PLCG2 Gene (Protein Coding)

Phospholipase C Gamma 2

GC16P081773
GIFtS:
52
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system recept... See more...

Aliases for PLCG2 Gene

Aliases for PLCG2 Gene

  • Phospholipase C Gamma 2 2 3 5
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 3 4
  • Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific) 2 3
  • Phosphoinositide Phospholipase C-Gamma-2 3 4
  • Phospholipase C-IV 3 4
  • PLC-Gamma-2 3 4
  • EC 3.1.4.11 4 51
  • PLC-IV 3 4
  • Phospholipase C-Gamma-2 4
  • APLAID 3
  • FCAS3 3
  • PLCG2 5

External Ids for PLCG2 Gene

Previous GeneCards Identifiers for PLCG2 Gene

  • GC16P072654
  • GC16P082773
  • GC16P081551
  • GC16P081593
  • GC16P081569
  • GC16P080370
  • GC16P081812
  • GC16P067566

Summaries for PLCG2 Gene

Entrez Gene Summary for PLCG2 Gene

  • The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

CIViC Summary for PLCG2 Gene

GeneCards Summary for PLCG2 Gene

PLCG2 (Phospholipase C Gamma 2) is a Protein Coding gene. Diseases associated with PLCG2 include Autoinflammation, Antibody Deficiency, And Immune Dysregulation and Familial Cold Autoinflammatory Syndrome 3. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is PLCG1.

UniProtKB/Swiss-Prot Summary for PLCG2 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

Tocris Summary for PLCG2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCG2 Gene

Additional gene information for PLCG2 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLCG2 Gene

Genomics for PLCG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PLCG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J081737 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.3 285 3.6 MXD4 CEBPA ZFP64 ZNF217 CTCF BHLHE40 ELF1 THAP11 CEBPB ZNF513 ENSG00000261218 PLCG2 CMIP GAN HSALNG0113013 SDR42E1
GH16J081778 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 259.1 +40.6 40604 2.6 TBP NR2C1 IKZF1 POLR2A BHLHE40 NONO CEBPB REST SIN3B MAX PLCG2 HSALNG0113013 SDR42E1
GH16J081783 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE dbSUPER 259.2 +45.7 45668 2.6 FEZF1 NR2C1 POLR2A ZNF843 PRDM6 BHLHE40 HNF4A IKZF1 NR2F1 HDGF PLCG2 HSALNG0113013 SDR42E1
GH16J081829 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 37.6 +93.4 93404 5.6 SP1 BCL11A POLR2A SIN3A VEZF1 IRF4 RUNX1 CTCF EBF1 SMC3 PLCG2 CMIP piR-43106-088 HSALNG0113013 SDR42E1
GH16J081795 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.8 +58.9 58872 4.2 SP1 BCL11A TRIM22 IRF4 GABPA EBF1 SMC3 SMARCA5 MAX CBFB HSALNG0113013 PLCG2 SDR42E1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLCG2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLCG2

Top Transcription factor binding sites by QIAGEN in the PLCG2 gene promoter:
  • AP-1
  • ATF-2
  • ATF6
  • CRE-BP1
  • FOXL1
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • Sox9

Genomic Locations for PLCG2 Gene

Latest Assembly
chr16:81,739,097-81,962,685
(GRCh38/hg38)
Size:
223,589 bases
Orientation:
Plus strand

Previous Assembly
chr16:81,812,896-81,996,290
(GRCh37/hg19 by Entrez Gene)
Size:
183,395 bases
Orientation:
Plus strand

chr16:81,772,702-81,991,899
(GRCh37/hg19 by Ensembl)
Size:
219,198 bases
Orientation:
Plus strand

Genomic View for PLCG2 Gene

Genes around PLCG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCG2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PLCG2 Gene

Proteins for PLCG2 Gene

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  • Protein details for PLCG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16885-PLCG2_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    Protein Accession:
    P16885
    Secondary Accessions:
    • D3DUL3
    • Q3ZTS2
    • Q59H45
    • Q969T5

    Protein attributes for PLCG2 Gene

    Size:
    1265 amino acids
    Molecular mass:
    147870 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated).
    SequenceCaution:
    • Sequence=AAA60112.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAQ76815.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAD92151.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA32194.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCG2 Gene

neXtProt entry for PLCG2 Gene

Protein Expression for PLCG2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PLCG2 Gene

P16885:
  • RVDSSNY
  • VYEEDMFSD
  • HCSVEQQ
  • GCRCIELDCWDGPDG
  • VLGARHLPK
  • SSHNTYL
  • DYTLSFWR
  • ELSDLVVY
  • VALNFQT
  • EIKEIRPGK

Post-translational modifications for PLCG2 Gene

  • Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for PLCG2

Domains & Families for PLCG2 Gene

Gene Families for PLCG2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PLCG2 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • SH3 domain signature
  • C2 domain
  • Pleckstrin-like
  • Phosphatidylinositol-specific phospholipase C, X domain
ProtoNet:

Suggested Antigen Peptide Sequences for PLCG2 Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase C-gamma-2 (PLCG2_HUMAN)
genes like me logo Genes that share domains with PLCG2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLCG2 Gene

Function for PLCG2 Gene

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  6. Cell Lines for research

Molecular function for PLCG2 Gene

UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence={ECO:0000269|PubMed:23000145};.
GENATLAS Biochemistry:
phospholipase C,gamma 2,phosphatidylinositol specific,involved in signal transduction

Enzyme Numbers (IUBMB) for PLCG2 Gene

Phenotypes From GWAS Catalog for PLCG2 Gene

Gene Ontology (GO) - Molecular Function for PLCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IPI 20624904
GO:0004435 phosphatidylinositol phospholipase C activity IEA,TAS --
GO:0004629 phospholipase C activity TAS --
GO:0005515 protein binding IEA,IPI 15644415
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCG2: view
genes like me logo Genes that share phenotypes with PLCG2: view

Human Phenotype Ontology for PLCG2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLCG2 Gene

MGI Knock Outs for PLCG2:

Animal Models for research

miRNA for PLCG2 Gene

miRTarBase miRNAs that target PLCG2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCG2

No data available for Transcription Factor Targets and HOMER Transcription for PLCG2 Gene

Localization for PLCG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCG2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 4
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with PLCG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLCG2 Gene

Pathways & Interactions for PLCG2 Gene

PathCards logo

SuperPathways for PLCG2 Gene

SuperPathway Contained pathways
1 IL-2 Pathway
ErbB Family Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
TREM1 Pathway
.43
PACAP Signaling
.37
PI3K Signaling in B-Lymphocyte
.35
2 superpathway of inositol phosphate compounds
Inositol phosphate metabolism
.60
superpathway of inositol phosphate compounds
.60
Phosphatidylinositol signaling system
.56
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
.35
D-myo-inositol-5-phosphate metabolism
.01
3 Immune response Fc epsilon RI pathway
Immune response BCR pathway
.44
Immune response Fc epsilon RI pathway
.44
Fc epsilon RI signaling pathway
.41
VEGF signaling pathway
.37
4 Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
.80
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
.80
Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
.51
Leukocyte transendothelial migration
.44
5 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
Activation of PKA through GPCR
.71
PKA Signaling
.56
genes like me logo Genes that share pathways with PLCG2: view

Pathways by source for PLCG2 Gene

15 GeneGo (Thomson Reuters) pathways for PLCG2 Gene
  • Anandamide biosynthesis and metabolism
  • Development EPO-induced MAPK pathway
  • Development GDNF family signaling
  • Development Prolactin receptor signaling
  • Development VEGF-family signaling
77 Qiagen pathways for PLCG2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
2 Cell Signaling Technology pathways for PLCG2 Gene
1 GeneTex pathway for PLCG2 Gene

SIGNOR curated interactions for PLCG2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PLCG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002316 follicular B cell differentiation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006661 phosphatidylinositol biosynthetic process IDA 11606584
genes like me logo Genes that share ontologies with PLCG2: view

Drugs & Compounds for PLCG2 Gene

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  1. Drug products for research

(21) Drugs for PLCG2 Gene - From: ClinicalTrials, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tyrosine Approved, Investigational Nutra 1128
Water Approved Pharma 0
myo-Inositol 1,4,5-trisphosphate Experimental Pharma 0
Calcium Nutra 6876
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(402) Additional Compounds for PLCG2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphoric acid
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
 257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
 91125-76-7, 29541-66-0, 51621-26-2

(5) Tocris Compounds for PLCG2 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCG2: view

Transcripts for PLCG2 Gene

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mRNA/cDNA for PLCG2 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCG2

Alternative Splicing Database (ASD) splice patterns (SP) for PLCG2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8:

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b ^ 34
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PLCG2 Gene

GeneLoc Exon Structure for
PLCG2

Expression for PLCG2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLCG2 Gene

mRNA expression in normal human tissues for PLCG2 Gene
mRNA expression by BioGPS for PLCG2 GenemRNA expression by GTEx for PLCG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCG2 Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for PLCG2 Gene

This gene is overexpressed in Lymph node (32.6) and Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCG2 Gene



Protein tissue co-expression partners for PLCG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLCG2

SOURCE GeneReport for Unigene cluster for PLCG2 Gene:

Hs.413111

Evidence on tissue expression from TISSUES for PLCG2 Gene

  • Blood(4.7)
  • Spleen(4.6)
  • Lymph node(3)
  • Bone marrow(2.8)
  • Kidney(2.5)
  • Intestine(2.5)
  • Heart(2.4)
  • Nervous system(2.2)
  • Muscle(2.2)
  • Liver(2.1)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCG2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • respiratory
  • skeleton
Regions:
Head and neck:
  • face
  • head
  • mouth
  • neck
  • nose
  • pharynx
  • thyroid
Thorax:
  • bronchus
  • lung
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with PLCG2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt for PLCG2 Gene

Orthologs for PLCG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCG2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PLCG2 30 31
  • 99.5 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PLCG2 31
  • 91 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PLCG2 30 31
  • 89.99 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PLCG2 30 31
  • 88.98 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Plcg2 30
  • 86.59 (n)
Mouse
(Mus musculus)
 Mammalia Plcg2 30 17 31
  • 86.56 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PLCG2 31
  • 76 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PLCG2 30 31
  • 75.13 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PLCG2 31
  • 80 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia plcg2 30
  • 67.66 (n)
Zebrafish
(Danio rerio)
 Actinopterygii plcg2 30 31
  • 63.99 (n)
 OneToMany
PLCG2 (2 of 2) 31
  • 52 (a)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8024 30
Fruit Fly
(Drosophila melanogaster)
 Insecta sl 31 32
  • 38 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea T01E8.3 32
  • 35 (a)
plc-3 31
  • 31 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PLC1 31
  • 24 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons PLC5 30
  • 47.28 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 38 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.6694 30
Species where no ortholog for PLCG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLCG2 Gene

ENSEMBL:
Gene Tree for PLCG2 (if available)
TreeFam:
Gene Tree for PLCG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLCG2: view image

Paralogs for PLCG2 Gene

Paralogs for PLCG2 Gene

(6) SIMAP similar genes for PLCG2 Gene using alignment to 4 proteins:

  • PLCG2_HUMAN
  • H3BMT7_HUMAN
  • H3BPZ3_HUMAN
  • H3BQV5_HUMAN
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Variants for PLCG2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PLCG2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
833741 Likely Benign: Familial cold autoinflammatory syndrome 3 81,937,806(+) C/T
NM_002661.5(PLCG2):c.3101C>T (p.Thr1034Met) 		MISSENSE
837107 Uncertain Significance: Familial cold autoinflammatory syndrome 3 81,889,258(+) C/A
NM_002661.5(PLCG2):c.852C>A (p.Phe284Leu) 		MISSENSE
837524 Uncertain Significance: Familial cold autoinflammatory syndrome 3 81,910,569(+) G/A
NM_002661.5(PLCG2):c.1783G>A (p.Gly595Arg) 		MISSENSE
837904 Uncertain Significance: Familial cold autoinflammatory syndrome 3 81,938,914(+) G/A
NM_002661.5(PLCG2):c.3312G>A (p.Val1104=) 		SYNONYMOUS
838585 Uncertain Significance: Familial cold autoinflammatory syndrome 3 81,912,610(+) A/T
NM_002661.5(PLCG2):c.1948A>T (p.Ser650Cys) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PLCG2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PLCG2 Gene

Variant ID Type Subtype PubMed ID
dgv375e201 CNV deletion 23290073
esv1008749 CNV insertion 20482838
esv1122914 CNV deletion 17803354
esv23360 CNV gain 19812545
esv2665175 CNV deletion 23128226
esv2673687 CNV deletion 23128226
esv26776 CNV gain 19812545
esv2678204 CNV deletion 23128226
esv2714792 CNV deletion 23290073
esv2714793 CNV deletion 23290073
esv2761926 CNV loss 21179565
esv3309178 CNV mobile element insertion