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Aliases for PLBD2 Gene

Aliases for PLBD2 Gene

  • Phospholipase B Domain Containing 2 2 3 5
  • Mannose-6-Phosphate Protein Associated Protein P76 2 3
  • Phospholipase B Domain-Containing Protein 2 3 4
  • Putative Phospholipase B-Like 2 3 4
  • Lamina Ancestor Homolog 2 3 4
  • LAMA-Like Protein 2 3 4
  • 76 KDa Protein 3 4
  • P76 3 4
  • Phospholipase B-Like 2 32 KDa Form 3
  • Phospholipase B-Like 2 45 KDa Form 3
  • PLB Homolog 2 (Dictyostelium) 2
  • PLB Homolog 2 3
  • EC 3.1.1.- 4
  • EC 3.1.1 56

External Ids for PLBD2 Gene

Previous GeneCards Identifiers for PLBD2 Gene

  • GC12P112281
  • GC12P113796
  • GC12P110807

Summaries for PLBD2 Gene

GeneCards Summary for PLBD2 Gene

PLBD2 (Phospholipase B Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is PLBD1.

UniProtKB/Swiss-Prot for PLBD2 Gene

Additional gene information for PLBD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLBD2 Gene

Genomics for PLBD2 Gene

GeneHancer (GH) Regulatory Elements for PLBD2 Gene

Promoters and enhancers for PLBD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J113356 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 629.1 +0.3 330 4.6 ZNF652 SP1 ZFX CTCF ELF3 MNT CBFA2T2 NKRF POLR2A ZNF384 PLBD2 SLC8B1 LOC105369989 RBM19 DDX54 SDSL RITA1 ENSG00000201208 RPL6 SDS
GH12J113333 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.1 -24.4 -24365 3.2 SP1 ZFX ZKSCAN8 NKRF ZNF121 ZNF687 BACH1 SP7 POLR2A SP5 SLC8B1 RBM19 PLBD2 RPL6 GC12M113308
GH12J113421 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 +63.9 63904 2.4 ZFX ZNF148 MLLT1 GTF2F1 ZNF24 TRIM24 SP7 ELF1 POLR2A SP1 SDSL RBM19 PLBD2 SLC8B1 SDS
GH12J113235 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 11.1 -116.2 -116170 13.4 SP1 MNT CBFA2T2 ZNF121 NFIB AHR NCOA3 MAFK MYC SP7 RITA1 RASAL1 TPCN1 IQCD DDX54 ENSG00000201208 PLBD2 ENSG00000277566
GH12J113403 Promoter/Enhancer 1.2 Ensembl ENCODE 11.2 +45.5 45535 1 MAFK SP1 SMARCA4 RXRA IKZF1 PHF21A HDAC1 ZNF341 ZNF316 NFE2 SDSL PLBD2 LHX5 SDS LOC105369989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PLBD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PLBD2 gene promoter:
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • HSF1 (long)
  • HSF1short
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for PLBD2 Gene

Genomic Locations for PLBD2 Gene
33,064 bases
Plus strand
31,088 bases
Plus strand

Genomic View for PLBD2 Gene

Genes around PLBD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLBD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLBD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLBD2 Gene

Proteins for PLBD2 Gene

  • Protein details for PLBD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative phospholipase B-like 2
    Protein Accession:
    Secondary Accessions:
    • F5H5E2

    Protein attributes for PLBD2 Gene

    589 amino acids
    Molecular mass:
    65472 Da
    Quaternary structure:
    • Interacts with IGF2R.

    Alternative splice isoforms for PLBD2 Gene


neXtProt entry for PLBD2 Gene

Selected DME Specific Peptides for PLBD2 Gene


Post-translational modifications for PLBD2 Gene

  • The p76 protein is synthesized as a 80 kDa precursor which is then processed into a N-terminal 32 kDa form and a C-terminal 45 kDa form.
  • Glycosylated; contains mannose 6-phosphate sugars.
  • Glycosylation at isoforms=2110, posLast=8888, posLast=231231, isoforms=2465, isoforms=2436, and posLast=515515
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PLBL2_HUMAN (1700)

Other Protein References for PLBD2 Gene

Domains & Families for PLBD2 Gene

Gene Families for PLBD2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PLBD2 Gene


Suggested Antigen Peptide Sequences for PLBD2 Gene

GenScript: Design optimal peptide antigens:
  • Phospholipase B domain-containing protein 2 (PLBL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase B-like family.
  • Belongs to the phospholipase B-like family.
genes like me logo Genes that share domains with PLBD2: view

Function for PLBD2 Gene

Molecular function for PLBD2 Gene

UniProtKB/Swiss-Prot Function:
Putative phospholipase.

Enzyme Numbers (IUBMB) for PLBD2 Gene

Phenotypes From GWAS Catalog for PLBD2 Gene

Gene Ontology (GO) - Molecular Function for PLBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLBD2: view
genes like me logo Genes that share phenotypes with PLBD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLBD2

CRISPR Products

miRNA for PLBD2 Gene

Clone Products

  • Applied Biological Materials (abm): Clones for PLBD2 - Now 50% OFF >
  • * PLBD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLBD2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLBD2 Gene

Localization for PLBD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLBD2 Gene

Lysosome lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLBD2 gene
Compartment Confidence
lysosome 3
plasma membrane 1
extracellular 1
cytosol 1
cytoskeleton 0
mitochondrion 0
endoplasmic reticulum 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for PLBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043202 lysosomal lumen IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PLBD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PLBD2 Gene

Pathways & Interactions for PLBD2 Gene

PathCards logo

SuperPathways for PLBD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PLBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLBD2: view

No data available for Pathways by source and SIGNOR curated interactions for PLBD2 Gene

Drugs & Compounds for PLBD2 Gene

No Compound Related Data Available

Transcripts for PLBD2 Gene

mRNA/cDNA for PLBD2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for PLBD2 Gene

Phospholipase B domain containing 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PLBD2 - Now 50% OFF >
  • * PLBD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PLBD2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PLBD2 Gene

No ASD Table

Relevant External Links for PLBD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLBD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLBD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLBD2 Gene

This gene is overexpressed in Adrenal Gland (x6.0).

Protein differential expression in normal tissues from HIPED for PLBD2 Gene

This gene is overexpressed in Liver (33.9), Amniocyte (12.7), and Adrenal (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PLBD2 Gene

Protein tissue co-expression partners for PLBD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PLBD2 Gene:


SOURCE GeneReport for Unigene cluster for PLBD2 Gene:


mRNA Expression by UniProt/SwissProt for PLBD2 Gene:

Tissue specificity: Ubiquitously expressed, with highest levels in heart, brain and liver.

Evidence on tissue expression from TISSUES for PLBD2 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with PLBD2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLBD2 Gene

Orthologs for PLBD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLBD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PLBD2 34 35
  • 99.02 (n)
(Bos Taurus)
Mammalia PLBD2 35 34
  • 86.13 (n)
(Mus musculus)
Mammalia Plbd2 17 35 34
  • 85.19 (n)
(Rattus norvegicus)
Mammalia Plbd2 34
  • 83.81 (n)
(Canis familiaris)
Mammalia PLBD2 34 35
  • 82.81 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
-- 35
  • 61 (a)
(Monodelphis domestica)
Mammalia PLBD2 35
  • 68 (a)
(Gallus gallus)
Aves PLBD2 34 35
  • 73.19 (n)
(Anolis carolinensis)
Reptilia PLBD2 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia plbd2 34
  • 64 (n)
fruit fly
(Drosophila melanogaster)
Insecta lama 35
  • 20 (a)
(Caenorhabditis elegans)
Secernentea Y37D8A.2 35 34
  • 49.56 (n)
F09B12.3 35
  • 38 (a)
Y54F10AM.8 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
-- 35
  • 40 (a)
Species where no ortholog for PLBD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PLBD2 Gene

Gene Tree for PLBD2 (if available)
Gene Tree for PLBD2 (if available)
Evolutionary constrained regions (ECRs) for PLBD2: view image

Paralogs for PLBD2 Gene

Paralogs for PLBD2 Gene

genes like me logo Genes that share paralogs with PLBD2: view

Variants for PLBD2 Gene

Sequence variations from dbSNP and Humsavar for PLBD2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000071535 -- 113,364,805(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000244651 -- 113,364,145(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000302217 -- 113,365,375(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000334826 -- 113,377,871(+) G/C intron_variant
rs1000367197 -- 113,382,397(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PLBD2 Gene

Variant ID Type Subtype PubMed ID
esv2746381 CNV deletion 23290073
esv3630792 CNV gain 21293372
esv3630797 CNV loss 21293372
esv3892265 CNV gain 25118596
nsv1127292 CNV deletion 24896259
nsv519540 CNV gain+loss 19592680

Variation tolerance for PLBD2 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PLBD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLBD2 Gene

Disorders for PLBD2 Gene

Additional Disease Information for PLBD2

No disorders were found for PLBD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLBD2 Gene

Publications for PLBD2 Gene

  1. Biochemical characterization and lysosomal localization of the mannose-6-phosphate protein p76 (hypothetical protein LOC196463). (PMID: 17105447) Jensen AG … Journet A (The Biochemical journal 2007) 2 3 4 58
  2. Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast. (PMID: 15193148) Morgan CP … Cockcroft S (The Biochemical journal 2004) 2 3 58
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. Quantitative analysis of PPT1 interactome in human neuroblastoma cells. (PMID: 26217791) Scifo E … Lalowski M (Data in brief 2015) 3 58

Products for PLBD2 Gene

Sources for PLBD2 Gene

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