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Aliases for PLPP3 Gene

Aliases for PLPP3 Gene

  • Phospholipid Phosphatase 3 2 3 3 5
  • Phosphatidate Phosphohydrolase Type 2b 3 4
  • Phosphatidic Acid Phosphatase Type 2B 2 3
  • Lipid Phosphate Phosphohydrolase 3 3 4
  • PPAP2B 3 4
  • LPP3 3 4
  • VCIP 3 4
  • Vascular Endothelial Growth Factor And Type I Collagen-Inducible Protein 4
  • Vascular Endothelial Growth Factor And Type I Collagen Inducible 3
  • Type-2 Phosphatidic Acid Phosphatase-Beta 3
  • Phosphatidic Acid Phosphatase 2b 4
  • EC 4
  • PAP2 Beta 3
  • PAP2-Beta 4
  • PAP-2b 4
  • Dri42 3
  • PAP2B 3
  • PAP2b 4

External Ids for PLPP3 Gene

Previous HGNC Symbols for PLPP3 Gene

  • PPAP2B

Summaries for PLPP3 Gene

Entrez Gene Summary for PLPP3 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for PLPP3 Gene

PLPP3 (Phospholipid Phosphatase 3) is a Protein Coding gene. Diseases associated with PLPP3 include Childhood Oligodendroglioma. Among its related pathways are ERK Signaling and Akt Signaling. An important paralog of this gene is ENSG00000284686.

UniProtKB/Swiss-Prot for PLPP3 Gene

  • Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

Gene Wiki entry for PLPP3 Gene

Additional gene information for PLPP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP3 Gene

Genomics for PLPP3 Gene

GeneHancer (GH) Regulatory Elements for PLPP3 Gene

Promoters and enhancers for PLPP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J056574 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 654.7 +66.7 66708 7.6 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 REST SMARCB1 PLPP3 C8A FYB2 C8B PRKAA2 RPL23AP85 GC01P056539
GH01J056505 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.1 +136.7 136667 7.1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 PAF1 SP5 NFYC ZHX2 PLPP3 ENSG00000284686 ENSG00000260971
GH01J056644 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.0 29 2.5 ARID4B KLF17 SIN3A DMAP1 YY1 ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 LOC101929935 PLPP3 PRKAA2 GC01M056607
GH01J056514 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.1 +129.0 128981 4.5 PKNOX1 ATF1 TCF12 POLR2B GATA2 FOS ATF7 RUNX3 NCOA1 JUNB PLPP3 ENSG00000284686 ENSG00000260971
GH01J056493 Promoter/Enhancer 1.7 EPDnew ENCODE dbSUPER 650.1 +149.7 149685 4.5 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 ETS1 YY1 ZNF213 NFKBIZ PLPP3 ENSG00000260971 ENSG00000284686
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLPP3 Gene

Genomic Locations for PLPP3 Gene
150,555 bases
Minus strand
150,556 bases
Minus strand

Genomic View for PLPP3 Gene

Genes around PLPP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP3 Gene

Proteins for PLPP3 Gene

  • Protein details for PLPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipid phosphatase 3
    Protein Accession:
    Secondary Accessions:
    • B2R651
    • D3DQ52
    • Q5U0F7
    • Q96GW0
    • Q99782

    Protein attributes for PLPP3 Gene

    311 amino acids
    Molecular mass:
    35116 Da
    Quaternary structure:
    • Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability.
    • Sequence=AAB50222.1; Type=Frameshift; Positions=225; Evidence={ECO:0000305};

neXtProt entry for PLPP3 Gene

Post-translational modifications for PLPP3 Gene

Other Protein References for PLPP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLPP3 Gene

Domains & Families for PLPP3 Gene

Gene Families for PLPP3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PLPP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PA-phosphatase related phosphoesterase family.
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP3: view

Function for PLPP3 Gene

Molecular function for PLPP3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.
UniProtKB/Swiss-Prot Induction:
By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA).

Enzyme Numbers (IUBMB) for PLPP3 Gene

Phenotypes From GWAS Catalog for PLPP3 Gene

Gene Ontology (GO) - Molecular Function for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 9705349
GO:0005515 protein binding IPI 20123964
GO:0008195 phosphatidate phosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IBA --
genes like me logo Genes that share ontologies with PLPP3: view
genes like me logo Genes that share phenotypes with PLPP3: view

Animal Models for PLPP3 Gene

MGI Knock Outs for PLPP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP3

miRNA for PLPP3 Gene

miRTarBase miRNAs that target PLPP3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP3 Gene

Localization for PLPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP3 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA,IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005912 adherens junction TAS 20123964
GO:0016020 membrane TAS 9305923
genes like me logo Genes that share ontologies with PLPP3: view

Pathways & Interactions for PLPP3 Gene

genes like me logo Genes that share pathways with PLPP3: view

Gene Ontology (GO) - Biological Process for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IDA 20123964
GO:0006470 protein dephosphorylation IEA --
GO:0006629 lipid metabolic process NAS 9705349
GO:0006644 phospholipid metabolic process IBA --
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with PLPP3: view

No data available for SIGNOR curated interactions for PLPP3 Gene

Drugs & Compounds for PLPP3 Gene

(5) Drugs for PLPP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(40) Additional Compounds for PLPP3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • C24:1 Cer
  • Ceramide (D18:1/24:1(15Z))
  • N-(15-cis)-Tetracosenoylsphingosine
  • N-(15Z-Tetracosenoyl)ceramide
  • N-(15Z-Tetracosenoyl)sphing-4-enine
  • C26 Cer
  • N-(Hexacosanoyl)ceramide
  • N-(Hexacosanoyl)sphing-4-enine
  • N-Hexacosanoylsphing-4-enine
  • (2S,3R,4E)-2-acylamino-1,3-Octadec-4-enediol
Ceramide (d18:1/12:0)
  • Cer(D18:1/12:0)
  • Dodecyl sphingosine
  • Laurylsphingosine
  • N-(Dodecanoyl)ceramide
  • N-(Dodecanoyl)sphing-4-enine
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-Octadec-4-enediol
  • (2S,3R,4E)-2-Acylaminooctadec-4-ene-1,3-diol
  • C16 Cer
  • C16 Ceramide
  • C16-0(Palmitoyl)ceramide
Ceramide (d18:1/18:0)
  • C18 Cer
  • Cer(D18:1/18:0)
  • N-(Octadecanoyl)-sphing-4-enine
  • N-(Octadecanoyl)ceramide
  • N-(Octadecanoyl)sphing-4-enine
genes like me logo Genes that share compounds with PLPP3: view

Transcripts for PLPP3 Gene

mRNA/cDNA for PLPP3 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP3 Gene

No ASD Table

Relevant External Links for PLPP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLPP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLPP3 Gene:


mRNA Expression by UniProt/SwissProt for PLPP3 Gene:

Tissue specificity: Ubiquitously expressed. Highly expressed in heart and placenta.

Evidence on tissue expression from TISSUES for PLPP3 Gene

  • Nervous system(4.9)
  • Lung(2.9)
  • Liver(2.6)
  • Pancreas(2.6)
  • Eye(2.5)
  • Thyroid gland(2.3)
  • Heart(2.2)
  • Muscle(2.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP3 Gene

Orthologs for PLPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPAP2B 34 33
  • 95.81 (n)
(Canis familiaris)
Mammalia PPAP2B 34 33
  • 93.03 (n)
(Bos Taurus)
Mammalia PPAP2B 34 33
  • 91.94 (n)
(Mus musculus)
Mammalia Ppap2b 34 33
  • 89.17 (n)
Plpp3 16
(Monodelphis domestica)
Mammalia PPAP2B 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Ppap2b 33
  • 88.75 (n)
(Ornithorhynchus anatinus)
Mammalia PPAP2B 34
  • 53 (a)
(Gallus gallus)
Aves PPAP2B 34 33
  • 79.96 (n)
(Anolis carolinensis)
Reptilia PPAP2B 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppap2b 33
  • 73.79 (n)
Str.15806 33
(Danio rerio)
Actinopterygii ppap2b 34 33
  • 70 (n)
Dr.28946 33
fruit fly
(Drosophila melanogaster)
Insecta wun 34
  • 32 (a)
CG11426 34
  • 29 (a)
wun2 34
  • 28 (a)
CG11425 34
  • 27 (a)
CG11438 34
  • 27 (a)
laza 34
  • 24 (a)
CG11437 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea F53C3.13 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for PLPP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP3 Gene

Gene Tree for PLPP3 (if available)
Gene Tree for PLPP3 (if available)
Evolutionary constrained regions (ECRs) for PLPP3: view image

Paralogs for PLPP3 Gene

genes like me logo Genes that share paralogs with PLPP3: view

Variants for PLPP3 Gene

Sequence variations from dbSNP and Humsavar for PLPP3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000013662 -- 56,527,596(-) A/G intron_variant
rs1000033977 -- 56,545,650(-) T/G intron_variant
rs1000110492 -- 56,520,604(-) C/A intron_variant
rs1000111438 -- 56,527,841(-) G/A intron_variant
rs1000176281 -- 56,519,117(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLPP3 Gene

Variant ID Type Subtype PubMed ID
dgv92e59 CNV tandem duplication 20981092
esv3349117 CNV insertion 20981092
esv3372563 CNV duplication 20981092
nsv945965 CNV duplication 23825009

Variation tolerance for PLPP3 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP3 Gene

Disorders for PLPP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPP3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
childhood oligodendroglioma
  • pediatric oligodendroglioma
- elite association - COSMIC cancer census association via MalaCards
Search PLPP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLPP3

genes like me logo Genes that share disorders with PLPP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP3 Gene

Publications for PLPP3 Gene

  1. Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. (PMID: 9305923) Kai M … Kanoh H (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. (PMID: 12660161) Humtsoe JO … Wary KK (The EMBO journal 2003) 3 4 22 58
  3. Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. (PMID: 18215144) Long JS … Pyne S (The Biochemical journal 2008) 3 22 58
  4. Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand. (PMID: 16099422) Humtsoe JO … Wary KK (Biochemical and biophysical research communications 2005) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PLPP3 Gene

Sources for PLPP3 Gene

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