This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentration... See more...

Aliases for PLCD3 Gene

Aliases for PLCD3 Gene

  • Phospholipase C Delta 3 2 3 5
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-3 3 4
  • Phosphoinositide Phospholipase C-Delta-3 3 4
  • PLC-Delta-3 3 4
  • EC 3.1.4.11 4 52
  • 1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Delta-3 3
  • Phospholipase C, Delta 3 2
  • Phospholipase C-Delta-3 4
  • PLC Delta3 3
  • KIAA1964 4

External Ids for PLCD3 Gene

Previous GeneCards Identifiers for PLCD3 Gene

  • GC17U990190
  • GC17P045239
  • GC17M043197
  • GC17M043664
  • GC17M040544
  • GC17M038952
  • GC17M043186

Summaries for PLCD3 Gene

Entrez Gene Summary for PLCD3 Gene

  • This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLCD3 Gene

PLCD3 (Phospholipase C Delta 3) is a Protein Coding gene. Diseases associated with PLCD3 include Hemifacial Microsomia. Among its related pathways are superpathway of inositol phosphate compounds and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCD1.

UniProtKB/Swiss-Prot Summary for PLCD3 Gene

  • Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.

Tocris Summary for PLCD3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCD3 Gene

Additional gene information for PLCD3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLCD3 Gene

Genomics for PLCD3 Gene

GeneHancer (GH) Regulatory Elements for PLCD3 Gene

Promoters and enhancers for PLCD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLCD3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLCD3

Top Transcription factor binding sites by QIAGEN in the PLCD3 gene promoter:
  • C/EBPalpha
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • STAT5A

Genomic Locations for PLCD3 Gene

Genomic Locations for PLCD3 Gene
chr17:45,108,959-45,133,354
(GRCh38/hg38)
Size:
24,396 bases
Orientation:
Minus strand
chr17:43,186,335-43,210,721
(GRCh37/hg19)
Size:
24,387 bases
Orientation:
Minus strand

Genomic View for PLCD3 Gene

Genes around PLCD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCD3 Gene

Proteins for PLCD3 Gene

  • Protein details for PLCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3E9-PLCD3_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
    Protein Accession:
    Q8N3E9
    Secondary Accessions:
    • Q8TEC1
    • Q8TF37
    • Q96FL6

    Protein attributes for PLCD3 Gene

    Size:
    789 amino acids
    Molecular mass:
    89258 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLCD3 Gene

Selected DME Specific Peptides for PLCD3 Gene

Q8N3E9:
  • GCRCVELD
  • GYRHIHLLS
  • CGYVLKP
  • SIVDPLV
  • SSHNTYL
  • VALNFQT
  • YPVILSLE
  • LVRFVVEDYD
  • YHGHTLT

Post-translational modifications for PLCD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLCD3 Gene

Domains & Families for PLCD3 Gene

Protein Domains for PLCD3 Gene

Suggested Antigen Peptide Sequences for PLCD3 Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase C, delta 3, isoform CRA_b (D3DX63_HUMAN)
  • Phospholipase C-delta-3 (PLCD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N3E9

UniProtKB/Swiss-Prot:

PLCD3_HUMAN :
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
Domain:
  • The C2 domain is a Ca(2+)-dependent membrane-targeting module.
  • The PH domain mediates interaction with the surface membrane by binding to PIP2.
genes like me logo Genes that share domains with PLCD3: view

Function for PLCD3 Gene

Molecular function for PLCD3 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=105.3 uM for PIP2 {ECO:0000269 PubMed:10336610}; Vmax=28.5 umol/min/mg enzyme {ECO:0000269 PubMed:10336610};
UniProtKB/Swiss-Prot Induction:
Down-regulated by Ca(2+) and cAMP.
GENATLAS Biochemistry:
phospholipase C,delta 3,involved in signal transduction

Enzyme Numbers (IUBMB) for PLCD3 Gene

Phenotypes From GWAS Catalog for PLCD3 Gene

Gene Ontology (GO) - Molecular Function for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IBA,IEA 21873635
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLCD3: view
genes like me logo Genes that share phenotypes with PLCD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCD3

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLCD3 Gene

Localization for PLCD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCD3 Gene

Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCD3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
cytosol 3
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLCD3: view

Pathways & Interactions for PLCD3 Gene

PathCards logo

SuperPathways for PLCD3 Gene

SuperPathway Contained pathways
1 superpathway of inositol phosphate compounds
2 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
3 CREB Pathway
.68
.68
.63
.50
4 Sweet Taste Signaling
.72
.72
.46
.37
5 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
genes like me logo Genes that share pathways with PLCD3: view

Pathways by source for PLCD3 Gene

1 GeneGo (Thomson Reuters) pathway for PLCD3 Gene
  • Anandamide biosynthesis and metabolism
38 Qiagen pathways for PLCD3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 GeneTex pathway for PLCD3 Gene

Gene Ontology (GO) - Biological Process for PLCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0016042 lipid catabolic process IEA --
GO:0032959 inositol trisphosphate biosynthetic process IBA 21873635
genes like me logo Genes that share ontologies with PLCD3: view

No data available for SIGNOR curated interactions for PLCD3 Gene

Drugs & Compounds for PLCD3 Gene

(6) Drugs for PLCD3 Gene - From: PharmGKB, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
Diltiazem Approved, Investigational Pharma Channel blocker 88
Water Approved Pharma 0
cyclic amp Experimental Pharma 0
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(568) Additional Compounds for PLCD3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PLCD3 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCD3: view

Transcripts for PLCD3 Gene

mRNA/cDNA for PLCD3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for PLCD3 Gene

GeneLoc Exon Structure for
PLCD3

Expression for PLCD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLCD3 Gene

Protein differential expression in normal tissues from HIPED for PLCD3 Gene

This gene is overexpressed in Spinal cord (24.6), Amniocyte (16.5), and Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCD3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLCD3

SOURCE GeneReport for Unigene cluster for PLCD3 Gene:

Hs.380094

mRNA Expression by UniProt/SwissProt for PLCD3 Gene:

Q8N3E9-PLCD3_HUMAN
Tissue specificity: Present in corneal epithelial cells (at protein level).

Evidence on tissue expression from TISSUES for PLCD3 Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with PLCD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCD3 Gene

Orthologs for PLCD3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLCD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCD3 30
  • 95.85 (n)
cow
(Bos Taurus)
Mammalia PLCD3 31 30
  • 87.94 (n)
OneToOne