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Aliases for PLD4 Gene

Aliases for PLD4 Gene

  • Phospholipase D Family Member 4 2 3 5
  • Phosphatidylcholine-Hydrolyzing Phospholipase D4 3 4
  • Choline Phosphatase 4 3 4
  • EC 4 56
  • C14orf175 3 4
  • PLD 4 3 4
  • Chromosome 14 Open Reading Frame 175 2
  • Phospholipase D Family, Member 4 2
  • Phospholipase D4 3

External Ids for PLD4 Gene

Previous HGNC Symbols for PLD4 Gene

  • C14orf175

Previous GeneCards Identifiers for PLD4 Gene

  • GC14P104464
  • GC14P105391
  • GC14P085585

Summaries for PLD4 Gene

GeneCards Summary for PLD4 Gene

PLD4 (Phospholipase D Family Member 4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol phospholipase C activity and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD3.

Additional gene information for PLD4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD4 Gene

Genomics for PLD4 Gene

GeneHancer (GH) Regulatory Elements for PLD4 Gene

Promoters and enhancers for PLD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I104924 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +1.1 1085 3 IRF4 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 SMARCA5 CBFB ELF1 PLD4 CLBA1 CEP170B GC14P104932 GC14P104934
GH14I104882 Enhancer 0.8 ENCODE dbSUPER 11.9 -42.3 -42317 0.3 KLF1 MAZ SP3 SP2 ZFP69B ZFHX2 GLIS2 GATA3 ZNF692 PRDM10 CEP170B PLD4 ENSG00000259067 GC14M104846
GH14I104842 Enhancer 0.7 Ensembl ENCODE 11.2 -80.8 -80814 2.2 CTCF SP1 POLR2A ZNF189 BACH1 MNT EZH2 ENSG00000258811 LINC00638 PLD4 ADSSL1 CEP170B CLBA1 ENSG00000258593
GH14I104656 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -265.4 -265429 6.8 HDGF BMI1 IRF4 RAD21 RARA ZNF121 EGR1 ATF7 ETV6 BCLAF1 C14orf180 TMEM179 PLD4 INF2 ENSG00000258736 LINC02280
GH14I105257 Enhancer 0.5 ENCODE dbSUPER 9.9 +332.9 332882 1 KLF1 PACS2 BRF1 NUDT14 JAG2 CLBA1 PLD4 GC14P105252
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLD4 gene promoter:

Genomic Locations for PLD4 Gene

Genomic Locations for PLD4 Gene
12,975 bases
Plus strand

Genomic View for PLD4 Gene

Genes around PLD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD4 Gene

Proteins for PLD4 Gene

  • Protein details for PLD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipase D4
    Protein Accession:
    Secondary Accessions:
    • Q6UWD2

    Protein attributes for PLD4 Gene

    506 amino acids
    Molecular mass:
    55626 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89202.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PLD4 Gene

Selected DME Specific Peptides for PLD4 Gene


Post-translational modifications for PLD4 Gene

  • Ubiquitination at Lys271 and isoforms=276
  • Modification sites at PhosphoSitePlus

Other Protein References for PLD4 Gene

Domains & Families for PLD4 Gene

Gene Families for PLD4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLD4 Gene

Suggested Antigen Peptide Sequences for PLD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase D family.
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD4: view

Function for PLD4 Gene

Molecular function for PLD4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A phosphatidylcholine + H(2)O = choline + a phosphatidate.

Enzyme Numbers (IUBMB) for PLD4 Gene

Phenotypes From GWAS Catalog for PLD4 Gene

Gene Ontology (GO) - Molecular Function for PLD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0004630 phospholipase D activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA --
genes like me logo Genes that share ontologies with PLD4: view

Phenotypes for PLD4 Gene

genes like me logo Genes that share phenotypes with PLD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLD4

CRISPR Products

miRNA for PLD4 Gene

miRTarBase miRNAs that target PLD4

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLD4 Gene

Localization for PLD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLD4 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PLD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PLD4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLD4 Gene

Pathways & Interactions for PLD4 Gene

genes like me logo Genes that share pathways with PLD4: view

Interacting Proteins for PLD4 Gene

Gene Ontology (GO) - Biological Process for PLD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006909 phagocytosis IEA --
GO:0016042 lipid catabolic process IEA --
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with PLD4: view

No data available for SIGNOR curated interactions for PLD4 Gene

Drugs & Compounds for PLD4 Gene

(3) Drugs for PLD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline Approved Nutra 176
Ethanolamine Experimental Pharma 0

(8) Additional Compounds for PLD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1w7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-eicosenoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/20:1)
  • GPCho(16:0/20:1n9)
  • GPCho(16:0/20:1w9)
  • GPCho(36:1)
genes like me logo Genes that share compounds with PLD4: view

Transcripts for PLD4 Gene

Unigene Clusters for PLD4 Gene

Phospholipase D family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2: - -
SP3: - - -

Relevant External Links for PLD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLD4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.3), Brain - Substantia nigra (x5.3), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for PLD4 Gene

This gene is overexpressed in Lymph node (36.1), Blymphocyte (13.0), Plasma (7.0), and Monocytes (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLD4 Gene

Protein tissue co-expression partners for PLD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLD4 Gene:


SOURCE GeneReport for Unigene cluster for PLD4 Gene:

genes like me logo Genes that share expression patterns with PLD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLD4 Gene

Orthologs for PLD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLD4 33
  • 98.53 (n)
(Canis familiaris)
Mammalia PLD4 33 34
  • 84.99 (n)
(Bos Taurus)
Mammalia PLD4 33 34
  • 82.35 (n)
(Rattus norvegicus)
Mammalia Pld4 33
  • 79.11 (n)
(Mus musculus)
Mammalia Pld4 33 16 34
  • 78.7 (n)
(Ornithorhynchus anatinus)
Mammalia PLD4 34
  • 62 (a)
(Monodelphis domestica)
Mammalia PLD4 34
  • 59 (a)
(Gallus gallus)
Aves PLD4 33 34
  • 59.2 (n)
(Anolis carolinensis)
Reptilia PLD4 34
  • 49 (a)
(Danio rerio)
Actinopterygii si:dkeyp-110e4.6 33
  • 53.53 (n)
PLD4 (2 of 2) 34
  • 50 (a)
PLD4 (1 of 2) 34
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8932 33
fruit fly
(Drosophila melanogaster)
Insecta CG9248 34
  • 34 (a)
CG43345 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T05C3.6 33
  • 44.75 (n)
Y51A2D.13 34
  • 27 (a)
E04F6.4 34
  • 18 (a)
Species where no ortholog for PLD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PLD4 Gene

Gene Tree for PLD4 (if available)
Gene Tree for PLD4 (if available)

Paralogs for PLD4 Gene

Paralogs for PLD4 Gene

(3) SIMAP similar genes for PLD4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PLD4: view

Variants for PLD4 Gene

Sequence variations from dbSNP and Humsavar for PLD4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000008445 -- 104,928,966(+) G/T intron_variant
rs1000075004 -- 104,930,334(+) T/G intron_variant
rs1000142192 -- 104,924,808(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000524825 -- 104,929,091(+) C/T intron_variant
rs1000546330 -- 104,933,489(+) C/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLD4 Gene

Variant ID Type Subtype PubMed ID
nsv1049253 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv566099 CNV gain 21841781
nsv566139 CNV loss 21841781
nsv952276 CNV deletion 24416366

Variation tolerance for PLD4 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD4 Gene

Disorders for PLD4 Gene

Additional Disease Information for PLD4

No disorders were found for PLD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLD4 Gene

Publications for PLD4 Gene

  1. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y … Yamamoto K (Nature genetics 2012) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. PLD4 promotes M1 macrophages to perform antitumor effects in colon cancer cells. (PMID: 27840999) Gao L … Li XA (Oncology reports 2017) 3 58
  5. Genetics of rheumatoid arthritis contributes to biology and drug discovery. (PMID: 24390342) Okada Y … Plenge RM (Nature 2014) 3 58

Products for PLD4 Gene

Sources for PLD4 Gene

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