This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] See more...

Aliases for PLCB3 Gene

Aliases for PLCB3 Gene

  • Phospholipase C Beta 3 2 3 5
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 3 4
  • Phospholipase C, Beta 3 (Phosphatidylinositol-Specific) 2 3
  • Phosphoinositide Phospholipase C-Beta-3 3 4
  • EC 3.1.4.11 4 50
  • Phospholipase C-Beta-3 4
  • PLC Beta 3 3
  • PLC-Beta-3 4
  • SMDCD 3
  • PLCB3 5

External Ids for PLCB3 Gene

Previous GeneCards Identifiers for PLCB3 Gene

  • GC11P066534
  • GC11P065700
  • GC11P064269
  • GC11P063794
  • GC11P063775
  • GC11P064019
  • GC11P060321

Summaries for PLCB3 Gene

Entrez Gene Summary for PLCB3 Gene

  • This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for PLCB3 Gene

PLCB3 (Phospholipase C Beta 3) is a Protein Coding gene. Diseases associated with PLCB3 include Spondylometaphyseal Dysplasia With Corneal Dystrophy and Multiple Endocrine Neoplasia. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is PLCB1.

UniProtKB/Swiss-Prot Summary for PLCB3 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCB3 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCB3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLCB3 Gene

Genomics for PLCB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLCB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLCB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLCB3

Top Transcription factor binding sites by QIAGEN in the PLCB3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NF-kappaB1
  • Pax-5
  • SEF-1 (1)

Genomic Locations for PLCB3 Gene

Latest Assembly
chr11:64,251,530-64,269,452
(GRCh38/hg38)
Size:
17,923 bases
Orientation:
Plus strand

Previous Assembly
chr11:64,019,002-64,036,924
(GRCh37/hg19 by Entrez Gene)
Size:
17,923 bases
Orientation:
Plus strand

chr11:64,018,995-64,036,622
(GRCh37/hg19 by Ensembl)
Size:
17,628 bases
Orientation:
Plus strand

Genomic View for PLCB3 Gene

Genes around PLCB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB3 Gene

Proteins for PLCB3 Gene

  • Protein details for PLCB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01970-PLCB3_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
    Protein Accession:
    Q01970
    Secondary Accessions:
    • A5PKZ6
    • G5E960
    • Q8N1A4

    Protein attributes for PLCB3 Gene

    Size:
    1234 amino acids
    Molecular mass:
    138799 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with SHANK2 (By similarity). Interacts with LPAR2 (PubMed:15143197).
    SequenceCaution:
    • Sequence=AAH32659.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLCB3 Gene

    Alternative splice isoforms for PLCB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCB3 Gene

Selected DME Specific Peptides for PLCB3 Gene

Q01970:
  • KRVETAL
  • GCRCVELD
  • YVEVDMFGLPVDTRRK
  • FEMSSFVETK
  • KVVLPTLA
  • GHRILPV
  • EQLTKSP
  • RVDSSNY
  • EFMRRPDK
  • KAYTKLKLQV
  • IVDGIVAN
  • SSVEMYRQ
  • ITHGFTMTT
  • RIYPKGTR
  • QQAKMAEYCR
  • EFVEYNK
  • QLSRIYP
  • LKPEFMRR
  • ISGQFLS
  • SSHNTYL
  • VALNFQT
  • LSFENHVDS
  • DVLEAIAE
  • DSSNYMPQ

Post-translational modifications for PLCB3 Gene

  • Ubiquitination at Lys804
  • Modification sites at PhosphoSitePlus

Other Protein References for PLCB3 Gene

Domains & Families for PLCB3 Gene

Gene Families for PLCB3 Gene

Protein Domains for PLCB3 Gene

Suggested Antigen Peptide Sequences for PLCB3 Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase C-beta-3 (PLCB3_HUMAN)
genes like me logo Genes that share domains with PLCB3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLCB3 Gene

Function for PLCB3 Gene

Molecular function for PLCB3 Gene

UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11; Evidence={ECO:0000269|PubMed:9188725};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:43484, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:57880, ChEBI:CHEBI:58433; Evidence={ECO:0000250|UniProtKB:Q99JE6};.
GENATLAS Biochemistry:
phospholipase C,beta 3,phosphatidyl inositol specific,involved in signal transduction,excluded as a candidate in the tumorigenesis of endocrine tumor (see MEN1)

Enzyme Numbers (IUBMB) for PLCB3 Gene

Phenotypes From GWAS Catalog for PLCB3 Gene

Gene Ontology (GO) - Molecular Function for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IBA,IDA 9188725
GO:0004629 phospholipase C activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21822282
GO:0005516 calmodulin binding IDA 12821674
genes like me logo Genes that share ontologies with PLCB3: view
genes like me logo Genes that share phenotypes with PLCB3: view

Human Phenotype Ontology for PLCB3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PLCB3 Gene

MGI Knock Outs for PLCB3:

Animal Models for research

  • Taconic Biosciences Mouse Models for PLCB3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCB3

No data available for Transcription Factor Targets and HOMER Transcription for PLCB3 Gene

Localization for PLCB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLCB3 Gene

Cytoplasm. Membrane. Nucleus. Note=And particulate fractions. {ECO:0000250 UniProtKB:Q99JE6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCB3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0032991 protein-containing complex IDA 18468998
genes like me logo Genes that share ontologies with PLCB3: view

Pathways & Interactions for PLCB3 Gene

PathCards logo

SuperPathways for PLCB3 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.45
.40
2 Aldosterone synthesis and secretion
3 Development Endothelin-1/EDNRA signaling
.41
.41
.41
4 superpathway of inositol phosphate compounds
5 Sweet Taste Signaling
.72
.72
.46
.44
.37
genes like me logo Genes that share pathways with PLCB3: view

Pathways by source for PLCB3 Gene

23 GeneGo (Thomson Reuters) pathways for PLCB3 Gene
  • Anandamide biosynthesis and metabolism
  • Cell adhesion Integrin inside-out signaling
  • CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
  • Cytoskeleton remodeling FAK signaling
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
55 Qiagen pathways for PLCB3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 Cell Signaling Technology pathway for PLCB3 Gene
1 GeneTex pathway for PLCB3 Gene

SIGNOR curated interactions for PLCB3 Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PLCB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure IDA 18468998
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
genes like me logo Genes that share ontologies with PLCB3: view

Drugs & Compounds for PLCB3 Gene

(7) Drugs for PLCB3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
myo-Inositol 1,4,5-trisphosphate Experimental Pharma 0
Calcium Nutra 6959
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(392) Additional Compounds for PLCB3 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PLCB3 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCB3: view

Transcripts for PLCB3 Gene

mRNA/cDNA for PLCB3 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCB3

Alternative Splicing Database (ASD) splice patterns (SP) for PLCB3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10: - - -
SP11:

ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: