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Aliases for PLIN5 Gene

Aliases for PLIN5 Gene

  • Perilipin 5 2 3 5
  • Lipid Storage Droplet Protein 5 2 3 4
  • Perilipin-5 3 4
  • LSDP5 3 4
  • OXPAT 3 4
  • LSDA5 3
  • PAT-1 4
  • MLDP 3

External Ids for PLIN5 Gene

Previous GeneCards Identifiers for PLIN5 Gene

  • GC19M004473
  • GC19M004284

Summaries for PLIN5 Gene

Entrez Gene Summary for PLIN5 Gene

  • Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007 [PubMed 17234449]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PLIN5 Gene

PLIN5 (Perilipin 5) is a Protein Coding gene. Among its related pathways are PPAR signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and lipase binding. An important paralog of this gene is PLIN3.

UniProtKB/Swiss-Prot for PLIN5 Gene

  • Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).

Additional gene information for PLIN5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLIN5 Gene

Genomics for PLIN5 Gene

GeneHancer (GH) Regulatory Elements for PLIN5 Gene

Promoters and enhancers for PLIN5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004539 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1011 -5.3 -5259 2.8 ZFX CBFA2T2 ELF3 SP1 POLR2A CEBPG ZNF148 SMARCA4 RELA SP5 PLIN5 LRG1 ENSG00000267385 GC19P004539 KDM4B TICAM1 SEMA6B ZBTB7A YJU2 GC19P004547
GH19J004534 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 1012.9 +0.1 58 1.5 MNT ZKSCAN8 SP1 AHR KLF14 PPARG SP5 EGR1 KAT8 GLIS2 PLIN5 ENSG00000267385 PLIN4
GH19J004536 Enhancer 0.7 ENCODE dbSUPER 1011.7 -1.8 -1841 0.7 SP1 RXRA YY1 CUX1 HNF4A MAX EGR1 PLIN5 GC19M004536 GC19P004539 ENSG00000267385 LRG1
GH19J004516 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 10.7 +16.8 16753 3.7 ZKSCAN8 ELF3 SP1 CEBPG TFE3 PPARG PRDM1 KAT8 RXRA ZIC2 PLIN4 CACTIN YJU2 CACTIN-AS1 DPP9-AS1 ENSG00000267030 APBA3 ENSG00000267769 SH3GL1 KDM4B
GH19J003965 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 +566.4 566423 6 MNT ZKSCAN8 SP1 ELF3 ZNF652 MAFK FOS ELF1 SP7 ZBTB7A DAPK3 APBA3 ENSG00000267030 CACTIN-AS1 CACTIN YJU2 ENSG00000267769 CELF5 FZR1 DPP9-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLIN5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLIN5 Gene

Genomic Locations for PLIN5 Gene
chr19:4,522,531-4,535,224
(GRCh38/hg38)
Size:
12,694 bases
Orientation:
Minus strand
chr19:4,522,543-4,535,236
(GRCh37/hg19)
Size:
12,694 bases
Orientation:
Minus strand

Genomic View for PLIN5 Gene

Genes around PLIN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLIN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLIN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLIN5 Gene

Proteins for PLIN5 Gene

  • Protein details for PLIN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00G26-PLIN5_HUMAN
    Recommended name:
    Perilipin-5
    Protein Accession:
    Q00G26
    Secondary Accessions:
    • A2RRC1
    • Q6ZS68

    Protein attributes for PLIN5 Gene

    Size:
    463 amino acids
    Molecular mass:
    50791 Da
    Quaternary structure:
    • Homooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE (By similarity).
    SequenceCaution:
    • Sequence=BAC87086.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for PLIN5 Gene

Post-translational modifications for PLIN5 Gene

  • Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLIN5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLIN5 Gene

Domains & Families for PLIN5 Gene

Gene Families for PLIN5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLIN5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLIN5 Gene

GenScript: Design optimal peptide antigens:
  • Lipid storage droplet protein 5 (PLIN5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00G26

UniProtKB/Swiss-Prot:

PLIN5_HUMAN :
  • Belongs to the perilipin family.
Family:
  • Belongs to the perilipin family.
genes like me logo Genes that share domains with PLIN5: view

Function for PLIN5 Gene

Molecular function for PLIN5 Gene

UniProtKB/Swiss-Prot Function:
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).
UniProtKB/Swiss-Prot Induction:
Increased by endurance and sprint interval training.

Phenotypes From GWAS Catalog for PLIN5 Gene

Gene Ontology (GO) - Molecular Function for PLIN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035473 lipase binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with PLIN5: view
genes like me logo Genes that share phenotypes with PLIN5: view

Animal Models for PLIN5 Gene

MGI Knock Outs for PLIN5:
  • Plin5 Plin5<tm1Tosu>
  • Plin5 Plin5<tm1e(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLIN5

Clone Products

  • Applied Biological Materials (abm): Clones for PLIN5 - Now 50% OFF >
  • * PLIN5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLIN5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLIN5 Gene

Localization for PLIN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLIN5 Gene

Lipid droplet. Cytoplasm. Mitochondrion. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm. {ECO:0000250 UniProtKB:Q8BVZ1}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLIN5 gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PLIN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
GO:0005811 colocalizes_with lipid droplet ISS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with PLIN5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLIN5 Gene

Pathways & Interactions for PLIN5 Gene

PathCards logo

SuperPathways for PLIN5 Gene

SuperPathway Contained pathways
1 PPAR signaling pathway
genes like me logo Genes that share pathways with PLIN5: view

Pathways by source for PLIN5 Gene

1 KEGG pathway for PLIN5 Gene

Gene Ontology (GO) - Biological Process for PLIN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010867 positive regulation of triglyceride biosynthetic process ISS,IEA --
GO:0010884 positive regulation of lipid storage ISS,IEA --
GO:0010890 positive regulation of sequestering of triglyceride IEA,ISS --
GO:0010897 negative regulation of triglyceride catabolic process IEA,ISS --
GO:0019915 lipid storage IEA --
genes like me logo Genes that share ontologies with PLIN5: view

No data available for SIGNOR curated interactions for PLIN5 Gene

Drugs & Compounds for PLIN5 Gene

No Compound Related Data Available

Transcripts for PLIN5 Gene

mRNA/cDNA for PLIN5 Gene

Unigene Clusters for PLIN5 Gene

Perilipin 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLIN5

Clone Products

  • Applied Biological Materials (abm): Clones for PLIN5 - Now 50% OFF >
  • * PLIN5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLIN5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PLIN5 Gene

No ASD Table

Relevant External Links for PLIN5 Gene

GeneLoc Exon Structure for
PLIN5
ECgene alternative splicing isoforms for
PLIN5

Expression for PLIN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLIN5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLIN5 Gene

This gene is overexpressed in Liver (x8.3), Muscle - Skeletal (x5.5), Pancreas (x4.9), Ovary (x4.4), and Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for PLIN5 Gene

This gene is overexpressed in Adipocyte (25.9), Liver (18.4), Pancreas (10.0), and Ovary (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLIN5 Gene



Protein tissue co-expression partners for PLIN5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLIN5 Gene:

PLIN5

SOURCE GeneReport for Unigene cluster for PLIN5 Gene:

Hs.131034

mRNA Expression by UniProt/SwissProt for PLIN5 Gene:

Q00G26-PLIN5_HUMAN
Tissue specificity: Expressed in skeletal muscle, liver, heart and kidney.

Evidence on tissue expression from TISSUES for PLIN5 Gene

  • Heart(4.4)
  • Liver(4.4)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with PLIN5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLIN5 Gene

Orthologs for PLIN5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLIN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLIN5 35 34
  • 98.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLIN5 35 34
  • 86.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLIN5 35 34
  • 85.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plin5 34
  • 77.31 (n)
mouse
(Mus musculus)
Mammalia Plin5 17 35 34
  • 76.86 (n)
oppossum
(Monodelphis domestica)
Mammalia PLIN5 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLIN5 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia PLIN5 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:rp71-61h23.4 35
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lea-1 35
  • 5 (a)
OneToMany
Species where no ortholog for PLIN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLIN5 Gene

ENSEMBL:
Gene Tree for PLIN5 (if available)
TreeFam:
Gene Tree for PLIN5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLIN5: view image

Paralogs for PLIN5 Gene

Paralogs for PLIN5 Gene

(3) SIMAP similar genes for PLIN5 Gene using alignment to 3 proteins:

  • PLIN5_HUMAN
  • K7EIX1_HUMAN
  • K7ELW7_HUMAN
genes like me logo Genes that share paralogs with PLIN5: view

Variants for PLIN5 Gene

Sequence variations from dbSNP and Humsavar for PLIN5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000183024 -- 4,530,825(-) A/G intron_variant
rs1000344424 -- 4,533,244(-) C/T intron_variant
rs1000404285 -- 4,529,006(-) G/C intron_variant
rs1000579252 -- 4,523,076(-) G/A 3_prime_UTR_variant
rs1000634010 -- 4,534,209(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLIN5 Gene

Variant ID Type Subtype PubMed ID
esv2718022 CNV deletion 23290073
esv2718023 CNV deletion 23290073
esv3555906 CNV deletion 23714750
nsv1113959 CNV deletion 24896259
nsv428361 CNV loss 18775914
nsv578444 CNV gain 21841781
nsv833720 CNV loss 17160897

Variation tolerance for PLIN5 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLIN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLIN5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLIN5 Gene

Disorders for PLIN5 Gene

Additional Disease Information for PLIN5

No disorders were found for PLIN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLIN5 Gene

Publications for PLIN5 Gene

  1. LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. (PMID: 17234449) Dalen KT … Nebb HI (Biochimica et biophysica acta 2007) 2 3 4 58
  2. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5. (PMID: 23129790) Shepherd SO … Shaw CS (The Journal of physiology 2013) 3 4 58
  3. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. (PMID: 19638644) Kimmel AR … Londos C (Journal of lipid research 2010) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men. (PMID: 26447519) Vigelso A … Helge JW (Physiological research 2016) 3 58

Products for PLIN5 Gene

Sources for PLIN5 Gene

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