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The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. ... See more...
Aliases for PLEKHG4 Gene
Aliases for PLEKHG4 Gene
External Ids for PLEKHG4 Gene
- HGNC: 24501
- Entrez Gene: 25894
- Ensembl: ENSG00000196155
- OMIM: 609526
- UniProtKB: Q58EX7
Previous HGNC Symbols for PLEKHG4 Gene
- SCA4
Previous GeneCards Identifiers for PLEKHG4 Gene
- GC16P065870
- GC16P053184
Summaries for PLEKHG4 Gene
-
The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for PLEKHG4 Gene
PLEKHG4 (Pleckstrin Homology And RhoGEF Domain Containing G4) is a Protein Coding gene. Diseases associated with PLEKHG4 include Spinocerebellar Ataxia 4 and Israeli Tick Typhus. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG4B.
UniProtKB/Swiss-Prot Summary for PLEKHG4 Gene
-
Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
Additional gene information for PLEKHG4 Gene
- HGNC(24501)
- Entrez Gene(25894)
- Ensembl(ENSG00000196155)
- OMIM(609526)
- UniProtKB(Q58EX7)
- Open Targets Platform(ENSG00000196155)
- Search for PLEKHG4 at DataMed
- Search for PLEKHG4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLEKHG4 Gene
Genomics for PLEKHG4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PLEKHG4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLEKHG4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLEKHG4
- Top Transcription factor binding sites by QIAGEN in the PLEKHG4 gene promoter:
-
- E2F
- E2F-3a
- E2F-4
Genomic Locations for PLEKHG4 Gene
Genomic Locations for PLEKHG4 Gene
- chr16:67,277,510-67,289,500
- (GRCh38/hg38)
- Size:
- 11,991 bases
- Orientation:
- Plus strand
- chr16:67,311,413-67,323,403
- (GRCh37/hg19)
- Size:
- 11,991 bases
- Orientation:
- Plus strand
Genomic View for PLEKHG4 Gene
Genes around PLEKHG4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by HGNC
- 16q22.1 by Entrez Gene
- 16q22.1 by Ensembl
PLEKHG4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLEKHG4 Gene
Proteins for PLEKHG4 Gene
-
Protein details for PLEKHG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q58EX7-PKHG4_HUMAN
- Recommended name:
- Puratrophin-1
- Protein Accession:
- Q58EX7
- Q4G0J8
- Q4H485
- Q56A69
- Q9H7K4
- Q9UFW0
Protein attributes for PLEKHG4 Gene
- Size:
- 1191 amino acids
- Molecular mass:
- 130803 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH82974.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB15765.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for PLEKHG4 Gene
Post-translational modifications for PLEKHG4 Gene
Other Protein References for PLEKHG4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Puratrophin 1 Polyclonal Antibody and Immunotag™ PLEKHG4 Antibody
- Novus Biologicals Antibodies for PLEKHG4
-
Abcam antibodies for PLEKHG4
- Invitrogen Antibodies for PLEKHG4 (AFLGC-PLEKHG4)
-
Biorbyt antibodies for PLEKHG4
Protein Products
-
OriGene Purified Proteins for PLEKHG4
- Search Origene for MassSpec and Protein Over-expression Lysates for PLEKHG4
- Origene Custom Protein Services for PLEKHG4
-
Abcam proteins for PLEKHG4
No data available for DME Specific Peptides for PLEKHG4 Gene
Domains & Families for PLEKHG4 Gene
Gene Families for PLEKHG4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PLEKHG4 Gene
- InterPro:
- Blocks:
-
- DH domain
- ProtoNet:
Suggested Antigen Peptide Sequences for PLEKHG4 Gene
- GenScript: Design optimal peptide antigens:
-
- Pleckstrin homology domain protein (C5IFI8_HUMAN)
- Purkinje cell atrophy-associated protein 1 (PKHG4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLEKHG4 Gene
Function for PLEKHG4 Gene
Molecular function for PLEKHG4 Gene
- UniProtKB/Swiss-Prot Function:
- Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
Phenotypes From GWAS Catalog for PLEKHG4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for PLEKHG4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLEKHG4 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHG4
miRNA for PLEKHG4 Gene
- miRTarBase miRNAs that target PLEKHG4
-
- hsa-miR-335-5p (MIRT018367)
- hsa-miR-124-3p (MIRT022840)
- hsa-miR-93-3p (MIRT038911)
- hsa-miR-331-3p (MIRT043462)
- hsa-miR-632 (MIRT712868)
- hsa-miR-4288 (MIRT712869)
- hsa-miR-6828-3p (MIRT712870)
- hsa-miR-346 (MIRT712871)
- hsa-miR-4261 (MIRT712872)
- hsa-miR-6502-5p (MIRT712873)
- hsa-miR-1301-5p (MIRT712874)
- hsa-miR-767-3p (MIRT712875)
- hsa-miR-654-3p (MIRT712876)
- hsa-miR-3688-3p (MIRT712877)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLEKHG4
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Clone Products
- Applied Biological Materials (abm): Clones for PLEKHG4 - Select products 50% OFF >
- * PLEKHG4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- MG221235
- MR221235
- MR221235L3
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- RC209583L3
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- RC226331
- RC226331L3
- RC226331L4
- RC226353
- RC226353L3
- RC226353L4
- RC226354
- RC226354L3
- RC226354L4
- RC226355
- RC226355L3
- RC226355L4
- RG209583
- RG226331
- RG226353
- RG226354
- RG226355
- RR201981
- MR221235L3V
- MR221235L4V
- RC209583L3V
- RC209583L4V
- RC226331L3V
- RC226331L4V
- RC226353L3V
- RC226353L4V
- RC226354L3V
- RC226354L4V
- RC226355L3V
- RC226355L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PLEKHG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLEKHG4
Cell Line Products
-
Horizon Cell Lines for PLEKHG4
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEKHG4 Gene
Localization for PLEKHG4 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG4 Gene
Pathways & Interactions for PLEKHG4 Gene
Interacting Proteins for PLEKHG4 Gene
Selected Interacting proteins:
Q58EX7-PKHG4_HUMAN
ENSP00000353646
for PLEKHG4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PLEKHG4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0090630 | activation of GTPase activity | IEA | -- |
No data available for Pathways by source for PLEKHG4 Gene
Transcripts for PLEKHG4 Gene
mRNA/cDNA for PLEKHG4 Gene
- 5 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360461 6782 nts (view in UCSC)
- ENST00000379344 4512 nts (view in UCSC)
- ENST00000393966 2182 nts (view in UCSC)
- ENST00000427155 4455 nts (view in UCSC)
- ENST00000450733 4480 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PLEKHG4 - Select products 50% OFF >
- * PLEKHG4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PLEKHG4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLEKHG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLEKHG4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLEKHG4
- Browse OriGene Inhibitory RNA Products For PLEKHG4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHG4
Clone Products
- Applied Biological Materials (abm): Clones for PLEKHG4 - Select products 50% OFF >
- * PLEKHG4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG221235
- MR221235
- MR221235L3
- MR221235L4
- RC209583
- RC209583L3
- RC209583L4
- RC226331
- RC226331L3
- RC226331L4
- RC226353
- RC226353L3
- RC226353L4
- RC226354
- RC226354L3
- RC226354L4
- RC226355
- RC226355L3
- RC226355L4
- RG209583
- RG226331
- RG226353
- RG226354
- RG226355
- RR201981
- MR221235L3V
- MR221235L4V
- RC209583L3V
- RC209583L4V
- RC226331L3V
- RC226331L4V
- RC226353L3V
- RC226353L4V
- RC226354L3V
- RC226354L4V
- RC226355L3V
- RC226355L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PLEKHG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLEKHG4
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - |
| ExUns: | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: |
Relevant External Links for PLEKHG4 Gene
- GeneLoc Exon Structure for
- PLEKHG4
Expression for PLEKHG4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
- Granulosa Cells Primary Follicle
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PLEKHG4 Gene
This gene is overexpressed in Testis (x8.7).
This gene is overexpressed in Plasma (37.2), Ovary (16.4), and Testis (14.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLEKHG4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLEKHG4
SOURCE GeneReport for Unigene cluster for PLEKHG4 Gene:
Hs.188781mRNA Expression by UniProt/SwissProt for PLEKHG4 Gene:
Q58EX7-PKHG4_HUMAN
Tissue specificity:
Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower extent in other neurons (at protein level). Widely expressed at low levels. More strongly expressed in testis and pancreas.
Evidence on tissue expression from TISSUES for PLEKHG4 Gene
- Nervous system(4.4)
- Skin(4.4)
- Spleen(4.3)
- Eye(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHG4 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- head
Limb:
- foot
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for PLEKHG4
Gene Expression Assay Products
Orthologs for PLEKHG4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLEKHG4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PLEKHG4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PLEKHG4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Plekhg4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Plekhg4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PLEKHG4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PLEKHG4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PLEKHG4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PLEKHG4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | plekhg4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | plekhg4 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG33275 31 |
|
ManyToMany | |
| CG30456 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8422 30 |
|
- Species where no ortholog for PLEKHG4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PLEKHG4 Gene
- ENSEMBL:
- Gene Tree for PLEKHG4 (if available)
- TreeFam:
- Gene Tree for PLEKHG4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLEKHG4: view image
Paralogs for PLEKHG4 Gene
Paralogs for PLEKHG4 Gene
(2) SIMAP similar genes for PLEKHG4 Gene using alignment to 10 proteins:
- PKHG4_HUMAN
- C5IFI8_HUMAN
- H3BME5_HUMAN
- H3BPA8_HUMAN
- H3BPQ5_HUMAN
- H3BQ60_HUMAN
- H3BQE6_HUMAN
- H3BQP9_HUMAN
- H3BSU4_HUMAN
- J3QSC9_HUMAN
Variants for PLEKHG4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLEKHG4 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 770254 | Benign: not provided | 67,285,354(+) | A/G | MISSENSE_VARIANT | |
| 808058 | Uncertain Significance: not provided | 67,281,107(+) | C/T | SYNONYMOUS_VARIANT | |
| rs11860295 | Likely Benign: not specified. - | 67,282,331(+) | C/Tp.Thr412Ile | MISSENSE_VARIANT | |
| rs3868142 | Likely Benign: not specified. - | 67,286,320(+) | G/Ap.Arg830His | MISSENSE_VARIANT | |
| rs8044843 | Likely Benign: not specified. - | 67,284,339(+) | A/Gp.Asp525Gly | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1144771 | CNV | deletion | 24896259 |
| nsv457513 | CNV | loss | 19166990 |
| nsv471092 | CNV | gain | 18288195 |
| nsv522852 | CNV | gain | 19592680 |
| nsv524363 | CNV | loss | 19592680 |
| nsv524492 | CNV | loss | 19592680 |
| nsv572905 | CNV | loss | 21841781 |
| nsv572906 | CNV | loss | 21841781 |
| nsv827707 | CNV | loss | 20364138 |
| nsv827708 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
16.61;
97.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLEKHG4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG4 Gene
Disorders for PLEKHG4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia 4 |
|
|
| israeli tick typhus |
|
|
| epidemic typhus |
|
|
| autosomal dominant cerebellar ataxia type iii |
|
|
| siberian tick typhus |
|
|
Search PLEKHG4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLEKHG4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PLEKHG4 Gene
Publications for PLEKHG4 Gene
- Mutations of the puratrophin-1 (PLEKHG4) gene on chromosome 16q22.1 are not a common genetic cause of cerebellar ataxia in a European population. (PMID: 16491300) Wieczorek S … Epplen JT (Journal of human genetics 2006) 2 3 23 41
- An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains. (PMID: 16001362) Ishikawa K … Mizusawa H (American journal of human genetics 2005) 2 3 4 23
- [Study on the single-nucleotide substitution (c.-16C to T) of the PURATROPHIN-1 gene in Chinese patients with spinocerebellar ataxia]. (PMID: 19065522) Zhou Y … Tang B (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2008) 3 41
- Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia. (PMID: 17611710) Amino T … Mizusawa H (Journal of human genetics 2007) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for PLEKHG4 Gene
- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for PLEKHG4
- Search Origene for MassSpec and Protein Over-expression Lysates for PLEKHG4
- Origene Custom Protein Services for PLEKHG4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLEKHG4
- Browse OriGene Inhibitory RNA Products For PLEKHG4
- OriGene qPCR primer pairs for PLEKHG4
- OriGene CRISPR knockouts for PLEKHG4
- MG221235
- MR221235
- MR221235L3
- MR221235L4
- RC209583
- RC209583L3
- RC209583L4
- RC226331
- RC226331L3
- RC226331L4
- RC226353
- RC226353L3
- RC226353L4
- RC226354
- RC226354L3
- RC226354L4
- RC226355
- RC226355L3
- RC226355L4
- RG209583
- RG226331
- RG226353
- RG226354
- RG226355
- RR201981
- MR221235L3V
- MR221235L4V
- RC209583L3V
- RC209583L4V
- RC226331L3V
- RC226331L4V
- RC226353L3V
- RC226353L4V
- RC226354L3V
- RC226354L4V
- RC226355L3V
- RC226355L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PLEKHG4
- Sino Biological Human cDNA Clone for PLEKHG4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PLEKHG4
- Novus Biologicals proteins and lysates for PLEKHG4
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- Abcam antibodies for PLEKHG4
- Abcam proteins for PLEKHG4
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- Browse Primary Antibodies
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- Invitrogen Antibodies for PLEKHG4 (AFLGC-PLEKHG4)
- VectorBuilder Custom and pre-made DNA vectors for PLEKHG4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PLEKHG4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PLEKHG4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PLEKHG4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PLEKHG4
- antibodies-online: Show 7 available PLEKHG4 Antibodies ranked by validation data
- Compare Top PLEKHG4 Antibodies
- antibodies-online: Search results for available PLEKHG4 related products ranked by validation data
- antibodies-online: Search results for available PLEKHG4 related products ranked by validation data
- Horizon Cell Lines for PLEKHG4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLEKHG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLEKHG4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PLEKHG4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLEKHG4
- Biorbyt antibodies for PLEKHG4
Sources for PLEKHG4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB