Aliases for PLCB1 Gene
External Ids for PLCB1 Gene
Previous GeneCards Identifiers for PLCB1 Gene
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLCB1 Gene
PLCB1 (Phospholipase C Beta 1) is a Protein Coding gene. Diseases associated with PLCB1 include Epileptic Encephalopathy, Early Infantile, 12 and Malignant Migrating Partial Seizures Of Infancy. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is PLCB3.
UniProtKB/Swiss-Prot Summary for PLCB1 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.