PLK3 Gene (Protein Coding)

Polo Like Kinase 3

GC01P044799
GIFtS:
43
The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cy... See more...

Aliases for PLK3 Gene

Aliases for PLK3 Gene

  • Polo Like Kinase 3 2 3 5
  • FNK 2 3 4
  • PRK 2 3 4
  • Cytokine-Inducible Serine/Threonine-Protein Kinase 3 4
  • Serine/Threonine-Protein Kinase PLK3 3 4
  • Proliferation-Related Kinase 3 4
  • FGF-Inducible Kinase 3 4
  • Polo-Like Kinase 3 2 4
  • EC 2.7.11.21 4 51
  • PLK-3 3 4
  • CNK 3 4
  • Polo-Like Kinase 3 (Drosophila) 2
  • Cytokine-Inducible Kinase 2
  • EC 2.7.11 51
  • PLK3 5

External Ids for PLK3 Gene

Previous HGNC Symbols for PLK3 Gene

  • CNK

Previous GeneCards Identifiers for PLK3 Gene

  • GC01P044679
  • GC01P044934
  • GC01P045038
  • GC01P045265
  • GC01P043379

Summaries for PLK3 Gene

Entrez Gene Summary for PLK3 Gene

  • The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]

GeneCards Summary for PLK3 Gene

PLK3 (Polo Like Kinase 3) is a Protein Coding gene. Diseases associated with PLK3 include Breast Cancer. Among its related pathways are Tuberculosis and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PLK2.

UniProtKB/Swiss-Prot Summary for PLK3 Gene

  • Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

Tocris Summary for PLK3 Gene

  • Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues.

Gene Wiki entry for PLK3 Gene

Additional gene information for PLK3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLK3 Gene

Genomics for PLK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PLK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLK3

Top Transcription factor binding sites by QIAGEN in the PLK3 gene promoter:
  • AP-1
  • ATF-2
  • ATF6
  • c-Jun
  • FOXO1
  • FOXO1a
  • LyF-1
  • Nkx2-5
  • Pax-4a

Genomic Locations for PLK3 Gene

Genomic Locations for PLK3 Gene
chr1:44,799,952-44,805,995
(GRCh38/hg38)
Size:
6,044 bases
Orientation:
Plus strand
chr1:45,265,897-45,271,667
(GRCh37/hg19)
Size:
5,771 bases
Orientation:
Plus strand

Genomic View for PLK3 Gene

Genes around PLK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLK3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PLK3 Gene

Proteins for PLK3 Gene

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  • Protein details for PLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4B4-PLK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PLK3
    Protein Accession:
    Q9H4B4
    Secondary Accessions:
    • Q15767
    • Q5JR99
    • Q96CV1

    Protein attributes for PLK3 Gene

    Size:
    646 amino acids
    Molecular mass:
    71629 Da
    Quaternary structure:
    • Interacts (via the POLO-box domain) with CIB1; leading to inhibit PLK3 kinase activity. Interacts with GOLGB1.
    SequenceCaution:
    • Sequence=AAC50637.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLK3 Gene

neXtProt entry for PLK3 Gene

Selected DME Specific Peptides for PLK3 Gene

Q9H4B4:
  • ILHRDLK
  • GPEADVW
  • LGKGGFA
  • LKETYRCI
  • HRDLKLGN
  • KPHQREK
  • YVAPEVL
  • SPRDRPSI
  • TICGTPNY
  • MELKVGDFGLAARLEP
  • ILHRDLKLGNFFI

Post-translational modifications for PLK3 Gene

  • Phosphorylated in an ATM-dependent manner following DNA damage. Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLK3 Gene

Gene Families for PLK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PLK3 Gene

InterPro:
Blocks:
  • POLO box duplicated region
ProtoNet:

Suggested Antigen Peptide Sequences for PLK3 Gene

GenScript: Design optimal peptide antigens:
  • Proliferation-related kinase (PLK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H4B4

UniProtKB/Swiss-Prot:

PLK3_HUMAN :
  • The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK3 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity). The POLO box domains mediates localization to the centrosome.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Domain:
  • The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK3 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them (By similarity). The POLO box domains mediates localization to the centrosome.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
genes like me logo Genes that share domains with PLK3: view

Function for PLK3 Gene

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Molecular function for PLK3 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.21;.
UniProtKB/Swiss-Prot Induction:
Cytokine and cellular adhesion trigger induction. Down-regulated in a majority of lung carcinoma samples.

Enzyme Numbers (IUBMB) for PLK3 Gene

Phenotypes From GWAS Catalog for PLK3 Gene

Gene Ontology (GO) - Molecular Function for PLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0002039 p53 binding IDA 11447225
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 14968113
genes like me logo Genes that share ontologies with PLK3: view
genes like me logo Genes that share phenotypes with PLK3: view

Animal Models for PLK3 Gene

MGI Knock Outs for PLK3:

Animal Model Products

CRISPR Products

miRNA for PLK3 Gene

miRTarBase miRNAs that target PLK3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLK3 Gene

Localization for PLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLK3 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications. {ECO:0000269 PubMed:17264206}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLK3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
golgi apparatus 5
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for PLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IBA 21873635
GO:0005634 nucleus IBA,IDA 19490146
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 17264206
GO:0005737 cytoplasm IBA,IDA 19490146
genes like me logo Genes that share ontologies with PLK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLK3 Gene

Pathways & Interactions for PLK3 Gene

genes like me logo Genes that share pathways with PLK3: view

Pathways by source for PLK3 Gene

1 GeneGo (Thomson Reuters) pathway for PLK3 Gene
  • Cell cycle Regulation of G1/S transition (part 1)
1 Cell Signaling Technology pathway for PLK3 Gene

SIGNOR curated interactions for PLK3 Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for PLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 17264206
GO:0000086 G2/M transition of mitotic cell cycle TAS 16481012
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19490146
GO:0000278 mitotic cell cycle IBA 21873635
GO:0000302 response to reactive oxygen species IDA 11447225
genes like me logo Genes that share ontologies with PLK3: view

Drugs & Compounds for PLK3 Gene

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  1. Drug

(17) Drugs for PLK3 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Rigosertib Investigational Pharma PI3K/PLK1 inhibitor 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
Cyclapolin 9 Pharma Selective, ATP-competitive PLK1 inhibitor 0
GW843682X Pharma PLK1/PLK3 inhibitor,potent and selective, Selective inhibitor of PLK1 and PLK3 0

(2) Additional Compounds for PLK3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
SBE 13 hydrochloride
1052532-15-6

(5) Tocris Compounds for PLK3 Gene

Compound Action Cas Number
Cyclapolin 9 Selective, ATP-competitive PLK1 inhibitor 40533-25-3
GW 843682X Selective inhibitor of PLK1 and PLK3 660868-91-7
Ro 3280 Potent and selective PLK1 inhibitor 1062243-51-9
SBE 13 hydrochloride Potent and selective PLK1 inhibitor 1052532-15-6
TC-S 7005 Potent and selective PLK2 inhibitor 1082739-92-1

(10) ApexBio Compounds for PLK3 Gene

Compound Action Cas Number
BI6727 (Volasertib) Plk inhibitor,highly potent 755038-65-4
Cyclapolin 9 40533-25-3
GSK461364 Plk1 inhibitor 929095-18-1
GW843682X PLK1/PLK3 inhibitor,potent and selective 660868-91-7
HMN-214 Plk inhibitor,broad-spectrum anti-tumor agent 173529-46-9
MLN0905 Potent PLK1 inhibitor 1228960-69-7
NMS-1286937 1034616-18-6
Poloxime 17302-61-3
Rigosertib PI3K/PLK1 inhibitor 592542-59-1
TC-S 7005 1082739-92-1
genes like me logo Genes that share compounds with PLK3: view

Drug Products

Transcripts for PLK3 Gene

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mRNA/cDNA for PLK3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLK3

Alternative Splicing Database (ASD) splice patterns (SP) for PLK3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for PLK3 Gene

GeneLoc Exon Structure for
PLK3

Expression for PLK3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLK3 Gene

mRNA expression in normal human tissues for PLK3 Gene
mRNA expression by GTEx for PLK3 GenemRNA expression by BioGPS for PLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLK3 Gene

This gene is overexpressed in Whole Blood (x6.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLK3

SOURCE GeneReport for Unigene cluster for PLK3 Gene:

Hs.632415

mRNA Expression by UniProt/SwissProt for PLK3 Gene:

Q9H4B4-PLK3_HUMAN
Tissue specificity: Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.

Evidence on tissue expression from TISSUES for PLK3 Gene

  • Nervous system(4.5)
  • Heart(4.2)
  • Bone marrow(2.5)
  • Intestine(2.5)
  • Kidney(2.5)
  • Skin(2.4)
  • Liver(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with PLK3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLK3 Gene

Orthologs for PLK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PLK3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PLK3 31
  • 99 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PLK3 30 31
  • 90.61 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PLK3 30 31
  • 90.47 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Plk3 30 17 31
  • 88.38 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Plk3 30
  • 88.16 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia PLK3 31
  • 67 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PLK3 31
  • 59 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PLK3 30 31
  • 70.29 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PLK3 31
  • 63 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia plk3 30
  • 64.54 (n)
Str.19671 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.19981 30
Zebrafish
(Danio rerio)
 Actinopterygii plk3 30 31
  • 61.94 (n)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CDC5 31
  • 29 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.8152 31
  • 38 (a)
 OneToMany
Species where no ortholog for PLK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLK3 Gene

ENSEMBL:
Gene Tree for PLK3 (if available)
TreeFam:
Gene Tree for PLK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLK3: view image

Paralogs for PLK3 Gene

Paralogs for PLK3 Gene

(12) SIMAP similar genes for PLK3 Gene using alignment to 1 proteins:

  • PLK3_HUMAN
genes like me logo Genes that share paralogs with PLK3: view

Variants for PLK3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLK3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
713801 Benign: not provided 44,803,006(+) G/A SYNONYMOUS_VARIANT
720741 Benign: not provided 44,804,484(+) C/T SYNONYMOUS_VARIANT
722532 Benign: not provided 44,803,264(+) C/T INTRON_VARIANT
770845 Benign: not provided 44,801,630(+) C/A SYNONYMOUS_VARIANT
775133 Benign: not provided 44,801,723(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PLK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLK3 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV loss 19166990
nsv546145 CNV loss 21841781
nsv546146 CNV loss 21841781
nsv546147 CNV loss 21841781
nsv950705 CNV deletion 24416366

Variation tolerance for PLK3 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLK3 Gene

Disorders for PLK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PLK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLK3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PLK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLK3 Gene

Publications for PLK3 Gene

  1. Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. (PMID: 8702627) Li B … Dai W (The Journal of biological chemistry 1996) 2 3 4 23
  2. Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells. (PMID: 17804415) Wang L … Lu L (The Journal of biological chemistry 2007) 3 4 23
  3. Polo-like kinase 3 is required for entry into S phase. (PMID: 17264206) Zimmerman WC … Erikson RL (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 23
  4. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. (PMID: 16481012) Bahassi el M … Stambrook PJ (Mutation research 2006) 3 4 23
  5. Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis. (PMID: 16478733) Jiang N … Dai W (The Journal of biological chemistry 2006) 3 4 23

ExternalLinks

View latest publications for PLK3 gene in Mastermind

Products for PLK3 Gene

  • Addgene plasmids for PLK3
  • Signalway ELISA kits for PLK3
  • Signalway Proteins for PLK3

Sources for PLK3 Gene