Aliases for PLEKHA4 Gene
External Ids for PLEKHA4 Gene
Previous GeneCards Identifiers for PLEKHA4 Gene
This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
GeneCards Summary for PLEKHA4 Gene
PLEKHA4 (Pleckstrin Homology Domain Containing A4) is a Protein Coding gene. Among its related pathways are PI Metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is PLEKHA7.
UniProtKB/Swiss-Prot Summary for PLEKHA4 Gene
Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.