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This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
PLCXD1 (Phosphatidylinositol Specific Phospholipase C X Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphoric diester hydrolase activity. An important paralog of this gene is PLCXD2.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XJ000275 | Promoter/Enhancer | 1.2 | Ensembl dbSUPER | 250.7 | +0.6 | 645 | 3.6 | ZBTB10 MXD4 IKZF1 ZNF217 BHLHE40 ZIC2 THAP11 SIN3A SMAD4 SAP130 | PLCXD1 piR-48389-025 GTPBP6 | |
GH0XJ000278 | Promoter/Enhancer | 1.8 | Ensembl CraniofacialAtlas dbSUPER | 0.4 | +5.3 | 5345 | 5.4 | CHD2 TBP SP1 CEBPA MNT IKZF1 SMAD5 BHLHE40 ZEB1 ELF1 | piR-48389-025 GTPBP6 PLCXD1 | |
GH0XJ000267 | Promoter/Enhancer | 1 | Ensembl dbSUPER | 0.4 | -6.9 | -6855 | 3 | MXD4 HOMEZ KLF7 TEAD3 SP2 KAT7 ZNF48 TFAP4 KLF1 ARID4B | PLCXD1 piR-32287-163 | |
GH0XJ000264 | Enhancer | 0.8 | Ensembl | 0.4 | -11.3 | -11255 | 0.6 | CEBPA FOXA2 SMAD4 SAP130 RXRA RARA ZBTB33 THRB JUND CREM | piR-32287-163 PLCXD1 | |
GH0XJ000285 | Enhancer | 0.5 | Ensembl | 0.4 | +9.1 | 9145 | 0.2 | FOXA2 PAX8 HMG20A KDM1A ZNF18 ZNF184 MNT POLR2A SSRP1 | lnc-SHOX-4 piR-34822-336 PLCXD1 GTPBP6 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008081 | phosphoric diester hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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Phosphatidylinositol-3,4,5-trisphosphate |
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PI(16:0/16:0) |
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PI(16:0/16:1(9Z)) |
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PI(16:0/16:2(9Z,12Z)) |
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PI(16:0/18:0) |
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182509-29-1 |
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Compound | Action | Cas Number |
---|---|---|
AACOCF3 | Phospholipase A2 inhibitor | 149301-79-1 |
Edelfosine | Selective PI-PLC inhibitor, also PAF receptor agonist | 77286-66-9 |
m-3M3FBS | Phospholipase C activator | 200933-14-8 |
o-3M3FBS | Inactive analog of m-3M3FBS (Cat. No. 1941) | 313981-55-4 |
U 73122 | Phospholipase C inhibitor | 112648-68-7 |
Compound | Action | Cas Number |
---|---|---|
D609 | PC-PLC inhibitor | 83373-60-8 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | PLCXD1 30 31 |
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OneToOne | |
Cow (Bos Taurus) |
Mammalia | PLCXD1 31 |
|
OneToMany | |
-- 31 |
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OneToMany | |||
-- 31 |
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OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | PLCXD1 31 |
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OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC100909600 30 |
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Mouse (Mus musculus) |
Mammalia | Plcxd1 31 |
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OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PLCXD1 31 |
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OneToOne | |
Chicken (Gallus gallus) |
Aves | PLCXD1 30 31 |
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OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PLCXD1 31 |
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OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | plcxd1 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | LOC563489 30 |
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PLCXD1 31 |
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OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10747 31 |
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OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F38E9.1 31 |
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OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4187n106 | CNV | deletion | 24896259 |
esv1006189 | CNV | deletion | 20482838 |
esv2658490 | CNV | deletion | 23128226 |
esv2663649 | CNV | deletion | 23128226 |
esv27600 | CNV | gain+loss | 19812545 |
esv2969346 | CNV | duplication | 24192839 |
esv3382952 | CNV | duplication | 20981092 |
nsv1075293 | CNV | deletion | 25765185 |
nsv1076233 | CNV | deletion | 25765185 |
nsv1077604 | CNV | duplication | 25765185 |
nsv1125140 | CNV | duplication | 24896259 |
nsv1132797 | CNV | duplication | 24896259 |
nsv1137704 | CNV | deletion | 24896259 |
nsv1140084 | CNV | duplication | 24896259 |
nsv1147800 | CNV | duplication | 26484159 |
nsv1153299 | CNV | duplication | 26484159 |
No disorders were found for PLCXD1 Gene.