The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All t... See more...

Aliases for PLPP2 Gene

Aliases for PLPP2 Gene

  • Phospholipid Phosphatase 2 2 3 4 5
  • Phosphatidate Phosphohydrolase Type 2c 3 4
  • Phosphatidic Acid Phosphatase Type 2C 2 3
  • Lipid Phosphate Phosphohydrolase 2 3 4
  • Phosphatidic Acid Phosphatase 2c 3 4
  • PAP2-Gamma 3 4
  • EC 3.1.3.4 4 52
  • PAP2-G 3 4
  • PPAP2C 3 4
  • PAP-2c 3 4
  • PAP2c 3 4
  • LPP2 3 4
  • Phosphatidic Acid Phosphohydrolase Type 2c 3
  • Type-2 Phosphatidic Acid Phosphatase-Gamma 3

External Ids for PLPP2 Gene

Previous HGNC Symbols for PLPP2 Gene

  • PPAP2C

Previous GeneCards Identifiers for PLPP2 Gene

  • GC19M000282
  • GC19M000287

Summaries for PLPP2 Gene

Entrez Gene Summary for PLPP2 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLPP2 Gene

PLPP2 (Phospholipid Phosphatase 2) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and triacylglycerol biosynthesis. An important paralog of this gene is PLPP1.

UniProtKB/Swiss-Prot Summary for PLPP2 Gene

  • Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Gene Wiki entry for PLPP2 Gene

Additional gene information for PLPP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPP2 Gene

Genomics for PLPP2 Gene

GeneHancer (GH) Regulatory Elements for PLPP2 Gene

Promoters and enhancers for PLPP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000288 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 531.4 +1.1 1100 3.4 HNRNPK ZNF217 USF1 TEAD4 CLOCK ZBTB26 RFX1 PRPF4 TBX3 ZKSCAN8 PLPP2 WASH5P GZMM MISP RNF126 C2CD4C VN2R11P
GH19J000266 Enhancer 1 ENCODE 21.4 +24.2 24214 0.8 ZNF217 EP300 CTCF NRF1 TCF12 ZFX ZIC2 ZBTB26 TARDBP REST FJ601684-208 piR-35312-016 PLPP2 CIRBP C2CD4C WDR18
GH19J000294 Enhancer 0.7 ENCODE 18.5 -3.6 -3629 1.4 CTCF REST ZBTB26 SMC3 EZH2 MYNN ZKSCAN1 RAD21 GABPB1 FOXP2 PLPP2 MG828561 ENSG00000267124
GH19J000282 Enhancer 0.4 dbSUPER 15.5 +9.2 9170 0.5 CTCF ADNP ZMYM3 KDM1A PLPP2 THEG C2CD4C VN2R11P
GH19J000747 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.1 -460.5 -460480 9.4 ZNF217 TCF12 USF1 SP1 PHF8 FOS ZFX ZIC2 POLR2A KDM6A MISP PRTN3 ELANE CFD FSTL3 PLPP2 TPGS1 RF00017-2714 lnc-PALM-1 PALM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPP2

Genomic Locations for PLPP2 Gene

Genomic Locations for PLPP2 Gene
chr19:281,040-291,435
(GRCh38/hg38)
Size:
10,396 bases
Orientation:
Minus strand
chr19:281,040-291,435
(GRCh37/hg19)
Size:
10,396 bases
Orientation:
Minus strand

Genomic View for PLPP2 Gene

Genes around PLPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP2 Gene

Proteins for PLPP2 Gene

  • Protein details for PLPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43688-PLPP2_HUMAN
    Recommended name:
    Phospholipid phosphatase 2
    Protein Accession:
    O43688
    Secondary Accessions:
    • A6NLV0
    • E9PAY8

    Protein attributes for PLPP2 Gene

    Size:
    288 amino acids
    Molecular mass:
    32574 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for PLPP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP2 Gene

Selected DME Specific Peptides for PLPP2 Gene

O43688:
  • RLSFYSGHSSF
  • RRWVFVLLDVLC
  • KHHWSDVLVGLLQGALVA
  • GTFLFGAA
  • GEAYLVYTDRLYSRS

Post-translational modifications for PLPP2 Gene

  • Glycosylation at Asn139
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PLPP2_HUMAN (1460)

Domains & Families for PLPP2 Gene

Gene Families for PLPP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPP2 Gene

Blocks:
  • PA-phosphatase related phosphoesterase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLPP2 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidic acid phosphatase 2c (LPP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43688

UniProtKB/Swiss-Prot:

PLPP2_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP2: view

Function for PLPP2 Gene

Molecular function for PLPP2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sphingosine, zinc ions and propanolol.

Enzyme Numbers (IUBMB) for PLPP2 Gene

Phenotypes From GWAS Catalog for PLPP2 Gene

Gene Ontology (GO) - Molecular Function for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 9607309
GO:0005515 protein binding IPI 25416956
GO:0008195 phosphatidate phosphatase activity IBA,IEA 21873635
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with PLPP2: view
genes like me logo Genes that share phenotypes with PLPP2: view

Animal Models for PLPP2 Gene

MGI Knock Outs for PLPP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLPP2

CRISPR Products

miRNA for PLPP2 Gene

miRTarBase miRNAs that target PLPP2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP2 Gene

Localization for PLPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane TAS,IEA 9607309
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP2: view

Pathways & Interactions for PLPP2 Gene

genes like me logo Genes that share pathways with PLPP2: view

Gene Ontology (GO) - Biological Process for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0006644 phospholipid metabolic process IBA 21873635
GO:0016311 dephosphorylation IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046839 phospholipid dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with PLPP2: view

No data available for SIGNOR curated interactions for PLPP2 Gene

Drugs & Compounds for PLPP2 Gene

(5) Drugs for PLPP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(38) Additional Compounds for PLPP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/24:1(15Z))
  • C24:1 Cer
  • Ceramide (D18:1/24:1(15Z))
  • N-(15-cis)-Tetracosenoylsphingosine
  • N-(15Z-Tetracosenoyl)ceramide
  • N-(15Z-Tetracosenoyl)sphing-4-enine
Cer(d18:1/26:0)
  • C26 Cer
  • N-(Hexacosanoyl)ceramide
  • N-(Hexacosanoyl)sphing-4-enine
  • N-Hexacosanoylsphing-4-enine
  • (2S,3R,4E)-2-acylamino-1,3-Octadec-4-enediol
Ceramide (d18:1/12:0)
  • Cer(D18:1/12:0)
  • Dodecyl sphingosine
  • Laurylsphingosine
  • N-(Dodecanoyl)ceramide
  • N-(Dodecanoyl)sphing-4-enine
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-Octadec-4-enediol
  • (2S,3R,4E)-2-Acylaminooctadec-4-ene-1,3-diol
  • C16 Cer
  • C16 Ceramide
  • C16-0(Palmitoyl)ceramide
Ceramide (d18:1/18:0)
  • C18 Cer
  • Cer(D18:1/18:0)
  • N-(Octadecanoyl)-sphing-4-enine
  • N-(Octadecanoyl)ceramide
  • N-(Octadecanoyl)sphing-4-enine
genes like me logo Genes that share compounds with PLPP2: view

Transcripts for PLPP2 Gene

mRNA/cDNA for PLPP2 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP2 Gene

No ASD Table

Relevant External Links for PLPP2 Gene

GeneLoc Exon Structure for
PLPP2

Expression for PLPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPP2

mRNA Expression by UniProt/SwissProt for PLPP2 Gene:

O43688-PLPP2_HUMAN
Tissue specificity: Found mainly in brain, pancreas and placenta.

Evidence on tissue expression from TISSUES for PLPP2 Gene

  • Intestine(3.5)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with PLPP2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP2 Gene

Orthologs for PLPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAP2C 31 30
  • 93.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPAP2C 31 30
  • 87.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPAP2C 31 30
  • 86.17 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ppap2c 31 30
  • 83.91 (n)
OneToOne
Plpp2 17
rat
(Rattus norvegicus)
Mammalia Ppap2c 30
  • 83.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2C 31
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPAP2C 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858471 30
  • 75.12 (n)
PPAP2C 31
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAP2C 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppap2c 30
  • 70.26 (n)
MGC75849 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29343 30
zebrafish
(Danio rerio)
Actinopterygii LOC563806 30
  • 69.38 (n)
PPAP2C (1 of 2) 31
  • 63 (a)
OneToMany
ppap2c 31
  • 62 (a)
OneToMany
wufj16e10 30
fruit fly
(Drosophila melanogaster)
Insecta CG11426 31
  • 27 (a)
ManyToMany
CG11437 31
  • 27 (a)
ManyToMany
CG11425 31
  • 27 (a)
ManyToMany
wun 31
  • 26 (a)
ManyToMany
CG11438 31
  • 26 (a)
ManyToMany
laza 31
  • 25 (a)
ManyToMany
wun2 31
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53C3.13 31
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToMany
Species where no ortholog for PLPP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP2 Gene

ENSEMBL:
Gene Tree for PLPP2 (if available)
TreeFam:
Gene Tree for PLPP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPP2: view image

Paralogs for PLPP2 Gene

genes like me logo Genes that share paralogs with PLPP2: view

Variants for PLPP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPP2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1138439 - p.Ala180Val

Additional dbSNP identifiers (rs#s) for PLPP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLPP2 Gene

Variant ID Type Subtype PubMed ID
dgv3419n100 CNV gain 25217958
esv2422333 CNV duplication 17116639
esv2758742 CNV gain 17122850
esv2763195 CNV gain 21179565
esv3348527 CNV duplication 20981092
esv3643341 CNV gain 21293372
esv3643342 CNV gain 21293372
esv3643343 CNV loss 21293372
esv3643344 CNV gain 21293372
nsv1058440 CNV gain 25217958
nsv1072828 CNV deletion 25765185
nsv428360 CNV gain 18775914
nsv833702 CNV loss 17160897
nsv953937 CNV deletion 24416366
nsv9653 CNV gain 18304495

Variation tolerance for PLPP2 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.78; 83.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP2 Gene

Human Gene Mutation Database (HGMD)
PLPP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP2 Gene

Disorders for PLPP2 Gene

Additional Disease Information for PLPP2

No disorders were found for PLPP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLPP2 Gene

Publications for PLPP2 Gene

  1. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. (PMID: 9607309) Hooks SB … Lynch KR (FEBS letters 1998) 2 3 4 23 54
  2. Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. (PMID: 9570154) Leung DW … White T (DNA and cell biology 1998) 2 3 4 54
  3. Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. (PMID: 18215144) Long JS … Pyne S (The Biochemical journal 2008) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. (PMID: 9705349) Roberts R … Morris AJ (The Journal of biological chemistry 1998) 3 4 54

Products for PLPP2 Gene

Sources for PLPP2 Gene