The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Altern... See more...

Aliases for PLPP1 Gene

Aliases for PLPP1 Gene

  • Phospholipid Phosphatase 1 2 3 4 5
  • PAP-2a 2 3 4
  • LPP1 2 3 4
  • Phosphatidate Phosphohydrolase Type 2a 3 4
  • Phosphatidic Acid Phosphatase Type 2A 2 3
  • Phosphatidic Acid Phosphatase 2a 3 4
  • EC 3.1.3.4 4 50
  • PPAP2A 3 4
  • Phosphatidic Acid Phosphohydrolase Type 2a 3
  • Type-2 Phosphatidic Acid Phosphatase Alpha 3
  • Lipid Phosphate Phosphohydrolase 1a 3
  • Lipid Phosphate Phosphohydrolase 1 4
  • EC 3.1.3.106 4
  • EC 3.1.3.81 4
  • PAP2-Alpha 4
  • EC 3.1.3.- 4
  • LLP1a 3
  • PLPP1 5
  • PAP2a 4
  • PAP2 3

External Ids for PLPP1 Gene

Previous HGNC Symbols for PLPP1 Gene

  • PPAP2A

Summaries for PLPP1 Gene

Entrez Gene Summary for PLPP1 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for PLPP1 Gene

PLPP1 (Phospholipid Phosphatase 1) is a Protein Coding gene. Diseases associated with PLPP1 include Myxosarcoma. Among its related pathways are Androgen receptor signaling pathway and triacylglycerol biosynthesis. An important paralog of this gene is PLPP2.

UniProtKB/Swiss-Prot Summary for PLPP1 Gene

  • Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).

Gene Wiki entry for PLPP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLPP1 Gene

Genomics for PLPP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLPP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLPP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLPP1

Genomic Locations for PLPP1 Gene

Latest Assembly
chr5:55,424,850-55,535,075
(GRCh38/hg38)
Size:
110,226 bases
Orientation:
Minus strand

Previous Assembly
chr5:54,720,682-54,830,792
(GRCh37/hg19 by Entrez Gene)
Size:
110,111 bases
Orientation:
Minus strand

chr5:54,720,682-54,830,878
(GRCh37/hg19 by Ensembl)
Size:
110,197 bases
Orientation:
Minus strand

Genomic View for PLPP1 Gene

Genes around PLPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP1 Gene

Proteins for PLPP1 Gene

  • Protein details for PLPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14494-PLPP1_HUMAN
    Recommended name:
    Phospholipid phosphatase 1
    Protein Accession:
    O14494
    Secondary Accessions:
    • B7ZKN8
    • G3XA95
    • O60457
    • O60463
    • Q17RZ4

    Protein attributes for PLPP1 Gene

    Size:
    284 amino acids
    Molecular mass:
    32156 Da
    Quaternary structure:
    • Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity (By similarity). Can also form heterooligomers with PLPP2 and PLPP3 (By similarity).

    Alternative splice isoforms for PLPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLPP1 Gene

Selected DME Specific Peptides for PLPP1 Gene

O14494:
  • DESIKYP
  • RLSFYSGHSSF
  • SIGRLRPHF
  • HTTLHET
  • ALYLQARM
  • GTFLFGAA
  • SIYVGLSR

Post-translational modifications for PLPP1 Gene

  • N-glycosylated (PubMed:9305923, PubMed:10962286). N-linked sugars are of the complex type. N-glycosylation is not required for the phosphatase activity (By similarity).
  • Glycosylation at Asn142
  • Modification sites at PhosphoSitePlus

Other Protein References for PLPP1 Gene

Domains & Families for PLPP1 Gene

Gene Families for PLPP1 Gene

Protein Domains for PLPP1 Gene

InterPro:
Blocks:
  • PA-phosphatase related phosphoesterase

Suggested Antigen Peptide Sequences for PLPP1 Gene

GenScript: Design optimal peptide antigens:
  • Phosphatidic acid phosphatase 2a (LPP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14494

UniProtKB/Swiss-Prot:

PLPP1_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP1: view

Function for PLPP1 Gene

Molecular function for PLPP1 Gene

UniProtKB/Swiss-Prot Function:
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:27429, ChEBI:CHEBI:15377, ChEBI:CHEBI:17815, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608; EC=3.1.3.4; Evidence={ECO:0000269|PubMed:10962286, ECO:0000269|PubMed:9305923, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:43244, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546; Evidence={ECO:0000269|PubMed:9305923, ECO:0000269|PubMed:9607309};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate; Xref=Rhea:RHEA:46736, ChEBI:CHEBI:15377, ChEBI:CHEBI:17408, ChEBI:CHEBI:43474, ChEBI:CHEBI:77589; Evidence={ECO:0000269|PubMed:10962286, ECO:0000269|PubMed:9305923, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate; Xref=Rhea:RHEA:50884, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:75937, ChEBI:CHEBI:84973; Evidence={ECO:0000269|PubMed:9305923, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:33155, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57970, ChEBI:CHEBI:64683; EC=3.1.3.106; Evidence={ECO:0000250|UniProtKB:Q61469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence={ECO:0000250|UniProtKB:Q61469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:27449, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58608, ChEBI:CHEBI:59996; EC=3.1.3.81; Evidence={ECO:0000250|UniProtKB:Q61469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine; Xref=Rhea:RHEA:27518, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57756, ChEBI:CHEBI:60119; Evidence={ECO:0000269|PubMed:17379599, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate; Xref=Rhea:RHEA:33743, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:52639, ChEBI:CHEBI:57674; Evidence={ECO:0000269|PubMed:9305923, ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate; Xref=Rhea:RHEA:62040, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:45815, ChEBI:CHEBI:85376; Evidence={ECO:0000269|PubMed:9705349};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate; Xref=Rhea:RHEA:62160, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:71466, ChEBI:CHEBI:145465; Evidence={ECO:0000269|PubMed:9607309};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:41255, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:64839, ChEBI:CHEBI:75466; Evidence={ECO:0000250|UniProtKB:O08564};.
UniProtKB/Swiss-Prot Induction:
By androgens.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=98 uM for 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate {ECO:0000269|PubMed:9607309}; KM=170 uM for (9Z)-octadecenoyl-sn-glycero-3-phosphate {ECO:0000269|PubMed:9607309}; KM=116 uM for N-(9Z-octadecenoyl)-ethanolamine phosphate {ECO:0000269|PubMed:9607309}; Vmax=0.54 nmol/min/mg enzyme with 1,2-dihexadecanoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.50 nmol/min/mg enzyme with (9Z)-octadecenoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.30 nmol/min/mg enzyme with N-(octanoyl)-sphing-4-enine-1-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=0.32 nmol/min/mg enzyme with sphing-4-enine 1-phosphate as substrate {ECO:0000269|PubMed:9705349}; Vmax=41 nmol/min/mg enzyme with 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9607309}; Vmax=33 nmol/min/mg enzyme with (9Z)-octadecenoyl-sn-glycero-3-phosphate as substrate {ECO:0000269|PubMed:9607309}; Vmax=29 nmol/min/mg enzyme with N-(9Z-octadecenoyl)-ethanolamine phosphate as substrate {ECO:0000269|PubMed:9607309};
UniProtKB/Swiss-Prot EnzymeRegulation:
Magnesium-independent phospholipid phosphatase (PubMed:9305923). Insensitive to N-ethylmaleimide (PubMed:9305923). Inhibited by sphingosine, zinc ions and modestly by propanolol (PubMed:9305923, PubMed:9705349). Inhibited by vanadate (PubMed:10962286).

Enzyme Numbers (IUBMB) for PLPP1 Gene

Phenotypes From GWAS Catalog for PLPP1 Gene

Gene Ontology (GO) - Molecular Function for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000810 diacylglycerol diphosphate phosphatase activity ISS --
GO:0005515 protein binding IPI 32296183
GO:0008195 phosphatidate phosphatase activity IEA,NAS 9570154
GO:0016787 hydrolase activity IEA --
GO:0042392 sphingosine-1-phosphate phosphatase activity TAS --
genes like me logo Genes that share ontologies with PLPP1: view
genes like me logo Genes that share phenotypes with PLPP1: view

Animal Models for research

  • Taconic Biosciences Mouse Models for PLPP1

miRNA for PLPP1 Gene

miRTarBase miRNAs that target PLPP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLPP1 Gene

Localization for PLPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP1 Gene

Cell membrane. Multi-pass membrane protein. Apical cell membrane. Multi-pass membrane protein. Membrane raft. Multi-pass membrane protein. Membrane, caveola. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLPP1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IBA,IDA 9705349
GO:0005901 caveola ISS --
GO:0016020 membrane IEA,IDA 9305923
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLPP1: view

Pathways & Interactions for PLPP1 Gene

genes like me logo Genes that share pathways with PLPP1: view

UniProtKB/Swiss-Prot O14494-PLPP1_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for PLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006670 sphingosine metabolic process IDA 9705349
GO:0006672 ceramide metabolic process IDA 9305923
GO:0007165 signal transduction IBA,IMP 15461590
genes like me logo Genes that share ontologies with PLPP1: view

No data available for SIGNOR curated interactions for PLPP1 Gene

Drugs & Compounds for PLPP1 Gene

(6) Drugs for PLPP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Sphingosine Experimental Pharma 0
Phosphate Experimental Pharma 0
sphinganine Pharma 0
Sphingosine-1-phosphate Pharma endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(42) Additional Compounds for PLPP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/12:0)
  • Cer(d18:1/12:0)
  • Dodecyl sphingosine
  • Laurylsphingosine
  • N-(Dodecanoyl)ceramide
  • N-(Dodecanoyl)sphing-4-enine
74713-60-3
Cer(d18:1/16:0)
  • (2S,3R,4E)-2-Acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-Acylaminooctadec-4-ene-1,3-diol
  • C16 Cer
  • C16 Ceramide
  • C16-0(Palmitoyl)ceramide
24696-26-2
Cer(d18:1/18:0)
  • C18 Cer
  • Cer(d18:1/18:0)
  • N-(Octadecanoyl)-sphing-4-enine
  • N-(Octadecanoyl)ceramide
  • N-(Octadecanoyl)sphing-4-enine
2304-81-6
Cer(d18:1/18:1(9Z))
  • C18:1 Cer
  • Cer(d18:1/18:1(9Z))
  • N-(9Z-Octadecenoyl)-ceramide
  • N-(9Z-Octadecenoyl)-sphing-4-enine
  • N-(Oleoyl)-ceramide
5966-28-9
Cer(d18:1/20:0)
  • Cer(D18:1/20:0)
  • N-(Eicosanoyl)ceramide
  • N-(Eicosanoyl)sphing-4-enine
  • N-(Icosanoyl)ceramide
  • N-(Icosanoyl)sphing-4-enine
7344-02-7
genes like me logo Genes that share compounds with PLPP1: view

Transcripts for PLPP1 Gene

mRNA/cDNA for PLPP1 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLPP1

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP1 Gene

No ASD Table

Relevant External Links for PLPP1 Gene

GeneLoc Exon Structure for
PLPP1

Expression for PLPP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLPP1

mRNA Expression by UniProt/SwissProt for PLPP1 Gene:

O14494-PLPP1_HUMAN
Tissue specificity: Widely expressed with highest expression found in prostate (PubMed:9305923). Found to be down-regulated in colon adenocarcinomas (PubMed:9570154).

Evidence on tissue expression from TISSUES for PLPP1 Gene

  • Nervous system(4.8)
  • Lung(4.3)
  • Liver(2.6)
  • Heart(2.4)
  • Muscle(2.3)
  • Kidney(2.3)
  • Intestine(2.1)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with PLPP1: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLPP1 Gene

Orthologs for PLPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPAP2A 29 30
  • 99.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPAP2A 30
  • 84 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PPAP2A 30
  • 79 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppap2a 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPAP2A 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2A 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPAP2A 30
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPAP2A 30
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29191 29
Zebrafish
(Danio rerio)
Actinopterygii LOC569053 29
  • 63.65 (n)
PPAP2A 30
  • 54 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9193 29
Fruit Fly
(Drosophila melanogaster)
Insecta wun 29 30
  • 51 (n)
ManyToMany
CG11425 30
  • 31 (a)
ManyToMany
CG11426 30
  • 29 (a)
ManyToMany
CG11437 30
  • 28 (a)
ManyToMany
CG11438 30
  • 27 (a)
ManyToMany
laza 30
  • 27 (a)
ManyToMany
wun2 30
  • 27 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012445 29
  • 50.15 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_F53C3.13 29
  • 49.27 (n)
F53C3.13 30
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 32 (a)
OneToMany
Species where no ortholog for PLPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for PLPP1 Gene

ENSEMBL:
Gene Tree for PLPP1 (if available)
TreeFam:
Gene Tree for PLPP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLPP1: view image
Alliance of Genome Resources:
Additional Orthologs for PLPP1

Paralogs for PLPP1 Gene

genes like me logo Genes that share paralogs with PLPP1: view

Variants for PLPP1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLPP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLPP1 Gene

Variant ID Type Subtype PubMed ID
dgv3090n106 CNV deletion 24896259
esv1622290 CNV insertion 17803354
esv1648958 CNV insertion 17803354
esv1709723 CNV deletion 17803354
esv2436029 CNV insertion 19546169
esv2675371 CNV deletion 23128226
esv2730190 CNV deletion 23290073
esv3565929 CNV deletion 23714750
nsv1074296 CNV deletion 25765185
nsv328978 CNV deletion 16902084
nsv4834 CNV insertion 18451855
nsv830304 CNV gain+loss 17160897

Variation tolerance for PLPP1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLPP1
Leiden Open Variation Database (LOVD)
PLPP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLPP1 Gene

Disorders for PLPP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPP1 Gene - From: COP

Disorder Aliases PubMed IDs
myxosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search PLPP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLPP1

genes like me logo Genes that share disorders with PLPP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP1 Gene

Publications for PLPP1 Gene

  1. Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. (PMID: 15461590) Zhao Y … Natarajan V (The Biochemical journal 2005) 3 4 22
  2. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. (PMID: 12909631) Smyth SS … Morris AJ (The Journal of biological chemistry 2003) 3 4 22
  3. Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. (PMID: 10962286) Roberts RZ … Morris AJ (Biochimica et biophysica acta 2000) 3 4 22
  4. Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP. (PMID: 9468526) Ulrix W … Verhoeven G (The Journal of biological chemistry 1998) 3 4 22
  5. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. (PMID: 9705349) Roberts R … Morris AJ (The Journal of biological chemistry 1998) 3 4 22

Products for PLPP1 Gene

Sources for PLPP1 Gene