Aliases for PLGLA Gene

Aliases for PLGLA Gene

  • Plasminogen Like A (Pseudogene) 2 3 5
  • Plasminogen-Related Protein A 3 4
  • Plasminogen Pseudogene 2 2 3
  • Plasminogen-Like A1 2 3
  • Plasminogen-Like A 2 3
  • PLGLA1 3 4
  • PLGP2 3 4
  • PRGA 3 4
  • Plasminogen-Like Protein A1 4
  • Plasminogen-Like Protein A 4
  • EC 52

External Ids for PLGLA Gene

Previous HGNC Symbols for PLGLA Gene

  • PLGP2
  • PLGLA1

Previous GeneCards Identifiers for PLGLA Gene

  • GC02P106355
  • GC02U901555
  • GC02P106998
  • GC02P100772

Summaries for PLGLA Gene

GeneCards Summary for PLGLA Gene

PLGLA (Plasminogen Like A (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot Summary for PLGLA Gene

  • May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

Additional gene information for PLGLA Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLGLA Gene

Genomics for PLGLA Gene

GeneHancer (GH) Regulatory Elements for PLGLA Gene

Promoters and enhancers for PLGLA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J105743 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.4 -634.9 -634906 7.5 NRF1 PHF8 ZFX POLR2A ZNF263 ZBTB26 SAP30 RELA TGIF2 RAD21 ENSG00000235522 ENSG00000238273 NCK2 PLGLA C2orf49 TGFBRAP1 HSALNG0017603
GH02J106020 Enhancer 0.8 Ensembl ENCODE 4.8 -361.1 -361072 2.1 ZIC2 OSR2 ZNF76 ZNF335 ZNF843 RCOR1 FEZF1 GLIS1 MAZ GATA2 ECRG4 PLGLA piR-42491-133
GH02J106019 Enhancer 0.2 Ensembl 5.9 -362.5 -362513 0.4 PLGLA piR-42491-133 ECRG4
GH02J106384 Enhancer 0.9 Ensembl ENCODE 0.7 +2.6 2631 0.9 KDM6A SMARCC2 SKI TEAD1 FOXA2 MIER3 MXD4 JUND FOXP1 SMAD4 lnc-CD8B2-2 PLGLA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLGLA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLGLA gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RelA
  • Sox9
  • SRF
  • SRF (504 AA)

Genomic Locations for PLGLA Gene

Genomic Locations for PLGLA Gene
10,918 bases
Plus strand
11,466 bases
Plus strand

Genomic View for PLGLA Gene

Genes around PLGLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLGLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLGLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLGLA Gene

Proteins for PLGLA Gene

  • Protein details for PLGLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Plasminogen-like protein A
    Protein Accession:

    Protein attributes for PLGLA Gene

    96 amino acids
    Molecular mass:
    10915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLGLA Gene

Selected DME Specific Peptides for PLGLA Gene


Post-translational modifications for PLGLA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLGLA Gene

Protein Domains for PLGLA Gene


Suggested Antigen Peptide Sequences for PLGLA Gene

GenScript: Design optimal peptide antigens:
  • Plasminogen-like protein A1 (PLGA_HUMAN)
genes like me logo Genes that share domains with PLGLA: view

No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLGLA Gene

Function for PLGLA Gene

Molecular function for PLGLA Gene

UniProtKB/Swiss-Prot Function:
May bind non-covalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction (By similarity).

Enzyme Numbers (IUBMB) for PLGLA Gene

Phenotypes From GWAS Catalog for PLGLA Gene

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLGLA Gene

Localization for PLGLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLGLA Gene


No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PLGLA Gene

Pathways & Interactions for PLGLA Gene

PathCards logo

SuperPathways for PLGLA Gene

No Data Available

Interacting Proteins for PLGLA Gene

Selected Interacting proteins: Q15195-PLGA_HUMAN for PLGLA Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PLGLA Gene


No data available for Pathways by source and SIGNOR curated interactions for PLGLA Gene

Drugs & Compounds for PLGLA Gene

No Compound Related Data Available

Transcripts for PLGLA Gene

mRNA/cDNA for PLGLA Gene

2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PLGLA Gene

No ASD Table

Relevant External Links for PLGLA Gene

GeneLoc Exon Structure for

Expression for PLGLA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLGLA Gene

mRNA differential expression in normal tissues according to GTEx for PLGLA Gene

This gene is overexpressed in Liver (x46.2).

Protein differential expression in normal tissues from HIPED for PLGLA Gene

This gene is overexpressed in Cervix (40.4), Serum (18.9), and Plasma (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLGLA Gene

Protein tissue co-expression partners for PLGLA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLGLA

SOURCE GeneReport for Unigene cluster for PLGLA Gene:


mRNA Expression by UniProt/SwissProt for PLGLA Gene:

Tissue specificity: Expressed in liver.
genes like me logo Genes that share expression patterns with PLGLA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLGLA Gene

Orthologs for PLGLA Gene

Evolution for PLGLA Gene

Gene Tree for PLGLA (if available)
Gene Tree for PLGLA (if available)

No data available for Orthologs for PLGLA Gene

Paralogs for PLGLA Gene

(4) SIMAP similar genes for PLGLA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PLGLA: view

No data available for Paralogs for PLGLA Gene

Variants for PLGLA Gene

Structural Variations from Database of Genomic Variants (DGV) for PLGLA Gene

Variant ID Type Subtype PubMed ID
dgv4034n100 CNV gain 25217958
dgv6988n54 CNV loss 21841781
esv2720482 CNV deletion 23290073
esv3591865 CNV loss 21293372
esv3591871 CNV loss 21293372
esv3591872 CNV gain 21293372
nsv834322 CNV gain 17160897
nsv963679 CNV duplication 23825009

Additional Variant Information for PLGLA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for PLGLA Gene

Disorders for PLGLA Gene

Additional Disease Information for PLGLA

No disorders were found for PLGLA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLGLA Gene

Publications for PLGLA Gene

  1. Homologous plasminogen N-terminal and plasminogen-related gene A and B peptides. Characterization of cDNAs and recombinant fusion proteins. (PMID: 10092845) Lewis VO … Schaller J (European journal of biochemistry 1999) 3 4 54
  2. Characterization of the 5'-flanking regions of plasminogen-related genes A and B. (PMID: 9074645) Kida M … Ichinose A (FEBS letters 1997) 3 23 54
  3. Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PMID: 1554698) Ichinose A (Biochemistry 1992) 3 4 54
  4. Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PMID: 1986355) Ichinose A … Davie EW (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for PLGLA Gene

Sources for PLGLA Gene