The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involv... See more...

Aliases for PLG Gene

Aliases for PLG Gene

  • Plasminogen 2 3 4 5
  • EC 3.4.21.7 4 50
  • EC 3.4.21 50
  • Plasmin 3
  • PLG 5

External Ids for PLG Gene

Previous GeneCards Identifiers for PLG Gene

  • GC06P160476
  • GC06P160996
  • GC06P161032
  • GC06P161093
  • GC06P161123
  • GC06P158569

Summaries for PLG Gene

Entrez Gene Summary for PLG Gene

  • The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein which inhibits angiogenesis. Plasmin degrades many blood plasma proteins, including fibrin-containing blood clots. As a serine protease, plasmin cleaves many products in addition to fibrin such as fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin is inactivated by proteins such as alpha-2-macroglobulin and alpha-2-antiplasmin in addition to inhibitors of the various plasminogen activators. Plasminogen also interacts with plasminogen receptors which results in the retention of plasmin on cell surfaces and in plasmin-induced cell signaling. The localization of plasminogen on cell surfaces plays a role in the degradation of extracellular matrices, cell migration, inflamation, wound healing, oncogenesis, metastasis, myogenesis, muscle regeneration, neurite outgrowth, and fibrinolysis. This protein may also play a role in acute respiratory distress syndrome (ARDS) which, in part, is caused by enhanced clot formation and the suppression of fibrinolysis. Compared to other mammals, the cluster of plasminogen-like genes to which this gene belongs has been rearranged in catarrhine primates. [provided by RefSeq, May 2020]

GeneCards Summary for PLG Gene

PLG (Plasminogen) is a Protein Coding gene. Diseases associated with PLG include Plasminogen Deficiency, Type I and Plg-Related Hereditary Angioedema With Normal C1inh. Among its related pathways are Cell adhesion_ECM remodeling and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and serine-type endopeptidase activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot Summary for PLG Gene

  • Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
  • Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

Gene Wiki entry for PLG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLG Gene

Genomics for PLG Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J160702 Promoter 0.6 EPDnew 250.7 +0.0 32 0.1 RXRA HNF4A SP1 REST TAF1 ATF3 PLG HSALNG0054836 MAP3K4
GH06J160703 Enhancer 0.7 ENCODE 0.7 +2.6 2557 2 YY1 HOMEZ FOXA2 RXRA RARA SOX5 JUND HNF4A LCORL MAX HSALNG0054836 MAP3K4 PLG
GH06J160697 Enhancer 0.6 ENCODE 0.7 -4.3 -4273 0.8 YY1 RXRA ZBTB33 SOX5 JUND HNF4A ZNF48 MAX SP1 HNF1A ENSG00000224477 piR-57307-003 SNORA29 PLG piR-32855-003 LPA
GH06J160766 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 0.2 +65.2 65151 1.6 BCLAF1 ZNF654 KLF11 HOMEZ CTCF SIN3A THAP11 SMC3 GABPB1 CREM ENSG00000287558 HSALNG0054843 PLG MAP3K4
GH06J160667 Enhancer 0.7 Ensembl 0.3 -34.1 -34143 0.5 ZNF654 REST CTCF SMAD4 RXRA RAD21 SMC3 TEAD3 SCRT1 ZNF48 LPA ENSG00000243831 lnc-LPA-4 PLG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLG

Top Transcription factor binding sites by QIAGEN in the PLG gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • ATF-2
  • c-Jun
  • POU3F2 (N-Oct-5b)

Genomic Locations for PLG Gene

Latest Assembly
chr6:160,702,193-160,754,097
(GRCh38/hg38)
Size:
51,905 bases
Orientation:
Plus strand

Previous Assembly
chr6:161,123,225-161,175,129
(GRCh37/hg19 by Entrez Gene)
Size:
51,905 bases
Orientation:
Plus strand

chr6:161,123,270-161,174,347
(GRCh37/hg19 by Ensembl)
Size:
51,078 bases
Orientation:
Plus strand

Genomic View for PLG Gene

Genes around PLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLG Gene

Proteins for PLG Gene

  • Protein details for PLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00747-PLMN_HUMAN
    Recommended name:
    Plasminogen
    Protein Accession:
    P00747
    Secondary Accessions:
    • Q15146
    • Q5TEH4
    • Q6PA00

    Protein attributes for PLG Gene

    Size:
    810 amino acids
    Molecular mass:
    90569 Da
    Quaternary structure:
    • Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT (PubMed:10889192, PubMed:16043488). Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation (PubMed:9102401, PubMed:19712047). Interacts (via Kringle 4 domain) with ADA; the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824). Angiostatin: Interacts with ATP5F1A; the interaction inhibits most of the angiogenic effects of angiostatin (PubMed:10077593).
    • (Microbial infection) Interacts with Staphylococcus aureus protein FnbB; this interaction provides active plasmin on the surface of bacteria cells.
    Miscellaneous:
    • Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.

    Three dimensional structures from OCA and Proteopedia for PLG Gene

neXtProt entry for PLG Gene

Selected DME Specific Peptides for PLG Gene

P00747:
  • CRNPDGD
  • LEENYCRNP
  • PGVYVRVS
  • PSKFPNKNLK
  • GCARPNKPGVY
  • PWCYTTDP
  • CDIPRCTTPPP
  • TMSGLECQ
  • VLTAAHC
  • HFCGGTLISPEWV
  • YRGTSSTT
  • DSCQGDSGG
  • LPVIENKVCNR
  • AQEPHRH
  • GDSGGPL
  • TNPRAGLEKNYCRNPDGD
  • CQSWSSM
  • YLSECKTGNGKNYRGT
  • HNRTPENFPC
  • FQYHSKEQQCV
  • LQGVTSWG
  • VRWEYCNL
  • PNKPGVY
  • VQDCYHGDG
  • NYCRNPD
  • CQGDSGGP
  • YKVILGAH
  • TGWGETQ
  • SQSPHAHGY
  • GQSYRGT
  • WVLTAAH
  • DIALLKLSSP
  • SGGPLVC
  • RDVVLFEK
  • WGETQGT
  • PWCFTTDP
  • WPWQVSL
  • CRAFQYHSK

Post-translational modifications for PLG Gene

  • N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).
  • In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.
  • Glycosylation at Asn150, Ser268, Asn308, and Thr365
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PLMN_HUMAN (502)

Other Protein References for PLG Gene

Antibodies for research

Domains & Families for PLG Gene

Gene Families for PLG Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for PLG Gene

InterPro:
Blocks:
  • Kringle
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • N/apple PAN
  • Apple-like

Suggested Antigen Peptide Sequences for PLG Gene

GenScript: Design optimal peptide antigens:
  • Plasminogen (PLMN_HUMAN)
  • PLG protein (Q9UMI2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P00747

UniProtKB/Swiss-Prot:

PLMN_HUMAN :
  • Kringle domains mediate interaction with CSPG4.
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
Domain:
  • Kringle domains mediate interaction with CSPG4.
Family:
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with PLG: view

Function for PLG Gene

Molecular function for PLG Gene

UniProtKB/Swiss-Prot Function:
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
UniProtKB/Swiss-Prot Function:
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.; EC=3.4.21.7; Evidence={ECO:0000269|PubMed:2143188};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.
GENATLAS Biochemistry:
plasminogen

Enzyme Numbers (IUBMB) for PLG Gene

Phenotypes From GWAS Catalog for PLG Gene

Gene Ontology (GO) - Molecular Function for PLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 9603964
GO:0004252 serine-type endopeptidase activity IMP 18070902
GO:0005102 signaling receptor binding IPI 20028034
GO:0005515 protein binding IPI 134998
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with PLG: view
genes like me logo Genes that share phenotypes with PLG: view

Human Phenotype Ontology for PLG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLG Gene

MGI Knock Outs for PLG:
  • Plg Plg<tm1Jld>
  • Plg Plg<tm1Dco>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLG

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for PLG Gene

Localization for PLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLG Gene

Secreted. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLG gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 3
nucleus 3
cytosol 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for PLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA,IDA 6216475
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 14699093
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with PLG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLG Gene

Pathways & Interactions for PLG Gene

genes like me logo Genes that share pathways with PLG: view

Pathways by source for PLG Gene

4 GeneGo (Thomson Reuters) pathways for PLG Gene
  • Cell adhesion PLAU signaling
  • Cell adhesion_Cell-matrix glycoconjugates
  • Cell adhesion_ECM remodeling
  • Cell adhesion_Plasmin signaling
2 Qiagen pathways for PLG Gene
  • Glioma Invasiveness
  • UPA-UPAR Pathway
1 Cell Signaling Technology pathway for PLG Gene

SIGNOR curated interactions for PLG Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006508 proteolysis IMP 18070902
GO:0007596 blood coagulation IMP 1986355
GO:0007599 hemostasis IEA --
GO:0008285 negative regulation of cell proliferation TAS 8910613
genes like me logo Genes that share ontologies with PLG: view

Drugs & Compounds for PLG Gene

(42) Drugs for PLG Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tranexamic Acid Approved Pharma Target, inhibitor 499
Aprotinin Approved, Investigational, Withdrawn Pharma Target, inhibitor Inhibitor of bovine pancreatic trypsin 28
Alteplase Approved Pharma Target, activator 0
Aminocaproic acid Approved, Investigational Pharma Target, inhibitor 33
Anistreplase Approved Pharma Target, activator 0

(15) Additional Compounds for PLG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLG: view

Transcripts for PLG Gene

mRNA/cDNA for PLG Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLG

Alternative Splicing Database (ASD) splice patterns (SP) for PLG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: - -
SP2:
SP3:
SP4:
SP5: - - - - - - - - - - - - -
SP6:

Relevant External Links for PLG Gene

GeneLoc Exon Structure for
PLG

Expression for PLG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLG Gene

This gene is overexpressed in Liver (x50.7).

Protein differential expression in normal tissues from HIPED for PLG Gene

This gene is overexpressed in Serum (23.8), Plasma (18.2), and Synovial fluid (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLG Gene



Protein tissue co-expression partners for PLG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLG

SOURCE GeneReport for Unigene cluster for PLG Gene:

Hs.143436

mRNA Expression by UniProt/SwissProt for PLG Gene:

P00747-PLMN_HUMAN
Tissue specificity: Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Evidence on tissue expression from TISSUES for PLG Gene

  • Liver(5)
  • Kidney(4.9)
  • Heart(3.7)
  • Blood(3.6)
  • Nervous system(3.1)
  • Intestine(2.9)
  • Skin(2.8)
  • Eye(2.8)
  • Lung(2.8)
  • Muscle(2.7)
  • Pancreas(2.5)
  • Adrenal gland(2.5)
  • Gall bladder(2.3)
  • Spleen(2.3)
  • Urine(2.2)
  • Bone marrow(2.2)
  • Bone(2.2)
  • Lymph node(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PLG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • pharynx
  • skull
  • tooth
Thorax:
  • heart
  • lung
  • trachea
Abdomen:
  • duodenum
  • intestine
  • kidney
  • small intestine
  • stomach
Pelvis:
  • ureter
General:
  • blood
  • blood vessel
  • peripheral nervous system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with PLG: view

Orthologs for PLG Gene

This gene was present in the common ancestor of animals.

Orthologs for PLG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLG 29 30
  • 99.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLG 29 30
  • 83.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLG 29 30
  • 80.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Plg 29
  • 79.48 (n)
Mouse
(Mus musculus)
Mammalia Plg 29 16 30
  • 78.89 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 62 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PLG 29
  • 66.62 (n)
-- 30
  • 63 (a)
ManyToMany
-- 30
  • 51 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 63 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496227 29
  • 62.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24267 29
Zebrafish
(Danio rerio)
Actinopterygii plg 29 30
  • 60.03 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8759 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG1299 31
  • 39 (a)
CG11836 31
  • 37 (a)
CG13744 31
  • 35 (a)
Tequila 30 31
  • 6 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea try-1 29
  • 46.19 (n)
C07G1.1 31
  • 35 (a)
svh-1 30
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 38 (a)
OneToMany
Species where no ortholog for PLG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLG Gene

ENSEMBL:
Gene Tree for PLG (if available)
TreeFam:
Gene Tree for PLG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLG: view image
Alliance of Genome Resources:
Additional Orthologs for PLG

Paralogs for PLG Gene

(18) SIMAP similar genes for PLG Gene using alignment to 4 proteins:

  • PLMN_HUMAN
  • A6PVI2_HUMAN
  • Q5TEH5_HUMAN
  • Q9UMI2_HUMAN

Pseudogenes.org Pseudogenes for PLG Gene

genes like me logo Genes that share paralogs with PLG: view

Variants for PLG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLG Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
1029782 Uncertain Significance: Plasminogen deficiency, type I 160,713,044(+) G/A
NM_000301.5(PLG):c.466G>A (p.Asp156Asn)
MISSENSE
1032300 Uncertain Significance: Plasminogen deficiency, type I 160,707,780(+) G/C
NM_000301.5(PLG):c.266G>C (p.Arg89Thr)
MISSENSE
830236 Pathogenic: Plasminogen deficiency, type I 160,718,392(+) T/G
NM_000301.5(PLG):c.886T>G (p.Cys296Gly)
MISSENSE
871034 Likely Benign: not provided 160,731,806(+) G/A
NM_000301.5(PLG):c.1500G>A (p.Thr500=)
SYNONYMOUS
930467 Uncertain Significance: Plasminogen deficiency, type I 160,752,252(+) A/G
NM_000301.5(PLG):c.2263A>G (p.Ser755Gly)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLG Gene

Variant ID Type Subtype PubMed ID
dgv1845e212 CNV loss 25503493
esv1302715 CNV insertion 17803354
esv2759484 CNV gain+loss 17122850
esv3302656 CNV tandem duplication 20981092
esv3303034 CNV tandem duplication 20981092
esv3332475 CNV insertion 20981092
esv3342512 CNV insertion 20981092
esv3422389 CNV duplication 20981092
esv3611443 CNV loss 21293372
nsv1019113 CNV gain 25217958
nsv1026543 CNV gain 25217958
nsv1125893 CNV tandem duplication 24896259
nsv1129273 CNV insertion 24896259
nsv522424 CNV loss 19592680
nsv522773 CNV loss 19592680
nsv5571 CNV insertion 18451855
nsv605005 CNV gain 21841781
nsv965782 CNV duplication 23825009
nsv965783 CNV duplication 23825009
nsv965784 CNV duplication 23825009
nsv969466 CNV duplication 23825009
nsv970189 CNV duplication 23825009

Variation tolerance for PLG Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLG Gene

Human Gene Mutation Database (HGMD)
PLG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLG
Leiden Open Variation Database (LOVD)
PLG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLG Gene

Disorders for PLG Gene

MalaCards: The human disease database

(148) MalaCards diseases for PLG Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
plasminogen deficiency, type i
  • dysplasminogenemia
plg-related hereditary angioedema with normal c1inh
  • plg-related hae with normal c1 inhibitor
hereditary angioedema
  • hane
angioedema, hereditary, type i
  • hae1
ligneous conjunctivitis
  • conjunctivitis lignosa
- elite association - COSMIC cancer census association via MalaCards
Search PLG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PLMN_HUMAN
  • Plasminogen deficiency (PLGD) [MIM:217090]: A disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. {ECO:0000269 PubMed:10233898, ECO:0000269 PubMed:1427790, ECO:0000269 PubMed:1986355, ECO:0000269 PubMed:6216475, ECO:0000269 PubMed:6238949, ECO:0000269 PubMed:8392398, ECO:0000269 PubMed:9242524, ECO:0000269 PubMed:9858247}. Note=The disease is caused by variants affecting the gene represented in this entry.

Genatlas disease for PLG Gene

thrombosis,recurrent,dysplasminogenemic type

Additional Disease Information for PLG

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PLG: view

Publications for PLG Gene

  1. Plasminogen alleles influence susceptibility to invasive aspergillosis. (PMID: 18566672) Zaas AK … Schwartz DA (PLoS genetics 2008) 3 40 72
  2. Binding of the NG2 proteoglycan to kringle domains modulates the functional properties of angiostatin and plasmin(ogen). (PMID: 10889192) Goretzki L … Stallcup WB (The Journal of biological chemistry 2000) 3 4 22
  3. Angiostatin binds ATP synthase on the surface of human endothelial cells. (PMID: 10077593) Moser TL … Pizzo SV (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 22
  4. Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis. (PMID: 10233898) Schuster V … Kreth HW (Blood 1999) 3 4 72
  5. Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis. (PMID: 9242524) Schuster V … Kreth HW (Blood 1997) 3 4 72

Products for PLG Gene

  • Addgene plasmids for PLG

Sources for PLG Gene