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The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]
PLK3 (Polo Like Kinase 3) is a Protein Coding gene. Diseases associated with PLK3 include Breast Cancer. Among its related pathways are Tuberculosis and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PLK2.
Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0002039 | p53 binding | IDA | 11447225 |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
GO:0005515 | protein binding | IPI | 14968113 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000922 | spindle pole | IBA | 21873635 |
GO:0005634 | nucleus | IBA,IDA | 19490146 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IEA,IDA | 17264206 |
GO:0005737 | cytoplasm | IBA,IDA | 19490146 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of TP53 Activity | ||
2 | FoxO signaling pathway | ||
3 | Gene Expression |
.48
|
|
4 | TP53 Regulates Transcription of Cell Cycle Genes | ||
5 | DNA Damage |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | IMP | 17264206 |
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | 16481012 |
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 19490146 |
GO:0000278 | mitotic cell cycle | IBA | 21873635 |
GO:0000302 | response to reactive oxygen species | IDA | 11447225 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
Rigosertib | Investigational | Pharma | PI3K/PLK1 inhibitor | 0 | ||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
Cyclapolin 9 | Pharma | Selective, ATP-competitive PLK1 inhibitor | 0 | |||
GW843682X | Pharma | PLK1/PLK3 inhibitor,potent and selective, Selective inhibitor of PLK1 and PLK3 | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
SBE 13 hydrochloride |
|
1052532-15-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
Cyclapolin 9 | Selective, ATP-competitive PLK1 inhibitor | 40533-25-3 |
GW 843682X | Selective inhibitor of PLK1 and PLK3 | 660868-91-7 |
Ro 3280 | Potent and selective PLK1 inhibitor | 1062243-51-9 |
SBE 13 hydrochloride | Potent and selective PLK1 inhibitor | 1052532-15-6 |
TC-S 7005 | Potent and selective PLK2 inhibitor | 1082739-92-1 |
Compound | Action | Cas Number |
---|---|---|
BI6727 (Volasertib) | Plk inhibitor,highly potent | 755038-65-4 |
Cyclapolin 9 | 40533-25-3 | |
GSK461364 | Plk1 inhibitor | 929095-18-1 |
GW843682X | PLK1/PLK3 inhibitor,potent and selective | 660868-91-7 |
HMN-214 | Plk inhibitor,broad-spectrum anti-tumor agent | 173529-46-9 |
MLN0905 | Potent PLK1 inhibitor | 1228960-69-7 |
NMS-1286937 | 1034616-18-6 | |
Poloxime | 17302-61-3 | |
Rigosertib | PI3K/PLK1 inhibitor | 592542-59-1 |
TC-S 7005 | 1082739-92-1 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PLK3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PLK3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PLK3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Plk3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Plk3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | PLK3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PLK3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PLK3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PLK3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | plk3 30 |
|
||
Str.19671 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.19981 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | plk3 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC5 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8152 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713801 | Benign: not provided | 44,803,006(+) | G/A | SYNONYMOUS_VARIANT | |
720741 | Benign: not provided | 44,804,484(+) | C/T | SYNONYMOUS_VARIANT | |
722532 | Benign: not provided | 44,803,264(+) | C/T | INTRON_VARIANT | |
770845 | Benign: not provided | 44,801,630(+) | C/A | SYNONYMOUS_VARIANT | |
775133 | Benign: not provided | 44,801,723(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|