The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa ... See more...

Aliases for PLCB2 Gene

Aliases for PLCB2 Gene

  • Phospholipase C Beta 2 2 3 5
  • 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-2 3 4
  • Phosphoinositide Phospholipase C-Beta-2 3 4
  • EC 3.1.4.11 4 51
  • PLC-Beta-2 3 4
  • Phospholipase C, Beta 2 2
  • Phospholipase C-Beta-2 4
  • FLJ38135 2
  • PLCB2 5

External Ids for PLCB2 Gene

Previous GeneCards Identifiers for PLCB2 Gene

  • GC15M035947
  • GC15M033475
  • GC15M038159
  • GC15M038296
  • GC15M038367
  • GC15M040580
  • GC15M017423

Summaries for PLCB2 Gene

Entrez Gene Summary for PLCB2 Gene

  • The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]

GeneCards Summary for PLCB2 Gene

PLCB2 (Phospholipase C Beta 2) is a Protein Coding gene. Diseases associated with PLCB2 include Prostate Leiomyosarcoma and Night Blindness, Congenital Stationary, Type 1H. Among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCB1.

UniProtKB/Swiss-Prot Summary for PLCB2 Gene

  • The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Tocris Summary for PLCB2 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLCB2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PLCB2 Gene

Genomics for PLCB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PLCB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLCB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PLCB2

Top Transcription factor binding sites by QIAGEN in the PLCB2 gene promoter:
  • E47
  • ER-alpha
  • Nkx2-5
  • p53
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1

Genomic Locations for PLCB2 Gene

Genomic Locations for PLCB2 Gene
chr15:40,278,176-40,307,945
(GRCh38/hg38)
Size:
29,770 bases
Orientation:
Minus strand
chr15:40,570,377-40,600,174
(GRCh37/hg19)
Size:
29,798 bases
Orientation:
Minus strand

Genomic View for PLCB2 Gene

Genes around PLCB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLCB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLCB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLCB2 Gene

Proteins for PLCB2 Gene

  • Protein details for PLCB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00722-PLCB2_HUMAN
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    Protein Accession:
    Q00722
    Secondary Accessions:
    • A8K6J2
    • B9EGH5

    Protein attributes for PLCB2 Gene

    Size:
    1185 amino acids
    Molecular mass:
    134024 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with RAC1 (PubMed:1644792). Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (PubMed:23625927).
    Miscellaneous:
    • The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.

    Three dimensional structures from OCA and Proteopedia for PLCB2 Gene

    Alternative splice isoforms for PLCB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLCB2 Gene

Selected DME Specific Peptides for PLCB2 Gene

Q00722:
  • GCRCVELD
  • PLNHYFI
  • LCPRPEID
  • EFMRRPDK
  • ITHGFTMTT
  • RIYPKGTR
  • QQAKMAEYCR
  • ISGQFLS
  • SSHNTYL
  • VALNFQT
  • LSFENHVDS
  • DSSNYMPQ
  • EAIAESAFKTS
  • YNKRQMSR

Post-translational modifications for PLCB2 Gene

  • Ubiquitination at Lys761
  • Modification sites at PhosphoSitePlus

Domains & Families for PLCB2 Gene

Gene Families for PLCB2 Gene

Protein Domains for PLCB2 Gene

Suggested Antigen Peptide Sequences for PLCB2 Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase C-beta-2 (PLCB2_HUMAN)
genes like me logo Genes that share domains with PLCB2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PLCB2 Gene

Function for PLCB2 Gene

Molecular function for PLCB2 Gene

UniProtKB/Swiss-Prot Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11;.
GENATLAS Biochemistry:
phospholipase C,beta 2,predominantly expressed in hematopoietic cells,critical to many chemoattractant elicited responses,involved in signal transduction

Enzyme Numbers (IUBMB) for PLCB2 Gene

Phenotypes From GWAS Catalog for PLCB2 Gene

Gene Ontology (GO) - Molecular Function for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IBA,IMP 8519600
GO:0004629 phospholipase C activity IEA,TAS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21115837
GO:0008081 phosphoric diester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLCB2: view
genes like me logo Genes that share phenotypes with PLCB2: view

Animal Models for PLCB2 Gene

MGI Knock Outs for PLCB2:

Animal Model Products

CRISPR Products

miRNA for PLCB2 Gene

miRTarBase miRNAs that target PLCB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCB2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLCB2 Gene

Localization for PLCB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLCB2 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PLCB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PLCB2 Gene

Pathways & Interactions for PLCB2 Gene

PathCards logo

SuperPathways for PLCB2 Gene

SuperPathway Contained pathways
1 Development Angiotensin activation of ERK
.73
.73
.68
.65
.54
.45
.40
2 Aldosterone synthesis and secretion
3 Inositol phosphate metabolism (KEGG)
4 Sweet Taste Signaling
.72
.72
.46
.44
.37
5 fMLP Pathway
.44
.43
.42
.39
.31
genes like me logo Genes that share pathways with PLCB2: view

Pathways by source for PLCB2 Gene

25 GeneGo (Thomson Reuters) pathways for PLCB2 Gene
  • Anandamide biosynthesis and metabolism
  • Cell adhesion Integrin inside-out signaling
  • CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
  • Cytoskeleton remodeling FAK signaling
  • Development A2B receptor- action via G-protein alpha s
1 R&D Systems pathway for PLCB2 Gene
56 Qiagen pathways for PLCB2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Aldosterone Signaling in Epithelial Cells
1 GeneTex pathway for PLCB2 Gene

SIGNOR curated interactions for PLCB2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PLCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process TAS 1644792
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS 7649993
genes like me logo Genes that share ontologies with PLCB2: view

Drugs & Compounds for PLCB2 Gene

(4) Drugs for PLCB2 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Calcium Nutra 6556
AACOCF3 Pharma Inhibitor of cPLA2/anandamide hydrolysis/FAAH, Phospholipase A2 inhibitor 0

(395) Additional Compounds for PLCB2 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for PLCB2 Gene

Compound Action Cas Number
AACOCF3 Phospholipase A2 inhibitor 149301-79-1
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist 77286-66-9
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLCB2: view

Transcripts for PLCB2 Gene

mRNA/cDNA for PLCB2 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PLCB2

Alternative Splicing Database (ASD) splice patterns (SP) for PLCB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - - - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b
SP1: - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12: - - -
SP13: - - -
SP14:
SP15:

Relevant External Links for PLCB2 Gene

GeneLoc Exon Structure for
PLCB2

Expression for PLCB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLCB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLCB2 Gene

This gene is overexpressed in Whole Blood (x16.9) and Spleen (x6.9).

Protein differential expression in normal tissues from HIPED for PLCB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.7) and Spleen (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLCB2 Gene



Protein tissue co-expression partners for PLCB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PLCB2

SOURCE GeneReport for Unigene cluster for PLCB2 Gene:

Hs.355888

Evidence on tissue expression from TISSUES for PLCB2 Gene

  • Liver(4.4)
  • Nervous system(3.6)
  • Blood(3.1)
  • Intestine(2.8)
  • Lung(2.6)
  • Spleen(2.5)
  • Stomach(2.4)
  • Bone marrow(2.4)
  • Pancreas(2.3)
  • Lymph node(2.3)
  • Skin(2.2)
  • Muscle(2.1)
  • Kidney(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with PLCB2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLCB2 Gene

Orthologs for PLCB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLCB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PLCB2 30 31
  • 99.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PLCB2 30 31
  • 89.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PLCB2 30 31
  • 89.3 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Plcb2 30 17 31
  • 85.57 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Plcb2 30
  • 85.25 (n)
Oppossum
(Monodelphis domestica)
Mammalia PLCB2 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PLCB2 30 31
  • 72.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PLCB2 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia plcb2 30
  • 68.16 (n)
Zebrafish
(Danio rerio)
Actinopterygii PLCB2 31
  • 45 (a)
OneToOne
Dr.11385 30
Fruit Fly
(Drosophila melanogaster)
Insecta Plc21C 31
  • 34 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y75B12B.6 32
  • 30 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToMany
Species where no ortholog for PLCB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PLCB2 Gene

ENSEMBL:
Gene Tree for PLCB2 (if available)
TreeFam:
Gene Tree for PLCB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PLCB2: view image

Paralogs for PLCB2 Gene

(8) SIMAP similar genes for PLCB2 Gene using alignment to 6 proteins:

  • PLCB2_HUMAN
  • B9EGH5_HUMAN
  • H0YK35_HUMAN
  • H0YKR9_HUMAN
  • H0YNI4_HUMAN
  • Q9BVT6_HUMAN
genes like me logo Genes that share paralogs with PLCB2: view

Variants for PLCB2 Gene