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The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
PLD2 (Phospholipase D2) is a Protein Coding gene. Diseases associated with PLD2 include Ewing Sarcoma and Tooth Agenesis. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol binding and N-acylphosphatidylethanolamine-specific phospholipase D activity. An important paralog of this gene is PLD1.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004630 | phospholipase D activity | TAS | -- |
GO:0005515 | protein binding | IPI | 16407827 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0035091 | phosphatidylinositol binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0005794 | Golgi apparatus | IBA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0098793 | presynapse | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glycerophospholipid biosynthesis |
.01
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2 | Metabolism |
.40
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3 | Phospholipase D signaling pathway | ||
4 | Acyl chain remodelling of PE |
.30
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5 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006654 | phosphatidic acid biosynthetic process | TAS | -- |
GO:0007010 | cytoskeleton organization | TAS | 9395408 |
GO:0007264 | small GTPase mediated signal transduction | TAS | 9582313 |
GO:0016042 | lipid catabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
oleic acid | Approved, Investigational, Vet_approved | Pharma | Agonist, Full agonist, Activator, Activation | 0 | ||
Choline | Approved | Nutra | Target, product of | 223 | ||
Choline salicylate | Approved | Nutra | Target, product of | 0 | ||
Water | Approved | Pharma | 0 | |||
Zinc | Approved, Investigational | Pharma | 1594 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
LysoPA(0:0/16:0) |
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LysoPA(0:0/18:0) |
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LysoPA(0:0/18:1(9Z)) |
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LysoPA(0:0/18:2(9Z,12Z)) |
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LysoPA(16:0/0:0) |
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Compound | Action | Cas Number |
---|---|---|
AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
m-3M3FBS | Phospholipase C activator | 200933-14-8 |
o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
U 73122 | Phospholipase C inhibitor | 112648-68-7 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24 | ^ | 25a | · | 25b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: | |||||||||||||||||||
SP4: | |||||||||||||||||||
SP5: | |||||||||||||||||||
SP6: | |||||||||||||||||||
SP7: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PLD2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PLD2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Pld2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Pld2 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PLD2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PLD2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PLD2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pld2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | pld2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Pld 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | pld-1 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPO14 31 33 |
|
OneToMany | |
Barley (Hordeum vulgare) |
Liliopsida | Hv.2078 30 |
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Corn (Zea mays) |
Liliopsida | Zm.50 30 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711166 | Likely Benign: not provided | 4,816,632(+) | C/T | MISSENSE_VARIANT | |
713669 | Benign: not provided | 4,810,930(+) | G/A | MISSENSE_VARIANT | |
721643 | Benign: not provided | 4,817,140(+) | C/T | INTRON_VARIANT | |
721862 | Benign: not provided | 4,818,485(+) | C/T | INTRON_VARIANT | |
722410 | Benign: not provided | 4,817,012(+) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
ewing sarcoma |
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tooth agenesis |
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pheochromocytoma |
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breast cancer |
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