Aliases for PLCB3 Gene
External Ids for PLCB3 Gene
Previous GeneCards Identifiers for PLCB3 Gene
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
GeneCards Summary for PLCB3 Gene
PLCB3 (Phospholipase C Beta 3) is a Protein Coding gene. Diseases associated with PLCB3 include Multiple Endocrine Neoplasia, Type I. Among its related pathways are Apelin signaling pathway and Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is PLCB1.
UniProtKB/Swiss-Prot for PLCB3 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.