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Aliases for PLEKHG3 Gene

Aliases for PLEKHG3 Gene

  • Pleckstrin Homology And RhoGEF Domain Containing G3 2 3 5
  • KIAA0599 2 3 4
  • Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 3 2 3
  • PH Domain-Containing Family G Member 3 3 4
  • Pleckstrin Homology Domain Containing, Family G, Member 3 3
  • Pleckstrin Homology Domain-Containing Family G Member 3 3
  • ARHGEF43 3

External Ids for PLEKHG3 Gene

Previous HGNC Symbols for PLEKHG3 Gene

  • KIAA0599

Previous GeneCards Identifiers for PLEKHG3 Gene

  • GC14P064240
  • GC14P065172
  • GC14P045343

Summaries for PLEKHG3 Gene

GeneCards Summary for PLEKHG3 Gene

PLEKHG3 (Pleckstrin Homology And RhoGEF Domain Containing G3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is PLEKHG1.

Additional gene information for PLEKHG3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLEKHG3 Gene

Genomics for PLEKHG3 Gene

GeneHancer (GH) Regulatory Elements for PLEKHG3 Gene

Promoters and enhancers for PLEKHG3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J064700 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 680.3 +1.9 1929 10.4 FOXA2 ARID4B SIN3A YY1 FOS SP3 SP5 MXD4 REST SMARCB1 PLEKHG3 MAX ENSG00000214770 PPP1R36 GPX2 CHURC1 SYNE2 MTHFD1 ZBTB1 LOC102723809
GH14J064737 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.3 +33.9 33881 0.1 PLEKHG3 PPP1R36 GC14P064746 PIR60020
GH14J064714 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +17.1 17059 14 PKNOX1 CLOCK FOXA2 ZFP64 SIN3A YY1 ETS1 GLIS2 FOS RXRA PLEKHG3 ZBTB1 PPP1R36 MAX ZBTB25 CHURC1 GC14P064746 PIR60020
GH14J064745 Enhancer 0.9 Ensembl ENCODE dbSUPER 20.8 +42.1 42128 2.2 CTCF ZNF600 RAD21 NR2F2 GC14P064746 PIR60020 PLEKHG3 PPP1R36 GPX2 HSPA2 MIR7855 SPTB
GH14J064754 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +53.6 53597 5.5 KLF17 RAD21 GLIS2 ZNF143 RCOR1 FOS DEK ZNF654 USF2 CEBPB CHURC1 PLEKHG3 PPP1R36 RPPH1-2P CHURC1-FNTB GPX2 SPTB ZBTB1 GC14P064746 PIR60020
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLEKHG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLEKHG3 gene promoter:
  • FOXO4
  • GATA-6
  • c-Myb
  • Elk-1
  • AML1a
  • LUN-1
  • Ik-3
  • Tal-1beta
  • E47

Genomic Locations for PLEKHG3 Gene

Genomic Locations for PLEKHG3 Gene
46,146 bases
Plus strand
42,791 bases
Plus strand

Genomic View for PLEKHG3 Gene

Genes around PLEKHG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEKHG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEKHG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEKHG3 Gene

Proteins for PLEKHG3 Gene

  • Protein details for PLEKHG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology domain-containing family G member 3
    Protein Accession:
    Secondary Accessions:
    • A1L389
    • B5MEC9
    • O60339
    • Q6GMS3
    • Q6P4B1
    • Q7L3S3
    • Q86SW7
    • Q8TEF5
    • Q96EW6
    • Q9BT82

    Protein attributes for PLEKHG3 Gene

    1219 amino acids
    Molecular mass:
    134412 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB84995.1; Type=Miscellaneous discrepancy; Note=Intron retention. There are two regions of intron retention within the sequence which cause it to shift frame.; Evidence={ECO:0000305}; Sequence=CAD66586.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PLEKHG3 Gene


neXtProt entry for PLEKHG3 Gene

Post-translational modifications for PLEKHG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PLEKHG3 Gene

Domains & Families for PLEKHG3 Gene

Protein Domains for PLEKHG3 Gene

Suggested Antigen Peptide Sequences for PLEKHG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLEKHG3: view

No data available for UniProtKB/Swiss-Prot for PLEKHG3 Gene

Function for PLEKHG3 Gene

Gene Ontology (GO) - Molecular Function for PLEKHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with PLEKHG3: view
genes like me logo Genes that share phenotypes with PLEKHG3: view

Animal Models for PLEKHG3 Gene

MGI Knock Outs for PLEKHG3:
  • Plekhg3 Plekhg3<tm1b(EUCOMM)Hmgu>

Animal Model Products

miRNA for PLEKHG3 Gene

miRTarBase miRNAs that target PLEKHG3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLEKHG3 Gene

Localization for PLEKHG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEKHG3 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
  • Centrosome (2)
  • Cytokinetic bridge (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PLEKHG3 Gene

Pathways & Interactions for PLEKHG3 Gene

SuperPathways for PLEKHG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLEKHG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with PLEKHG3: view

No data available for Pathways by source and SIGNOR curated interactions for PLEKHG3 Gene

Drugs & Compounds for PLEKHG3 Gene

No Compound Related Data Available

Transcripts for PLEKHG3 Gene

Unigene Clusters for PLEKHG3 Gene

Pleckstrin homology domain containing, family G (with RhoGef domain) member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEKHG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^
SP1: -
SP2: - - - - - -
SP3: -
SP7: - - - - -
SP10: -

ExUns: 18

Relevant External Links for PLEKHG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLEKHG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLEKHG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLEKHG3 Gene

This gene is overexpressed in Placenta (22.9), Pancreas (15.5), Islet of Langerhans (13.5), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLEKHG3 Gene

Protein tissue co-expression partners for PLEKHG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLEKHG3 Gene:


SOURCE GeneReport for Unigene cluster for PLEKHG3 Gene:


Evidence on tissue expression from TISSUES for PLEKHG3 Gene

  • Pancreas(4.2)
  • Spleen(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with PLEKHG3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEKHG3 Gene

Orthologs for PLEKHG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLEKHG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLEKHG3 34 33
  • 92.97 (n)
(Canis familiaris)
Mammalia PLEKHG3 34 33
  • 84.59 (n)
(Bos Taurus)
Mammalia PLEKHG3 34 33
  • 81.84 (n)
(Rattus norvegicus)
Mammalia Plekhg3 33
  • 81.73 (n)
(Mus musculus)
Mammalia Plekhg3 16 34 33
  • 81.65 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
-- 34
  • 53 (a)
(Monodelphis domestica)
Mammalia PLEKHG3 34
  • 55 (a)
(Gallus gallus)
Aves PLEKHG3 34
  • 50 (a)
(Anolis carolinensis)
Reptilia PLEKHG3 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497371 33
  • 58.32 (n)
Str.10469 33
(Danio rerio)
Actinopterygii PLEKHG3 (2 of 2) 34
  • 64 (a)
LOC101886323 33
  • 53.98 (n)
PLEKHG3 (1 of 2) 34
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta GEFmeso 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea uig-1 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for PLEKHG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLEKHG3 Gene

Gene Tree for PLEKHG3 (if available)
Gene Tree for PLEKHG3 (if available)
Evolutionary constrained regions (ECRs) for PLEKHG3: view image

Paralogs for PLEKHG3 Gene

Paralogs for PLEKHG3 Gene

(3) SIMAP similar genes for PLEKHG3 Gene using alignment to 5 proteins:

  • G3V278_HUMAN
  • G3V2V2_HUMAN
  • G3V311_HUMAN
  • G3V3I3_HUMAN Pseudogenes for PLEKHG3 Gene

genes like me logo Genes that share paralogs with PLEKHG3: view

Variants for PLEKHG3 Gene

Sequence variations from dbSNP and Humsavar for PLEKHG3 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000145896 -- 64,716,176(+) C/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000223451 -- 64,708,214(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000253433 -- 64,730,556(+) C/T intron_variant
rs1000286042 -- 64,743,820(+) G/T 3_prime_UTR_variant
rs1000334298 -- 64,736,503(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLEKHG3 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073
nsv1035833 CNV gain 25217958
nsv1049097 CNV gain 25217958
nsv1309 CNV insertion 18451855
nsv952853 CNV deletion 24416366

Variation tolerance for PLEKHG3 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLEKHG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEKHG3 Gene

Disorders for PLEKHG3 Gene

Additional Disease Information for PLEKHG3

No disorders were found for PLEKHG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLEKHG3 Gene

Publications for PLEKHG3 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. (PMID: 27555588) Nguyen TT … Heo WD (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D … Clayton PE (Journal of molecular endocrinology 2014) 3 58
  5. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A … Comb MJ (Molecular & cellular proteomics : MCP 2014) 4 58

Products for PLEKHG3 Gene

  • Biorbyt antibodies for PLEKHG3

Sources for PLEKHG3 Gene

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