This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011] See more...

Aliases for PLCD4 Gene

Aliases for PLCD4 Gene

  • Phospholipase C Delta 4 2 3 5
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-4 3 4
  • Phosphoinositide Phospholipase C-Delta-4 3 4
  • EC 3.1.4.11 4 51
  • Phospholipase C, Delta 4 2
  • Phospholipase C-Delta-4 4
  • PLC-Delta-4 4
  • PLC Delta4 3
  • HPLCD4 4
  • PLCD4 5

External Ids for PLCD4 Gene

Previous GeneCards Identifiers for PLCD4 Gene

  • GC02U990230
  • GC02P218193
  • GC02P219436
  • GC02P219675
  • GC02P219298
  • GC02P219180
  • GC02P211325
  • GC02P219473

Summaries for PLCD4 Gene

Entrez Gene Summary for PLCD4 Gene

  • This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

GeneCards Summary for PLCD4 Gene

PLCD4 (Phospholipase C Delta 4) is a Protein Coding gene. Diseases associated with PLCD4 include Colorectal Cancer, Hereditary Nonpolyposis, Type 4. Among its related pathways are Sweet Taste Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCD3.

UniProtKB/Swiss-Prot Summary for PLCD4 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
  • [Isoform 2]: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.

Tocris Summary for PLCD4 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD4 Gene

Additional gene information for PLCD4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLCD4 Gene

Genomics for PLCD4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLCD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218606 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 611.3 +1.0 1016 1.8 FOXA1 PKNOX1 RCOR1 CTCF CHD2 GATA2 POLR2A PLCD4 CNOT9 lnc-CNOT9-1 BCS1L
GH02J218605 Enhancer 0.6 Ensembl ENCODE 611.3 -1.1 -1088 1.3 SP1 YY1 RCOR1 CHD2 GATA2 PLCD4 RF00026-614 RNU6-136P CNOT9
GH02J218566 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.5 -37.7 -37744 5.1 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 SOX13 CNOT9 USP37 NONHSAG030533.2 AAMP PLCD4 BCS1L NHEJ1 CNPPD1 SLC23A3 ZNF142
GH02J218781 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 17.2 +176.7 176730 6 HNRNPL GATAD2A REST TFE3 RCOR2 RBFOX2 RXRB IRF2 BRD4 SP1 CYP27A1 MN297769 PLCD4 SLC23A3 BCS1L TTLL4 GMPPA NHEJ1 CNOT9 ENSG00000272644
GH02J218730 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +125.9 125915 4.4 CREB1 GATAD2A ATF7 TEAD4 TFE3 LEF1 SOX13 IKZF1 NFKBIZ RCOR2 SLC11A1 CYP27A1 PLCD4 RNF25 ZNF142 BCS1L PNKD TMBIM1 TTLL4 USP37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLCD4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLCD4

Top Transcription factor binding sites by QIAGEN in the PLCD4 gene promoter:
  • AP-1
  • ATF6
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • GATA-1
  • STAT5A

Genomic Locations for PLCD4 Gene

Genomic Locations for PLCD4 Gene
chr2:218,606,871-218,637,186
(GRCh38/hg38)
Size:
30,316 bases
Orientation:
Plus strand
chr2:219,472,488-219,501,909
(GRCh37/hg19)
Size:
29,422 bases
Orientation:
Plus strand

Genomic View for PLCD4 Gene

Genes around PLCD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD4 Gene

Proteins for PLCD4 Gene

  • Protein details for PLCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRC7-PLCD4_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
    Protein Accession:
    Q9BRC7
    Secondary Accessions:
    • Q53FS8

    Protein attributes for PLCD4 Gene

    Size:
    762 amino acids
    Molecular mass:
    87585 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with GRIP1 (By similarity).
    • [Isoform 2]: Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (inactive GDP-bound form); high-affinity interaction (PubMed:30194280).
    • [Isoform 1]: Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunit GNAI3 (inactive GDP-bound form); low-affinity interaction (PubMed:30194280).
    Miscellaneous:
    • [Isoform 1]: Acceptor splice site between exons 4 and 5 is non-canonical but conserved through species for that particular gene.
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for PLCD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCD4 Gene

Selected DME Specific Peptides for PLCD4 Gene

Q9BRC7:
  • FYEISSFSE
  • SSFSETKA
  • PLNHYFI
  • GYRHIHLLS
  • DTARQET
  • NQDGKMS
  • GYVLKPDFLRD
  • AKPSFSISDV
  • DGFLSYLCS
  • QERLDQWLSDWFQRGDKNQDG
  • HLTEILGEQLLSTTLDG
  • CGYVLKP
  • CLPIYQDMTQPL
  • SIVDPLV
  • TDQDLLLMQEG
  • DYDWKSRNDF
  • GCQMVAMNMQTAG
  • SGTLEGEEFV
  • LMNVEMD
  • MRKVRSKSWKKLR
  • DGMTVWH
  • SSHNTYL
  • EGYIRALKRGCRCVEVD
  • SGKLRHVLSMDGFL
  • VDPLVKV
  • EYAFSLFQ
  • YPVILSLE
  • LTKRAEVQELFE
  • RVYPSGLRTDSSN
  • YHGHTLT
  • SSVEGYIR
  • ILCPALS

Post-translational modifications for PLCD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PLCD4 Gene

Protein Domains for PLCD4 Gene

Suggested Antigen Peptide Sequences for PLCD4 Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase C-delta-4 (PLCD4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRC7

UniProtKB/Swiss-Prot:

PLCD4_HUMAN :
  • The PDZ-binding motif mediates the interaction with GRIP1.
Domain:
  • The PDZ-binding motif mediates the interaction with GRIP1.
  • The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.
  • The PH domain is not a critical determinant of the membrane localization.
  • The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
genes like me logo Genes that share domains with PLCD4: view

Function for PLCD4 Gene

Molecular function for PLCD4 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11;.
GENATLAS Biochemistry:
phospholipase C,delta 4,involved in signal transduction

Enzyme Numbers (IUBMB) for PLCD4 Gene

Phenotypes From GWAS Catalog for PLCD4 Gene

Gene Ontology (GO) - Molecular Function for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA,IBA 21873635
GO:0004629 phospholipase C activity IEA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCD4: view
genes like me logo Genes that share phenotypes with PLCD4: view

Animal Models for PLCD4 Gene

MGI Knock Outs for PLCD4:
  • Plcd4 Plcd4<tm1Kfu>
  • Plcd4 Plcd4<tm2b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCD4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCD4

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PLCD4 Gene

Localization for PLCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD4 Gene

Membrane. Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCD4 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PLCD4: view

Pathways & Interactions for PLCD4 Gene

PathCards logo

SuperPathways for PLCD4 Gene

SuperPathway Contained pathways
1 Inositol phosphate metabolism (KEGG)
2 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
3 CREB Pathway
.68
.68
.63
.50
4 Sweet Taste Signaling
.72
.72
.46
.37
5 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
genes like me logo Genes that share pathways with PLCD4: view

Pathways by source for PLCD4 Gene

1 GeneGo (Thomson Reuters) pathway for PLCD4 Gene
  • Anandamide biosynthesis and metabolism
38 Qiagen pathways for PLCD4 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 GeneTex pathway for PLCD4 Gene

Gene Ontology (GO) - Biological Process for PLCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007340 acrosome reaction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032959 inositol trisphosphate biosynthetic process IBA --
genes like me logo Genes that share ontologies with PLCD4: view

No data available for SIGNOR curated interactions for PLCD4 Gene

Drugs & Compounds for PLCD4 Gene

(3) Drugs for PLCD4 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Calcium Nutra 6556
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(389) Additional Compounds for PLCD4 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PLCD4 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD4: view

Transcripts for PLCD4 Gene

mRNA/cDNA for PLCD4 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCD4

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: -
SP8:
SP9: -
SP10:

ExUns: 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PLCD4 Gene

GeneLoc Exon Structure for
PLCD4

Expression for PLCD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLCD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCD4 Gene

This gene is overexpressed in Muscle - Skeletal (x13.1).

Protein differential expression in normal tissues from HIPED for PLCD4 Gene

This gene is overexpressed in Retina (39.6) and Tonsil (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PLCD4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLCD4

SOURCE GeneReport for Unigene cluster for PLCD4 Gene:

Hs.632528

mRNA Expression by UniProt/SwissProt for PLCD4 Gene:

Q9BRC7-PLCD4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.

Evidence on tissue expression from TISSUES for PLCD4 Gene

  • Nervous system(4.4)
  • Kidney(4.2)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with PLCD4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCD4 Gene

Orthologs for PLCD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLCD4 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLCD4 30 31
  • 86.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLCD4 30 31
  • 85.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Plcd4 30
  • 79.59 (n)
Mouse
(Mus musculus)
Mammalia Plcd4 30 17 31
  • 79.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PLCD4 31
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC424214 30
  • 67.12 (n)
PLCD4 31
  • 57 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PLCD4 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia plcd4 30
  • 63.64 (n)
Zebrafish
(Danio rerio)
Actinopterygii plcd4a 30 31
  • 61.99 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D00638g 30
  • 46.26 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR024W 30
  • 45.14 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PLC1 30
  • 43.92 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PLC4 30
  • 45.12 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01266 30
  • 46.89 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes plc1 30
  • 44.49 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
OneToMany
Species where no ortholog for PLCD4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PLCD4 Gene

ENSEMBL:
Gene Tree for PLCD4 (if available)
TreeFam:
Gene Tree for PLCD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLCD4: view image

Paralogs for PLCD4 Gene

(12) SIMAP similar genes for PLCD4 Gene using alignment to 6 proteins:

  • PLCD4_HUMAN
  • C9JAE4_HUMAN
  • C9JEA7_HUMAN
  • F2Z3H8_HUMAN
  • H7C237_HUMAN
  • H7C281_HUMAN
genes like me logo Genes that share paralogs with PLCD4: view

Variants for PLCD4 Gene

Additional dbSNP identifiers (rs#s) for PLCD4 Gene

Variation tolerance for PLCD4 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLCD4 Gene

Human Gene Mutation Database (HGMD)
PLCD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLCD4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for PLCD4 Gene

Disorders for PLCD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLCD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colorectal cancer, hereditary nonpolyposis, type 4
  • hnpcc4
- elite association - COSMIC cancer census association via MalaCards
Search PLCD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PLCD4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PLCD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLCD4 Gene

Publications for PLCD4 Gene

  1. Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization. (PMID: 10702683) Kim H … Park SH (Cytogenetics and cell genetics 1999) 2 3 4 23
  2. Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. (PMID: 15140260) Leung DW … Singer JW (Molecular cancer 2004) 3 4 23
  3. A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins. (PMID: 30194280) Maziarz M … Garcia-Marcos M (The Journal of biological chemistry 2018) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 41

Products for PLCD4 Gene

  • Signalway Proteins for PLCD4

Sources for PLCD4 Gene