Aliases for PLCB3 Gene
External Ids for PLCB3 Gene
Previous GeneCards Identifiers for PLCB3 Gene
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
GeneCards Summary for PLCB3 Gene
PLCB3 (Phospholipase C Beta 3) is a Protein Coding gene. Diseases associated with PLCB3 include Spondylometaphyseal Dysplasia With Corneal Dystrophy and Multiple Endocrine Neoplasia. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is PLCB1.
UniProtKB/Swiss-Prot Summary for PLCB3 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.