The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All t... See more...

Aliases for PLPP2 Gene

Aliases for PLPP2 Gene

  • Phospholipid Phosphatase 2 2 3 4 5
  • PAP-2c 2 3 4
  • LPP2 2 3 4
  • Phosphatidate Phosphohydrolase Type 2c 3 4
  • Phosphatidic Acid Phosphatase Type 2C 2 3
  • Lipid Phosphate Phosphohydrolase 2 3 4
  • Phosphatidic Acid Phosphatase 2c 3 4
  • PAP2-Gamma 3 4
  • EC 3.1.3.4 4 50
  • PAP2-G 3 4
  • PPAP2C 3 4
  • PAP2c 3 4
  • Phosphatidic Acid Phosphohydrolase Type 2c 3
  • Type-2 Phosphatidic Acid Phosphatase-Gamma 3
  • EC 3.1.3.- 4
  • PLPP2 5

External Ids for PLPP2 Gene

Previous HGNC Symbols for PLPP2 Gene

  • PPAP2C

Previous GeneCards Identifiers for PLPP2 Gene

  • GC19M000282
  • GC19M000287
  • GC19M000340
  • GC19M000371
  • GC19M000447

Summaries for PLPP2 Gene

Entrez Gene Summary for PLPP2 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLPP2 Gene

PLPP2 (Phospholipid Phosphatase 2) is a Protein Coding gene. Diseases associated with PLPP2 include Myxosarcoma. Among its related pathways are triacylglycerol biosynthesis and Sphingolipid metabolism. An important paralog of this gene is PLPP1.

UniProtKB/Swiss-Prot Summary for PLPP2 Gene

  • Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:16467304). Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly (PubMed:16467304). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity).

Gene Wiki entry for PLPP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPP2 Gene

Genomics for PLPP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLPP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000288 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 281.4 +1.1 1078 3.4 POLR2A CEBPB ETS1 ZNF341 MAX ZNF217 ETV4 ZNF316 TEAD3 TBP PLPP2 HSALNG0122851-001 WASH5P GZMM MISP RNF126 C2CD4C HSALNG0122850 OR4F17
GH19J000266 Enhancer 1 ENCODE 21.4 +24.2 24192 0.8 BCLAF1 ZNF654 MYC IKZF1 ZNF600 ZIC2 MXD4 NONO CTCF REST FJ601684-208 HSALNG0122847 HSALNG0122849-001 HSALNG0122849-002 piR-35312-016 PLPP2 CIRBP C2CD4C OR4F17
GH19J000294 Enhancer 0.6 ENCODE 18.5 -3.7 -3651 1.4 REST CTCF SMC3 GABPB1 ZKSCAN1 RAD21 ZNF143 GMEB1 XRCC5 MYNN HSALNG0122851-002 PLPP2 HSALNG0122851-001 ENSG00000267124 MIER2
GH19J000281 Enhancer 0.6 Ensembl dbSUPER 11.4 +10.5 10512 1.4 ZIC2 PRDM10 NR2C1 OSR2 NFXL1 EZH2 HSALNG0122850 VN2R11P lnc-OR4F17-9 THEG PLPP2 C2CD4C WASH5P OR4F17
GH19J000310 Promoter/Enhancer 0.8 Ensembl ENCODE 8.2 -19.0 -18988 3.2 POLR2A SP1 TRIM22 ZSCAN4 MIER2 PLPP2 ENSG00000267124 HSALNG0122853 RF00017-2439
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPP2

Genomic Locations for PLPP2 Gene

Latest Assembly
chr19:281,040-291,413
(GRCh38/hg38)
Size:
10,374 bases
Orientation:
Minus strand

Previous Assembly
chr19:281,043-291,403
(GRCh37/hg19 by Entrez Gene)
Size:
10,361 bases
Orientation:
Minus strand

chr19:281,040-291,393
(GRCh37/hg19 by Ensembl)
Size:
10,354 bases
Orientation:
Minus strand

Genomic View for PLPP2 Gene

Genes around PLPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP2 Gene

Proteins for PLPP2 Gene

  • Protein details for PLPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43688-PLPP2_HUMAN
    Recommended name:
    Phospholipid phosphatase 2
    Protein Accession:
    O43688
    Secondary Accessions:
    • A6NLV0
    • E9PAY8

    Protein attributes for PLPP2 Gene

    Size:
    288 amino acids
    Molecular mass:
    32574 Da
    Quaternary structure:
    • Forms functional homodimers and homooligomers (PubMed:18215144). Can also form heterooligomers with PLPP1 and PLPP3 (PubMed:18215144).

    Alternative splice isoforms for PLPP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP2 Gene

Selected DME Specific Peptides for PLPP2 Gene

O43688:
  • RLSFYSGHSSF
  • RRWVFVLLDVLC
  • KHHWSDVLVGLLQGALVA
  • GTFLFGAA
  • GEAYLVYTDRLYSRS

Post-translational modifications for PLPP2 Gene

Domains & Families for PLPP2 Gene

Gene Families for PLPP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for PLPP2 Gene

InterPro:
Blocks:
  • PA-phosphatase related phosphoesterase

Suggested Antigen Peptide Sequences for PLPP2 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidic acid phosphatase 2c (LPP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43688

UniProtKB/Swiss-Prot:

PLPP2_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP2: view

Function for PLPP2 Gene

Molecular function for PLPP2 Gene

UniProtKB/Swiss-Prot Function:
Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9705349, PubMed:9607309, PubMed:16467304). Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly (PubMed:16467304). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence={ECO:0000269|PubMed:16467304, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:43244, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546; Evidence={ECO:0000269|PubMed:9607309};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate; Xref=Rhea:RHEA:46736, ChEBI:CHEBI:15377, ChEBI:CHEBI:17408, ChEBI:CHEBI:43474, ChEBI:CHEBI:77589; Evidence={ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate; Xref=Rhea:RHEA:50884, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75937, ChEBI:CHEBI:84973; Evidence={ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate; Xref=Rhea:RHEA:33743, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate; Xref=Rhea:RHEA:62040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:45815, ChEBI:CHEBI:85376; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate; Xref=Rhea:RHEA:62160, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:71466, ChEBI:CHEBI:145465; Evidence={ECO:0000269|PubMed:9607309};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=150 uM for 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate {ECO:0000269|PubMed:9607309}; KM=340 uM for (9Z)-octadecenoyl-sn-glycero-3-phosphate {ECO:0000269|PubMed:9607309}; KM=138 uM for N-oleoyl ethanolamine phosphatidic acid {ECO:0000269|PubMed:9607309}; Vmax=0.15 nmol/min/mg enzyme with 1,2-dihexadecanoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.20 nmol/min/mg enzyme with (9Z)-octadecenoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.17 nmol/min/mg enzyme with N-(octanoyl)-sphing-4-enine-1-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.69 nmol/min/mg enzyme with sphing-4-enine 1-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=34 nmol/min/mg enzyme with 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9607309}; Vmax=49 nmol/min/mg enzyme with (9Z)-octadecenoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9607309}; Vmax=17 nmol/min/mg enzyme with N-oleoyl ethanolamine phosphatidic acid as substrate {ECO:0000269|PubMed:9607309};
UniProtKB/Swiss-Prot EnzymeRegulation:
Magnesium-independent phospholipid phosphatase (PubMed:9705349). Insensitive to N-ethylmaleimide (PubMed:9705349). Inhibited by sphingosine, zinc ions and modestly by propanolol (PubMed:9705349, PubMed:9607309).

Enzyme Numbers (IUBMB) for PLPP2 Gene

Phenotypes From GWAS Catalog for PLPP2 Gene

Gene Ontology (GO) - Molecular Function for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008195 phosphatidate phosphatase activity IEA,IDA 9705349
GO:0016787 hydrolase activity IEA --
GO:0042392 sphingosine-1-phosphate phosphatase activity IDA 9705349
GO:0042577 lipid phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with PLPP2: view
genes like me logo Genes that share phenotypes with PLPP2: view

Animal Models for PLPP2 Gene

MGI Knock Outs for PLPP2:

Animal Models for research

  • Taconic Biosciences Mouse Models for PLPP2

miRNA for PLPP2 Gene

miRTarBase miRNAs that target PLPP2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP2

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLPP2 Gene

Localization for PLPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP2 Gene

Membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Early endosome membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 5
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA 16467304
GO:0005783 endoplasmic reticulum IEA,IDA 16467304
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PLPP2: view

Pathways & Interactions for PLPP2 Gene

genes like me logo Genes that share pathways with PLPP2: view

UniProtKB/Swiss-Prot O43688-PLPP2_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for PLPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006670 sphingosine metabolic process IDA 9705349
GO:0006672 ceramide metabolic process IDA 9705349
GO:0007165 signal transduction IBA 21873635
genes like me logo Genes that share ontologies with PLPP2: view

No data available for SIGNOR curated interactions for PLPP2 Gene

Drugs & Compounds for PLPP2 Gene

(5) Drugs for PLPP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(38) Additional Compounds for PLPP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/12:0)
  • Cer(d18:1/12:0)
  • Dodecyl sphingosine
  • Laurylsphingosine
  • N-(Dodecanoyl)ceramide
  • N-(Dodecanoyl)sphing-4-enine
74713-60-3
Cer(d18:1/16:0)
  • (2S,3R,4E)-2-Acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-Acylaminooctadec-4-ene-1,3-diol
  • C16 Cer
  • C16 Ceramide
  • C16-0(Palmitoyl)ceramide
24696-26-2
Cer(d18:1/18:0)
  • C18 Cer
  • Cer(d18:1/18:0)
  • N-(Octadecanoyl)-sphing-4-enine
  • N-(Octadecanoyl)ceramide
  • N-(Octadecanoyl)sphing-4-enine
2304-81-6
Cer(d18:1/18:1(9Z))
  • C18:1 Cer
  • Cer(d18:1/18:1(9Z))
  • N-(9Z-Octadecenoyl)-ceramide
  • N-(9Z-Octadecenoyl)-sphing-4-enine
  • N-(Oleoyl)-ceramide
5966-28-9
Cer(d18:1/20:0)
  • Cer(D18:1/20:0)
  • N-(Eicosanoyl)ceramide
  • N-(Eicosanoyl)sphing-4-enine
  • N-(Icosanoyl)ceramide
  • N-(Icosanoyl)sphing-4-enine
7344-02-7
genes like me logo Genes that share compounds with PLPP2: view

Transcripts for PLPP2 Gene

mRNA/cDNA for PLPP2 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP2 Gene

No ASD Table

Relevant External Links for PLPP2 Gene

GeneLoc Exon Structure for
PLPP2

Expression for PLPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPP2

mRNA Expression by UniProt/SwissProt for PLPP2 Gene:

O43688-PLPP2_HUMAN
Tissue specificity: Found mainly in brain, pancreas and placenta.

Evidence on tissue expression from TISSUES for PLPP2 Gene

  • Intestine(3.8)
  • Nervous system(3)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with PLPP2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP2 Gene

Orthologs for PLPP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPAP2C 29 30
  • 93.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPAP2C 29 30
  • 87.58 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPAP2C 29 30
  • 86.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppap2c 29 30
  • 83.91 (n)
OneToOne
Plpp2 16
Rat
(Rattus norvegicus)
Mammalia Ppap2c 29
  • 83.78 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2C 30
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPAP2C 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100858471 29
  • 75.12 (n)
PPAP2C 30
  • 71 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPAP2C 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppap2c 29
  • 70.26 (n)
MGC75849 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.29343 29
Zebrafish
(Danio rerio)
Actinopterygii LOC563806 29
  • 69.38 (n)
PPAP2C (1 of 2) 30
  • 63 (a)
OneToMany
ppap2c 30
  • 62 (a)
OneToMany
wufj16e10 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG11426 30
  • 27 (a)
ManyToMany
CG11437 30
  • 27 (a)
ManyToMany
CG11425 30
  • 27 (a)
ManyToMany
wun 30
  • 26 (a)
ManyToMany
CG11438 30
  • 26 (a)
ManyToMany
laza 30
  • 25 (a)
ManyToMany
wun2 30
  • 25 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea F53C3.13 30
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 27 (a)
OneToMany
Species where no ortholog for PLPP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLPP2 Gene

ENSEMBL:
Gene Tree for PLPP2 (if available)
TreeFam:
Gene Tree for PLPP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPP2: view image
Alliance of Genome Resources:
Additional Orthologs for PLPP2

Paralogs for PLPP2 Gene

genes like me logo Genes that share paralogs with PLPP2: view

Variants for PLPP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPP2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1138439 -- p.Ala180Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLPP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLPP2 Gene

Variant ID Type Subtype PubMed ID
dgv3419n100 CNV gain 25217958
esv2422333 CNV duplication 17116639
esv2758742 CNV gain 17122850
esv2763195 CNV gain 21179565
esv3348527 CNV duplication 20981092
esv3643341 CNV gain 21293372
esv3643342 CNV gain 21293372
esv3643343 CNV loss 21293372
esv3643344 CNV gain 21293372
nsv1058440 CNV gain 25217958
nsv1072828 CNV deletion 25765185
nsv428360 CNV gain 18775914
nsv833702 CNV loss 17160897
nsv953937 CNV deletion 24416366
nsv9653 CNV gain 18304495

Variation tolerance for PLPP2 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.78; 83.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP2 Gene

Human Gene Mutation Database (HGMD)
PLPP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP2
Leiden Open Variation Database (LOVD)
PLPP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLPP2 Gene

Disorders for PLPP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPP2 Gene - From: COP

Disorder Aliases PubMed IDs
myxosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search PLPP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLPP2

genes like me logo Genes that share disorders with PLPP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP2 Gene

Publications for PLPP2 Gene

  1. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. (PMID: 9607309) Hooks SB … Lynch KR (FEBS letters 1998) 2 3 4 22
  2. Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. (PMID: 18215144) Long JS … Pyne S (The Biochemical journal 2008) 3 4 22
  3. Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. (PMID: 9570154) Leung DW … White T (DNA and cell biology 1998) 2 3 4
  4. Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. (PMID: 16467304) Morris KE … Brindley DN (The Journal of biological chemistry 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PLPP2 Gene

Sources for PLPP2 Gene