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Aliases for PLD6 Gene
Aliases for PLD6 Gene
External Ids for PLD6 Gene
- HGNC: 30447
- NCBI Entrez Gene: 201164
- Ensembl: ENSG00000179598
- OMIM®: 614960
- UniProtKB/Swiss-Prot: Q8N2A8
Previous GeneCards Identifiers for PLD6 Gene
- GC17M017048
- GC17M016857
- GC17M017104
Summaries for PLD6 Gene
GeneCards Summary for PLD6 Gene
PLD6 (Phospholipase D Family Member 6) is a Protein Coding gene. Diseases associated with PLD6 include Heavy Chain Disease and Retinitis Pigmentosa 49. Among its related pathways are Glycerophospholipid biosynthesis and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cardiolipin hydrolase activity.
UniProtKB/Swiss-Prot Summary for PLD6 Gene
-
Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).
Additional gene information for PLD6 Gene
- HGNC (30447)
- NCBI Entrez Gene (201164)
- Ensembl (ENSG00000179598)
- OMIM® (614960)
- UniProtKB/Swiss-Prot (Q8N2A8)
- Open Targets Platform(ENSG00000179598)
- Search for PLD6 at DataMed
- Search for PLD6 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLD6 Gene
Genomics for PLD6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PLD6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PLD6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLD6
- Top Transcription factor binding sites by QIAGEN in the PLD6 gene promoter:
-
- AhR
- Arnt
- CUTL1
- GR
- GR-alpha
- GR-beta
- NRSF form 1
- NRSF form 2
- p300
- POU3F2
Genomic Locations for PLD6 Gene
Latest Assembly
- chr17:17,200,990-17,206,905
- (GRCh38/hg38)
- Size:
- 5,916 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:17,104,309-17,109,647
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 5,339 bases
- Orientation:
- Minus strand
- chr17:17,104,309-17,109,629
- (GRCh37/hg19 by Ensembl)
- Size:
- 5,321 bases
- Orientation:
- Minus strand
Genomic View for PLD6 Gene
Genes around PLD6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by HGNC
- 17p11.2 by Entrez Gene
- 17p11.2 by Ensembl
PLD6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PLD6 Gene
Proteins for PLD6 Gene
-
Protein details for PLD6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N2A8-PLD6_HUMAN
- Recommended name:
- Mitochondrial cardiolipin hydrolase
- Protein Accession:
- Q8N2A8
- Q8N5Y1
Protein attributes for PLD6 Gene
- Size:
- 252 amino acids
- Molecular mass:
- 28273 Da
- Quaternary structure:
-
- Homodimer (PubMed:17028579). Interacts with MOV10L1 (By similarity). Interacts with MIGA1 and MIGA2; possibly facilitating homodimer formation (PubMed:26711011).
Protein Expression for PLD6 Gene
Post-translational modifications for PLD6 Gene
Other Protein References for PLD6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for PLD6
- Novus Biologicals Antibodies for PLD6
- Invitrogen Antibodies for PLD6 (AFLGC-PLD6)
-
Biorbyt antibodies for PLD6
-
Custom Antibody ServicesProSci Antibodies for PLD6
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PLD6
- Origene Custom Protein Services for PLD6
- Novus Biologicals proteins for PLD6
Assay products for research
- antibodies-online: Search results for available PLD6 related products ranked by validation data
No data available for DME Specific Peptides for PLD6 Gene
Domains & Families for PLD6 Gene
Gene Families for PLD6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for PLD6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PLD6 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55057 (B4DHV4_HUMAN)
- Protein zucchini homolog (PLD6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N2A8UniProtKB/Swiss-Prot:
PLD6_HUMAN :- In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.
- Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
- Domain:
-
- In contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site.
- Family:
-
- Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
Function for PLD6 Gene
Molecular function for PLD6 Gene
- UniProtKB/Swiss-Prot Function:
- Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- SsDNA hydrolase activity does not depend upon, but it stimulated by, the presence of Ca(2+) and Mn(2+).
Enzyme Numbers (IUBMB) for PLD6 Gene
Phenotypes From GWAS Catalog for PLD6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004519 | endonuclease activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 26711011 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PLD6 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLD6 - Starting at $85 >
- * PLD6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLD6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLD6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLD6
miRNA for PLD6 Gene
- miRTarBase miRNAs that target PLD6
-
- hsa-miR-484 (MIRT042096)
- hsa-miR-6867-3p (MIRT489557)
- hsa-miR-4685-3p (MIRT489558)
- hsa-miR-4287 (MIRT489559)
- hsa-miR-7113-3p (MIRT489560)
- hsa-miR-4469 (MIRT489561)
- hsa-miR-4667-3p (MIRT489562)
- hsa-miR-1470 (MIRT489563)
- hsa-miR-589-3p (MIRT489564)
- hsa-miR-6513-5p (MIRT637571)
- hsa-miR-887-5p (MIRT637572)
- hsa-miR-3913-5p (MIRT637573)
- hsa-miR-3122 (MIRT637574)
- hsa-miR-450a-1-3p (MIRT637575)
- hsa-miR-6780a-5p (MIRT637576)
- hsa-miR-6779-5p (MIRT637577)
- hsa-miR-3689c (MIRT637578)
- hsa-miR-3689b-3p (MIRT637579)
- hsa-miR-3689a-3p (MIRT637580)
- hsa-miR-30b-3p (MIRT637581)
- hsa-miR-1273h-5p (MIRT637582)
- hsa-miR-6788-5p (MIRT637583)
- hsa-miR-30c-2-3p (MIRT637584)
- hsa-miR-30c-1-3p (MIRT637585)
- hsa-miR-7977 (MIRT637586)
- hsa-miR-6799-5p (MIRT637587)
- hsa-miR-6883-5p (MIRT637588)
- hsa-miR-6785-5p (MIRT637589)
- hsa-miR-4728-5p (MIRT637590)
- hsa-miR-149-3p (MIRT637591)
- hsa-miR-7106-5p (MIRT637592)
- hsa-miR-6087 (MIRT637593)
- hsa-miR-4795-5p (MIRT637594)
- hsa-miR-342-3p (MIRT637595)
- hsa-miR-383-3p (MIRT637596)
- hsa-miR-1228-3p (MIRT637597)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLD6
- Browse OriGene Inhibitory RNA Products For PLD6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLD6
Clone products for research
- Applied Biological Materials (abm): Clones for PLD6 - Starting at $45 >
- * PLD6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLD6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLD6
Cell Lines for research
-
Horizon Cell Lines for PLD6
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLD6 Gene
Localization for PLD6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PLD6 Gene
- Mitochondrion outer membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| extracellular | 3 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLD6 Gene
Pathways & Interactions for PLD6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis |
.01
|
|
| 2 | Metabolism |
.40
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | Mitotic Prophase | ||
| 5 | PIWI-interacting RNA (piRNA) biogenesis | ||
Pathways by source for PLD6 Gene
1 BioSystems pathway for PLD6 Gene
8 Reactome pathways for PLD6 Gene
Interacting Proteins for PLD6 Gene
GPS-Prot Interaction Network for PLD6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0007286 | spermatid development | ISS | -- |
| GO:0008053 | mitochondrial fusion | IMP | 17028579 |
No data available for SIGNOR curated interactions for PLD6 Gene
Drugs & Compounds for PLD6 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| CE(22:0) |
|
61510-09-6 |
|
|||
| PC(18:1(9Z)e/2:0) |
|
|
||||
| PC(20:2(11Z,14Z)/18:1(11Z)) |
|
|
||||
| PC(22:4(7Z,10Z,13Z,16Z)/18:1(11Z)) |
|
2461-62-3 |
|
|||
| Phosphatidylcholines Group A |
|
4235-95-4, 18194-24-6, 92345-33-0, 944466-40-4, 253127-60-5, 203393-41-3, 85046-19-1, 56421-10-4, 53595-24-7, 27098-24-4, 59403-51-9, 85082-02-6, 26853-31-6, 17708-90-6, 203393-39-9, 35418-59-8, 17041-44-0, 35418-58-7, 2701-19-1, 1191905-21-1, 85082-03-7, 324054-21-9, 182820-31-1 |
|
Transcripts for PLD6 Gene
mRNA/cDNA for PLD6 Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000321560 2578 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PLD6 - Starting at $85 >
- * PLD6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PLD6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PLD6
-
Santa Cruz Biotechnology (SCBT) CRISPR for PLD6
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PLD6
- Browse OriGene Inhibitory RNA Products For PLD6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLD6
Clone products for research
- Applied Biological Materials (abm): Clones for PLD6 - Starting at $45 >
- * PLD6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PLD6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PLD6
Relevant External Links for PLD6 Gene
- GeneLoc Exon Structure for
- PLD6
Expression for PLD6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PLD6 Gene
This gene is overexpressed in Testis (x5.8).
This gene is overexpressed in Plasma (43.1), Ovary (19.4), and Testis (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLD6 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLD6
SOURCE GeneReport for Unigene cluster for PLD6 Gene:
Hs.729079mRNA Expression by UniProt/SwissProt for PLD6 Gene:
Q8N2A8-PLD6_HUMAN
Tissue specificity:
Widely expressed. Expression is not limited to testis and ovary.
Evidence on tissue expression from TISSUES for PLD6 Gene
- Nervous system(4.4)
Primer products for research
-
OriGene qPCR primer pairs for PLD6
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLD6 Gene
Orthologs for PLD6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLD6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PLD6 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PLD6 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Pld6 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Pld6 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PLD6 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pld6 30 |
|
||
| Str.16063 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16857 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | pld6 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | zuc 31 |
|
OneToOne |
- Species where no ortholog for PLD6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PLD6 Gene
- ENSEMBL:
- Gene Tree for PLD6 (if available)
- TreeFam:
- Gene Tree for PLD6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PLD6: view image
Paralogs for PLD6 Gene
No data available for Paralogs for PLD6 Gene
Variants for PLD6 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLD6 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116547825 | Benign: not provided | 17,202,965(-) |
G/A NM_178836.4(PLD6):c.561C>T (p.Leu187=) |
SYNONYMOUS | |
| rs11551966 | - |
p.Arg108His |
|||
| rs17856924 | - |
p.Leu42Pro |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Gene Damage Index Score:
0.36;
7.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PLD6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PLD6
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD6 Gene
Disorders for PLD6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| heavy chain disease |
|
|
| retinitis pigmentosa 49 |
|
|
Search PLD6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PLD6
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PLD6 Gene
Publications for PLD6 Gene
- Measuring Phospholipase D Enzymatic Activity Through Biochemical and Imaging Methods. (PMID: 28063496) Philip F … Frohman MA (Methods in enzymology 2017) 2 3
- Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. (PMID: 26711011) Zhang Y … Tong C (Molecular cell 2016) 3 4
- piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. (PMID: 21397848) Huang H … Frohman MA (Developmental cell 2011) 3 4
- A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. (PMID: 17028579) Choi SY … Frohman MA (Nature cell biology 2006) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for PLD6 Gene
- Custom Antibody ServicesOriGene Antibodies for PLD6
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- Custom Assay Services
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- OriGene qPCR primer pairs for PLD6
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- Sino Biological Human cDNA Clone for PLD6
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for PLD6
- Novus Biologicals proteins for PLD6
- Browse Antibodies
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- Browse ELISA Kits
- Invitrogen Antibodies for PLD6 (AFLGC-PLD6)
- VectorBuilder Custom and pre-made DNA vectors for PLD6 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 9 available PLD6 Antibodies ranked by validation data
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- antibodies-online: Search results for available PLD6 related products ranked by validation data
- antibodies-online: Show 10 available PLD6 Proteins ranked by validation data
- Compare Top PLD6 Proteins
- Custom Antibody ServicesProSci Antibodies for PLD6
- Search for PLD6 Proteins at ProSci
- Horizon Cell Lines for PLD6
- Browse GeneCopoeia Cell Lines
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for PLD6
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- Biorbyt antibodies for PLD6
Sources for PLD6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB