Aliases for PLP2 Gene
External Ids for PLP2 Gene
Previous GeneCards Identifiers for PLP2 Gene
This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]
GeneCards Summary for PLP2 Gene
PLP2 (Proteolipid Protein 2) is a Protein Coding gene. Diseases associated with PLP2 include Choline Deficiency Disease and Neuronal Ceroid Lipofuscinosis. Gene Ontology (GO) annotations related to this gene include ion transmembrane transporter activity and chemokine binding. An important paralog of this gene is CMTM5.
UniProtKB/Swiss-Prot for PLP2 Gene
May play a role in cell differentiation in the intestinal epithelium.