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Aliases for PLIN4 Gene

Aliases for PLIN4 Gene

  • Perilipin 4 2 3 5
  • KIAA1881 2 3 4
  • Adipocyte Protein S3-12 3 4
  • Perilipin-4 3 4
  • S3-12 3

External Ids for PLIN4 Gene

Previous HGNC Symbols for PLIN4 Gene

  • KIAA1881

Previous GeneCards Identifiers for PLIN4 Gene

  • GC19M004456
  • GC19M004263

Summaries for PLIN4 Gene

Entrez Gene Summary for PLIN4 Gene

  • Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PLIN4 Gene

PLIN4 (Perilipin 4) is a Protein Coding gene. Among its related pathways are PPAR signaling pathway. An important paralog of this gene is PLIN3.

UniProtKB/Swiss-Prot for PLIN4 Gene

  • May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).

Additional gene information for PLIN4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLIN4 Gene

Genomics for PLIN4 Gene

GeneHancer (GH) Regulatory Elements for PLIN4 Gene

Promoters and enhancers for PLIN4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004516 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 600.7 +0.1 70 3.7 ELF3 ZKSCAN8 CEBPG TFE3 SP1 PPARG PRDM1 KAT8 RXRA ZBTB8A PLIN4 CACTIN YJU2 CACTIN-AS1 DPP9-AS1 ENSG00000267030 APBA3 ENSG00000267769 SH3GL1 KDM4B
GH19J004510 Enhancer 0.5 Ensembl dbSUPER 6.2 +7.0 7040 0.2 BCL11B PLIN4 GC19P004486
GH19J004534 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 0.4 -16.6 -16625 1.5 CC2D1A SP1 ZKSCAN8 MNT ZNF121 CSDE1 AHR PPARG SP5 KLF14 PLIN5 ENSG00000267385 PLIN4
GH19J004523 Enhancer 0.9 Ensembl 0.7 -4.9 -4860 0.4 ELF3 CTCF ZNF148 PPARG SP5 ZNF644 KAT8 RXRA CEBPA GATAD2A PLIN5 PLIN4
GH19J004532 Promoter/Enhancer 1.4 Ensembl dbSUPER 0.4 -13.4 -13360 0.2 MNT RERE TFE3 PPARG KAT8 RXRA ZNF600 RXRB FOXA2 IRF2 PLIN5 ENSG00000267385 PLIN4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLIN4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLIN4 Gene

Genomic Locations for PLIN4 Gene
chr19:4,502,180-4,518,541
(GRCh38/hg38)
Size:
16,362 bases
Orientation:
Minus strand
chr19:4,502,192-4,517,716
(GRCh37/hg19)
Size:
15,525 bases
Orientation:
Minus strand

Genomic View for PLIN4 Gene

Genes around PLIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLIN4 Gene

Proteins for PLIN4 Gene

  • Protein details for PLIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q06-PLIN4_HUMAN
    Recommended name:
    Perilipin-4
    Protein Accession:
    Q96Q06
    Secondary Accessions:
    • A6NEI2

    Protein attributes for PLIN4 Gene

    Size:
    1357 amino acids
    Molecular mass:
    134431 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLIN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLIN4 Gene

Post-translational modifications for PLIN4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLIN4 Gene

Domains & Families for PLIN4 Gene

Gene Families for PLIN4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PLIN4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLIN4 Gene

GenScript: Design optimal peptide antigens:
  • KIAA1881 protein (A8E631_HUMAN)
  • Adipocyte protein S3-12 (PLIN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96Q06

UniProtKB/Swiss-Prot:

PLIN4_HUMAN :
  • Belongs to the perilipin family.
Family:
  • Belongs to the perilipin family.
genes like me logo Genes that share domains with PLIN4: view

Function for PLIN4 Gene

Molecular function for PLIN4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated during adipocyte differentiation.

Phenotypes From GWAS Catalog for PLIN4 Gene

genes like me logo Genes that share phenotypes with PLIN4: view

Animal Models for PLIN4 Gene

MGI Knock Outs for PLIN4:

Animal Model Products

CRISPR Products

miRNA for PLIN4 Gene

miRTarBase miRNAs that target PLIN4

Clone Products

  • Applied Biological Materials (abm): Clones for PLIN4 - Now 50% OFF >
  • * PLIN4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLIN4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLIN4 Gene

Localization for PLIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLIN4 Gene

Cell membrane. Cytoplasm. Lipid droplet. Note=Nascent lipid droplet surface-associated; association with lipid droplets is triacylglycerol synthesis-dependent. {ECO:0000250 UniProtKB:O88492}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLIN4 gene
Compartment Confidence
plasma membrane 4
cytosol 4
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Lipid droplets (3)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid droplet IDA,IEA 21498505
GO:0005829 cytosol IDA,IBA --
GO:0005886 plasma membrane IBA,IDA --
GO:0016020 membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA,IBA --
genes like me logo Genes that share ontologies with PLIN4: view

Pathways & Interactions for PLIN4 Gene

PathCards logo

SuperPathways for PLIN4 Gene

SuperPathway Contained pathways
1 PPAR signaling pathway
genes like me logo Genes that share pathways with PLIN4: view

Pathways by source for PLIN4 Gene

1 KEGG pathway for PLIN4 Gene

Interacting Proteins for PLIN4 Gene

Gene Ontology (GO) - Biological Process for PLIN4 Gene

None

No data available for SIGNOR curated interactions for PLIN4 Gene

Drugs & Compounds for PLIN4 Gene

(2) Drugs for PLIN4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceryl Trioleate Investigational Pharma 0
Tricaprylin Investigational Pharma 0

(3) Additional Compounds for PLIN4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Triglycerides Group A
  • 1-Palmitoyl-2-stearoyl-3-arachidonoyl-glycerol
  • TAG(16:0/18:0/20:4)
  • TAG(16:0/18:0/20:4n6)
  • TAG(16:0/18:0/20:4W6)
  • TAG(54:4)
Triglycerides Group C
  • 2,3-Di(octadecanoyloxy)propyl octadecanoate
  • Glyceryl tristearate
  • Stearic acid triglycerin ester
  • Stearin
  • Trioctadecanoin
620-64-4
Triglycerides Group D
  • 1,2,3-Propanol tridecanoate
  • 1,2,3-Tridecanoylglycerol
  • Capric acid triglyceride
  • Capric triglyceride
  • Caprin
621-71-6, 30773-83-2, 555-44-2
genes like me logo Genes that share compounds with PLIN4: view

Transcripts for PLIN4 Gene

mRNA/cDNA for PLIN4 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for PLIN4 Gene

Perilipin 4:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PLIN4 - Now 50% OFF >
  • * PLIN4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLIN4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PLIN4 Gene

No ASD Table

Relevant External Links for PLIN4 Gene

GeneLoc Exon Structure for
PLIN4
ECgene alternative splicing isoforms for
PLIN4

Expression for PLIN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLIN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLIN4 Gene

This gene is overexpressed in Adipose - Subcutaneous (x12.2), Adipose - Visceral (Omentum) (x7.1), Muscle - Skeletal (x6.6), and Breast - Mammary Tissue (x4.9).

Protein differential expression in normal tissues from HIPED for PLIN4 Gene

This gene is overexpressed in Adipocyte (33.3) and Nasopharynx (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLIN4 Gene



Protein tissue co-expression partners for PLIN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLIN4 Gene:

PLIN4

SOURCE GeneReport for Unigene cluster for PLIN4 Gene:

Hs.591387

Evidence on tissue expression from TISSUES for PLIN4 Gene

  • Liver(4.3)
  • Nervous system(4.1)
  • Heart(2.7)
  • Intestine(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with PLIN4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLIN4 Gene

Orthologs for PLIN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLIN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLIN4 35 34
  • 91.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLIN4 35 34
  • 74.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLIN4 35 34
  • 71.03 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plin4 34
  • 67.72 (n)
mouse
(Mus musculus)
Mammalia Plin4 17 35 34
  • 67.19 (n)
oppossum
(Monodelphis domestica)
Mammalia PLIN4 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLIN4 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii PLIN4 35
  • 13 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lea-1 35
  • 16 (a)
OneToMany
Species where no ortholog for PLIN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLIN4 Gene

ENSEMBL:
Gene Tree for PLIN4 (if available)
TreeFam:
Gene Tree for PLIN4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLIN4: view image

Paralogs for PLIN4 Gene

Paralogs for PLIN4 Gene

(1) SIMAP similar genes for PLIN4 Gene using alignment to 1 proteins:

  • PLIN4_HUMAN
genes like me logo Genes that share paralogs with PLIN4: view

Variants for PLIN4 Gene

Sequence variations from dbSNP and Humsavar for PLIN4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs62115190 benign, not specified 4,511,718(-) T/A/C coding_sequence_variant, missense_variant
rs1000003012 -- 4,507,390(-) A/C intron_variant
rs1000165921 -- 4,509,602(-) C/T intron_variant
rs1000349607 -- 4,505,968(-) C/G intron_variant
rs1000361826 -- 4,502,295(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PLIN4 Gene

Variant ID Type Subtype PubMed ID
dgv1695n106 CNV deletion 24896259
dgv497e201 CNV deletion 23290073
dgv6232n54 CNV loss 21841781
esv1218220 CNV insertion 17803354
esv1468103 CNV deletion 17803354
esv1932333 CNV deletion 18987734
esv23799 CNV loss 19812545
esv2675390 CNV deletion 23128226
esv2718014 CNV deletion 23290073
esv2718015 CNV deletion 23290073
esv2718016 CNV deletion 23290073
esv2718019 CNV deletion 23290073
esv2718020 CNV deletion 23290073
esv2718021 CNV deletion 23290073
esv2892 OTHER complex 18987735
esv3101568 CNV deletion 24192839
esv3555905 CNV deletion 23714750
esv5020 CNV loss 18987735
esv5592 CNV loss 19470904
esv990843 CNV deletion 20482838
nsv1071502 CNV deletion 25765185
nsv1118612 CNV duplication 24896259
nsv1142015 CNV deletion 24896259
nsv1146825 CNV deletion 26484159
nsv137949 CNV deletion 16902084
nsv138483 CNV deletion 16902084
nsv428361 CNV loss 18775914
nsv470116 CNV loss 18288195
nsv578444 CNV gain 21841781
nsv578447 CNV loss 21841781
nsv578449 CNV loss 21841781
nsv833720 CNV loss 17160897
nsv954626 CNV deletion 24416366

Variation tolerance for PLIN4 Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.58; 99.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLIN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLIN4
Human Gene Mutation Database (HGMD)
PLIN4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLIN4 Gene

Disorders for PLIN4 Gene

Additional Disease Information for PLIN4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLIN4 Gene

Publications for PLIN4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. (PMID: 19638644) Kimmel AR … Londos C (Journal of lipid research 2010) 2 3 58
  3. Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males. (PMID: 20495294) Sone Y … Otsuka Y (Journal of nutritional science and vitaminology 2010) 3 45 58
  4. Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms. (PMID: 29361938) Maia-Landim A … Lancho JL (BMC complementary and alternative medicine 2018) 3 58
  5. A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets. (PMID: 29626194) Čopič A … Jackson CL (Nature communications 2018) 3 58

Products for PLIN4 Gene

Sources for PLIN4 Gene

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