The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to a... See more...

Aliases for PLPP3 Gene

Aliases for PLPP3 Gene

  • Phospholipid Phosphatase 3 2 3 4 5
  • LPP3 2 3 4
  • Phosphatidate Phosphohydrolase Type 2b 3 4
  • Phosphatidic Acid Phosphatase Type 2B 2 3
  • Lipid Phosphate Phosphohydrolase 3 3 4
  • EC 3.1.3.4 4 50
  • PPAP2B 3 4
  • PAP-2b 2 4
  • VCIP 3 4
  • Vascular Endothelial Growth Factor And Type I Collagen-Inducible Protein 4
  • Vascular Endothelial Growth Factor And Type I Collagen Inducible 3
  • Type-2 Phosphatidic Acid Phosphatase-Beta 3
  • Phosphatidic Acid Phosphatase 2b 4
  • EC 3.1.3.- 4
  • PAP2 Beta 3
  • PAP2-Beta 4
  • Dri42 3
  • PAP2B 3
  • PLPP3 5
  • PAP2b 4

External Ids for PLPP3 Gene

Previous HGNC Symbols for PLPP3 Gene

  • PPAP2B

Summaries for PLPP3 Gene

Entrez Gene Summary for PLPP3 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for PLPP3 Gene

PLPP3 (Phospholipid Phosphatase 3) is a Protein Coding gene. Diseases associated with PLPP3 include Myxosarcoma. Among its related pathways are Integrin Pathway and Nanog in Mammalian ESC Pluripotency. An important paralog of this gene is ENSG00000284686.

UniProtKB/Swiss-Prot Summary for PLPP3 Gene

  • Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:27694435). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:9607309, PubMed:23591818, PubMed:27694435). Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (PubMed:27694435). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (PubMed:23591818).
  • Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:20123964, PubMed:21569306). Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis (PubMed:12660161, PubMed:16099422).

Gene Wiki entry for PLPP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPP3 Gene

Genomics for PLPP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLPP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J056572 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 254.7 +68.1 68071 10.3 ZNF654 ZNF600 ZNF580 ZMYM3 CEBPA ZSCAN16 POLR2A ZIC2 ZBTB10 CHD4 PLPP3 C8A FYB2 C8B RPSAP20 PRKAA2 lnc-FYB2-4 RPL23AP85 lnc-PRKAA2-9 ENSG00000284686
GH01J056505 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.1 +136.7 136667 7.1 IKZF1 SSRP1 ZMYM3 KLF9 CEBPA ATF3 NFIC YY1 MXD4 CEBPB PLPP3 HSALNG0003886 lnc-FYB2-5 ENSG00000284686 HSALNG0003885
GH01J056644 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.4 -405 3.4 ZNF600 CEBPA ZSCAN16 ZIC2 ZBTB10 ZNF341 THAP11 SAP130 RARA YY1 LOC101929935 PLPP3 PRKAA2 RF00017-201 piR-39858-023 FYB2
GH01J056514 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 250.1 +129.0 128981 4.5 BCLAF1 NCOR1 IKZF1 ZMYM3 ATF2 JUND REST HES1 BHLHE40 ZNF217 lnc-FYB2-5 PLPP3 HSALNG0003886 ENSG00000284686
GH01J056493 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 250.1 +149.7 149685 4.5 IKZF1 CEBPA ATF3 CHD4 YY1 KLF11 FEZF1 HOMEZ THAP11 FOXA2 PLPP3 HSALNG0003885 HSALNG0003886 lnc-FYB2-5 ENSG00000284686
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPP3

Genomic Locations for PLPP3 Gene

Latest Assembly
chr1:56,494,761-56,645,301
(GRCh38/hg38)
Size:
150,541 bases
Orientation:
Minus strand

Previous Assembly
chr1:56,960,433-57,045,236
(GRCh37/hg19 by Entrez Gene)
Size:
84,804 bases
Orientation:
Minus strand

chr1:56,960,419-57,110,974
(GRCh37/hg19 by Ensembl)
Size:
150,556 bases
Orientation:
Minus strand

Genomic View for PLPP3 Gene

Genes around PLPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP3 Gene

Proteins for PLPP3 Gene

  • Protein details for PLPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14495-PLPP3_HUMAN
    Recommended name:
    Phospholipid phosphatase 3
    Protein Accession:
    O14495
    Secondary Accessions:
    • B2R651
    • D3DQ52
    • Q5U0F7
    • Q96GW0
    • Q99782

    Protein attributes for PLPP3 Gene

    Size:
    311 amino acids
    Molecular mass:
    35116 Da
    Quaternary structure:
    • Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity (PubMed:14725715). Can also form heterooligomers with other PLPP2 and PLPP3 (PubMed:18215144). Interacts with CTNND1; negatively regulates the PLPP3-mediated stabilization of beta-catenin/CTNNB1 (PubMed:20123964).
    SequenceCaution:
    • Sequence=AAB50222.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for PLPP3 Gene

Selected DME Specific Peptides for PLPP3 Gene

O14495:
  • DESIKYP
  • SIGRLRPHF

Post-translational modifications for PLPP3 Gene

  • N-glycosylated (PubMed:9705349). Contains high-mannose oligosaccharides (PubMed:9705349).
  • Glycosylation at Asn170
  • Modification sites at PhosphoSitePlus

Other Protein References for PLPP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for PLPP3 Gene

Gene Families for PLPP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for PLPP3 Gene

InterPro:
Blocks:
  • PA-phosphatase related phosphoesterase

Suggested Antigen Peptide Sequences for PLPP3 Gene

GenScript: Design optimal peptide antigens:
  • Vascular endothelial growth factor and type I collagen-inducible protein (LPP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14495

UniProtKB/Swiss-Prot:

PLPP3_HUMAN :
  • The integrin-binding motif mediates the binding to integrin alpha-5/beta-1 (ITGA5:ITGB1) and integrin alpha-V/beta-3 (ITGAV:ITGB3) and is required for the function in integrin-mediated cell-cell adhesion.
  • Belongs to the PA-phosphatase related phosphoesterase family.
Domain:
  • The integrin-binding motif mediates the binding to integrin alpha-5/beta-1 (ITGA5:ITGB1) and integrin alpha-V/beta-3 (ITGAV:ITGB3) and is required for the function in integrin-mediated cell-cell adhesion.
  • The dityrosine basolateral targeting motif mediates localization to the basolateral membrane in polarized cells.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP3: view

Function for PLPP3 Gene

Molecular function for PLPP3 Gene

UniProtKB/Swiss-Prot Function:
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:27694435). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:9607309, PubMed:23591818, PubMed:27694435). Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (PubMed:27694435). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (PubMed:23591818).
UniProtKB/Swiss-Prot Function:
Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:20123964, PubMed:21569306). Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis (PubMed:12660161, PubMed:16099422).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence={ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:43244, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546; Evidence={ECO:0000269|PubMed:9607309};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate; Xref=Rhea:RHEA:46736, ChEBI:CHEBI:15377, ChEBI:CHEBI:17408, ChEBI:CHEBI:43474, ChEBI:CHEBI:77589; Evidence={ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate; Xref=Rhea:RHEA:50884, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75937, ChEBI:CHEBI:84973; Evidence={ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence={ECO:0000269|PubMed:27694435, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate; Xref=Rhea:RHEA:33743, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate; Xref=Rhea:RHEA:62040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:45815, ChEBI:CHEBI:85376; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate; Xref=Rhea:RHEA:62160, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:71466, ChEBI:CHEBI:145465; Evidence={ECO:0000269|PubMed:9607309};.
UniProtKB/Swiss-Prot Induction:
By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=100 uM for 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate {ECO:0000269|PubMed:9607309}; KM=110 uM for (9Z)-octadecenoyl-sn-glycero-3-phosphate {ECO:0000269|PubMed:9607309}; KM=56 uM for N-oleoyl ethanolamine phosphatidic acid {ECO:0000269|PubMed:9607309}; Vmax=0.27 nmol/min/mg enzyme with 1,2-dihexadecanoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.46 nmol/min/mg enzyme with (9Z)-octadecenoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.36 nmol/min/mg enzyme with N-(octanoyl)-sphing-4-enine-1-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.24 nmol/min/mg enzyme with sphing-4-enine 1-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=13 nmol/min/mg enzyme with 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9607309}; Vmax=15 nmol/min/mg enzyme with (9Z)-octadecenoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9607309}; Vmax=29 nmol/min/mg enzyme with N-(9Z-octadecenoyl)-ethanolamine phosphate as substrate {ECO:0000269|PubMed:9607309};
UniProtKB/Swiss-Prot EnzymeRegulation:
Magnesium-independent phospholipid phosphatase (PubMed:9705349). Insensitive to N-ethylmaleimide (PubMed:9705349). Inhibited by sphingosine, zinc ions and modestly by propanolol (PubMed:9705349).

Enzyme Numbers (IUBMB) for PLPP3 Gene

Phenotypes From GWAS Catalog for PLPP3 Gene

Gene Ontology (GO) - Molecular Function for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IDA 12660161
GO:0005515 protein binding IPI 20123964
GO:0008195 phosphatidate phosphatase activity IBA,IDA 9305923
GO:0016787 hydrolase activity IEA --
GO:0042392 sphingosine-1-phosphate phosphatase activity IBA,IDA 9305923
genes like me logo Genes that share ontologies with PLPP3: view
genes like me logo Genes that share phenotypes with PLPP3: view

Animal Models for PLPP3 Gene

MGI Knock Outs for PLPP3:

Animal Models for research

  • Taconic Biosciences Mouse Models for PLPP3

miRNA for PLPP3 Gene

miRTarBase miRNAs that target PLPP3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP3 Gene

Localization for PLPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP3 Gene

Cell membrane. Multi-pass membrane protein. Basolateral cell membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane. Multi-pass membrane protein. Membrane raft. Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi. {ECO:0000269 PubMed:23591818}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
golgi apparatus 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA,IDA 23591818
GO:0005802 trans-Golgi network IDA 23591818
genes like me logo Genes that share ontologies with PLPP3: view

Pathways & Interactions for PLPP3 Gene

PathCards logo

SuperPathways for PLPP3 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with PLPP3: view

Pathways by source for PLPP3 Gene

63 Qiagen pathways for PLPP3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

UniProtKB/Swiss-Prot O14495-PLPP3_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IDA 20123964
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IBA,IEA --
GO:0006670 sphingosine metabolic process IDA 9305923
GO:0006672 ceramide metabolic process IDA 9305923
genes like me logo Genes that share ontologies with PLPP3: view

No data available for SIGNOR curated interactions for PLPP3 Gene

Drugs & Compounds for PLPP3 Gene

(5) Drugs for PLPP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(40) Additional Compounds for PLPP3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/12:0)
  • Cer(d18:1/12:0)
  • Dodecyl sphingosine
  • Laurylsphingosine
  • N-(Dodecanoyl)ceramide
  • N-(Dodecanoyl)sphing-4-enine
74713-60-3
Cer(d18:1/16:0)
  • (2S,3R,4E)-2-Acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-Acylaminooctadec-4-ene-1,3-diol
  • C16 Cer
  • C16 Ceramide
  • C16-0(Palmitoyl)ceramide
24696-26-2
Cer(d18:1/18:0)
  • C18 Cer
  • Cer(d18:1/18:0)
  • N-(Octadecanoyl)-sphing-4-enine
  • N-(Octadecanoyl)ceramide
  • N-(Octadecanoyl)sphing-4-enine
2304-81-6
Cer(d18:1/18:1(9Z))
  • C18:1 Cer
  • Cer(d18:1/18:1(9Z))
  • N-(9Z-Octadecenoyl)-ceramide
  • N-(9Z-Octadecenoyl)-sphing-4-enine
  • N-(Oleoyl)-ceramide
5966-28-9
Cer(d18:1/20:0)
  • Cer(D18:1/20:0)
  • N-(Eicosanoyl)ceramide
  • N-(Eicosanoyl)sphing-4-enine
  • N-(Icosanoyl)ceramide
  • N-(Icosanoyl)sphing-4-enine
7344-02-7
genes like me logo Genes that share compounds with PLPP3: view

Transcripts for PLPP3 Gene

mRNA/cDNA for PLPP3 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP3

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP3 Gene

No ASD Table

Relevant External Links for PLPP3 Gene

GeneLoc Exon Structure for
PLPP3

Expression for PLPP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPP3

mRNA Expression by UniProt/SwissProt for PLPP3 Gene:

O14495-PLPP3_HUMAN
Tissue specificity: Ubiquitously expressed (PubMed:9305923, PubMed:12660161). Highly expressed in heart and placenta (PubMed:9305923).

Evidence on tissue expression from TISSUES for PLPP3 Gene

  • Nervous system(4.9)
  • Eye(3)
  • Pancreas(3)
  • Lung(2.9)
  • Liver(2.7)
  • Kidney(2.7)
  • Heart(2.7)
  • Thyroid gland(2.7)
  • Muscle(2.6)
  • Skin(2.4)
  • Intestine(2.2)
  • Spleen(2.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP3 Gene

Orthologs for PLPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPAP2B 29 30
  • 95.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPAP2B 29 30
  • 93.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPAP2B 29 30
  • 91.94 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppap2b 29 30
  • 89.17 (n)
OneToOne
Plpp3 16
Oppossum
(Monodelphis domestica)
Mammalia PPAP2B 30
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppap2b 29
  • 88.75 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2B 30
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPAP2B 29 30
  • 79.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPAP2B 30
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppap2b 29
  • 73.79 (n)
Str.15806 29
Zebrafish
(Danio rerio)
Actinopterygii ppap2b 29 30
  • 70 (n)
OneToOne
Dr.28946 29
Fruit Fly
(Drosophila melanogaster)
Insecta wun 30
  • 32 (a)
ManyToMany
CG11426 30
  • 29 (a)
ManyToMany
wun2 30
  • 28 (a)
ManyToMany
CG11425 30
  • 27 (a)
ManyToMany
CG11438 30
  • 27 (a)
ManyToMany
laza 30
  • 24 (a)
ManyToMany
CG11437 30
  • 23 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea F53C3.13 30
  • 27 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 27 (a)
OneToMany
Species where no ortholog for PLPP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLPP3 Gene

ENSEMBL:
Gene Tree for PLPP3 (if available)
TreeFam:
Gene Tree for PLPP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPP3: view image
Alliance of Genome Resources:
Additional Orthologs for PLPP3

Paralogs for PLPP3 Gene

genes like me logo Genes that share paralogs with PLPP3: view

Variants for PLPP3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLPP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLPP3 Gene

Variant ID Type Subtype PubMed ID
dgv92e59 CNV tandem duplication 20981092
esv3349117 CNV insertion 20981092
esv3372563 CNV duplication 20981092
nsv945965 CNV duplication 23825009

Variation tolerance for PLPP3 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP3 Gene

Human Gene Mutation Database (HGMD)
PLPP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP3
Leiden Open Variation Database (LOVD)
PLPP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPP3 Gene

Disorders for PLPP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPP3 Gene - From: COP

Disorder Aliases PubMed IDs
myxosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search PLPP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLPP3

genes like me logo Genes that share disorders with PLPP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP3 Gene

Publications for PLPP3 Gene

  1. Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. (PMID: 9305923) Kai M … Kanoh H (The Journal of biological chemistry 1997) 2 3 4 22
  2. Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. (PMID: 18215144) Long JS … Pyne S (The Biochemical journal 2008) 3 4 22
  3. Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand. (PMID: 16099422) Humtsoe JO … Wary KK (Biochemical and biophysical research communications 2005) 3 4 22
  4. Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. (PMID: 12660161) Humtsoe JO … Wary KK (The EMBO journal 2003) 3 4 22
  5. Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. (PMID: 27694435) Touat-Hamici Z … Ninio E (Cardiovascular research 2016) 3 4

Products for PLPP3 Gene

Sources for PLPP3 Gene