The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accur... See more...

Aliases for PLEK2 Gene

Aliases for PLEK2 Gene

  • Pleckstrin 2 2 3 5
  • Pleckstrin-2 3 4
  • Pleckstrin 2 Homolog 3

External Ids for PLEK2 Gene

Previous GeneCards Identifiers for PLEK2 Gene

  • GC14M065358
  • GC14M061647
  • GC14M065843
  • GC14M066923
  • GC14M067853
  • GC14M048023

Summaries for PLEK2 Gene

Entrez Gene Summary for PLEK2 Gene

  • The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]

GeneCards Summary for PLEK2 Gene

PLEK2 (Pleckstrin 2) is a Protein Coding gene. Diseases associated with PLEK2 include Pyosalpinx. An important paralog of this gene is PLEK.

UniProtKB/Swiss-Prot Summary for PLEK2 Gene

  • May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.

Gene Wiki entry for PLEK2 Gene

Additional gene information for PLEK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLEK2 Gene

Genomics for PLEK2 Gene

GeneHancer (GH) Regulatory Elements for PLEK2 Gene

Promoters and enhancers for PLEK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLEK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLEK2 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • Elk-1
  • FosB
  • Fra-1
  • JunB
  • NF-1
  • Olf-1

Genomic Locations for PLEK2 Gene

Genomic Locations for PLEK2 Gene
chr14:67,385,659-67,412,174
(GRCh38/hg38)
Size:
26,516 bases
Orientation:
Minus strand
chr14:67,853,700-67,878,917
(GRCh37/hg19)
Size:
25,218 bases
Orientation:
Minus strand

Genomic View for PLEK2 Gene

Genes around PLEK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLEK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLEK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLEK2 Gene

Proteins for PLEK2 Gene

  • Protein details for PLEK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYT0-PLEK2_HUMAN
    Recommended name:
    Pleckstrin-2
    Protein Accession:
    Q9NYT0
    Secondary Accessions:
    • Q96JT0

    Protein attributes for PLEK2 Gene

    Size:
    353 amino acids
    Molecular mass:
    39971 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLEK2 Gene

neXtProt entry for PLEK2 Gene

Post-translational modifications for PLEK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLEK2 Gene

No data available for DME Specific Peptides for PLEK2 Gene

Domains & Families for PLEK2 Gene

Gene Families for PLEK2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PLEK2 Gene

GenScript: Design optimal peptide antigens:
  • Pleckstrin-2 (PLEK2_HUMAN)
genes like me logo Genes that share domains with PLEK2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLEK2 Gene

Function for PLEK2 Gene

Molecular function for PLEK2 Gene

UniProtKB/Swiss-Prot Function:
May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
GENATLAS Biochemistry:
pleckstrin 2 mouse homolog,ubiquitously expressed

Phenotypes From GWAS Catalog for PLEK2 Gene

Gene Ontology (GO) - Molecular Function for PLEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032266 phosphatidylinositol-3-phosphate binding IEA --
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA --
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IEA --
genes like me logo Genes that share ontologies with PLEK2: view
genes like me logo Genes that share phenotypes with PLEK2: view

Animal Model Products

CRISPR Products

miRNA for PLEK2 Gene

miRTarBase miRNAs that target PLEK2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLEK2 Gene

Localization for PLEK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLEK2 Gene

Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLEK2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 3
nucleus 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0031258 lamellipodium membrane IEA --
genes like me logo Genes that share ontologies with PLEK2: view

Pathways & Interactions for PLEK2 Gene

PathCards logo

SuperPathways for PLEK2 Gene

No Data Available

Interacting Proteins for PLEK2 Gene

Gene Ontology (GO) - Biological Process for PLEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IEA --
GO:0031346 positive regulation of cell projection organization IEA --
GO:0031532 actin cytoskeleton reorganization IBA,IEA 21873635
GO:0035556 intracellular signal transduction IEA --
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly IEA --
genes like me logo Genes that share ontologies with PLEK2: view

No data available for Pathways by source and SIGNOR curated interactions for PLEK2 Gene

Drugs & Compounds for PLEK2 Gene

(1) Additional Compounds for PLEK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PLEK2: view

Transcripts for PLEK2 Gene

mRNA/cDNA for PLEK2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLEK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1:
SP2: - - -
SP3: -

Relevant External Links for PLEK2 Gene

GeneLoc Exon Structure for
PLEK2
ECgene alternative splicing isoforms for
PLEK2

Expression for PLEK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLEK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLEK2 Gene

This gene is overexpressed in Adrenal Gland (x9.5), Liver (x5.5), and Colon - Transverse (x4.7).

Protein differential expression in normal tissues from HIPED for PLEK2 Gene

This gene is overexpressed in Fetal testis (34.0), Testis (22.7), and Adrenal (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLEK2 Gene



Protein tissue co-expression partners for PLEK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLEK2 Gene:

PLEK2

SOURCE GeneReport for Unigene cluster for PLEK2 Gene:

Hs.170473
genes like me logo Genes that share expression patterns with PLEK2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLEK2 Gene

Orthologs for PLEK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLEK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLEK2 33 32
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLEK2 33 32
  • 91.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLEK2 33 32
  • 90.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Plek2 17 33 32
  • 89.8 (n)
rat
(Rattus norvegicus)
Mammalia Plek2 32
  • 89.24 (n)
oppossum
(Monodelphis domestica)
Mammalia PLEK2 33
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLEK2 33
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLEK2 33 32
  • 73.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLEK2 33
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii plek2 33 32
  • 60.95 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 27 (a)
OneToMany
Species where no ortholog for PLEK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLEK2 Gene

ENSEMBL:
Gene Tree for PLEK2 (if available)
TreeFam:
Gene Tree for PLEK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLEK2: view image

Paralogs for PLEK2 Gene

Paralogs for PLEK2 Gene

(4) SIMAP similar genes for PLEK2 Gene using alignment to 5 proteins:

  • PLEK2_HUMAN
  • G3V337_HUMAN
  • H0YIZ5_HUMAN
  • H0YJ64_HUMAN
  • H0YJD0_HUMAN
genes like me logo Genes that share paralogs with PLEK2: view

Variants for PLEK2 Gene

Sequence variations from dbSNP and Humsavar for PLEK2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000170281 -- 67,409,110(-) A/T intron_variant
rs1000221076 -- 67,408,615(-) G/A intron_variant
rs1000311255 -- 67,386,532(-) T/A downstream_transcript_variant
rs1000371365 -- 67,396,234(-) G/A intron_variant
rs1000420788 -- 67,396,020(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLEK2 Gene

Variant ID Type Subtype PubMed ID
esv2661146 CNV deletion 23128226
esv2748804 CNV deletion 23290073
esv2748805 CNV deletion 23290073
esv2751285 CNV gain 17911159
nsv1318 CNV insertion 18451855
nsv1319 CNV deletion 18451855
nsv456331 CNV gain 19166990
nsv470651 CNV gain 18288195
nsv509539 CNV insertion 20534489
nsv564961 CNV gain 21841781

Variation tolerance for PLEK2 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLEK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLEK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLEK2 Gene

Disorders for PLEK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLEK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pyosalpinx
  • pyosalpingitis
- elite association - COSMIC cancer census association via MalaCards
Search PLEK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLEK2

genes like me logo Genes that share disorders with PLEK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLEK2 Gene

Publications for PLEK2 Gene

  1. Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading. (PMID: 17658464) Hamaguchi N … Fukui Y (Biochemical and biophysical research communications 2007) 2 3 23 56
  2. Pleckstrin homology domains and the cytoskeleton. (PMID: 11911883) Lemmon MA … Abrams CS (FEBS letters 2002) 2 3 23 56
  3. PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. (PMID: 17008542) Bach TL … Abrams CS (Blood 2007) 3 23 56
  4. Cloning, expression and chromosomal assignment of human pleckstrin 2. (PMID: 15865208) Inazu T … Miyamoto K (Molecular biology reports 2005) 3 23 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for PLEK2 Gene

Sources for PLEK2 Gene