Aliases for PLCB1 Gene
- Phospholipase C Beta 1 2 3 5
- PLC-I 2 3 4
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-1 3 4
- Phospholipase C, Beta 1 (Phosphoinositide-Specific) 2 3
- Phosphoinositide Phospholipase C 2 3
- Phospholipase C-I 3 4
- EC 220.127.116.11 4 50
- PLC-Beta-1 3 4
- KIAA0581 2 4
- PLC-154 3 4
- PLC154 2 3
- 1-Phosphatidyl-D-Myo-Inositol-4,5-Bisphosphate 3
External Ids for PLCB1 Gene
Previous GeneCards Identifiers for PLCB1 Gene
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PLCB1 Gene
PLCB1 (Phospholipase C Beta 1) is a Protein Coding gene. Diseases associated with PLCB1 include Developmental And Epileptic Encephalopathy 12 and Malignant Migrating Partial Seizures Of Infancy. Among its related pathways are Apelin signaling pathway and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is PLCB3.
UniProtKB/Swiss-Prot Summary for PLCB1 Gene
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier.
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.