Aliases for PLD2 Gene
External Ids for PLD2 Gene
Previous GeneCards Identifiers for PLD2 Gene
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PLD2 Gene
PLD2 (Phospholipase D2) is a Protein Coding gene. Diseases associated with PLD2 include Tooth Agenesis and Pheochromocytoma. Among its related pathways are Alpha-synuclein signaling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD1.
UniProtKB/Swiss-Prot Summary for PLD2 Gene
Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.