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Aliases for PLGLB2 Gene

Aliases for PLGLB2 Gene

  • Plasminogen-Like B2 2 3 5
  • Plasminogen-Related Protein B 3 4
  • Plasminogen Pseudogene 1 2 3
  • PLGP1 3 4
  • Plasminogen-Related Protein A 3
  • Plasminogen-Like Protein A1 3
  • Plasminogen-Like Protein A 3
  • Plasminogen-Like Protein B 3
  • Type B Plasminogen Related 3
  • PLGLA1 3
  • PLGLA 3
  • PLGP2 3
  • PRGA 3
  • PLGL 4
  • PRGB 4

External Ids for PLGLB2 Gene

Previous HGNC Symbols for PLGLB2 Gene

  • PLGP1

Previous GeneCards Identifiers for PLGLB2 Gene

  • GC00U921622
  • GC02P087887
  • GC02P088045
  • GC02P088050

Summaries for PLGLB2 Gene

GeneCards Summary for PLGLB2 Gene

PLGLB2 (Plasminogen-Like B2) is a Protein Coding gene. An important paralog of this gene is PLGLB1.

UniProtKB/Swiss-Prot for PLGLB2 Gene

  • May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Gene Wiki entry for PLGLB2 Gene

Additional gene information for PLGLB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGLB2 Gene

Genomics for PLGLB2 Gene

GeneHancer (GH) Regulatory Elements for PLGLB2 Gene

Promoters and enhancers for PLGLB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J087748 Promoter 0.5 EPDnew 650.7 0.0 -11 0.1 PLGLB2 GC02P087738 ENSG00000284879
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLGLB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLGLB2 gene promoter:
  • MRF-2
  • FOXO1a
  • FOXO1
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • TBP
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for PLGLB2 Gene

Genomic Locations for PLGLB2 Gene
11,390 bases
Plus strand
11,390 bases
Plus strand

Genomic View for PLGLB2 Gene

Genes around PLGLB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGLB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGLB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLB2 Gene

Proteins for PLGLB2 Gene

  • Protein details for PLGLB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Plasminogen-like protein B
    Protein Accession:
    Secondary Accessions:
    • Q580R1
    • Q580R1

    Protein attributes for PLGLB2 Gene

    96 amino acids
    Molecular mass:
    10971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLB2 Gene

Post-translational modifications for PLGLB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLGLB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLGLB2 Gene

Domains & Families for PLGLB2 Gene

Gene Families for PLGLB2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PLGLB2 Gene


Suggested Antigen Peptide Sequences for PLGLB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLGLB2: view

No data available for UniProtKB/Swiss-Prot for PLGLB2 Gene

Function for PLGLB2 Gene

Molecular function for PLGLB2 Gene

UniProtKB/Swiss-Prot Function:
May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.
genes like me logo Genes that share phenotypes with PLGLB2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLGLB2 Gene

Localization for PLGLB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLB2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLGLB2 gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLGLB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLGLB2: view

Pathways & Interactions for PLGLB2 Gene

SuperPathways for PLGLB2 Gene

No Data Available

Interacting Proteins for PLGLB2 Gene

Gene Ontology (GO) - Biological Process for PLGLB2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PLGLB2 Gene

Drugs & Compounds for PLGLB2 Gene

No Compound Related Data Available

Transcripts for PLGLB2 Gene

mRNA/cDNA for PLGLB2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(122) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLGLB2 Gene

Plasminogen-like B2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLB2 Gene

No ASD Table

Relevant External Links for PLGLB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLGLB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLGLB2 Gene

mRNA differential expression in normal tissues according to GTEx for PLGLB2 Gene

This gene is overexpressed in Liver (x34.4).

Protein differential expression in normal tissues from HIPED for PLGLB2 Gene

This gene is overexpressed in Serum (59.0) and Skin (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLGLB2 Gene

Protein tissue co-expression partners for PLGLB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLGLB2 Gene:


SOURCE GeneReport for Unigene cluster for PLGLB2 Gene:


Evidence on tissue expression from TISSUES for PLGLB2 Gene

  • Liver(4.6)
  • Muscle(4)
genes like me logo Genes that share expression patterns with PLGLB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLGLB2 Gene

Orthologs for PLGLB2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PLGLB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
Species where no ortholog for PLGLB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLGLB2 Gene

Gene Tree for PLGLB2 (if available)
Gene Tree for PLGLB2 (if available)

Paralogs for PLGLB2 Gene

Paralogs for PLGLB2 Gene

(4) SIMAP similar genes for PLGLB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLGLB2: view

Variants for PLGLB2 Gene

Sequence variations from dbSNP and Humsavar for PLGLB2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001594829 -- 87,747,918(+) G/A upstream_transcript_variant
rs1001930945 -- 87,749,082(+) A/G intron_variant
rs1002541870 -- 87,753,672(+) C/T intron_variant
rs1004935061 -- 87,758,153(+) G/C 3_prime_UTR_variant
rs1005433062 -- 87,746,964(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLGLB2 Gene

Variant ID Type Subtype PubMed ID
dgv1141e212 CNV loss 25503493
dgv3887n100 CNV gain 25217958
dgv3888n100 CNV gain 25217958
dgv3889n100 CNV loss 25217958
dgv3893n100 CNV gain 25217958
dgv3900n100 CNV gain 25217958
dgv3901n100 CNV gain+loss 25217958
dgv3908n100 CNV gain 25217958
dgv3909n100 CNV loss 25217958
dgv61n16 CNV deletion 17901297
esv2759073 CNV gain+loss 17122850
esv2760646 CNV gain+loss 21179565
esv2763649 CNV gain+loss 21179565
esv33176 CNV loss 17666407
nsv1072005 CNV deletion 25765185
nsv1130752 CNV deletion 24896259
nsv1148611 CNV deletion 26484159
nsv428398 CNV loss 18775914
nsv516958 CNV gain+loss 19592680
nsv519198 CNV loss 19592680
nsv7316 OTHER inversion 18451855
nsv834287 CNV gain 17160897
nsv834288 CNV gain 17160897
nsv979034 CNV duplication 23825009
nsv979040 CNV duplication 23825009

Variation tolerance for PLGLB2 Gene

Gene Damage Index Score: 0.80; 16.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLGLB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLGLB2 Gene

Disorders for PLGLB2 Gene

Additional Disease Information for PLGLB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLGLB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGLB2 Gene

Publications for PLGLB2 Gene

  1. A plasminogen-related gene is expressed in cancer cells. (PMID: 1379800) Weissbach L … Treadwell BV (Biochemical and biophysical research communications 1992) 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Expression of plasminogen-related gene B varies among normal tissues and increases in cancer tissues. (PMID: 10069369) Tateno T … Ichinose A (FEBS letters 1999) 3 22 58

Products for PLGLB2 Gene

Sources for PLGLB2 Gene

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