Aliases for PLD3 Gene
External Ids for PLD3 Gene
Previous GeneCards Identifiers for PLD3 Gene
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
GeneCards Summary for PLD3 Gene
PLD3 (Phospholipase D Family Member 3) is a Protein Coding gene. Diseases associated with PLD3 include Spinocerebellar Ataxia 46 and Acute Conjunctivitis. Among its related pathways are G-AlphaQ Signaling and Metabolism. Gene Ontology (GO) annotations related to this gene include phospholipase D activity and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD4.
UniProtKB/Swiss-Prot Summary for PLD3 Gene
May be involved in APP processing.