Aliases for PLEKHG7 Gene

Aliases for PLEKHG7 Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G7 2 3
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 7 2 3
  • Pleckstrin Homology Domain-Containing Family G Member 7 3 4
  • PH Domain-Containing Family G Member 7 3 4
  • Chromosome 12 Open Reading Frame 74 5
  • C12orf74 5

External Ids for PLEKHG7 Gene

Previous GeneCards Identifiers for PLEKHG7 Gene

  • GC12P091654
  • GC12P093130
  • GC12P090197
  • GC12P092721

Summaries for PLEKHG7 Gene

GeneCards Summary for PLEKHG7 Gene

PLEKHG7 (Pleckstrin Homology And RhoGEF Domain Containing G7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG5.

Additional gene information for PLEKHG7 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLEKHG7 Gene

Genomics for PLEKHG7 Gene

GeneHancer (GH) Regulatory Elements for PLEKHG7 Gene

Promoters and enhancers for PLEKHG7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J092702 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 757.2 +0.1 103 1.9 ETV6 HLF NKRF POLR2A SP1 MLLT1 ZNF687 RELA HNF1A IKZF1 PLEKHG7 C12orf74 piR-39300-042
GH12J092744 Enhancer 0.8 Ensembl ENCODE 17.6 +43.4 43369 2.8 CTCF POLR2A ZNF692 JUN JUND SP1 SCRT2 SCRT1 FOS STAT3 PLEKHG7 C12orf74 EEA1 UBE2N piR-43106-047 piR-55194-100
GH12J092753 Enhancer 0.6 Ensembl ENCODE 18.5 +51.4 51358 3.6 NR2F2 JUN MAX RXRA PLEKHG7 EEA1 C12orf74 piR-43106-047 piR-55194-100
GH12J092759 Enhancer 0.8 Ensembl ENCODE 10.4 +57.1 57058 1 L3MBTL2 SMARCA4 FOSL2 IKZF1 CEBPB JUN NFE2 JUND MAX MGA C12orf74 PLEKHG7 piR-43106-047 piR-55194-100
GH12J092784 Enhancer 1 Ensembl ENCODE 5.7 +82.2 82158 3.6 FOXK2 CTCF MIXL1 CC2D1A MAX RAD21 MNT ZNF652 MAFK ZSCAN21 PLEKHG7 UBE2N piR-55194-100 piR-43106-047 EEA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLEKHG7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLEKHG7 gene promoter:
  • c-Myb
  • MRF-2
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for PLEKHG7 Gene

Genomic Locations for PLEKHG7 Gene
chr12:92,702,843-92,772,745
(GRCh38/hg38)
Size:
69,903 bases
Orientation:
Plus strand
chr12:93,115,281-93,166,231
(GRCh37/hg19)
Size:
50,951 bases
Orientation:
Plus strand

Genomic View for PLEKHG7 Gene

Genes around PLEKHG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG7 Gene

Proteins for PLEKHG7 Gene

  • Protein details for PLEKHG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZR37-PKHG7_HUMAN
    Recommended name:
    Pleckstrin homology domain-containing family G member 7
    Protein Accession:
    Q6ZR37
    Secondary Accessions:
    • B2RNR7

    Protein attributes for PLEKHG7 Gene

    Size:
    379 amino acids
    Molecular mass:
    44301 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PLEKHG7 Gene

Post-translational modifications for PLEKHG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEKHG7 Gene

No data available for DME Specific Peptides for PLEKHG7 Gene

Domains & Families for PLEKHG7 Gene

Gene Families for PLEKHG7 Gene

Protein Domains for PLEKHG7 Gene

Suggested Antigen Peptide Sequences for PLEKHG7 Gene

GenScript: Design optimal peptide antigens:
  • Pleckstrin homology domain-containing family G member 7 (PKHG7_HUMAN)
genes like me logo Genes that share domains with PLEKHG7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLEKHG7 Gene

Function for PLEKHG7 Gene

Phenotypes From GWAS Catalog for PLEKHG7 Gene

Gene Ontology (GO) - Molecular Function for PLEKHG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with PLEKHG7: view
genes like me logo Genes that share phenotypes with PLEKHG7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHG7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHG7 Gene

Localization for PLEKHG7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHG7 gene
Compartment Confidence
nucleus 1
cytosol 1
mitochondrion 0
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PLEKHG7 Gene

Pathways & Interactions for PLEKHG7 Gene

PathCards logo

SuperPathways for PLEKHG7 Gene

No Data Available

Interacting Proteins for PLEKHG7 Gene

Gene Ontology (GO) - Biological Process for PLEKHG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
genes like me logo Genes that share ontologies with PLEKHG7: view

No data available for Pathways by source and SIGNOR curated interactions for PLEKHG7 Gene

Drugs & Compounds for PLEKHG7 Gene

No Compound Related Data Available

Transcripts for PLEKHG7 Gene

mRNA/cDNA for PLEKHG7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHG7

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG7 Gene

No ASD Table

Relevant External Links for PLEKHG7 Gene

GeneLoc Exon Structure for
PLEKHG7
ECgene alternative splicing isoforms for
PLEKHG7

Expression for PLEKHG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLEKHG7 Gene

mRNA differential expression in normal tissues according to GTEx for PLEKHG7 Gene

This gene is overexpressed in Cervix - Endocervix (x7.3), Nerve - Tibial (x6.3), and Fallopian Tube (x6.0).

Protein differential expression in normal tissues from HIPED for PLEKHG7 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLEKHG7 Gene



Protein tissue co-expression partners for PLEKHG7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLEKHG7 Gene:

PLEKHG7

SOURCE GeneReport for Unigene cluster for PLEKHG7 Gene:

Hs.591013

Evidence on tissue expression from TISSUES for PLEKHG7 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with PLEKHG7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHG7 Gene

Orthologs for PLEKHG7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEKHG7 33
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLEKHG7 33
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEKHG7 33
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLEKHG7 33
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLEKHG7 33
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEKHG7 33
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plekhg7 33
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.12 33
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 36 (a)
OneToOne
Species where no ortholog for PLEKHG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLEKHG7 Gene

ENSEMBL:
Gene Tree for PLEKHG7 (if available)
TreeFam:
Gene Tree for PLEKHG7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLEKHG7: view image

Paralogs for PLEKHG7 Gene

Paralogs for PLEKHG7 Gene

genes like me logo Genes that share paralogs with PLEKHG7: view

Variants for PLEKHG7 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG7 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000051737 -- 92,758,365(+) T/C intron_variant
rs1000062714 -- 92,754,425(+) A/G intron_variant
rs1000202512 -- 92,740,114(+) G/A intron_variant
rs1000233437 -- 92,751,981(+) C/A intron_variant
rs1000252878 -- 92,736,667(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG7 Gene

Variant ID Type Subtype PubMed ID
dgv2787n54 CNV gain 21841781
dgv498e212 CNV gain 25503493
esv2746207 CNV deletion 23290073
esv2761762 CNV loss 21179565
nsv455691 CNV gain 19166990
nsv559764 CNV loss 21841781
nsv7234 OTHER inversion 18451855

Variation tolerance for PLEKHG7 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLEKHG7 Gene

Human Gene Mutation Database (HGMD)
PLEKHG7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLEKHG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG7 Gene

Disorders for PLEKHG7 Gene

Additional Disease Information for PLEKHG7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLEKHG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG7 Gene

Publications for PLEKHG7 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for PLEKHG7 Gene

Sources for PLEKHG7 Gene