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PLEKHO1 (Pleckstrin Homology Domain Containing O1) is a Protein Coding gene. Diseases associated with PLEKHO1 include Noonan Syndrome 1. An important paralog of this gene is PLEKHO2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 20580715 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0032587 | ruffle membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007520 | myoblast fusion | IEA | -- |
GO:0008360 | regulation of cell shape | IEA | -- |
GO:0051451 | myoblast migration | IEA | -- |
GO:0072673 | lamellipodium morphogenesis | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||
SP9: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PLEKHO1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PLEKHO1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PLEKHO1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Plekho1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PLEKHO1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Plekho1 30 |
|
||
Chicken (Gallus gallus) |
Aves | PLEKHO1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PLEKHO1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | plekho1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC562940 30 |
|
||
plekho1b 31 |
|
OneToMany | |||
plekho1a 31 |
|
OneToMany | |||
Dr.29665 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1078943 | CNV | deletion | 25765185 |
nsv1143465 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
noonan syndrome 1 |
|
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