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Aliases for PLET1 Gene

Aliases for PLET1 Gene

  • Placenta Expressed Transcript 1 2 3 5
  • C11orf34 3 4
  • Placenta-Expressed Transcript 1 Protein 3
  • Chromosome 11 Open Reading Frame 34 2
  • Placenta-Expressed Transcript 1 2

External Ids for PLET1 Gene

Previous HGNC Symbols for PLET1 Gene

  • C11orf34

Previous GeneCards Identifiers for PLET1 Gene

  • GC11M112140
  • GC11U900122
  • GC11M112119

Summaries for PLET1 Gene

GeneCards Summary for PLET1 Gene

PLET1 (Placenta Expressed Transcript 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for PLET1 Gene

  • Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).

Additional gene information for PLET1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLET1 Gene

Genomics for PLET1 Gene

GeneHancer (GH) Regulatory Elements for PLET1 Gene

Promoters and enhancers for PLET1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J112225 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.1 +32.6 32624 5.3 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FOS SP3 PTS LOC283140 PLET1 TIMM8B ENSG00000255292 SDHD BCO2 RPS6P16
GH11J112231 Enhancer 0.7 ENCODE 13.1 +28.7 28711 1.1 SOX13 IRF2 SAP130 ZNF644 ZNF48 RARA ZNF205 ZNF614 HOMEZ SOX5 PLET1 ENSG00000255292 LOC283140 RPS6P16 PTS
GH11J112254 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +5.4 5367 1.7 HDGF BCOR PKNOX1 ATF1 ZNF211 SUZ12 JUN ZSCAN4 CDC5L IRF9 ENSG00000268472 PLET1 RPS6P16 PTS
GH11J112267 Enhancer 0.8 ENCODE dbSUPER 0.4 -6.7 -6725 0.9 MEIS2 RXRA CEBPB MAX CEBPG YY1 NR2F2 TEAD3 SP1 JUND ST13P10 LOC283140 PLET1 PTS
GH11J112253 Enhancer 0.8 ENCODE dbSUPER 0.4 +7.0 6964 1.4 HDGF ZNF639 BCOR ZSCAN4 CEBPB CDC5L IRF9 POLR2A ZNF18 LOC283140 ENSG00000268472 PLET1 RPS6P16 PTS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLET1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PLET1 Gene

Genomic Locations for PLET1 Gene
chr11:112,248,153-112,260,860
(GRCh38/hg38)
Size:
12,708 bases
Orientation:
Minus strand
chr11:112,118,876-112,131,583
(GRCh37/hg19)
Size:
12,708 bases
Orientation:
Minus strand

Genomic View for PLET1 Gene

Genes around PLET1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLET1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLET1 Gene

Proteins for PLET1 Gene

  • Protein details for PLET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UQ28-PLET1_HUMAN
    Recommended name:
    Placenta-expressed transcript 1 protein
    Protein Accession:
    Q6UQ28
    Secondary Accessions:
    • Q6UQ24
    • Q6UQ25
    • Q6UQ27

    Protein attributes for PLET1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23385 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLET1 Gene

Post-translational modifications for PLET1 Gene

Other Protein References for PLET1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLET1 Gene

Domains & Families for PLET1 Gene

Gene Families for PLET1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PLET1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLET1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLET1: view

No data available for UniProtKB/Swiss-Prot for PLET1 Gene

Function for PLET1 Gene

Molecular function for PLET1 Gene

UniProtKB/Swiss-Prot Function:
Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity).

Phenotypes From GWAS Catalog for PLET1 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLET1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLET1 Gene

Localization for PLET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLET1 Gene

Apical cell membrane; Lipid-anchor, GPI-anchor. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLET1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PLET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane ISS,IBA --
genes like me logo Genes that share ontologies with PLET1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLET1 Gene

Pathways & Interactions for PLET1 Gene

genes like me logo Genes that share pathways with PLET1: view

Interacting Proteins for PLET1 Gene

Gene Ontology (GO) - Biological Process for PLET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion ISS --
GO:0006501 C-terminal protein lipidation TAS --
GO:0030154 cell differentiation IEA --
GO:0030335 positive regulation of cell migration IBA,ISS --
GO:0035313 wound healing, spreading of epidermal cells ISS,IBA --
genes like me logo Genes that share ontologies with PLET1: view

No data available for SIGNOR curated interactions for PLET1 Gene

Drugs & Compounds for PLET1 Gene

No Compound Related Data Available

Transcripts for PLET1 Gene

mRNA/cDNA for PLET1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLET1

Alternative Splicing Database (ASD) splice patterns (SP) for PLET1 Gene

No ASD Table

Relevant External Links for PLET1 Gene

GeneLoc Exon Structure for
PLET1
ECgene alternative splicing isoforms for
PLET1

Expression for PLET1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLET1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLET1 Gene

This gene is overexpressed in Pituitary (x6.7).

Protein differential expression in normal tissues from HIPED for PLET1 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLET1 Gene



Protein tissue co-expression partners for PLET1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLET1 Gene:

PLET1
genes like me logo Genes that share expression patterns with PLET1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLET1 Gene

Orthologs for PLET1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PLET1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf34 33
  • 99.36 (n)
PLET1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H11orf34 33
  • 61.3 (n)
PLET1 34
  • 29 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf34 33
  • 56.52 (n)
PLET1 34
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plet1 33
  • 55.48 (n)
mouse
(Mus musculus)
Mammalia Plet1 16 33
  • 55.39 (n)
1600029D21Rik 34
  • 26 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLET1 34
  • 30 (a)
OneToOne
Species where no ortholog for PLET1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PLET1 Gene

ENSEMBL:
Gene Tree for PLET1 (if available)
TreeFam:
Gene Tree for PLET1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLET1: view image

Paralogs for PLET1 Gene

No data available for Paralogs for PLET1 Gene

Variants for PLET1 Gene

Sequence variations from dbSNP and Humsavar for PLET1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000103241 -- 112,254,318(-) GTGGTG/GTG intron_variant
rs1000204814 -- 112,249,982(-) A/G intron_variant
rs1000377507 -- 112,247,865(-) G/A downstream_transcript_variant
rs1000399129 -- 112,262,235(-) A/G upstream_transcript_variant
rs1000686652 -- 112,256,318(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLET1 Gene

Variant ID Type Subtype PubMed ID
dgv148e201 CNV deletion 23290073
dgv706e59 CNV duplication 20981092
esv2661060 CNV deletion 23128226
esv2677815 CNV deletion 23128226
esv2745078 CNV deletion 23290073
esv3415331 CNV duplication 20981092
nsv1138075 CNV deletion 24896259

Variation tolerance for PLET1 Gene

Gene Damage Index Score: 2.52; 44.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLET1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLET1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLET1 Gene

Disorders for PLET1 Gene

Additional Disease Information for PLET1

No disorders were found for PLET1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLET1 Gene

Publications for PLET1 Gene

  1. PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human. (PMID: 15203209) Zhao SH … Tuggle CK (Genomics 2004) 3 4 58
  2. Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. (PMID: 18195351) Depreter MG … Blackburn CC (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for PLET1 Gene

Sources for PLET1 Gene

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