Aliases for PLCG1 Gene
- Phospholipase C Gamma 1 2 3 5
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 3 4
- Phospholipase C, Gamma 1 (Formerly Subtype 148) 2 3
- Phosphoinositide Phospholipase C-Gamma-1 3 4
- Phospholipase C-II 3 4
- PLC-Gamma-1 3 4
- EC 18.104.22.168 4 56
- PLC-148 3 4
- PLC-II 3 4
- PLC1 3 4
- 1-Phosphatidyl-D-Myo-Inositol-4,5-Bisphosphate 3
- Monophosphatidylinositol Phosphodiesterase 3
External Ids for PLCG1 Gene
Previous HGNC Symbols for PLCG1 Gene
Previous GeneCards Identifiers for PLCG1 Gene
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLCG1 Gene
PLCG1 (Phospholipase C Gamma 1) is a Protein Coding gene. Diseases associated with PLCG1 include Mycobacterium Kansasii and Paroxysmal Nocturnal Hemoglobinuria. Among its related pathways are Human cytomegalovirus infection and Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants. Gene Ontology (GO) annotations related to this gene include calcium ion binding and obsolete signal transducer activity. An important paralog of this gene is PLCG2.
UniProtKB/Swiss-Prot for PLCG1 Gene
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.