PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009] See more...

Aliases for PLCH1 Gene

Aliases for PLCH1 Gene

  • Phospholipase C Eta 1 2 3 5
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Eta-1 2 3 4
  • Phosphoinositide Phospholipase C-Eta-1 3 4
  • Phospholipase C-Like Protein 3 3 4
  • Phospholipase C-Like 3 2 3
  • EC 3.1.4.11 4 52
  • PLC-Eta-1 3 4
  • PLC-L3 3 4
  • PLCL3 3 4
  • Phospholipase C, Eta 1 2
  • Phospholipase C-Eta1a 3
  • Phospholipase C-Eta1b 3
  • Phospholipase C-Eta-1 4
  • PLC Eta 1 3
  • KIAA1069 4

External Ids for PLCH1 Gene

Previous HGNC Symbols for PLCH1 Gene

  • PLCL3

Previous GeneCards Identifiers for PLCH1 Gene

  • GC03M156577
  • GC03M156680
  • GC03M155094
  • GC03M152592

Summaries for PLCH1 Gene

Entrez Gene Summary for PLCH1 Gene

  • PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]

GeneCards Summary for PLCH1 Gene

PLCH1 (Phospholipase C Eta 1) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and Proton Pump Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCH2.

UniProtKB/Swiss-Prot Summary for PLCH1 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCH1 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Additional gene information for PLCH1 Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLCH1 Gene

Genomics for PLCH1 Gene

GeneHancer (GH) Regulatory Elements for PLCH1 Gene

Promoters and enhancers for PLCH1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J155743 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 500.7 -0.6 -617 5 ZNF217 EP300 TCF12 NRF1 POLR2G PHF8 TEAD4 ZBTB26 TRIM28 SAP30 ENSG00000214919 PLCH1 C3orf33 SLC33A1 lnc-C3orf33-1
GH03J155685 Promoter 0.3 EPDnew 500.2 +60.0 59991 0.1 PLCH1 piR-33123-008 ENSG00000214919
GH03J155701 Enhancer 0.9 Ensembl ENCODE 26.9 +41.7 41688 4.4 CTCF ZIC2 REST RAD21 TRIM22 ATF2 SMC3 ZNF341 OSR2 MYNN PLCH1 ENSG00000214919 PLCH1-AS1 SLC33A1 piR-33123-008
GH03J155714 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 20 +30.7 30688 2 TCF7 TGIF2 ZBTB7A TEAD1 FOXA2 CEBPB SAP130 POLR2A FOXP1 SMAD4 PLCH1 ENSG00000214919 SLC33A1 piR-33123-008
GH03J155663 Enhancer 0.9 Ensembl ENCODE 21.3 +79.6 79626 4.3 FOXA2 USF1 GABPA FOS FOSL2 FOSL1 NR3C1 EZH2 SIN3A FOXP1 PLCH1 ENSG00000214919 PLCH1-AS2 SLC33A1 piR-33123-008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLCH1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLCH1

Top Transcription factor binding sites by QIAGEN in the PLCH1 gene promoter:
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • CUTL1
  • FOXO1
  • FOXO1a
  • FOXO4
  • POU6F1 (c2)

Genomic Locations for PLCH1 Gene

Genomic Locations for PLCH1 Gene
chr3:155,375,580-155,745,089
(GRCh38/hg38)
Size:
369,510 bases
Orientation:
Minus strand
chr3:155,093,369-155,462,856
(GRCh37/hg19)
Size:
369,488 bases
Orientation:
Minus strand

Genomic View for PLCH1 Gene

Genes around PLCH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCH1 Gene

Proteins for PLCH1 Gene

  • Protein details for PLCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KWH8-PLCH1_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
    Protein Accession:
    Q4KWH8
    Secondary Accessions:
    • Q29RV9
    • Q4KWH9
    • Q68CN0
    • Q86XK4
    • Q9H9U2
    • Q9UPT3

    Protein attributes for PLCH1 Gene

    Size:
    1693 amino acids
    Molecular mass:
    189223 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14129.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PLCH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCH1 Gene

Selected DME Specific Peptides for PLCH1 Gene

Q4KWH8:
  • CGYVLKP
  • SSHNTYL
  • ELSDLVVY
  • HGYTLTSK

Post-translational modifications for PLCH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLCH1 Gene

Protein Domains for PLCH1 Gene

Suggested Antigen Peptide Sequences for PLCH1 Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase C-like protein 3 (PLCH1_HUMAN)
genes like me logo Genes that share domains with PLCH1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLCH1 Gene

Function for PLCH1 Gene

Molecular function for PLCH1 Gene

UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11;.

Enzyme Numbers (IUBMB) for PLCH1 Gene

Phenotypes From GWAS Catalog for PLCH1 Gene

Gene Ontology (GO) - Molecular Function for PLCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IBA 21873635
GO:0005509 calcium ion binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLCH1: view
genes like me logo Genes that share phenotypes with PLCH1: view

Animal Model Products

CRISPR Products

miRNA for PLCH1 Gene

miRTarBase miRNAs that target PLCH1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCH1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCH1 Gene

Localization for PLCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCH1 Gene

Cytoplasm. Membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCH1 gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA 15702972
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLCH1: view

Pathways & Interactions for PLCH1 Gene

genes like me logo Genes that share pathways with PLCH1: view

Pathways by source for PLCH1 Gene

2 KEGG pathways for PLCH1 Gene
1 Qiagen pathway for PLCH1 Gene
  • Phospholipase-C Pathway
1 GeneTex pathway for PLCH1 Gene

Gene Ontology (GO) - Biological Process for PLCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032959 inositol trisphosphate biosynthetic process IBA 21873635
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with PLCH1: view

No data available for SIGNOR curated interactions for PLCH1 Gene

Drugs & Compounds for PLCH1 Gene

(3) Drugs for PLCH1 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Calcium Approved Nutra 7884
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(388) Additional Compounds for PLCH1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
Inositol 1,4,5-trisphosphate
  • 1,4,5-Insp3
  • D-myo-Inositol 1,4,5-trisphosphate
  • D-myo-INOSITOL-1,4,5-triphosphATE
  • Ins(1,4,5)P3
  • InsP3
88269-39-0

(5) Tocris Compounds for PLCH1 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCH1: view

Transcripts for PLCH1 Gene

mRNA/cDNA for PLCH1 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCH1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCH1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2: -
SP3: - - -

Relevant External Links for PLCH1 Gene

GeneLoc Exon Structure for
PLCH1

Expression for PLCH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLCH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCH1 Gene

This gene is overexpressed in Testis (x6.8), Brain - Anterior cingulate cortex (BA24) (x6.0), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for PLCH1 Gene

This gene is overexpressed in Stomach (12.5), Neutrophil (6.9), and Colon muscle (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCH1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLCH1

SOURCE GeneReport for Unigene cluster for PLCH1 Gene:

Hs.567423

mRNA Expression by UniProt/SwissProt for PLCH1 Gene:

Q4KWH8-PLCH1_HUMAN
Tissue specificity: Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.

Evidence on tissue expression from TISSUES for PLCH1 Gene

  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with PLCH1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCH1 Gene

Orthologs for PLCH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PLCH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCH1 31 30
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLCH1 31 30
  • 88.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Plch1 17 31 30
  • 85.47 (n)
rat
(Rattus norvegicus)
Mammalia Plch1 30
  • 84.27 (n)
dog
(Canis familiaris)
Mammalia PLCH1 31 30
  • 80.15 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCH1 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLCH1 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCH1 31 30
  • 67.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCH1 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia plch1 30
  • 65.53 (n)
Str.18757 30
zebrafish
(Danio rerio)
Actinopterygii plch1 31
  • 68 (a)
OneToOne
LOC566479 30
  • 61.37 (n)
Species where no ortholog for PLCH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLCH1 Gene

ENSEMBL:
Gene Tree for PLCH1 (if available)
TreeFam:
Gene Tree for PLCH1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLCH1: view image

Paralogs for PLCH1 Gene

(4) SIMAP similar genes for PLCH1 Gene using alignment to 1 proteins:

  • PLCH1_HUMAN
genes like me logo Genes that share paralogs with PLCH1: view

Variants for PLCH1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLCH1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
711902 Benign: not provided 155,482,186(-) A/G SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
714211 Benign: not provided 155,482,555(-) G/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
767940 Benign: not provided 155,500,799(-) C/T INTRON_VARIANT
774172 Benign: not provided 155,482,672(-) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
774851 Benign: not provided 155,481,195(-) G/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for PLCH1 Gene

Structural Variations from Database of Genomic Variants (DGV) for PLCH1 Gene

Variant ID Type Subtype PubMed ID
dgv2623n106 CNV deletion 24896259
dgv782e201 CNV deletion 23290073
dgv833n67 CNV loss 20364138
esv1066703 CNV deletion 17803354
esv1067146 CNV insertion 17803354
esv1964556 CNV deletion 18987734
esv2205471 CNV deletion 18987734
esv2441511 CNV deletion 19546169
esv2587266 CNV deletion 19546169
esv2662421 CNV deletion 23128226
esv2726087 CNV deletion 23290073
esv2726089 CNV deletion 23290073
esv2763309 CNV gain 21179565
esv3304733 CNV mobile element insertion 20981092
esv3309511 CNV mobile element insertion 20981092
esv3328862 CNV insertion 20981092
esv3433279 CNV insertion 20981092
esv3562763 CNV deletion 23714750
esv3598273 CNV loss 21293372
esv3598278 CNV loss 21293372
esv3598279 CNV loss 21293372
esv3598281 CNV loss 21293372
esv7423 CNV loss 19470904
nsv1009618 CNV gain 25217958
nsv1073688 CNV deletion 25765185
nsv1078953 CNV insertion 25765185
nsv1123699 CNV deletion 24896259
nsv1136777 CNV deletion 24896259
nsv1139173 CNV deletion 24896259
nsv474617 CNV novel sequence insertion 20440878
nsv829763 CNV gain 17160897
nsv967244 CNV deletion 23825009

Variation tolerance for PLCH1 Gene

Residual Variation Intolerance Score: 1.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLCH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLCH1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLCH1 Gene

Disorders for PLCH1 Gene

Additional Disease Information for PLCH1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PLCH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLCH1 Gene

Publications for PLCH1 Gene

  1. Molecular cloning and characterization of a novel phospholipase C, PLC-eta. (PMID: 15702972) Hwang JI … Suh PG (The Biochemical journal 2005) 2 3 4 54
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 54
  5. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3 54

Products for PLCH1 Gene

Sources for PLCH1 Gene