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Aliases for PLD3 Gene

Aliases for PLD3 Gene

  • Phospholipase D Family Member 3 2 3 5
  • Phospholipase D3 2 3 4
  • Phosphatidylcholine-Hydrolyzing Phospholipase D3 3 4
  • Choline Phosphatase 3 3 4
  • HindIII K4L Homolog 3 4
  • EC 4 56
  • Phospholipase D Family, Member 3 2
  • EC 3.1.4 56
  • HU-K4 3
  • SCA46 3
  • Hu-K4 4
  • PLD 3 4
  • AD19 3
  • HUK4 3

External Ids for PLD3 Gene

Previous GeneCards Identifiers for PLD3 Gene

  • GC19P041505
  • GC19P041257
  • GC19P045530
  • GC19P045546
  • GC19P045557
  • GC19P040854
  • GC19P037290

Summaries for PLD3 Gene

Entrez Gene Summary for PLD3 Gene

  • This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for PLD3 Gene

PLD3 (Phospholipase D Family Member 3) is a Protein Coding gene. Diseases associated with PLD3 include Spinocerebellar Ataxia 46 and Acute Conjunctivitis. Among its related pathways are Innate Immune System and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include phospholipase D activity and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD4.

UniProtKB/Swiss-Prot for PLD3 Gene

Additional gene information for PLD3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLD3 Gene

Genomics for PLD3 Gene

GeneHancer (GH) Regulatory Elements for PLD3 Gene

Promoters and enhancers for PLD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J040347 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 613.9 0.0 -24 2.8 ZNF473 SP1 ZNF652 ZFX ELF3 MNT CBFA2T2 NKRF POLR2A MLLT1 PLD3 C19orf47 ZNF780B SNRPA ENSG00000269843 HNRNPUL1 SUPT5H ZNF780A CYP2G1P ZNF546
GH19J040365 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 605.8 +18.5 18476 3.4 SP1 ZNF148 MAFK EGR1 GLIS2 POLR2A ZBTB8A RFX1 ZIC2 NFE2L2 PLD3 ENSG00000206925 SERTAD1 SERTAD3 TTC9B HIPK4 PRX MIR6796 ENSG00000279759
GH19J040441 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 +95.8 95824 5.4 HDGF SP1 CC2D1A ZFX ELF3 MNT SIX5 ZNF148 NKRF POLR2A SERTAD3 ENSG00000268366 LOC105372489 HNRNPUL1 CCDC97 SNRPA ZNF780B ENSG00000269843 FBL CYP2F2P
GH19J040190 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.1 -157.0 -157024 3.2 ZFX SIX5 ZNF148 NKRF ZNF121 ZNF384 ZSCAN21 ZBTB7A YY1 TRIM24 MAP3K10 ZNF780B NUMBL SNRPA ENSG00000269843 CYP2G1P FBL PSMC4 SUPT5H EID2B
GH19J040229 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.7 -118.8 -118824 1.2 ZNF121 MAFK ELF1 PRDM1 PRDM10 ZNF316 SCRT2 POLR2A ZBTB48 SCRT1 PLD3 C19orf47 ENSG00000206925 HIPK4 CNTD2 PIR38327
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLD3 gene promoter:
  • AREB6
  • c-Myc
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP2
  • Max1
  • Pax-5

Genomic Locations for PLD3 Gene

Genomic Locations for PLD3 Gene
32,015 bases
Plus strand
32,015 bases
Plus strand

Genomic View for PLD3 Gene

Genes around PLD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLD3 Gene

Proteins for PLD3 Gene

  • Protein details for PLD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholipase D3
    Protein Accession:
    Secondary Accessions:
    • Q92853
    • Q9BW87

    Protein attributes for PLD3 Gene

    490 amino acids
    Molecular mass:
    54705 Da
    Quaternary structure:
    • Interacts with APP.
    • Sequence=AAB16799.1; Type=Frameshift; Positions=52; Evidence={ECO:0000305};

neXtProt entry for PLD3 Gene

Selected DME Specific Peptides for PLD3 Gene


Post-translational modifications for PLD3 Gene

  • Glycosylated.
  • Glycosylation at posLast=236236, posLast=387387, posLast=9797, and isoforms=132
  • Ubiquitination at isoforms=11, posLast=309309, and isoforms=157
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Domains & Families for PLD3 Gene

Gene Families for PLD3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PLD3 Gene

Suggested Antigen Peptide Sequences for PLD3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59669, highly similar to Homo sapiens phospholipase D family, member 3 (PLD3), transcript variant 1, mRNA (B4DEL6_HUMAN)
  • Phosphatidylcholine-hydrolyzing phospholipase D3 (PLD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase D family.
  • Belongs to the phospholipase D family.
genes like me logo Genes that share domains with PLD3: view

Function for PLD3 Gene

Molecular function for PLD3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in APP processing.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=;.

Enzyme Numbers (IUBMB) for PLD3 Gene

Phenotypes From GWAS Catalog for PLD3 Gene

Gene Ontology (GO) - Molecular Function for PLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004630 phospholipase D activity TAS,IEA --
GO:0005515 protein binding IPI 20195357
GO:0016787 hydrolase activity IEA --
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA --
genes like me logo Genes that share ontologies with PLD3: view
genes like me logo Genes that share phenotypes with PLD3: view

Human Phenotype Ontology for PLD3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLD3 Gene

MGI Knock Outs for PLD3:
  • Pld3 Pld3<tm1e(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for PLD3 Gene

miRTarBase miRNAs that target PLD3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLD3

Clone Products

  • Applied Biological Materials (abm): Clones for PLD3 - Now 50% OFF >
  • * PLD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLD3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Transcription Factor Targets and HOMER Transcription for PLD3 Gene

Localization for PLD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLD3 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLD3 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
nucleus 2
cytosol 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PLD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLD3 Gene

Pathways & Interactions for PLD3 Gene

genes like me logo Genes that share pathways with PLD3: view

Gene Ontology (GO) - Biological Process for PLD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLD3: view

No data available for SIGNOR curated interactions for PLD3 Gene

Drugs & Compounds for PLD3 Gene

(3) Drugs for PLD3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline Approved Nutra 204
Ethanolamine Experimental Pharma 0

(8) Additional Compounds for PLD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
  • 1-(Hexadec-1-enyl)-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • 1-[(1Z)-Hexadec-1-enyl]-2-palmitoyl-sn-glycero-3-phosphoethanolamine zwitterion
  • PE(P-16:0/16:0)
  • 2-Hexadecanoyl-1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine
  • 1-(1-Enyl-palmitoyl)-2-vaccenoyl-sn-glycero-3-phosphoethanolamine
  • GPEtn(16:0/18:1)
  • GPEtn(16:0/18:1n7)
  • GPEtn(16:0/18:1W7)
  • GPEtn(34:1)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-Hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
  • 2-(9Z,12Z-Octadecadienoyl)-1-hexadecyl-sn-glycero-3-phosphocholine
  • PC Ae C34:2
  • PC(16:0E/18:2(9Z,12Z))
  • PC(O-34:2)
genes like me logo Genes that share compounds with PLD3: view

Transcripts for PLD3 Gene

Unigene Clusters for PLD3 Gene

Phospholipase D family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLD3

Clone Products

  • Applied Biological Materials (abm): Clones for PLD3 - Now 50% OFF >
  • * PLD3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLD3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PLD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - -
SP8: - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - -
SP14: - - - -
SP16: -
SP17: - - -

ExUns: 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP4: - -
SP9: -

Relevant External Links for PLD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLD3 Gene

Protein differential expression in normal tissues from HIPED for PLD3 Gene

This gene is overexpressed in Amniocyte (16.3) and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLD3 Gene

Protein tissue co-expression partners for PLD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLD3 Gene:


SOURCE GeneReport for Unigene cluster for PLD3 Gene:


mRNA Expression by UniProt/SwissProt for PLD3 Gene:

Tissue specificity: Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.

Evidence on tissue expression from TISSUES for PLD3 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Liver(4.6)
  • Intestine(4.5)
  • Eye(3.4)
  • Pancreas(3.3)
  • Stomach(2.3)
  • Adrenal gland(2)
  • Muscle(2)
  • Skin(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PLD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLD3 Gene

Orthologs for PLD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLD3 35 34
  • 99.7 (n)
(Canis familiaris)
Mammalia PLD3 35 34
  • 93.61 (n)
(Bos Taurus)
Mammalia PLD3 35 34
  • 91.97 (n)
(Rattus norvegicus)
Mammalia Pld3 34
  • 88.32 (n)
(Mus musculus)
Mammalia Pld3 17 35 34
  • 88.18 (n)
(Monodelphis domestica)
Mammalia PLD3 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia PLD3 35
  • 54 (a)
(Gallus gallus)
Aves PLD3 35
  • 44 (a)
(Anolis carolinensis)
Reptilia PLD3 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pld3 34
  • 57.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68676 34
(Danio rerio)
Actinopterygii pld3 35 34
  • 63.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000199 34
  • 57.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9248 35 34
  • 54.62 (n)
CG43345 35
  • 37 (a)
(Caenorhabditis elegans)
Secernentea F09G2.8 35 34
  • 47.28 (n)
(Oryza sativa)
Liliopsida Os06g0649900 34
  • 41.56 (n)
Species where no ortholog for PLD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLD3 Gene

Gene Tree for PLD3 (if available)
Gene Tree for PLD3 (if available)
Evolutionary constrained regions (ECRs) for PLD3: view image

Paralogs for PLD3 Gene

Paralogs for PLD3 Gene

(2) SIMAP similar genes for PLD3 Gene using alignment to 13 proteins:

  • M0QX50_HUMAN
  • M0QX99_HUMAN
  • M0QY94_HUMAN
  • M0R1F7_HUMAN
  • M0R2E7_HUMAN
  • M0R2W7_HUMAN
  • M0R3G9_HUMAN
genes like me logo Genes that share paralogs with PLD3: view

Variants for PLD3 Gene

Sequence variations from dbSNP and Humsavar for PLD3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs145999145 uncertain-significance, Alzheimer disease 19, - 40,371,688(+) G/A coding_sequence_variant, missense_variant
rs537053537 pathogenic, SPINOCEREBELLAR ATAXIA 46, Spinocerebellar ataxia 46 (SCA46) [MIM:617770] 40,374,524(+) T/C coding_sequence_variant, missense_variant
rs4819 likely-benign, not specified 40,378,026(+) G/A coding_sequence_variant, synonymous_variant
rs1000300232 -- 40,362,497(+) G/A intron_variant
rs1000355452 -- 40,352,100(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLD3 Gene

Variant ID Type Subtype PubMed ID
esv1638921 CNV insertion 17803354
esv2665673 CNV deletion 23128226
esv3644346 CNV loss 21293372
nsv476934 CNV novel sequence insertion 20440878
nsv833831 CNV loss 17160897

Variation tolerance for PLD3 Gene

Residual Variation Intolerance Score: 33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLD3 Gene

Disorders for PLD3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for PLD3 Gene - From: HGMD, OMIM, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 46
  • sca46
acute conjunctivitis
alzheimer disease 19
  • ad19
conjunctival folliculosis
  • acute follicular conjunctivitis
shipyard eye
  • ekc
- elite association - COSMIC cancer census association via MalaCards
Search PLD3 in MalaCards View complete list of genes associated with diseases


  • Spinocerebellar ataxia 46 (SCA46) [MIM:617770]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA46 is a slowly progressive, autosomal dominant form with onset in adulthood. {ECO:0000269 PubMed:29053796}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
  • Note=Genetic variants in PLD3 have been suggested to be associated with an increased risk for Alzheimer disease (PubMed:24336208, PubMed:25832409). Further studies, however, did not support PLD3 involvement in this disease (PubMed:25832408, PubMed:25832411, PubMed:25832413, PubMed:25832410, PubMed:26411346). {ECO:0000269 PubMed:24336208, ECO:0000269 PubMed:25832408, ECO:0000269 PubMed:25832409, ECO:0000269 PubMed:25832410, ECO:0000269 PubMed:25832411, ECO:0000269 PubMed:25832413, ECO:0000269 PubMed:26411346}.

Additional Disease Information for PLD3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PLD3: view

No data available for Genatlas for PLD3 Gene

Publications for PLD3 Gene

  1. Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum. (PMID: 15794758) Munck A … Hampe W (The FEBS journal 2005) 2 3 4 23 58
  2. A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily. (PMID: 9140189) Cao JX … Upton C (Virus research 1997) 2 3 4 58
  3. Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort. (PMID: 26411346) Cacace R … Belgium Neurology (BELNEU) Consortium and the European Early-Onset Dementia (EU EOD) Consortium (Human mutation 2015) 3 4 58
  4. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. (PMID: 24336208) Cruchaga C … Goate AM (Nature 2014) 3 4 58
  5. [Over-expression of phospholipase D3 inhibits Akt phosphorylation in C2C12 myoblasts]. (PMID: 20112697) Zhang J … Wang H (Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2009) 3 23 58

Products for PLD3 Gene