Aliases for PLK1 Gene
Aliases for PLK1 Gene
External Ids for PLK1 Gene
- HGNC: 9077
- Entrez Gene: 5347
- Ensembl: ENSG00000166851
- OMIM: 602098
- UniProtKB: P53350
Previous HGNC Symbols for PLK1 Gene
- PLK
Previous GeneCards Identifiers for PLK1 Gene
- GC16P023657
- GC16P023658
- GC16P023597
- GC16P023690
- GC16P021779
- GC16P023691
- GC16P023698
- GC16P023706
- GC16P023712
- GC16P023719
- GC16P023726
- GC16P023737
- GC16P023748
- GC16P023760
- GC16P023772
- GC16P023788
Summaries for PLK1 Gene
-
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
GeneCards Summary for PLK1 Gene
PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Transient Tic Disorder and Monoclonal Paraproteinemia. Among its related pathways are Mitotic Prophase and Mitotic Telophase/Cytokinesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PLK3.
UniProtKB/Swiss-Prot for PLK1 Gene
-
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143).
-
Polo-like kinases (PLKs) are a family of four serine/threonine protein kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. PLK1, -2 and -3 are ubiquitously expressed, whereas PLK4 is restricted to a few tissues.
Additional gene information for PLK1 Gene
- Monarch Initiative
- Search for PLK1 at DataMed
- Search for PLK1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLK1 Gene
Genomics for PLK1 Gene
GeneHancer (GH) Regulatory Elements for PLK1 Gene
Promoters and enhancers for PLK1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16I023676 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 550.8 | +1.0 | 954 | 3.8 | PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B | PLK1 PIR39200 DCTN5 ENSG00000260751 PALB2 ERN2 ENSG00000261723 NDUFAB1 RBBP6 SCNN1B | |
| GH16I023682 | Enhancer | 0.2 | FANTOM5 | 0.8 | +4.9 | 4883 | 0 | ERN2 DCTN5 PALB2 NDUFAB1 CHP2 PLK1 ENSG00000261266 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PLK1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PLK1 gene promoter:
Regulatory Element Products
Genomic Locations for PLK1 Gene
Genomic Locations for PLK1 Gene
- chr16:23,677,656-23,690,367
- (GRCh38/hg38)
- Size:
- 12,712 bases
- Orientation:
- Plus strand
- chr16:23,688,977-23,701,688
- (GRCh37/hg19)
Genomic View for PLK1 Gene
Genes around PLK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.2 by Ensembl
- 16p12.2 by Entrez Gene
- 16p12.2 by HGNC
PLK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLK1 Gene
Proteins for PLK1 Gene
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Protein details for PLK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53350-PLK1_HUMAN
- Recommended name:
- Serine/threonine-protein kinase PLK1
- Protein Accession:
- P53350
- Q15153
- Q99746
Protein attributes for PLK1 Gene
- Size:
- 603 amino acids
- Molecular mass:
- 68255 Da
- Quaternary structure:
-
- Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, CENPU and CDC25C. Interacts with isoform 3 of SGO1. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD. Interacts with ECT2; the interaction is stimulated upon phosphorylation of ECT2 on Thr-444. Interacts with PRC1. Interacts with KIF20A/MKLP2 (when phosphorylated), leading to the recruitment at the central spindle. Interacts (via POLO box domains) with PPP1R12A/MYPT1 (when previously phosphorylated by CDK1). Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with BIRC6/bruce. Interacts with CDK1-phosphorylated FRY; this interaction occurs in mitotic cells, but not in interphase cells. FRY interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with CDK1-phosphorylated DCTN6 during mitotic prometaphase; the interaction facilitates recruitment to kinetochores. Interacts with CEP68; the interaction phosphorylates CEP68 (PubMed:25503564). Interacts (via POLO-box domain) with DCTN1 (PubMed:20679239). Interacts with FOPNL in later G1, S, G2 and M phases of the cell cycle; this interaction recruits PLK1 to centrosomes, a step required for S phase progression (PubMed:24018379). Interacts with HSF1; this interaction increases upon heat shock but does not modulate neither HSF1 homotrimerization nor DNA-binding activities (PubMed:15661742, PubMed:18794143). Interacts with HNRNPU; this interaction induces phosphorylation of HNRNPU in mitosis (PubMed:25986610).
Protein Expression for PLK1 Gene
Selected DME Specific Peptides for PLK1 Gene
- P53350:
-
- TPREGDELARLP
- WSIGCIMYTLLVGKPPFETSCLKETY
- GHSFEVD
- VVLELCRRRSLLELHKRRKA
- TEPEARY
- LLNDEFFT
- LGKGGFA
- ESYLTVSSHPNSL
- KLGNLFLN
- GRFLGKGGFA
- HRDLKLGN
- VFAGKIV
- PPRFSIAPS
- KPHQREK
- LVGKPPFE
- RIKKNEYS
- NEYSIPKHINPVA
- YIAPEVL
- MVDKLLSSRSA
- VIHRDLK
- GYQLCDNSVGVLFND
- KELASRLRYAR
- RQEEAEDPA
- CGTPNYIAPE
Post-translational modifications for PLK1 Gene
- Catalytic activity is enhanced by phosphorylation of Thr-210. Phosphorylation at Thr-210 is first detected on centrosomes in the G2 phase of the cell cycle, peaks in prometaphase and gradually disappears from centrosomes during anaphase. Dephosphorylation at Thr-210 at centrosomes is probably mediated by protein phosphatase 1C (PP1C), via interaction with PPP1R12A/MYPT1. Autophosphorylation and phosphorylation of Ser-137 may not be significant for the activation of PLK1 during mitosis, but may enhance catalytic activity during recovery after DNA damage checkpoint. Phosphorylated in vitro by STK10.
- Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) in anaphase and following DNA damage, leading to its degradation by the proteasome. Ubiquitination is mediated via its interaction with FZR1/CDH1. Ubiquitination and subsequent degradation prevents entry into mitosis and is essential to maintain an efficient G2 DNA damage checkpoint. Monoubiquitination at Lys-492 by the BCR(KLHL22) ubiquitin ligase complex does not lead to degradation: it promotes PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.
- Ubiquitination at isoforms=19, Lys272, Lys480, and isoforms=492
- Modification sites at PhosphoSitePlus
Other Protein References for PLK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PLK1 (PLK1)
- R&D Systems Antibodies for PLK1 (PLKK)
-
Custom Antibody ServicesOriGene Antibodies for PLK1
- AP07487PU-N
- AP20264PU-N
- AP23177PU-N
- AP31885PU-N
- AP32818PU-N
- TA300014
- TA309215
- TA309216
- TA319250
- TA327377
- TA328018
- TA328019
- TA328020
- TA336437
- TA349604
- TA353386
- TA500383
- CF500383
- TA500388
- CF500388
- TA500389
- CF500389
- TA500393
- CF500393
- TA500395
- CF500395
- TA500396
- CF500396
- TA500401
- CF500401
- TA600111
- TA700111
- TA700137
- TA700138
- TA700139
- Novus Biologicals Antibodies for PLK1
-
Abcam antibodies for PLK1
- Invitrogen Antibodies for PLK1
- antibodies-online: Search results for 380 available PLK1 Antibodies ranked by validation data
- Compare Top PLK1 Antibodies
-
Recommended
- 291 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 110 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 56 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex PLK1 antibody for PLK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PLK1
- Sino Biological Antibodies for PLK1
Protein Products
- R&D Systems Proteins and Enzymes for PLK1
-
OriGene Purified Proteins for PLK1
- Search Origene for MassSpec and Protein Over-expression Lysates for PLK1
- Origene Custom Protein Services for PLK1
- Sino Biological Cell Lysates for PLK1
- Sino Biological Recombinant Proteins for PLK1
- antibodies-online: Search results for available PLK1 related products ranked by validation data
- Search GeneTex for Proteins for PLK1
-
Abcam proteins for PLK1
Assay Products
Domains & Families for PLK1 Gene
Gene Families for PLK1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for PLK1 Gene
Suggested Antigen Peptide Sequences for PLK1 Gene
Graphical View of Domain Structure for InterPro Entry
P53350UniProtKB/Swiss-Prot:
PLK1_HUMAN :- The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK1 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them. PLK1 can also create its own docking sites by mediating phosphorylation of serine-[phosphothreonine/phosphoserine]-(proline/X) motifs subsequently recognized by the POLO box domains.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
- Domain:
-
- The POLO box domains act as phosphopeptide-binding module that recognize and bind serine-[phosphothreonine/phosphoserine]-(proline/X) motifs. PLK1 recognizes and binds docking proteins that are already phosphorylated on these motifs, and then phosphorylates them. PLK1 can also create its own docking sites by mediating phosphorylation of serine-[phosphothreonine/phosphoserine]-(proline/X) motifs subsequently recognized by the POLO box domains.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
Function for PLK1 Gene
Molecular function for PLK1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation of Thr-210 by AURKA; phosphorylation by AURKA is enhanced by BORA. Once activated, activity is stimulated by binding target proteins. Binding of target proteins has no effect on the non-activated kinase. Several inhibitors targeting PLKs are currently in development and are under investigation in a growing number of clinical trials, such as BI 2536, an ATP-competitive PLK1 inhibitor or BI 6727, a dihydropteridinone that specifically inhibits the catalytic activity of PLK1.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning (PubMed:8991084, PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, PubMed:16980960, PubMed:17081991, PubMed:17351640, PubMed:17376779, PubMed:17617734, PubMed:18174154, PubMed:18331714, PubMed:18418051, PubMed:18477460, PubMed:18521620, PubMed:18615013, PubMed:19160488, PubMed:19351716, PubMed:19468300, PubMed:19468302, PubMed:19473992, PubMed:19509060, PubMed:19597481, PubMed:23455478, PubMed:23509069). Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (By similarity). Phosphorylates CEP68 and is required for its degradation (PubMed:25503564). Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope (PubMed:20679239). Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock (PubMed:15661742). Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression (PubMed:18794143).
- UniProtKB/Swiss-Prot Induction:
- By growth-stimulating agents.
Enzyme Numbers (IUBMB) for PLK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IMP | 17461553 |
| GO:0004672 | protein kinase activity | IEA,IMP | 17461553 |
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | -- |
| GO:0005515 | protein binding | IPI | 12493754 |
Phenotypes for PLK1 Gene
- MGI mutant phenotypes for PLK1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PLK1:
-
- Mitotic spindle defects
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with Ras
- Lamellipodia cells
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased G1 DNA content
- G0/1 arrest
- Transferrin accumulation in the perinuclear area
- Effect on mitosis
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased IL-8 secretion
- Increased number of mitotic cells
- Decreased Salmonella enterica Typhimurium invasion
- Decreased cell migration
- Decreased shRNA abundance
- Increased cell number in S
- Increased cell death HMECs cells
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased Hepatitis C virus replication
- Decreased viability of wild-type and TP53 knockout cells
- Misorientated spindle
- Increased viability with TRAIL
- Decreased cell proliferation
- Increased Nanog expression
- Increased cell migration
- Decreased viability after gemcitabine stimulation
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
- Decreased viability with poly (ADPa89ribose)a89polymerasea891 (PARP) inhibitor
- Decreased HIV-1 infection
- Increased simian virus 40 (SV40) infection
Animal Models for PLK1 Gene
- MGI Knock Outs for PLK1:
-
- Plk1 tm1b(EUCOMM)Hmgu
Animal Model Products
-
Taconic Biosciences Mouse Models for PLK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK1 gene
- Search ViGene Biosciences for PLK1
CRISPR Products
-
OriGene CRISPR knockouts for PLK1
- genomics-online: gRNA clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
- Applied Biological Materials CRISPR for PLK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK1
- GenScript: Design CRISPR guide RNA sequences for PLK1
miRNA for PLK1 Gene
- miRTarBase miRNAs that target PLK1
-
- hsa-mir-100-5p (MIRT000382)
- hsa-mir-16-5p (MIRT001430)
- hsa-mir-593-5p (MIRT006042)
- hsa-mir-155-5p (MIRT020615)
- hsa-mir-877-5p (MIRT037217)
- hsa-mir-874-3p (MIRT037761)
- hsa-mir-92a-1-5p (MIRT038920)
- hsa-let-7b-5p (MIRT051975)
- hsa-mir-10b-3p (MIRT053537)
- hsa-mir-1224-3p (MIRT194895)
- hsa-mir-2276-3p (MIRT194900)
- hsa-mir-3120-3p (MIRT194901)
- hsa-mir-886-3p (MIRT437846)
- hsa-mir-5047 (MIRT504614)
- hsa-mir-1301-3p (MIRT504615)
- hsa-mir-4660 (MIRT504616)
- hsa-mir-4708-3p (MIRT504617)
- hsa-mir-1322 (MIRT504618)
- hsa-mir-296-5p (MIRT732109)
- hsa-mir-509-3-5p (MIRT733590)
- hsa-mir-210-3p (MIRT734944)
- hsa-mir-22-3p (MIRT734983)
- hsa-let-7e-5p (MIRT734984)
- hsa-mir-3686 (MIRT735037)
- hsa-mir-1233-5p (MIRT736258)
- hsa-mir-183-5p (MIRT738182)
- hsa-mir-3150b-3p (MIRT740324)
- hsa-mir-3616-3p (MIRT741680)
- hsa-mir-3665 (MIRT742062)
- hsa-mir-4689 (MIRT747037)
- hsa-mir-4779 (MIRT748757)
- hsa-mir-4784 (MIRT748841)
- hsa-mir-505-5p (MIRT749587)
- hsa-mir-5189-3p (MIRT749869)
- hsa-mir-657 (MIRT753503)
- hsa-mir-6778-5p (MIRT755454)
- hsa-mir-6827-5p (MIRT757062)
- hsa-mir-6858-5p (MIRT757794)
- hsa-mir-874-5p (MIRT760341)
- hsa-mir-942-3p (MIRT760858)
miRNA Products
- Search ViGene Biosciences for PLK1
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for PLK1
- Browse OriGene Inhibitory RNA Products For PLK1
- genomics-online: shRNA clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK1 gene
Clone Products
- Sino Biological Human cDNA Clone for PLK1
- VectorBuilder custom plasmid, inducible vectors for PLK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PLK1
- Applied Biological Materials Clones for PLK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PLK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PLK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK1 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLK1 Gene
Localization for PLK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLK1 Gene
- Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=localization at the centrosome starts at the G1/S transition (PubMed:24018379). During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGO1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. Localization to the centrosome is required for S phase progression (PubMed:24018379). Colocalizes with HSF1 at the spindle poles during prometaphase (PubMed:18794143). {ECO:0000269 PubMed:18794143, ECO:0000269 PubMed:24018379}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IDA,IEA | 17617734 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0000780 | condensed nuclear chromosome, centromeric region | IEA | -- |
| GO:0000785 | chromatin | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLK1 Gene
Pathways & Interactions for PLK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Mitotic Metaphase and Anaphase |
.94
|
|
| 5 | PLK1 signaling events | ||
Pathways by source for PLK1 Gene
1 GeneTex pathway for PLK1 Gene
8 BioSystems pathways for PLK1 Gene
40 Reactome pathways for PLK1 Gene
- Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Anchoring of the basal body to the plasma membrane
- APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
- APC/C-mediated degradation of cell cycle proteins
4 KEGG pathways for PLK1 Gene
2 GeneGo (Thomson Reuters) pathways for PLK1 Gene
2 Qiagen pathways for PLK1 Gene
1 Cell Signaling Technology pathway for PLK1 Gene
Interacting Proteins for PLK1 Gene
Selected Interacting proteins:
ENSP00000300093
P53350-PLK1_HUMAN
for PLK1 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for PLK1 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000070 | mitotic sister chromatid segregation | IMP | 23455478 |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS,IDA | -- |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 18174154 |
| GO:0000278 | mitotic cell cycle | TAS,IMP | 18477460 |
| GO:0000281 | mitotic cytokinesis | IDA | 19468302 |
Drugs & Compounds for PLK1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | Experimental | Pharma | Target | 0 | ||
| 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea | Experimental | Pharma | Target | 0 | ||
| 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide | Experimental | Pharma | Target | 0 | ||
| 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol | Experimental | Pharma | Target | 0 | ||
| 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(5) Tocris Compounds for PLK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cyclapolin 9 | Selective, ATP-competitive PLK1 inhibitor | 40533-25-3 |
| GW 843682X | Selective inhibitor of PLK1 and PLK3 | 660868-91-7 |
| Ro 3280 | Potent and selective PLK1 inhibitor | 1062243-51-9 |
| SBE 13 hydrochloride | Potent and selective PLK1 inhibitor | 1052532-15-6 |
| TC-S 7005 | Potent and selective PLK2 inhibitor | 1082739-92-1 |
(18) ApexBio Compounds for PLK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bendamustine HCl | Cytostatic agent for non-Hodgkin lymphomas | 3543-75-7 |
| BI 2536 | Plk1 inhibitor,potent and ATP-competitive | 755038-02-9 |
| BI6727 (Volasertib) | Plk inhibitor,highly potent | 755038-65-4 |
| Cyclapolin 9 | 40533-25-3 | |
| GSK461364 | Plk1 inhibitor | 929095-18-1 |
| GW843682X | PLK1/PLK3 inhibitor,potent and selective | 660868-91-7 |
| HMN-214 | Plk inhibitor,broad-spectrum anti-tumor agent | 173529-46-9 |
| MLN0905 | Potent PLK1 inhibitor | 1228960-69-7 |
| NMS-1286937 | 1034616-18-6 | |
| Poloxime | 17302-61-3 | |
| Poloxin | PLK1 inhibitor | 321688-88-4 |
| Rigosertib | PI3K/PLK1 inhibitor | 592542-59-1 |
| Rigosertib (ON-01910,Estybon) | Plk1 inhibitor | 1225497-78-8 |
| Rigosertib sodium | 592542-60-4 | |
| Ro3280 | PLK1 inhibitor,potent and highly selective | 1062243-51-9 |
| SBE 13 HCl | Inactive Plk1 inhibitor | 1052532-15-6 |
| TAK960 | Oral and selective PLK1 inhibitor | 1137868-52-0 |
| TC-S 7005 | 1082739-92-1 |
Transcripts for PLK1 Gene
mRNA/cDNA for PLK1 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (512) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for PLK1
- genomics-online: gRNA clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
- Applied Biological Materials CRISPR for PLK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLK1
- GenScript: Design CRISPR guide RNA sequences for PLK1
miRNA Products
- Search ViGene Biosciences for PLK1
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for PLK1
- Browse OriGene Inhibitory RNA Products For PLK1
- genomics-online: shRNA clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PLK1 gene
Clone Products
- Sino Biological Human cDNA Clone for PLK1
- VectorBuilder custom plasmid, inducible vectors for PLK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PLK1
- Applied Biological Materials Clones for PLK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for PLK1 Gene
mRNA differential expression in normal tissues according to GTEx for PLK1 Gene
This gene is overexpressed in Testis (x6.2).
This gene is overexpressed in Breast (68.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PLK1 Gene:
PLK1SOURCE GeneReport for Unigene cluster for PLK1 Gene:
Hs.592049mRNA Expression by UniProt/SwissProt for PLK1 Gene:
P53350-PLK1_HUMAN
Tissue specificity:
Placenta and colon.
Evidence on tissue expression from TISSUES for PLK1 Gene
- Intestine(4.6)
- Lung(4.6)
- Nervous system(4.2)
- Liver(3.4)
- Skin(3.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for PLK1
-
OriGene qPCR primer pairs for PLK1
- genomics-online: primer clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLK1 Gene
Orthologs for PLK1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLK1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PLK1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PLK1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Plk1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Plk1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PLK1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PLK1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PLK1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PLK1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | plk1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | plk-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | plk1 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | polo 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004239 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | plk-1 33 34 |
|
||
| plk-2 34 |
|
OneToMany | |||
| plk-3 34 |
|
OneToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL006W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC5 33 34 36 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C06138g 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5715 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2496 33 |
|
- Species where no ortholog for PLK1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PLK1 Gene
(7) SIMAP similar genes for PLK1 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for PLK1 Gene
Variants for PLK1 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_041018 | A lung squamous cell carcinoma sample | p.Arg12Leu | |||
| rs1000208585 | -- | 23,681,487(+) | A/G | intron_variant | |
| rs1000460948 | -- | 23,686,549(+) | G/A | intron_variant | |
| rs1000732172 | -- | 23,679,670(+) | G/T | intron_variant | |
| rs1001713678 | -- | 23,681,757(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.13;
38.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLK1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLK1 Gene
Disorders for PLK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| transient tic disorder |
|
|
| monoclonal paraproteinemia |
|
|
| diffuse intrinsic pontine glioma |
|
|
| spinocerebellar ataxia 10 |
|
|
| adrenal rest tumor |
|
|
Search PLK1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PLK1_HUMAN- Note=Defects in PLK1 are associated with some cancers, such as gastric, thyroid or B-cell lymphomas. Expression is cancer increased in tumor tissues with a poor prognosis, suggesting a role in malignant transformations and carcinogenesis.
Additional Disease Information for PLK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for PLK1 Gene
Publications for PLK1 Gene
- Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors. (PMID: 8127874) Holtrich U … Strebhardt K (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22 58
- Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. (PMID: 19468302) Burkard ME … Jallepalli PV (PLoS biology 2009) 3 4 22 58
- Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. (PMID: 18615013) Macůrek L … Medema RH (Nature 2008) 3 4 22 58
- Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1. (PMID: 17376779) Matsumura S … Nishida E (The Journal of biological chemistry 2007) 3 4 22 58
- Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. (PMID: 17351640) Neef R … Barr FA (Nature cell biology 2007) 3 4 22 58
Products for PLK1 Gene
- R&D Systems Antibodies for PLK1 (PLK1)
- R&D Systems Antibodies for PLK1 (PLKK)
- R&D Systems Proteins and Enzymes for PLK1
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PLK1
- AP07487PU-N
- AP20264PU-N
- AP23177PU-N
- AP31885PU-N
- AP32818PU-N
- TA300014
- TA309215
- TA309216
- TA319250
- TA327377
- TA328018
- TA328019
- TA328020
- TA336437
- TA349604
- TA353386
- TA500383
- CF500383
- TA500388
- CF500388
- TA500389
- CF500389
- TA500393
- CF500393
- TA500395
- CF500395
- TA500396
- CF500396
- TA500401
- CF500401
- TA600111
- TA700111
- TA700137
- TA700138
- TA700139
- Browse OriGene ELISA Kits
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- OriGene Purified Proteins for PLK1
- Search Origene for MassSpec and Protein Over-expression Lysates for PLK1
- Origene Custom Protein Services for PLK1
- Origene shrna and RNAi products in human, mouse, rat for PLK1
- Browse OriGene Inhibitory RNA Products For PLK1
- OriGene qPCR primer pairs and template standards for PLK1
- OriGene qPCR primer pairs for PLK1
- OriGene CRISPR knockouts for PLK1
- OriGene ORF clones in human for PLK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PLK1
- GenScript: Next-day shipping of latest version cDNA ORF clones for PLK1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PLK1
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- GenScript: Design CRISPR guide RNA sequences for PLK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PLK1
- Sino Biological Human cDNA Clone for PLK1
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- Sino Biological Antibodies for PLK1
- Browse Sino Biological Assays
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PLK1
- Novus Biologicals lysates and proteins for PLK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PLK1
- Abcam proteins for PLK1
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for PLK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PLK1
- ApexBio compounds for PLK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLK1
- VectorBuilder custom plasmid, inducible vectors for PLK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PLK1
- antibodies-online: Search results for 380 available PLK1 Antibodies ranked by validation data
- Compare Top PLK1 Antibodies
- Recommended
- 291 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 ICS Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 110 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 ICS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 56 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 14 available PLK1 Elisa Kits ranked by validation data
- Compare Top PLK1 Elisa Kits
- antibodies-online: Search results for available PLK1 related products ranked by validation data
- GeneTex PLK1 antibody for PLK1
- Search GeneTex for Proteins for PLK1
- ViGene Biosciences adenoviral particle packaged cDNA for PLK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PLK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PLK1 gene
- Search ViGene Biosciences for PLK1
- Santa Cruz Biotechnology (SCBT) Antibodies for PLK1
- Search Santa Cruz Biotechnology (SCBT) for PLK1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PLK1
- genomics-online: cdna clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
- orf clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
- genomics-online: gRNA clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
- genomics-online: primer clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
- genomics-online: shRNA clones - Search results for 132 available PLK1 gene related products
- Overview of 132 available PLK1 gene related products
Sources for PLK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
