Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PLCB3 Gene

Aliases for PLCB3 Gene

  • Phospholipase C Beta 3 2 3 5
  • Phospholipase C, Beta 3 (Phosphatidylinositol-Specific) 2 3
  • Phosphoinositide Phospholipase C-Beta-3 3 4
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 3
  • Phospholipase C-Beta-3 4
  • EC 3.1.4.11 4
  • PLC Beta 3 3
  • PLC-Beta-3 4

External Ids for PLCB3 Gene

Previous GeneCards Identifiers for PLCB3 Gene

  • GC11P066534
  • GC11P065700
  • GC11P064269
  • GC11P063794
  • GC11P063775
  • GC11P064019
  • GC11P060321

Summaries for PLCB3 Gene

Entrez Gene Summary for PLCB3 Gene

  • This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for PLCB3 Gene

PLCB3 (Phospholipase C Beta 3) is a Protein Coding gene. Diseases associated with PLCB3 include Multiple Endocrine Neoplasia, Type I. Among its related pathways are Apelin signaling pathway and Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is PLCB1.

UniProtKB/Swiss-Prot for PLCB3 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCB3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCB3 Gene

Additional gene information for PLCB3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLCB3 Gene

Genomics for PLCB3 Gene

GeneHancer (GH) Regulatory Elements for PLCB3 Gene

Promoters and enhancers for PLCB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064237 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 663.9 -6.2 -6204 16.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPP1R14B PLCB3 FKBP2 LOC105369340 TRPT1 LOC102723878 VEGFB ENSG00000257086 TRMT112 SF1
GH11J064267 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 39.1 +19.2 19177 7.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC GPR137 ZFPL1 SF1 POLA2 PLCB3 ENSG00000257086 TRMT112 DNAJC4 FAU LOC102723878
GH11J064354 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.2 +106.5 106451 6.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A ZBTB7B YY1 RPS6KA4 PLCB3 LOC102723878 SF1 ZFPL1 ENSG00000257086 POLA2 SYVN1 VPS51 ATG2A
GH11J064331 Enhancer 1.5 Ensembl ENCODE dbSUPER 39.1 +80.4 80370 1.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A YBX1 IRF4 POLR2B ZNF207 GC11P064330 GC11P064331 POLA2 SF1 PLCB3 ZFPL1 ENSG00000257086 FAU ATG2A ZNHIT2
GH11J064205 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 22.5 -43.9 -43928 4.4 HDGF PKNOX1 SMAD1 ARNT YY1 POLR2B ZNF766 ZNF143 ZNF592 SMARCA4 FERMT3 TRPT1 ZFPL1 PLCB3 SF1 TRMT112 ENSG00000257086 GPR137 BAD ENSG00000257069
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLCB3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLCB3 gene promoter:
  • NF-kappaB1
  • E2F-3a
  • E2F
  • E2F-1
  • E2F-2
  • E2F-4
  • E2F-5
  • Pax-5
  • SEF-1 (1)

Genomic Locations for PLCB3 Gene

Genomic Locations for PLCB3 Gene
chr11:64,251,523-64,269,452
(GRCh38/hg38)
Size:
17,930 bases
Orientation:
Plus strand
chr11:64,018,995-64,036,924
(GRCh37/hg19)
Size:
17,930 bases
Orientation:
Plus strand

Genomic View for PLCB3 Gene

Genes around PLCB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB3 Gene

Proteins for PLCB3 Gene

  • Protein details for PLCB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01970-PLCB3_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
    Protein Accession:
    Q01970
    Secondary Accessions:
    • A5PKZ6
    • G5E960
    • Q8N1A4

    Protein attributes for PLCB3 Gene

    Size:
    1234 amino acids
    Molecular mass:
    138799 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with SHANK2 (By similarity). Interacts with LPAR2.
    SequenceCaution:
    • Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCB3 Gene

    Alternative splice isoforms for PLCB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCB3 Gene

Post-translational modifications for PLCB3 Gene

  • Ubiquitination at Lys804
  • Modification sites at PhosphoSitePlus

Other Protein References for PLCB3 Gene

No data available for DME Specific Peptides for PLCB3 Gene

Domains & Families for PLCB3 Gene

Gene Families for PLCB3 Gene

Suggested Antigen Peptide Sequences for PLCB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PLCB3: view

No data available for UniProtKB/Swiss-Prot for PLCB3 Gene

Function for PLCB3 Gene

Molecular function for PLCB3 Gene

UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
GENATLAS Biochemistry:
phospholipase C,beta 3,phosphatidyl inositol specific,involved in signal transduction,excluded as a candidate in the tumorigenesis of endocrine tumor (see MEN1)

Enzyme Numbers (IUBMB) for PLCB3 Gene

Phenotypes From GWAS Catalog for PLCB3 Gene

Gene Ontology (GO) - Molecular Function for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS --
GO:0004629 phospholipase C activity TAS --
GO:0004871 obsolete signal transducer activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15782111
genes like me logo Genes that share ontologies with PLCB3: view
genes like me logo Genes that share phenotypes with PLCB3: view

Animal Models for PLCB3 Gene

MGI Knock Outs for PLCB3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLCB3

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCB3 Gene

Localization for PLCB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCB3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCB3 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0032991 protein-containing complex IDA 18468998
genes like me logo Genes that share ontologies with PLCB3: view

Pathways & Interactions for PLCB3 Gene

genes like me logo Genes that share pathways with PLCB3: view

Pathways by source for PLCB3 Gene

SIGNOR curated interactions for PLCB3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure IDA 18468998
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
genes like me logo Genes that share ontologies with PLCB3: view

Drugs & Compounds for PLCB3 Gene

(6) Drugs for PLCB3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Water Approved Pharma 0
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(393) Additional Compounds for PLCB3 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PLCB3 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCB3: view

Transcripts for PLCB3 Gene

Unigene Clusters for PLCB3 Gene

Phospholipase C, beta 3 (phosphatidylinositol-specific):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLCB3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10: - - -
SP11:

ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PLCB3 Gene

GeneLoc Exon Structure for
PLCB3
ECgene alternative splicing isoforms for
PLCB3

Expression for PLCB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLCB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCB3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for PLCB3 Gene

This gene is overexpressed in Fetal gut (14.1) and Stomach (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCB3 Gene



Protein tissue co-expression partners for PLCB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PLCB3 Gene:

PLCB3

SOURCE GeneReport for Unigene cluster for PLCB3 Gene:

Hs.523761

Evidence on tissue expression from TISSUES for PLCB3 Gene

  • Liver(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with PLCB3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCB3 Gene

Orthologs for PLCB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCB3 34 33
  • 99.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PLCB3 34 33
  • 89.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PLCB3 34 33
  • 89.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Plcb3 33
  • 87.03 (n)
mouse
(Mus musculus)
Mammalia Plcb3 16 34 33
  • 86.81 (n)
oppossum
(Monodelphis domestica)
Mammalia PLCB3 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLCB3 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCB3 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia