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Aliases for PLGLB1 Gene

Aliases for PLGLB1 Gene

  • Plasminogen-Like B1 2 3 5
  • Plasminogen-Related Protein B 3 4
  • PLGP1 3 4
  • PLGL 3 4
  • PRGB 3 4
  • Plasminogen-Like Protein B 3
  • Type B Plasminogen Related 3
  • Plasminogen-Like 2
  • PLGLB1 PLGLB2 4
  • EC 3.4.21.7 56
  • PRP-B 3

External Ids for PLGLB1 Gene

Previous HGNC Symbols for PLGLB1 Gene

  • PLGL

Previous GeneCards Identifiers for PLGLB1 Gene

  • GC00U921621
  • GC02U900794
  • GC02M087083
  • GC02M087229

Summaries for PLGLB1 Gene

GeneCards Summary for PLGLB1 Gene

PLGLB1 (Plasminogen-Like B1) is a Protein Coding gene. An important paralog of this gene is PLGLB2.

UniProtKB/Swiss-Prot for PLGLB1 Gene

  • May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Additional gene information for PLGLB1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLGLB1 Gene

Genomics for PLGLB1 Gene

GeneHancer (GH) Regulatory Elements for PLGLB1 Gene

Promoters and enhancers for PLGLB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I087021 Promoter 0.5 EPDnew 550.8 0.0 -10 0.1 PLGLB1 PIR59562 GC02M086893
GH02I086620 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.4 +399.0 399041 3.7 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 SLC30A9 POLR2B SP3 SP5 RNF103 RNF103-CHMP3 CHMP3 RNU6-640P MRPL35 POLR1A PLGLB1 IMMT GC02P086603 GC02P086607
GH02I086805 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.1 +214.0 213998 5.3 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 CD8A CD8B SNORD94 CHMP3 RNU6-640P REEP1 PLGLB1 LOC105374846
GH02I086835 Enhancer 1 Ensembl ENCODE dbSUPER 7.2 +184.6 184649 2.9 ZNF282 ZNF687 CEBPB JUND IKZF1 CREB1 FOS PRDM10 PLGLB1 LOC730268 ANAPC1P1 CD8B CD8A
GH02I086032 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +984.2 984208 9.5 HDGF PKNOX1 FOXA2 RB1 ZSCAN4 GLI4 BATF IRF4 RAD21 YY1 POLR1A IMMT KDM3A USP39 TCF7L1 LOC105374845 LOC284950 ATOH8 RNU1-38P SNORD94
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLGLB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLGLB1 gene promoter:

Genomic Locations for PLGLB1 Gene

Genomic Locations for PLGLB1 Gene
chr2:87,002,559-87,021,852
(GRCh38/hg38)
Size:
19,294 bases
Orientation:
Minus strand
chr2:87,229,682-87,248,975
(GRCh37/hg19)

Genomic View for PLGLB1 Gene

Genes around PLGLB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGLB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGLB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLB1 Gene

Proteins for PLGLB1 Gene

  • Protein details for PLGLB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02325-PLGB_HUMAN
    Recommended name:
    Plasminogen-like protein B
    Protein Accession:
    Q02325
    Secondary Accessions:
    • Q580R1

    Protein attributes for PLGLB1 Gene

    Size:
    96 amino acids
    Molecular mass:
    10971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLB1 Gene

Selected DME Specific Peptides for PLGLB1 Gene

Q02325:
  • FQYHSKEQQCV
  • CRAFQYHSK

Post-translational modifications for PLGLB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLGLB1 Gene

Domains & Families for PLGLB1 Gene

Gene Families for PLGLB1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PLGLB1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLGLB1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PLGLB1 Gene

Function for PLGLB1 Gene

Molecular function for PLGLB1 Gene

UniProtKB/Swiss-Prot Function:
May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Enzyme Numbers (IUBMB) for PLGLB1 Gene

Phenotypes for PLGLB1 Gene

GenomeRNAi human phenotypes for PLGLB1:
genes like me logo Genes that share phenotypes with PLGLB1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLGLB1 Gene

Localization for PLGLB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLGLB1 gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLGLB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLGLB1: view

Pathways & Interactions for PLGLB1 Gene

SuperPathways for PLGLB1 Gene

No Data Available

Interacting Proteins for PLGLB1 Gene

Gene Ontology (GO) - Biological Process for PLGLB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PLGLB1 Gene

Drugs & Compounds for PLGLB1 Gene

No Compound Related Data Available

Transcripts for PLGLB1 Gene

mRNA/cDNA for PLGLB1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLGLB1 Gene

Plasminogen-like B1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLB1 Gene

No ASD Table

Relevant External Links for PLGLB1 Gene

GeneLoc Exon Structure for
PLGLB1
ECgene alternative splicing isoforms for
PLGLB1

Expression for PLGLB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLGLB1 Gene

mRNA differential expression in normal tissues according to GTEx for PLGLB1 Gene

This gene is overexpressed in Liver (x18.9), Brain - Cerebellar Hemisphere (x5.3), and Brain - Cerebellum (x5.0).

Protein differential expression in normal tissues from HIPED for PLGLB1 Gene

This gene is overexpressed in Serum (59.0) and Skin (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLGLB1 Gene



Protein tissue co-expression partners for PLGLB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLGLB1 Gene:

PLGLB1

SOURCE GeneReport for Unigene cluster for PLGLB1 Gene:

Hs.652174

Evidence on tissue expression from TISSUES for PLGLB1 Gene

  • Liver(4.7)
  • Muscle(4)
genes like me logo Genes that share expression patterns with PLGLB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLGLB1 Gene

Orthologs for PLGLB1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PLGLB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
OneToMany
Species where no ortholog for PLGLB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLGLB1 Gene

ENSEMBL:
Gene Tree for PLGLB1 (if available)
TreeFam:
Gene Tree for PLGLB1 (if available)

Paralogs for PLGLB1 Gene

Paralogs for PLGLB1 Gene

(4) SIMAP similar genes for PLGLB1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PLGLB1 Gene

genes like me logo Genes that share paralogs with PLGLB1: view

Variants for PLGLB1 Gene

Sequence variations from dbSNP and Humsavar for PLGLB1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000983139 -- 87,016,505(-) T/C intron_variant
rs1001255706 -- 87,022,948(-) G/A upstream_transcript_variant
rs1001256822 -- 87,022,299(-) C/T upstream_transcript_variant
rs1001328627 -- 87,017,476(-) C/G/T intron_variant
rs1003899757 -- 87,010,632(-) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PLGLB1 Gene

Variant ID Type Subtype PubMed ID
dgv1141e212 CNV loss 25503493
dgv3887n100 CNV gain 25217958
dgv3888n100 CNV gain 25217958
dgv3889n100 CNV loss 25217958
dgv3893n100 CNV gain 25217958
dgv3900n100 CNV gain 25217958
dgv3901n100 CNV gain+loss 25217958
dgv3908n100 CNV gain 25217958
dgv3909n100 CNV loss 25217958
dgv61n16 CNV deletion 17901297
esv2759073 CNV gain+loss 17122850
esv2760646 CNV gain+loss 21179565
esv2763649 CNV gain+loss 21179565
esv33176 CNV loss 17666407
nsv1072005 CNV deletion 25765185
nsv1130752 CNV deletion 24896259
nsv1148611 CNV deletion 26484159
nsv428398 CNV loss 18775914
nsv516958 CNV gain+loss 19592680
nsv519198 CNV loss 19592680
nsv7316 OTHER inversion 18451855
nsv834287 CNV gain 17160897
nsv834288 CNV gain 17160897
nsv979034 CNV duplication 23825009
nsv979040 CNV duplication 23825009

Variation tolerance for PLGLB1 Gene

Gene Damage Index Score: 1.31; 26.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLGLB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLGLB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLGLB1 Gene

Disorders for PLGLB1 Gene

Additional Disease Information for PLGLB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLGLB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGLB1 Gene

Publications for PLGLB1 Gene

  1. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PMID: 1554698) Ichinose A (Biochemistry 1992) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A plasminogen-related gene is expressed in cancer cells. (PMID: 1379800) Weissbach L … Treadwell BV (Biochemical and biophysical research communications 1992) 3 4 58

Products for PLGLB1 Gene

Sources for PLGLB1 Gene

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