External Ids for PLG Gene
Previous GeneCards Identifiers for PLG Gene
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
GeneCards Summary for PLG Gene
PLG (Plasminogen) is a Protein Coding gene. Diseases associated with PLG include Plasminogen Deficiency, Type I and Plg-Related Hereditary Angioedema With Normal C1inh. Among its related pathways are Matrix Metalloproteinases and Selenium Micronutrient Network. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and serine-type endopeptidase activity. An important paralog of this gene is PLAT.
UniProtKB/Swiss-Prot Summary for PLG Gene
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.