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Aliases for PLCL2 Gene

Aliases for PLCL2 Gene

  • Phospholipase C Like 2 2 3 5
  • Phospholipase C-Epsilon-2 3 4
  • Phospholipase C-L2 3 4
  • PLC-Epsilon-2 3 4
  • PLC-L(2) 3 4
  • PLC-L2 3 4
  • PLCE2 3 4
  • Inactive Phospholipase C-Like Protein 2 3
  • Phospholipase C, Epsilon 2 2
  • Phospholipase C-Like 2 2
  • EC 56
  • KIAA1092 4

External Ids for PLCL2 Gene

Previous HGNC Symbols for PLCL2 Gene

  • PLCE2

Previous GeneCards Identifiers for PLCL2 Gene

  • GC03P016855

Summaries for PLCL2 Gene

GeneCards Summary for PLCL2 Gene

PLCL2 (Phospholipase C Like 2) is a Protein Coding gene. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCL1.

UniProtKB/Swiss-Prot for PLCL2 Gene

  • May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

Additional gene information for PLCL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCL2 Gene

Genomics for PLCL2 Gene

GeneHancer (GH) Regulatory Elements for PLCL2 Gene

Promoters and enhancers for PLCL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I016883 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 562.7 +83.9 83866 7.3 HDGF SIN3A ZNF121 GLIS2 ZNF213 ZNF207 ZNF143 RUNX3 ZNF202 RXRA PLCL2 LOC105376972 MIR3714
GH03I016801 Enhancer 1 Ensembl ENCODE dbSUPER 555.1 -0.9 -879 1.3 ZBTB21 JUNB ATF2 GATA3 POLR2A IKZF1 CREB1 ATF7 ETV6 IKZF2 PLCL2 GC03M016771
GH03I016934 Promoter/Enhancer 0.9 EPDnew Ensembl dbSUPER 558 +130.5 130450 0.2 PLCL2 MIR3714 LOC105376972
GH03I016841 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.3 +40.7 40725 4.5 FOXA2 USF1 MAX EBF1 BATF YY1 RELA POLR2A HNF4G BCLAF1 PLCL2 ENSG00000271964 RFTN1 LOC105376972
GH03I016848 Enhancer 1 FANTOM5 Ensembl ENCODE 16.9 +47.1 47092 1.9 ZNF664 ZNF687 JUND RFX1 JUN BMI1 ELF1 SPI1 PLCL2 LOC105376972
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PLCL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLCL2 gene promoter:

Genomic Locations for PLCL2 Gene

Genomic Locations for PLCL2 Gene
287,956 bases
Plus strand

Genomic View for PLCL2 Gene

Genes around PLCL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCL2 Gene

Proteins for PLCL2 Gene

  • Protein details for PLCL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive phospholipase C-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K5V4
    • Q8N498
    • Q9H8L0
    • Q9UFP9

    Protein attributes for PLCL2 Gene

    1127 amino acids
    Molecular mass:
    125866 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA83044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLCL2 Gene


neXtProt entry for PLCL2 Gene

Selected DME Specific Peptides for PLCL2 Gene


Post-translational modifications for PLCL2 Gene

No Post-translational modifications

Domains & Families for PLCL2 Gene

Gene Families for PLCL2 Gene

Suggested Antigen Peptide Sequences for PLCL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCL2: view

No data available for UniProtKB/Swiss-Prot for PLCL2 Gene

Function for PLCL2 Gene

Molecular function for PLCL2 Gene

UniProtKB/Swiss-Prot Function:
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for PLCL2 Gene

Phenotypes From GWAS Catalog for PLCL2 Gene

Gene Ontology (GO) - Molecular Function for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0050811 GABA receptor binding IEA,IDA 16754670
genes like me logo Genes that share ontologies with PLCL2: view
genes like me logo Genes that share phenotypes with PLCL2: view

Animal Models for PLCL2 Gene

MGI Knock Outs for PLCL2:

miRNA for PLCL2 Gene

miRTarBase miRNAs that target PLCL2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCL2 Gene

Localization for PLCL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCL2 Gene

Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCL2 gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PLCL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLCL2 Gene

Pathways & Interactions for PLCL2 Gene

genes like me logo Genes that share pathways with PLCL2: view

Pathways by source for PLCL2 Gene

1 GeneTex pathway for PLCL2 Gene
1 PharmGKB pathway for PLCL2 Gene

Interacting Proteins for PLCL2 Gene

Gene Ontology (GO) - Biological Process for PLCL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002322 B cell proliferation involved in immune response IEA --
GO:0002337 B-1a B cell differentiation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
genes like me logo Genes that share ontologies with PLCL2: view

No data available for SIGNOR curated interactions for PLCL2 Gene

Drugs & Compounds for PLCL2 Gene

No Compound Related Data Available

Transcripts for PLCL2 Gene

Unigene Clusters for PLCL2 Gene

Phospholipase C-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCL2 Gene

No ASD Table

Relevant External Links for PLCL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLCL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCL2 Gene

Protein differential expression in normal tissues from HIPED for PLCL2 Gene

This gene is overexpressed in Frontal cortex (9.0), Heart (7.2), Pancreatic juice (6.8), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCL2 Gene

Protein tissue co-expression partners for PLCL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLCL2 Gene:


SOURCE GeneReport for Unigene cluster for PLCL2 Gene:


Evidence on tissue expression from TISSUES for PLCL2 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with PLCL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCL2 Gene

Orthologs for PLCL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLCL2 33 34
  • 99.62 (n)
(Ornithorhynchus anatinus)
Mammalia PLCL2 34
  • 93 (a)
(Canis familiaris)
Mammalia PLCL2 33 34
  • 92.43 (n)
(Rattus norvegicus)
Mammalia Plcl2 33
  • 90.38 (n)
(Mus musculus)
Mammalia Plcl2 33 16 34
  • 89.05 (n)
(Bos Taurus)
Mammalia PLCL2 33 34
  • 84.44 (n)
(Monodelphis domestica)
Mammalia PLCL2 34
  • 84 (a)
(Gallus gallus)
Aves PLCL2 33 34
  • 80.96 (n)
(Anolis carolinensis)
Reptilia PLCL2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plcl2 33
  • 77.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12143 33
(Danio rerio)
Actinopterygii PLCL2 34
  • 73 (a)
plcl2 33
  • 71.93 (n)
(Caenorhabditis elegans)
Secernentea pll-1 33 34
  • 49.38 (n)
plc-4 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for PLCL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLCL2 Gene

Gene Tree for PLCL2 (if available)
Gene Tree for PLCL2 (if available)

Paralogs for PLCL2 Gene

Paralogs for PLCL2 Gene

(10) SIMAP similar genes for PLCL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLCL2: view

Variants for PLCL2 Gene

Sequence variations from dbSNP and Humsavar for PLCL2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000001341 -- 17,030,051(+) C/T intron_variant
rs1000026772 -- 16,904,901(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000028562 -- 17,078,203(+) C/A intron_variant
rs1000036947 -- 16,819,475(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000042190 -- 16,883,963(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PLCL2 Gene

Variant ID Type Subtype PubMed ID
nsv955321 CNV duplication 24416366
nsv819815 CNV loss 19587683
nsv477499 CNV novel sequence insertion 20440878
nsv1127943 CNV deletion 24896259
esv3595411 CNV loss 21293372
esv3595410 CNV loss 21293372
esv3400051 CNV duplication 20981092
esv2676563 CNV deletion 23128226
esv2675677 CNV deletion 23128226
esv2424217 CNV insertion 19546169
dgv289e215 CNV deletion 23714750

Variation tolerance for PLCL2 Gene

Residual Variation Intolerance Score: 3.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLCL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCL2 Gene

Disorders for PLCL2 Gene

Additional Disease Information for PLCL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLCL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCL2 Gene

Publications for PLCL2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells GF … Anderson CA (Nature genetics 2011) 3 44 58
  3. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PMID: 19898481) Raychaudhuri S … Plenge RM (Nature genetics 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Identification and characterization of a new phospholipase C-like protein, PLC-L(2). (PMID: 10581172) Otsuki M … Takenawa T (Biochemical and biophysical research communications 1999) 3 22 58

Products for PLCL2 Gene

Sources for PLCL2 Gene

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