Aliases for PLEKHO1 Gene
Aliases for PLEKHO1 Gene
External Ids for PLEKHO1 Gene
- HGNC: 24310
- Entrez Gene: 51177
- Ensembl: ENSG00000023902
- OMIM: 608335
- UniProtKB: Q53GL0
Previous GeneCards Identifiers for PLEKHO1 Gene
- GC01P146935
- GC01P148388
- GC01P121502
Summaries for PLEKHO1 Gene
GeneCards Summary for PLEKHO1 Gene
PLEKHO1 (Pleckstrin Homology Domain Containing O1) is a Protein Coding gene. Diseases associated with PLEKHO1 include Colonic Benign Neoplasm. An important paralog of this gene is PLEKHO2.
UniProtKB/Swiss-Prot for PLEKHO1 Gene
-
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Additional gene information for PLEKHO1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHO1 Gene
Genomics for PLEKHO1 Gene
GeneHancer (GH) Regulatory Elements for PLEKHO1 Gene
Promoters and enhancers for PLEKHO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLEKHO1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PLEKHO1 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- Evi-1
- MyoD
- COMP1
- E47
- Tal-1
- STAT3
Regulatory Element Products
Genomic Locations for PLEKHO1 Gene
Genomic Locations for PLEKHO1 Gene
- chr1:150,149,183-150,164,720
- (GRCh38/hg38)
- Size:
- 15,538 bases
- Orientation:
- Plus strand
- chr1:150,121,373-150,136,916
- (GRCh37/hg19)
- Size:
- 15,544 bases
- Orientation:
- Plus strand
Genomic View for PLEKHO1 Gene
Genes around PLEKHO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
- 1q21.2 by Ensembl
PLEKHO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLEKHO1 Gene
Proteins for PLEKHO1 Gene
-
Protein details for PLEKHO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q53GL0-PKHO1_HUMAN
- Recommended name:
- Pleckstrin homology domain-containing family O member 1
- Protein Accession:
- Q53GL0
- Q336K5
- Q8IZ51
- Q9NRV3
- Q9UL48
Protein attributes for PLEKHO1 Gene
- Size:
- 409 amino acids
- Molecular mass:
- 46237 Da
- Quaternary structure:
-
- Heterodimer or homodimer. Interacts with CK2 and actin capping subunits (capping protein CP-alpha and CP-beta). CKIP1 and CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments. Interacts with ATM, IFP35, JUN, JUND, NMI and PI3K. Interacts with AKT1, AKT2 and AKT3 (each isozyme of PKB), PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P2.
- SequenceCaution:
-
- Sequence=AAF13461.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ13826.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PLEKHO1 Gene
Post-translational modifications for PLEKHO1 Gene
- C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PLEKHO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for PLEKHO1
- Invitrogen Antibodies for PLEKHO1
- GeneTex PLEKHO1 Antibody for PLEKHO1
-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for PLEKHO1
Protein Products
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OriGene Purified Proteins for PLEKHO1
- Search Origene for MassSpec and Protein Over-expression Lysates for PLEKHO1
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-
Abcam proteins for PLEKHO1
Assay Products
- antibodies-online: Search results for 9 available PLEKHO1 Elisa Kits ranked by validation data
- Compare Top PLEKHO1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for PLEKHO1 Gene
Domains & Families for PLEKHO1 Gene
Gene Families for PLEKHO1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PLEKHO1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLEKHO1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for PLEKHO1 Gene
Function for PLEKHO1 Gene
Molecular function for PLEKHO1 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFNG/IFN-gamma and IL2/interleukin-2 or in C2C12 cells.
Phenotypes From GWAS Catalog for PLEKHO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20580715 |
Phenotypes for PLEKHO1 Gene
- MGI mutant phenotypes for PLEKHO1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PLEKHO1:
Animal Models for PLEKHO1 Gene
- MGI Knock Outs for PLEKHO1:
-
- Plekho1 Plekho1<tm1Fhe>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PLEKHO1
-
CRISPR Products
-
OriGene CRISPR knockouts for PLEKHO1
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for PLEKHO1 Gene
- miRTarBase miRNAs that target PLEKHO1
-
- hsa-mir-149-5p (MIRT045557)
- hsa-mir-202-3p (MIRT498111)
- hsa-mir-5586-5p (MIRT498112)
- hsa-mir-5692a (MIRT498113)
- hsa-mir-129-5p (MIRT498114)
- hsa-mir-4500 (MIRT498115)
- hsa-mir-4458 (MIRT498116)
- hsa-mir-98-5p (MIRT498117)
- hsa-let-7d-5p (MIRT498118)
- hsa-let-7i-5p (MIRT498119)
- hsa-let-7g-5p (MIRT498120)
- hsa-let-7f-5p (MIRT498121)
- hsa-let-7e-5p (MIRT498122)
- hsa-let-7a-5p (MIRT498123)
- hsa-let-7c-5p (MIRT498124)
- hsa-let-7b-5p (MIRT498125)
- hsa-mir-6772-3p (MIRT535133)
- hsa-mir-4284 (MIRT535134)
- hsa-mir-4448 (MIRT535135)
- hsa-mir-4268 (MIRT535136)
- hsa-mir-610 (MIRT535137)
- hsa-mir-1304-3p (MIRT535138)
- hsa-mir-3667-3p (MIRT535139)
- hsa-mir-6890-3p (MIRT535140)
- hsa-mir-4279 (MIRT622696)
- hsa-mir-6778-3p (MIRT622697)
- hsa-mir-1976 (MIRT622698)
- hsa-mir-3653-5p (MIRT622699)
- hsa-mir-6747-3p (MIRT622700)
- hsa-mir-6727-3p (MIRT622701)
- hsa-mir-4722-3p (MIRT622702)
- hsa-mir-8062 (MIRT622703)
- hsa-mir-6513-3p (MIRT679959)
miRNA Products
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Clone Products
- Sino Biological Human cDNA Clone for PLEKHO1
- VectorBuilder custom plasmid, inducible vectors for PLEKHO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLEKHO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLEKHO1
- genomics-online: cdna clones - Search results for available PLEKHO1 gene related products
- orf clones - Search results for available PLEKHO1 gene related products
- Applied Biological Materials Clones for PLEKHO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PLEKHO1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLEKHO1 Gene
Localization for PLEKHO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLEKHO1 Gene
- Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Note=Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3-phosphate (PubMed:14729969). In C2C12 cells, with the absence of growth factor, it is found in the nucleus (PubMed:14729969). It rapidly translocates to the plasma membrane after insulin stimulation (PubMed:14729969). In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3 (PubMed:15706351). However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells (Probable). {ECO:0000269 PubMed:14729969, ECO:0000269 PubMed:15706351, ECO:0000305}.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 3 |
| cytosol | 2 |
| cytoskeleton | 1 |
| golgi apparatus | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0032587 | ruffle membrane | IEA | -- |
Pathways & Interactions for PLEKHO1 Gene
No Data Available
Interacting Proteins for PLEKHO1 Gene
Selected Interacting proteins:
Q53GL0-PKHO1_HUMAN
ENSP00000358120
for PLEKHO1 Gene via
UniProtKB
STRING
IID
MINT
GPS-Prot Interaction Network for PLEKHO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007520 | myoblast fusion | IEA | -- |
| GO:0008360 | regulation of cell shape | IEA | -- |
| GO:0051451 | myoblast migration | IEA | -- |
| GO:0072673 | lamellipodium morphogenesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PLEKHO1 Gene
Transcripts for PLEKHO1 Gene
mRNA/cDNA for PLEKHO1 Gene
- (6) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (217) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000369126 1809 bps (uc001ets.4)
- ENST00000369124 2050 bps (uc001ett.4)
- ENST00000479194 1025 bps (uc057kmt.1)
- ENST00000492304 685 bps (uc057kmu.1)
- ENST00000607609 3741 bps (uc057kmv.1)
Unigene Clusters for PLEKHO1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PLEKHO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLEKHO1
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- Applied Biological Materials CRISPR for PLEKHO1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHO1
- GenScript: Design CRISPR guide RNA sequences for PLEKHO1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLEKHO1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHO1
- genomics-online: shRNA clones - Search results for available PLEKHO1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PLEKHO1
- VectorBuilder custom plasmid, inducible vectors for PLEKHO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLEKHO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLEKHO1
- genomics-online: cdna clones - Search results for available PLEKHO1 gene related products
- orf clones - Search results for available PLEKHO1 gene related products
- Applied Biological Materials Clones for PLEKHO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
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| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
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| SP9: |
Expression for PLEKHO1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for PLEKHO1 Gene
This gene is overexpressed in Colon - Sigmoid (x4.6).
This gene is overexpressed in Peripheral blood mononuclear cells (20.8), Blymphocyte (10.5), Fetal Brain (8.9), and Fetal gut (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLEKHO1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PLEKHO1 Gene:
PLEKHO1SOURCE GeneReport for Unigene cluster for PLEKHO1 Gene:
Hs.438824mRNA Expression by UniProt/SwissProt for PLEKHO1 Gene:
Q53GL0-PKHO1_HUMAN
Tissue specificity:
Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat.
Evidence on tissue expression from TISSUES for PLEKHO1 Gene
- Lymph node(4.4)
- Muscle(4.4)
- Kidney(4.2)
- Liver(4.2)
- Nervous system(3.5)
- Heart(2.1)
Primer Products
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OriGene qPCR primer pairs and template standards for PLEKHO1
-
OriGene qPCR primer pairs for PLEKHO1
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Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHO1 Gene
Orthologs for PLEKHO1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PLEKHO1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PLEKHO1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PLEKHO1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Plekho1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PLEKHO1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Plekho1 33 |
|
||
| chicken (Gallus gallus) |
Aves | PLEKHO1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PLEKHO1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | plekho1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC562940 33 |
|
||
| plekho1b 34 |
|
OneToMany | |||
| plekho1a 34 |
|
OneToMany | |||
| Dr.29665 33 |
|
- Species where no ortholog for PLEKHO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PLEKHO1 Gene
- ENSEMBL:
- Gene Tree for PLEKHO1 (if available)
- TreeFam:
- Gene Tree for PLEKHO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLEKHO1: view image
Paralogs for PLEKHO1 Gene
Paralogs for PLEKHO1 Gene
Variants for PLEKHO1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000077007 | -- | 150,153,758(+) | G/A | intron_variant | |
| rs1000281247 | -- | 150,153,491(+) | G/A | intron_variant | |
| rs1000892977 | -- | 150,152,390(+) | C/T | intron_variant | |
| rs1000946285 | -- | 150,158,494(+) | T/C | intron_variant | |
| rs1001491082 | -- | 150,152,703(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1078943 | CNV | deletion | 25765185 |
| nsv1143465 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.07;
50.71% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLEKHO1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLEKHO1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHO1 Gene
Disorders for PLEKHO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colonic benign neoplasm |
|
|
Search PLEKHO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLEKHO1
No data available for UniProtKB/Swiss-Prot and Genatlas for PLEKHO1 Gene
Publications for PLEKHO1 Gene
- The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. (PMID: 17197158) Zhang L … He F (Cellular signalling 2007) 3 4 22 58
- The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein. (PMID: 15831458) Canton DA … Litchfield DW (Molecular and cellular biology 2005) 3 4 22 58
- The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane. (PMID: 15254037) Olsten ME … Litchfield DW (The Journal of biological chemistry 2004) 3 4 22 58
- Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. (PMID: 10799509) Bosc DG … Litchfield DW (The Journal of biological chemistry 2000) 2 3 4 58
- Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo. (PMID: 17942896) Tokuda E … Tsuruo T (Cancer research 2007) 3 4 58
Products for PLEKHO1 Gene
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- Sino Biological Human cDNA Clone for PLEKHO1
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PLEKHO1
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- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for PLEKHO1
- Abcam proteins for PLEKHO1
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- Search Knockout (KO) Validated Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for PLEKHO1
- VectorBuilder custom plasmid, inducible vectors for PLEKHO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PLEKHO1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 50 available PLEKHO1 Antibodies ranked by validation data
- Compare Top PLEKHO1 Antibodies
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- antibodies-online: Search results for 9 available PLEKHO1 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 7 available PLEKHO1 Proteins ranked by validation data
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- GeneTex PLEKHO1 Antibody for PLEKHO1
- Search GeneTex for Proteins for PLEKHO1
- Santa Cruz Biotechnology (SCBT) Antibodies for PLEKHO1
- Search Santa Cruz Biotechnology (SCBT) for PLEKHO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHO1
- Custom Antibody ServicesProSci Antibodies for PLEKHO1
- Search for PLEKHO1 Proteins at ProSci
- Horizon Cell Lines for PLEKHO1
- genomics-online: cdna clones - Search results for available PLEKHO1 gene related products
- orf clones - Search results for available PLEKHO1 gene related products
- genomics-online: gRNA clones - Search results for available PLEKHO1 gene related products
- genomics-online: primer clones - Search results for available PLEKHO1 gene related products
- genomics-online: shRNA clones - Search results for available PLEKHO1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLEKHO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLEKHO1
- GeneCopoeia miRNA 3'UTR Target clone products for PLEKHO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHO1
Sources for PLEKHO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt