Plus strand

Genomic View for PLPP4 Gene

Genes around PLPP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP4 Gene

Proteins for PLPP4 Gene

  • Protein details for PLPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZY2-PLPP4_HUMAN
    Recommended name:
    Phospholipid phosphatase 4
    Protein Accession:
    Q5VZY2
    Secondary Accessions:
    • A2RU82
    • Q08EQ2
    • Q0IIP2
    • Q495B4
    • Q5VZY1

    Protein attributes for PLPP4 Gene

    Size:
    271 amino acids
    Molecular mass:
    30395 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH70333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PLPP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP4 Gene

Post-translational modifications for PLPP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLPP4 Gene

Domains & Families for PLPP4 Gene

Gene Families for PLPP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q5VZY2

UniProtKB/Swiss-Prot:

PLPP4_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP4: view

Function for PLPP4 Gene

Molecular function for PLPP4 Gene

UniProtKB/Swiss-Prot Function:
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=104 uM for diacylglycerol pyrophosphate {ECO:0000269 PubMed:17590538}; KM=506 uM for phosphatidate {ECO:0000269 PubMed:17590538}; KM=580 uM for lysophosphatidate {ECO:0000269 PubMed:17590538};

Enzyme Numbers (IUBMB) for PLPP4 Gene

Phenotypes From GWAS Catalog for PLPP4 Gene

Gene Ontology (GO) - Molecular Function for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008195 phosphatidate phosphatase activity IDA,EXP 17590538
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IBA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with PLPP4: view
genes like me logo Genes that share phenotypes with PLPP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLPP4 Gene

Localization for PLPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP4 gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP4: view

Pathways & Interactions for PLPP4 Gene

genes like me logo Genes that share pathways with PLPP4: view

Pathways by source for PLPP4 Gene

Gene Ontology (GO) - Biological Process for PLPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0046839 phospholipid dephosphorylation IDA 17590538
genes like me logo Genes that share ontologies with PLPP4: view

No data available for SIGNOR curated interactions for PLPP4 Gene

Drugs & Compounds for PLPP4 Gene

(2) Drugs for PLPP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(12) Additional Compounds for PLPP4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1N7)
  • PA(16:0/18:1W7)
PA(16:0/18:1(9Z))
  • (2R)-1-(Palmitoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol 3-phosphate
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • PA(16:0/18:1)
PA(16:0/18:2(9Z,12Z))
  • 1-16:0-2-18:2-Phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • 16:0-18:2-PA
  • 2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with PLPP4: view

Transcripts for PLPP4 Gene

mRNA/cDNA for PLPP4 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP4 Gene

No ASD Table

Relevant External Links for PLPP4 Gene

GeneLoc Exon Structure for
PLPP4
ECgene alternative splicing isoforms for
PLPP4

Expression for PLPP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PLPP4 Gene:

PLPP4

mRNA Expression by UniProt/SwissProt for PLPP4 Gene:

Q5VZY2-PLPP4_HUMAN
Tissue specificity: Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow, thymus, prostate, liver and uterus.

Evidence on tissue expression from TISSUES for PLPP4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PLPP4: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP4 Gene

Orthologs for PLPP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLPP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAPDC1A 34 33
  • 99.75 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPAPDC1A 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAPDC1A 34 33
  • 94.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPAPDC1A 34 33
  • 93.48 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppapdc1a 33
  • 92.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPAPDC1A 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppapdc1a 34 33
  • 92 (n)
OneToOne
Plpp4 16
chicken
(Gallus gallus)
Aves PPAPDC1A 34 33
  • 84.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAPDC1A 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487728 33
  • 73.43 (n)
zebrafish
(Danio rerio)
Actinopterygii ppapdc1a 34
  • 75 (a)
OneToOne
LOC100334794 33
  • 73.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001941 33
  • 53.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12746 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPP1 36 34
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons LPP2 33
  • 49.09 (n)
rice
(Oryza sativa)
Liliopsida Os08g0359200 33
  • 47.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Species where no ortholog for PLPP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLPP4 Gene

ENSEMBL:
Gene Tree for PLPP4 (if available)
TreeFam:
Gene Tree for PLPP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPP4: view image

Paralogs for PLPP4 Gene

Paralogs for PLPP4 Gene

genes like me logo Genes that share paralogs with PLPP4: view

Variants for PLPP4 Gene

Sequence variations from dbSNP and Humsavar for PLPP4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000017278 -- 120,540,141(+) AAAAAA/AAAAA intron_variant
rs1000034138 -- 120,476,224(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000034605 -- 120,503,353(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000046609 -- 120,545,922(+) A/G intron_variant
rs1000070581 -- 120,533,481(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLPP4 Gene

Variant ID Type Subtype PubMed ID
dgv1402n54 CNV gain 21841781
dgv1403n54 CNV gain 21841781
dgv1404n54 CNV gain+loss 21841781
dgv174n67 CNV loss 20364138
dgv17e180 CNV gain 20482838
esv2546781 CNV deletion 19546169
esv26675 CNV gain 19812545
esv2669932 CNV deletion 23128226
esv2676968 CNV deletion 23128226
esv2741940 CNV deletion 23290073
esv3260274 CNV deletion 24192839
esv3546941 CNV deletion 23714750
esv3624729 CNV loss 21293372
esv3624730 CNV loss 21293372
esv995047 CNV deletion 20482838
nsv1119840 CNV deletion 24896259
nsv1119841 CNV deletion 24896259
nsv1121823 CNV deletion 24896259
nsv436106 CNV deletion 17901297
nsv498743 CNV loss 21111241
nsv508610 CNV deletion 20534489
nsv511435 CNV loss 21212237
nsv512187 CNV loss 21212237
nsv528787 CNV gain 19592680
nsv552222 CNV loss 21841781
nsv552223 CNV gain 21841781
nsv7572 CNV deletion 18451855
nsv821211 CNV deletion 20802225
nsv955610 CNV deletion 24416366

Variation tolerance for PLPP4 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP4 Gene

Disorders for PLPP4 Gene

No disorders were found for PLPP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP4 Gene

Publications for PLPP4 Gene

  1. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PMID: 17590538) Takeuchi M … Kamatani N (Gene 2007) 2 3 4 58
  2. Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells. (PMID: 28851360) Zhang X … Huang Y (Molecular cancer 2017) 3 58
  3. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R … Alzheimer's Disease Genetics Consortium (Alzheimer's & dementia : the journal of the Alzheimer's Association 2014) 3 58

Products for PLPP4 Gene

Sources for PLPP4 Gene

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