Aliases for PLD4 Gene
External Ids for PLD4 Gene
Previous HGNC Symbols for PLD4 Gene
Previous GeneCards Identifiers for PLD4 Gene
GeneCards Summary for PLD4 Gene
PLD4 (Phospholipase D Family Member 4) is a Protein Coding gene. Diseases associated with PLD4 include Nephrotic Syndrome, Type 7 and Doyne Honeycomb Retinal Dystrophy. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol phospholipase C activity and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD3.
UniProtKB/Swiss-Prot Summary for PLD4 Gene
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia.