Aliases for PLEKHO2 Gene

Aliases for PLEKHO2 Gene

  • Pleckstrin Homology Domain Containing O2 2 3 5
  • Pleckstrin Homology Domain-Containing Family O Member 2 3 4
  • Pleckstrin Homology Domain-Containing Family Q Member 1 3 4
  • PH Domain-Containing Family O Member 2 3 4
  • PH Domain-Containing Family Q Member 1 3 4
  • PLEKHQ1 3 4
  • Pleckstrin Homology Domain Containing, Family Q Member 1 2
  • Pleckstrin Homology Domain Containing, Family O Member 2 2
  • PH Domain-Containing Protein 3
  • PP1628 3
  • Pp9099 3

External Ids for PLEKHO2 Gene

Previous HGNC Symbols for PLEKHO2 Gene

  • PLEKHQ1

Previous GeneCards Identifiers for PLEKHO2 Gene

  • GC15P062924
  • GC15P065134
  • GC15P041959
  • GC15P064946
  • GC15P065430
  • GC15P071090
  • GC15P071610
  • GC15P071765
  • GC15P065457
  • GC15P066330
  • GC15P066884
  • GC15P067413
  • GC15P067939
  • GC15P068429
  • GC15P068941
  • GC15P070561

Summaries for PLEKHO2 Gene

GeneCards Summary for PLEKHO2 Gene

PLEKHO2 (Pleckstrin Homology Domain Containing O2) is a Protein Coding gene. Among its related pathways are Innate Immune System. An important paralog of this gene is ENSG00000249240.

Additional gene information for PLEKHO2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLEKHO2 Gene

Genomics for PLEKHO2 Gene

GeneHancer (GH) Regulatory Elements for PLEKHO2 Gene

Promoters and enhancers for PLEKHO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J064840 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 543.4 +2.4 2361 8.1 HNRNPK EP300 NRF1 POLR2G GTF2E2 PHF8 POLR2A ZBTB10 ZBTB11 TCF7 PLEKHO2 ANKDD1A RBPMS2 SPG21 OAZ2 TRIP4 ZNF609 ENSG00000249240 lnc-PIF1-1 ENSG00000287494
GH15J064822 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 534.6 -16.6 -16562 5 FOXK2 ZSCAN5C SIN3A USF1 POLR2G SP1 BCLAF1 PHF8 JUND PHB2 PLEKHO2 PIF1 RF00017-1816 RBPMS2 ANKDD1A SPG21
GH15J064835 Promoter/Enhancer 1.6 EPDnew ENCODE CraniofacialAtlas dbSUPER 523.3 -5.8 -5786 1.6 CTCF NRF1 POLR2G SP1 GABPA REST CUX1 RAD21 CTBP1 SKI PLEKHO2 RBPMS2 lnc-PIF1-1 piR-48820-040
GH15J064862 Promoter/Enhancer 0.5 EPDnew dbSUPER 500.4 +19.2 19172 0.1 PLEKHO2 ENSG00000249240 ENSG00000287494
GH15J064891 Promoter/Enhancer 2.3 EPDnew FANTOM5 ENCODE CraniofacialAtlas dbSUPER 62.6 +53.0 53020 7.8 ZBTB40 USF1 POLR2G SP1 FOS EP300 ZIC2 POLR2A CTCF RELA ANKDD1A PLEKHO2 SPG21 OAZ2 ZNF609 PARP16 RF00017-1817 lnc-SPG21-2 lnc-PLEKHO2-1 ENSG00000249240
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLEKHO2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLEKHO2

Top Transcription factor binding sites by QIAGEN in the PLEKHO2 gene promoter:
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • HEN1
  • MyoD
  • p53
  • ZIC2

Genomic Locations for PLEKHO2 Gene

Genomic Locations for PLEKHO2 Gene
chr15:64,841,883-64,868,002
(GRCh38/hg38)
Size:
26,120 bases
Orientation:
Plus strand
chr15:65,134,082-65,160,206
(GRCh37/hg19)
Size:
26,125 bases
Orientation:
Plus strand

Genomic View for PLEKHO2 Gene

Genes around PLEKHO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHO2 Gene

Proteins for PLEKHO2 Gene

  • Protein details for PLEKHO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD55-PKHO2_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family O member 2
    Protein Accession:
    Q8TD55
    Secondary Accessions:
    • Q7L4H4
    • Q8WYS8

    Protein attributes for PLEKHO2 Gene

    Size:
    490 amino acids
    Molecular mass:
    53350 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL55880.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLEKHO2 Gene

Post-translational modifications for PLEKHO2 Gene

  • Ubiquitination at Lys37
  • Modification sites at PhosphoSitePlus

Other Protein References for PLEKHO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLEKHO2 Gene

Domains & Families for PLEKHO2 Gene

Gene Families for PLEKHO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PLEKHO2 Gene

Blocks:
  • Pleckstrin-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PLEKHO2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ38884 fis, clone MESAN2017152, highly similar to Homo sapiens PH domain-containing protein (pp9099), mRNA (B3KTW8_HUMAN)
  • Pleckstrin homology domain-containing family Q member 1 (PKHO2_HUMAN)
genes like me logo Genes that share domains with PLEKHO2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLEKHO2 Gene

Function for PLEKHO2 Gene

Phenotypes From GWAS Catalog for PLEKHO2 Gene

genes like me logo Genes that share phenotypes with PLEKHO2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHO2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHO2 Gene

Localization for PLEKHO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHO2 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLEKHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with PLEKHO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLEKHO2 Gene

Pathways & Interactions for PLEKHO2 Gene

PathCards logo

SuperPathways for PLEKHO2 Gene

genes like me logo Genes that share pathways with PLEKHO2: view

Pathways by source for PLEKHO2 Gene

3 Reactome pathways for PLEKHO2 Gene

Gene Ontology (GO) - Biological Process for PLEKHO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with PLEKHO2: view

No data available for SIGNOR curated interactions for PLEKHO2 Gene

Drugs & Compounds for PLEKHO2 Gene

(1) Additional Compounds for PLEKHO2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLEKHO2: view

Transcripts for PLEKHO2 Gene

mRNA/cDNA for PLEKHO2 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHO2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHO2 Gene

No ASD Table

Relevant External Links for PLEKHO2 Gene

GeneLoc Exon Structure for
PLEKHO2

Expression for PLEKHO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLEKHO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLEKHO2 Gene

This gene is overexpressed in Whole Blood (x10.0) and Spleen (x4.8).

Protein differential expression in normal tissues from HIPED for PLEKHO2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Spleen (9.3), Monocytes (8.7), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLEKHO2 Gene



Protein tissue co-expression partners for PLEKHO2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLEKHO2

SOURCE GeneReport for Unigene cluster for PLEKHO2 Gene:

Hs.709337

Evidence on tissue expression from TISSUES for PLEKHO2 Gene

  • Liver(4.1)
  • Skin(4.1)
  • Pancreas(2.8)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PLEKHO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHO2 Gene

Orthologs for PLEKHO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEKHO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHO2 31 30
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLEKHO2 31 30
  • 87.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHO2 31 30
  • 86.46 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plekho2 30
  • 81.37 (n)
mouse
(Mus musculus)
Mammalia Plekho2 17 31 30
  • 81.17 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves PLEKHO2 30
  • 58.77 (n)
-- 31
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia plekho2 30
  • 57.96 (n)
zebrafish
(Danio rerio)
Actinopterygii PLEKHO2 31
  • 25 (a)
OneToMany
Species where no ortholog for PLEKHO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEKHO2 Gene

ENSEMBL:
Gene Tree for PLEKHO2 (if available)
TreeFam:
Gene Tree for PLEKHO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLEKHO2: view image

Paralogs for PLEKHO2 Gene

Paralogs for PLEKHO2 Gene

genes like me logo Genes that share paralogs with PLEKHO2: view

Variants for PLEKHO2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLEKHO2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs2010875 - p.Pro290Ser

Additional dbSNP identifiers (rs#s) for PLEKHO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLEKHO2 Gene

Variant ID Type Subtype PubMed ID
dgv31n68 CNV loss 17160897
nsv1049654 CNV loss 25217958
nsv569703 CNV loss 21841781
nsv833041 CNV loss 17160897

Variation tolerance for PLEKHO2 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLEKHO2 Gene

Human Gene Mutation Database (HGMD)
PLEKHO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLEKHO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHO2 Gene

Disorders for PLEKHO2 Gene

Additional Disease Information for PLEKHO2

No disorders were found for PLEKHO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHO2 Gene

Publications for PLEKHO2 Gene

  1. PLEKHO2 is essential for M-CSF-dependent macrophage survival. (PMID: 28627369) Zhang P … Zhang L (Cellular signalling 2017) 2 3 54
  2. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G … Boerwinkle E (PLoS genetics 2011) 3 41 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 54

Products for PLEKHO2 Gene

Sources for PLEKHO2 Gene