Aliases for PLEKHO1 Gene
External Ids for PLEKHO1 Gene
Previous GeneCards Identifiers for PLEKHO1 Gene
GeneCards Summary for PLEKHO1 Gene
PLEKHO1 (Pleckstrin Homology Domain Containing O1) is a Protein Coding gene. An important paralog of this gene is PLEKHO2.
UniProtKB/Swiss-Prot Summary for PLEKHO1 Gene
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.